Fndc5

Functionⁱ

Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.1 Publication

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of brown fat cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 22237023
response to muscle activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22237023

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fibronectin type III domain-containing protein 5 Alternative name(s): Fibronectin type III repeat-containing protein 2 Peroxisomal protein Short name: PeP Cleaved into the following chain: Irisin
Gene namesⁱ	Name:Fndc5 Synonyms:Frcp2, Pep
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1917614 Fndc5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	29 – 149	ExtracellularSequence analysisAdd BLAST	121
Transmembraneⁱ	150 – 170	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	171 – 209	CytoplasmicSequence analysisAdd BLAST	39

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Peroxisome, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST	28
ChainⁱPRO_0000328972	29 – 209	Fibronectin type III domain-containing protein 5Add BLAST	181
ChainⁱPRO_0000415858	29 – 140	IrisinAdd BLAST	112

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	36	N-linked (GlcNAc...) asparagine1 Publication		1
Glycosylationⁱ	81	N-linked (GlcNAc...) asparagine1 Publication		1

Post-translational modificationⁱ

The extracellular domain is cleaved and released from the cell membrane.

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q8K4Z2
PRIDEⁱ	Q8K4Z2

PTM databases

iPTMnetⁱ	Q8K4Z2
PhosphoSitePlusⁱ	Q8K4Z2

Expressionⁱ

Tissue specificityⁱ

In adult, it is highly expressed in skeletal muscle, heart and brain.2 Publications

Developmental stageⁱ

During embryonic development, it is detected almost exclusively in the skeletal muscle, and at lower level in brain. In skeletal muscle, it is induced after myoblast differentiation, when myotube formation is promoted.1 Publication

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000001334 Expressed in 184 organ(s), highest expression level in cardiac ventricle
Genevisibleⁱ	Q8K4Z2 MM

Interactionⁱ

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q8K4Z2, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q8K4Z2
STRINGⁱ	10090.ENSMUSP00000099660

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8K4Z2
SMRⁱ	Q8K4Z2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 124	Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST		92

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	207 – 209	Microbody targeting signalSequence analysis		3

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IESX Eukaryota ENOG410YC2F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004923
HOGENOMⁱ	HOG000082536
HOVERGENⁱ	HBG067308
InParanoidⁱ	Q8K4Z2
OMAⁱ	VTMKEMA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HLN
PhylomeDBⁱ	Q8K4Z2
TreeFamⁱ	TF325415

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 1 hit
SMARTⁱ	View protein in SMART SM00060 FN3, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8K4Z2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPPGPCAWPP RAALRLWLGC VCFALVQADS PSAPVNVTVR HLKANSAVVS 
        60         70         80         90        100
WDVLEDEVVI GFAISQQKKD VRMLRFIQEV NTTTRSCALW DLEEDTEYIV 
       110        120        130        140        150
HVQAISIQGQ SPASEPVLFK TPREAEKMAS KNKDEVTMKE MGRNQQLRTG 
       160        170        180        190        200
EVLIIVVVLF MWAGVIALFC RQYDIIKDNE PNNNKEKTKS ASETSTPEHQ 

GGGLLRSKI

Length:209

Mass (Da):23,321

Last modified:October 1, 2002 - v1

Checksum:ⁱ86A33DE8E4616507

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	13 – 14	AL → VV in BAB23815 (PubMed:16141072).Curated	2
Sequence conflictⁱ	64	I → L in BAB23815 (PubMed:16141072).Curated	1
Sequence conflictⁱ	124	E → A in BAB23815 (PubMed:16141072).Curated	1
Sequence conflictⁱ	130	S → P in BAB23815 (PubMed:16141072).Curated	1
Sequence conflictⁱ	158	V → C in BAB23815 (PubMed:16141072).Curated	1
Sequence conflictⁱ	171	R → A in BAB23815 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ401376 mRNA Translation: CAC82194.1 AK005096 mRNA Translation: BAB23815.1 AL606977 Genomic DNA No translation available. BC109183 mRNA Translation: AAI09184.1 BC109184 mRNA Translation: AAI09185.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18683.1
NCBI Reference Sequences More...RefSeqⁱ	NP_081678.1, NM_027402.4
UniGeneⁱ	Mm.44075

Genome annotation databases

Ensemblⁱ	ENSMUST00000102600; ENSMUSP00000099660; ENSMUSG00000001334
GeneIDⁱ	384061
KEGGⁱ	mmu:384061
UCSC genome browser More...UCSCⁱ	uc008uwe.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8K4Z2	Fibronectin type III domain-containing protein 5		RAT		209	UniRef100_Q8K4Z2

Protein	Similar proteins		Species	Score	Length	Source
Q8K4Z2	Fibronectin type III domain-containing protein 5		RAT		209	UniRef90_Q8K4Z2
Uncharacterized protein		PROCO		252
UPI0006436467		MICMU		261
UPI00038C3F5C		MICOH		210
UPI00035020A9		HETGA		210
+3

Protein	Similar proteins		Species	Score	Length	Source
Q8K4Z2	Fibronectin type III domain-containing protein 5		RAT		209	UniRef50_Q8K4Z2
Fibronectin type III domain-containing protein 5	)	HUMAN		212
Uncharacterized protein		PROCO		252
Uncharacterized protein		AOTNA		227
Fibronectin type III domain containing 5		PANTR		228
+156

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ401376 mRNA Translation: CAC82194.1 AK005096 mRNA Translation: BAB23815.1 AL606977 Genomic DNA No translation available. BC109183 mRNA Translation: AAI09184.1 BC109184 mRNA Translation: AAI09185.1
CCDSⁱ	CCDS18683.1
RefSeqⁱ	NP_081678.1, NM_027402.4
UniGeneⁱ	Mm.44075

3D structure databases

ProteinModelPortalⁱ	Q8K4Z2
SMRⁱ	Q8K4Z2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8K4Z2, 1 interactor
MINTⁱ	Q8K4Z2
STRINGⁱ	10090.ENSMUSP00000099660

PTM databases

iPTMnetⁱ	Q8K4Z2
PhosphoSitePlusⁱ	Q8K4Z2

Proteomic databases

PaxDbⁱ	Q8K4Z2
PRIDEⁱ	Q8K4Z2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000102600; ENSMUSP00000099660; ENSMUSG00000001334
GeneIDⁱ	384061
KEGGⁱ	mmu:384061
UCSCⁱ	uc008uwe.1 mouse

Organism-specific databases

CTDⁱ	252995
MGIⁱ	MGI:1917614 Fndc5

Phylogenomic databases

eggNOGⁱ	ENOG410IESX Eukaryota ENOG410YC2F LUCA
GeneTreeⁱ	ENSGT00390000004923
HOGENOMⁱ	HOG000082536
HOVERGENⁱ	HBG067308
InParanoidⁱ	Q8K4Z2
OMAⁱ	VTMKEMA
OrthoDBⁱ	EOG091G0HLN
PhylomeDBⁱ	Q8K4Z2
TreeFamⁱ	TF325415

Miscellaneous databases

ChiTaRSⁱ	Fndc5 mouse
Protein Ontology More...PROⁱ	PR:Q8K4Z2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001334 Expressed in 184 organ(s), highest expression level in cardiac ventricle
Genevisibleⁱ	Q8K4Z2 MM

Family and domain databases

CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold
Pfamⁱ	View protein in Pfam PF00041 fn3, 1 hit
SMARTⁱ	View protein in SMART SM00060 FN3, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FNDC5_MOUSE
Accessionⁱ	Q8K4Z2Primary (citable) accession number: Q8K4Z2 Secondary accession number(s): Q9DB97
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
	Last sequence update:	October 1, 2002
	Last modified:	September 12, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8K4Z2 (FNDC5_MOUSE)

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Fibronectin type III domain-containing protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Peroxisome

Plasma membrane

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Peroxisome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ