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Protein

Death domain-containing membrane protein NRADD

Gene

Nradd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity). Both isoform 1 and isoform 2 promote apoptosis.By similarity2 Publications

GO - Molecular functioni

  • neurotrophin p75 receptor binding Source: RGD

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • brain development Source: RGD
  • in utero embryonic development Source: RGD
  • positive regulation of cell death Source: RGD
  • signal transduction Source: InterPro

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Death domain-containing membrane protein NRADD
Alternative name(s):
Neurotrophin receptor homolog-2
Short name:
NRH2
Neurotrophin receptor-alike death domain protein
P75-like apoptosis-inducing death domain protein
Short name:
PLAIDD
Gene namesi
Name:Nradd
Synonyms:Nrh2, Plaidd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi708524 Nradd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 73Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini74 – 228CytoplasmicSequence analysisAdd BLAST155

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004153841 – 228Death domain-containing membrane protein NRADDAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Isoform 1 is N-glycosylated. Isoform 2 is not N-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K5A9
PRIDEiQ8K5A9

PTM databases

iPTMnetiQ8K5A9
PhosphoSitePlusiQ8K5A9

Expressioni

Tissue specificityi

Detected in embryo, including embryonic brain. Detected at very low levels in adult testis, spleen, thymus and lung.1 Publication

Developmental stagei

Highly expressed in embryo. Expressed at very low levels in adult.1 Publication

Gene expression databases

BgeeiENSRNOG00000020936 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiQ8K5A9 RN

Interactioni

Subunit structurei

Interacts with NTRK1 (By similarity). Isoform 1 and isoform 2 interact with NGFR. Interacts with SORT1.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8K5A9, 2 interactors
MINTiQ8K5A9
STRINGi10116.ENSRNOP00000028416

Structurei

3D structure databases

SMRiQ8K5A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 222DeathPROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 142Poly-Gln4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J99A Eukaryota
ENOG4111D5W LUCA
GeneTreeiENSGT00730000110974
HOGENOMiHOG000147886
HOVERGENiHBG071107
InParanoidiQ8K5A9
OMAiGCRLYLH
OrthoDBiEOG091G0QZB
PhylomeDBiQ8K5A9
TreeFamiTF106466

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PfamiView protein in Pfam
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8K5A9-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLHNVSKGVV YSDTALKGQD GDREGMWVGA GGALAPNTSS LFPPEPPGAS
60 70 80 90 100
SNIIPVYCAL LATVVLGLLA YVAFKCWRSR KQRQQLAKAR TVELGDPDRD
110 120 130 140 150
QRHGDSSVFV DSPHGLEPCI PSQGPHADLG CRLYLHIPQQ QQEEVQRLLI
160 170 180 190 200
LGEPAKGWQG LAGQLGYQAE AVETMACDQD PAYALLRDWA AQEGSGATLR
210 220
VLEDALTAIG REDVVQVLSS PAEGCSVV
Length:228
Mass (Da):24,400
Last modified:January 25, 2012 - v2
Checksum:i8B9B243656DCC525
GO
Isoform 2 (identifier: Q8K5A9-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     13-61: Missing.

Show »
Length:179
Mass (Da):19,475
Checksum:i3BBACE605ED9BA52
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159Q → R in AAM28824 (PubMed:12095158).Curated1
Sequence conflicti159Q → R in AAM28825 (PubMed:12095158).Curated1
Sequence conflicti159Q → R in AAN05632 (PubMed:12728256).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04223713 – 61Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497263 mRNA Translation: AAM28824.1
AF497264 mRNA Translation: AAM28825.1
AF534395 mRNA Translation: AAN05632.1
CH473954 Genomic DNA Translation: EDL77074.1
RefSeqiNP_640352.1, NM_139259.2
XP_006243983.1, XM_006243921.2 [Q8K5A9-2]
UniGeneiRn.40242

Genome annotation databases

EnsembliENSRNOT00000028416; ENSRNOP00000028416; ENSRNOG00000020936 [Q8K5A9-1]
GeneIDi246143
KEGGirno:246143
UCSCiRGD:708524 rat [Q8K5A9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497263 mRNA Translation: AAM28824.1
AF497264 mRNA Translation: AAM28825.1
AF534395 mRNA Translation: AAN05632.1
CH473954 Genomic DNA Translation: EDL77074.1
RefSeqiNP_640352.1, NM_139259.2
XP_006243983.1, XM_006243921.2 [Q8K5A9-2]
UniGeneiRn.40242

3D structure databases

SMRiQ8K5A9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K5A9, 2 interactors
MINTiQ8K5A9
STRINGi10116.ENSRNOP00000028416

PTM databases

iPTMnetiQ8K5A9
PhosphoSitePlusiQ8K5A9

Proteomic databases

PaxDbiQ8K5A9
PRIDEiQ8K5A9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028416; ENSRNOP00000028416; ENSRNOG00000020936 [Q8K5A9-1]
GeneIDi246143
KEGGirno:246143
UCSCiRGD:708524 rat [Q8K5A9-1]

Organism-specific databases

CTDi67169
RGDi708524 Nradd

Phylogenomic databases

eggNOGiENOG410J99A Eukaryota
ENOG4111D5W LUCA
GeneTreeiENSGT00730000110974
HOGENOMiHOG000147886
HOVERGENiHBG071107
InParanoidiQ8K5A9
OMAiGCRLYLH
OrthoDBiEOG091G0QZB
PhylomeDBiQ8K5A9
TreeFamiTF106466

Miscellaneous databases

PROiPR:Q8K5A9

Gene expression databases

BgeeiENSRNOG00000020936 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiQ8K5A9 RN

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PfamiView protein in Pfam
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRADD_RAT
AccessioniPrimary (citable) accession number: Q8K5A9
Secondary accession number(s): G3V8U7, Q8K5A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 25, 2012
Last modified: November 7, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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