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Protein

Trem-like transcript 1 protein

Gene

Treml1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface receptor that may play a role in the innate and adaptive immune response.1 Publication

GO - Molecular functioni

  • signaling receptor activity Source: MGI

GO - Biological processi

  • calcium-mediated signaling Source: MGI
  • negative regulation of signal transduction Source: MGI
  • platelet activation Source: UniProtKB
  • wound healing Source: UniProtKB

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Trem-like transcript 1 protein
Short name:
TLT-1
Alternative name(s):
Triggering receptor expressed on myeloid cells-like protein 1
Gene namesi
Name:Treml1
Synonyms:Tlt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1918576 Treml1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 175ExtracellularSequence analysisAdd BLAST155
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 317CytoplasmicSequence analysisAdd BLAST121

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025385621 – 317Trem-like transcript 1 proteinAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 105By similarity
Disulfide bondi53 ↔ 60By similarity
Lipidationi208S-palmitoyl cysteineBy similarity1
Modified residuei283PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ8K558
PeptideAtlasiQ8K558
PRIDEiQ8K558

PTM databases

iPTMnetiQ8K558
PhosphoSitePlusiQ8K558

Expressioni

Tissue specificityi

Highly expressed in bone marrow leukocytes, splenic megakaryocytes and platelets. Detected in brain, liver and in peritoneal monocytes.2 Publications

Gene expression databases

BgeeiENSMUSG00000023993
ExpressionAtlasiQ8K558 baseline and differential
GenevisibleiQ8K558 MM

Interactioni

Subunit structurei

When phosphorylated, interacts with PTPN11 (By similarity). When phosphorylated, interacts with PTPN6.By similarity1 Publication

Protein-protein interaction databases

BioGridi214639, 1 interactor
IntActiQ8K558, 1 interactor
MINTiQ8K558
STRINGi10090.ENSMUSP00000024792

Structurei

3D structure databases

ProteinModelPortaliQ8K558
SMRiQ8K558
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 122Ig-like V-typeAdd BLAST102

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi284 – 289ITIM6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 275Pro-richAdd BLAST31

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKSQ Eukaryota
ENOG411182M LUCA
GeneTreeiENSGT00470000042300
HOGENOMiHOG000154685
HOVERGENiHBG094092
InParanoidiQ8K558
KOiK14363
OMAiCHYRLQD
OrthoDBiEOG091G0TD0
PhylomeDBiQ8K558
TreeFamiTF337145

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDCYLLLLLL LLGLAGQGSA DSHPEVLQAP VGSSILVQCH YRLQDVRALK
60 70 80 90 100
VWCQFLQEGC HPLVTSAVDR RAPGNGRIFL TDLGGGLLQV EMVTLQEEDT
110 120 130 140 150
GEYGCVVEGA AGPQTLHRVS LLVLPPVPGP REGEEAEDEK ETYRIGTGSL
160 170 180 190 200
LEDPSLDPSA SAGPHEFRRR ENSIPLIWGA VLLLALVVVA VVIFAVMARK
210 220 230 240 250
KGNRLVVCGP SQSTGVPGMD PPSAAHRSSD SGLPSDIPHV RLDSPPSFDS
260 270 280 290 300
IYTGSSLDPP SSEPPAPPSQ PPLPPKVLMS SKSVTYATVV FPGGDKGKIA
310
SCEPVQDPPN SQTPPSK
Length:317
Mass (Da):33,522
Last modified:October 17, 2006 - v2
Checksum:i097E16B34D03E87B
GO
Isoform 2 (identifier: Q8K558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: S → RCQKQC

Show »
Length:322
Mass (Da):34,182
Checksum:i64E06AA0F2AAF34F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021127173S → RCQKQC in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078502 mRNA Translation: AAL85488.1
AY286071 mRNA Translation: AAP33393.1
AK017256 mRNA Translation: BAB30655.1
BC138399 mRNA Translation: AAI38400.1
CCDSiCCDS28866.1 [Q8K558-2]
RefSeqiNP_001276380.1, NM_001289451.1
NP_001276386.1, NM_001289457.1 [Q8K558-1]
NP_082039.1, NM_027763.2 [Q8K558-2]
UniGeneiMm.90177

Genome annotation databases

EnsembliENSMUST00000024792; ENSMUSP00000024792; ENSMUSG00000023993 [Q8K558-1]
ENSMUST00000224001; ENSMUSP00000153300; ENSMUSG00000023993 [Q8K558-2]
ENSMUST00000229215; ENSMUSP00000154866; ENSMUSG00000116425 [Q8K558-2]
ENSMUST00000229919; ENSMUSP00000154832; ENSMUSG00000116425 [Q8K558-1]
GeneIDi71326
KEGGimmu:71326
UCSCiuc008cxm.2 mouse [Q8K558-2]
uc008cxn.2 mouse [Q8K558-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRML1_MOUSE
AccessioniPrimary (citable) accession number: Q8K558
Secondary accession number(s): B2RRH0, Q9D3N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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