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Entry version 116 (18 Sep 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Sodium/calcium exchanger 2

Gene

Slc8a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the electrogenic exchange of Ca2+ against Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to cellular Ca2+ homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca2+ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:12818181). Plays a role in regulating urinary Ca2+ and Na+ excretion (PubMed:25498502).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Calcium transport is down-regulated by Na+ and stimulated by Ca2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi407Calcium 1By similarity1
Metal bindingi407Calcium 2By similarity1
Metal bindingi407Calcium 3By similarity1
Metal bindingi443Calcium 1By similarity1
Metal bindingi443Calcium 4By similarity1
Metal bindingi468Calcium 2By similarity1
Metal bindingi469Calcium 1By similarity1
Metal bindingi469Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi469Calcium 3By similarity1
Metal bindingi469Calcium 4By similarity1
Metal bindingi471Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi473Calcium 1By similarity1
Metal bindingi473Calcium 3By similarity1
Metal bindingi473Calcium 4By similarity1
Metal bindingi476Calcium 4By similarity1
Metal bindingi518Calcium 3By similarity1
Metal bindingi519Calcium 2By similarity1
Metal bindingi520Calcium 2By similarity1
Metal bindingi520Calcium 3By similarity1
Metal bindingi536Calcium 5By similarity1
Metal bindingi598Calcium 5By similarity1
Metal bindingi598Calcium 6By similarity1
Metal bindingi599Calcium 6By similarity1
Metal bindingi600Calcium 5; via carbonyl oxygenBy similarity1
Metal bindingi600Calcium 6By similarity1
Metal bindingi665Calcium 5By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processAntiport, Calcium transport, Ion transport, Sodium transport, Transport
LigandCalcium, Metal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-418359 Reduction of cytosolic Ca++ levels
R-MMU-425561 Sodium/Calcium exchangers
R-MMU-5578775 Ion homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/calcium exchanger 2
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 2
Solute carrier family 8 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc8a2Imported
Synonyms:Ncx21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107996 Slc8a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei721 – 741HelicalSequence analysisAdd BLAST21
Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Transmembranei786 – 806HelicalSequence analysisAdd BLAST21
Transmembranei823 – 843HelicalSequence analysisAdd BLAST21
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Transmembranei893 – 913HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No obvious phenotype. In hippocampus pyramidal neurons, calcium exchange activity is reduced by about half, suggesting that other, additional calcium exchangers are active in these neurons. In these neurons, the neurotransmitter glutamate triggers a sharp increase in cellular Ca2+ that does not depend on calcium exchanger activity. In contrast, the decrease to basal levels is mediated by calcium exchangers, and is considerably slower in mutant mice than in wild-type. Basal synaptic function is not impaired in mutant mice, but they display enhanced short-term plasticity and facilitated long-term potentiation, probably due to the slower decrease of Ca2+ after an initial impulse. Mutant mice display an increased capacity for spatial learning and memory (PubMed:12818181). Heterozygous mutants show increased basal urine volume and increased urinary secretion of Ca2+ and Na+ (PubMed:25498502).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043479621 – 921Sodium/calcium exchanger 2Add BLAST901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei622PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K596

PRoteomics IDEntifications database

More...
PRIDEi
Q8K596

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K596

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K596

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8K596

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in kidney cortex, in distal convoluted tubules and connecting segments (PubMed:25498502). Detected in brain and spinal cord (at protein level) (PubMed:12818181). Detected in brain, especially in hippocampus CA1, CA2 and CA3 fiels, dentate gyrus, cerebellum and brain cortex (PubMed:12818181).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030376 Expressed in 34 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8K596, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000128926

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8K596

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini389 – 482Calx-beta 1Sequence analysisAdd BLAST94
Domaini512 – 611Calx-beta 2Sequence analysisAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni248 – 267Putative calmodulin-binding regionBy similarityAdd BLAST20

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic Calx-beta domains bind the regulatory Ca2+. The first Calx-beta domain can bind up to four Ca2+ ions. The second domain can bind another two Ca2+ ions that are essential for calcium-regulated ion exchange.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1306 Eukaryota
ENOG410XPJP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158344

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000266971

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K596

KEGG Orthology (KO)

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KOi
K05849

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHSQCME

Database of Orthologous Groups

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OrthoDBi
490546at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K596

TreeFam database of animal gene trees

More...
TreeFami
TF314308

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR004836 Na_Ca_Ex
IPR032452 Na_Ca_Ex_C-exten
IPR004837 NaCa_Exmemb

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160 Calx-beta, 2 hits
PF01699 Na_Ca_ex, 2 hits
PF16494 Na_Ca_ex_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01259 NACAEXCHNGR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237 Calx_beta, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072 SSF141072, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00845 caca, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8K596-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPLALMGVV LLLGVPHCLG EATPTPSLPP PTANDSDASP EGCQGSYRCQ
60 70 80 90 100
PGVLLPVWEP EDPSLGDKVA RAVVYFVAMV YMFLGVSIIA DRFMASIEVI
110 120 130 140 150
TSKEKEITIT KANGETSVGT VRIWNETVSN LTLMALGSSA PEILLTVIEV
160 170 180 190 200
CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC VYVIPAGESR KIKHLRVFFV
210 220 230 240 250
TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLIFFPVCV VFAWMADKRL
260 270 280 290 300
LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGTE VPGELGALGT
310 320 330 340 350
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLMGIAKY YALLHQQKSR
360 370 380 390 400
AFYRIQATRL MTGAGNVLRR HAADAARRPG ATDGAPDDED DGASRIFFEP
410 420 430 440 450
SLYHCLENCG SVLLSVACQG GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT
460 470 480 490 500
LVFKPGETQK DLRIGIIDDD IFEEDEHFFV RLLNLRVGDA QGMFEPDGGG
510 520 530 540 550
RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT VDVRVVRSSG
560 570 580 590 600
ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE
610 620 630 640 650
YEKKDNFFIE LGQPQWLKRG ISALLLNQGN GDKKITAEQE EAQRIAEMGK
660 670 680 690 700
PVLGENNRLE VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFIEAVT
710 720 730 740 750
VSAGDEEEDE DGPREERLPS CFDYVMHFLT VFWKVLFACV PPTEYCNGWA
760 770 780 790 800
CFGVCILVIG VLTALIGDLA SHFGCTVGLK DSVNAVVFVA LGTSIPDTFA
810 820 830 840 850
SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY WAVQGRPFEV
860 870 880 890 900
RAGTLAFSVT LFTVFAFVCI AVLLYRRRPQ IGGELGGPRG PKLATTALFL
910 920
GLWFLYILFS SLEAYCHIRG F
Length:921
Mass (Da):100,711
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F5A378FF982073D
GO
Isoform 2 (identifier: Q8K596-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-628: Missing.

Show »
Length:915
Mass (Da):100,059
Checksum:i7ECA46A5FD88D85D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti260Y → C in BAB85834 (PubMed:12581871).Curated1
Sequence conflicti387D → G in BAB85834 (PubMed:12581871).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057980623 – 628Missing in isoform 2. 6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF503502 mRNA Translation: AAM22231.1
AC151733 Genomic DNA No translation available.
CH466654 Genomic DNA Translation: EDL42109.1
BC058704 mRNA Translation: AAH58704.1
BC080277 mRNA Translation: AAH80277.1
AB080745 mRNA Translation: BAB85834.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS20845.1 [Q8K596-1]
CCDS85220.1 [Q8K596-2]

NCBI Reference Sequences

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RefSeqi
NP_001334490.1, NM_001347561.1 [Q8K596-2]
NP_683748.1, NM_148946.3 [Q8K596-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000168693; ENSMUSP00000128926; ENSMUSG00000030376 [Q8K596-2]
ENSMUST00000211649; ENSMUSP00000147497; ENSMUSG00000030376 [Q8K596-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
110891

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:110891

UCSC genome browser

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UCSCi
uc009fgz.1 mouse [Q8K596-1]
uc012fac.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503502 mRNA Translation: AAM22231.1
AC151733 Genomic DNA No translation available.
CH466654 Genomic DNA Translation: EDL42109.1
BC058704 mRNA Translation: AAH58704.1
BC080277 mRNA Translation: AAH80277.1
AB080745 mRNA Translation: BAB85834.1
CCDSiCCDS20845.1 [Q8K596-1]
CCDS85220.1 [Q8K596-2]
RefSeqiNP_001334490.1, NM_001347561.1 [Q8K596-2]
NP_683748.1, NM_148946.3 [Q8K596-1]

3D structure databases

SMRiQ8K596
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8K596, 1 interactor
STRINGi10090.ENSMUSP00000128926

PTM databases

iPTMnetiQ8K596
PhosphoSitePlusiQ8K596
SwissPalmiQ8K596

Proteomic databases

PaxDbiQ8K596
PRIDEiQ8K596

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168693; ENSMUSP00000128926; ENSMUSG00000030376 [Q8K596-2]
ENSMUST00000211649; ENSMUSP00000147497; ENSMUSG00000030376 [Q8K596-1]
GeneIDi110891
KEGGimmu:110891
UCSCiuc009fgz.1 mouse [Q8K596-1]
uc012fac.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6543
MGIiMGI:107996 Slc8a2

Phylogenomic databases

eggNOGiKOG1306 Eukaryota
ENOG410XPJP LUCA
GeneTreeiENSGT00940000158344
HOGENOMiHOG000266971
InParanoidiQ8K596
KOiK05849
OMAiAHSQCME
OrthoDBi490546at2759
PhylomeDBiQ8K596
TreeFamiTF314308

Enzyme and pathway databases

ReactomeiR-MMU-418359 Reduction of cytosolic Ca++ levels
R-MMU-425561 Sodium/Calcium exchangers
R-MMU-5578775 Ion homeostasis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Slc8a2 mouse

Protein Ontology

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PROi
PR:Q8K596

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030376 Expressed in 34 organ(s), highest expression level in brain

Family and domain databases

Gene3Di2.60.40.2030, 2 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR004836 Na_Ca_Ex
IPR032452 Na_Ca_Ex_C-exten
IPR004837 NaCa_Exmemb
PfamiView protein in Pfam
PF03160 Calx-beta, 2 hits
PF01699 Na_Ca_ex, 2 hits
PF16494 Na_Ca_ex_C, 1 hit
PRINTSiPR01259 NACAEXCHNGR
SMARTiView protein in SMART
SM00237 Calx_beta, 2 hits
SUPFAMiSSF141072 SSF141072, 2 hits
TIGRFAMsiTIGR00845 caca, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAC2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K596
Secondary accession number(s): Q68EG0, Q8R504
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 9, 2015
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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