Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

One cut domain family member 3

Gene

Onecut3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi309 – 395CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi411 – 470HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 3
Alternative name(s):
One cut homeobox 3
Transcription factor ONECUT-3
Short name:
OC-3
Gene namesi
Name:Onecut3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1891409 Onecut3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002712191 – 490One cut domain family member 3Add BLAST490

Proteomic databases

MaxQBiQ8K557
PaxDbiQ8K557
PRIDEiQ8K557

PTM databases

PhosphoSitePlusiQ8K557

Expressioni

Tissue specificityi

Specifically expressed in brain, stomach and gut. Within the gut, expressed only in duodenum and jejunum.1 Publication

Developmental stagei

Expressed in the endoderm from the 14-somite stage. Aroound E9.5, present in the ventral prepancreatic and prehepatic regions (at protein level). At E14.5, expressed in brain, stomach and gut.2 Publications

Inductioni

Transcriptionally regulated by ONECUT1 in the developing endoderm.1 Publication

Gene expression databases

BgeeiENSMUSG00000045518
CleanExiMM_ONECUT3
GenevisibleiQ8K557 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053288

Structurei

3D structure databases

ProteinModelPortaliQ8K557
SMRiQ8K557
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 102Gly-richAdd BLAST61
Compositional biasi136 – 238Pro-richAdd BLAST103
Compositional biasi253 – 312Gly-richAdd BLAST60

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252 Eukaryota
ENOG410YWY4 LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000232114
HOVERGENiHBG005981
InParanoidiQ8K557
OMAiAMTMSCD
OrthoDBiEOG091G0E7H
PhylomeDBiQ8K557
TreeFamiTF318206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 1 hit
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS51042 CUT, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSLESLGG LHGVTHAQAG ELLSPGHARS AAAQHRSLVA SGRPGLVAGM
60 70 80 90 100
ASLLDGGGAG GGGAGGAGAA GAAGGGPDFR GELAGPLHPA MGMACEAPGL
110 120 130 140 150
GGTYTTLTPL QHLPPLAAVA DKFHQHAVAG AHGGHPHAHP HPATAPPPPP
160 170 180 190 200
PQRLAASVSG SFTLMRDERA ALASVGHLYG PYGKELPTMG SPLSPLPSAL
210 220 230 240 250
PPALHSAPQP PPPPPLAAYG APGHLAGDKL LPPAAFEPHA ALLGRAEDAL
260 270 280 290 300
ARGLPGGGGG AGGGGAAGGA AAGLLAPLGG LAAAGAHGPH SGGGGPGGGG
310 320 330 340 350
GAGGGSGGPG AGAAAEEINT KEVAQRITAE LKRYSIPQAI FAQRILCRSQ
360 370 380 390 400
GTLSDLLRNP KPWSKLKSGR ETFRRMWKWL QEPEFQRMSA LRLAACKRKE
410 420 430 440 450
QDQQKERALQ PKKQRLVFTD LQRRTLIAIF KENKRPSKEM QATISQQLGL
460 470 480 490
ELNTVSNFFM NARRRCMNRW AEEPGATPGT GTATATFSKA
Length:490
Mass (Da):49,571
Last modified:January 9, 2007 - v2
Checksum:iD9030944CED1BA06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64A → R in AAL86921 (PubMed:11944891).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY080897 mRNA Translation: AAL86921.1
BC058700 mRNA Translation: AAH58700.1
CCDSiCCDS24023.1
RefSeqiNP_631972.2, NM_139226.3
UniGeneiMm.250572

Genome annotation databases

EnsembliENSMUST00000051773; ENSMUSP00000053288; ENSMUSG00000045518
GeneIDi246086
KEGGimmu:246086
UCSCiuc007gdn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiONEC3_MOUSE
AccessioniPrimary (citable) accession number: Q8K557
Secondary accession number(s): Q6PDH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health