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UniProtKB - Q8K4Z0 (LGI2_MOUSE)
Protein
Leucine-rich repeat LGI family member 2
Gene
Lgi2
Organism
Mus musculus (Mouse)
Status
Functioni
Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells.
1 PublicationGO - Biological processi
- inhibitory synapse assembly Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-MMU-5682910, LGI-ADAM interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat LGI family member 2Alternative name(s): Leucine-rich glioma-inactivated protein 2 |
Gene namesi | Name:Lgi2 Synonyms:Kiaa1916 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2180196, Lgi2 |
VEuPathDBi | HostDB:ENSMUSG00000039252 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000017709 | 26 – 550 | Leucine-rich repeat LGI family member 2Add BLAST | 525 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 276 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 407 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q8K4Z0 |
PaxDbi | Q8K4Z0 |
PeptideAtlasi | Q8K4Z0 |
PRIDEi | Q8K4Z0 |
ProteomicsDBi | 265066 [Q8K4Z0-1] 265067 [Q8K4Z0-2] |
PTM databases
GlyConnecti | 2425, 2 N-Linked glycans (1 site) [Q8K4Z0-2] |
GlyGeni | Q8K4Z0, 4 sites |
PhosphoSitePlusi | Q8K4Z0 |
Expressioni
Tissue specificityi
Brain.1 Publication
Developmental stagei
Expressed in developing parvalbumin-positive basket cells.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000039252, Expressed in conjunctival fornix and 241 other tissues |
Genevisiblei | Q8K4Z0, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000040436 |
Miscellaneous databases
RNActi | Q8K4Z0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 62 | LRRNTAdd BLAST | 37 | |
Repeati | 83 – 104 | LRR 1Add BLAST | 22 | |
Repeati | 107 – 128 | LRR 2Add BLAST | 22 | |
Domaini | 140 – 190 | LRRCTAdd BLAST | 51 | |
Repeati | 224 – 266 | EAR 1PROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 270 – 312 | EAR 2PROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 316 – 363 | EAR 3PROSITE-ProRule annotationAdd BLAST | 48 | |
Repeati | 365 – 408 | EAR 4PROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 412 – 455 | EAR 5PROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 457 – 499 | EAR 6PROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 503 – 545 | EAR 7PROSITE-ProRule annotationAdd BLAST | 43 |
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QR53, Eukaryota |
GeneTreei | ENSGT00940000157294 |
InParanoidi | Q8K4Z0 |
OMAi | EAMFSHM |
OrthoDBi | 365688at2759 |
PhylomeDBi | Q8K4Z0 |
TreeFami | TF333155 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR009039, EAR IPR005492, EPTP IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF03736, EPTP, 6 hits PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 2 hits SM00082, LRRCT, 1 hit |
PROSITEi | View protein in PROSITE PS50912, EAR, 7 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8K4Z0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALWRGGGAL GLLLLSAACL IPPSAQVRRL ARCPATCSCT KESIICVGSS
60 70 80 90 100
WVPRIVPGDI SSLSLVNGTF LEIKDRMFSH LPSLQLLLLN SNSFTVIRDD
110 120 130 140 150
AFAGLFHLEY LFIEGNKIET ISRNAFRGLR DLTHLDLRGN KFECDCKAKW
160 170 180 190 200
LYLWLKMTNS TVSDVLCIGP PEYQEKKLNE VTSFDYECTT TGPQTDEAKQ
210 220 230 240 250
RGWQLELSLG FCELIFVFQH PLSDFVVHQT LPYQSVSVDT FNSKNDVYVA
260 270 280 290 300
IAQPSMENCM VLEWDHIEMN FRSYDNITGQ SIVGCKAILI DDQVFVVVAQ
310 320 330 340 350
LFGGSHIYKY DESWTKFVKF QDIEVSRISK PNDIELFEID DETFFIIADS
360 370 380 390 400
SKAGLSTVYK WNSKGFYSYQ SLHEWFRDTD AEFVDIDGKS HLILSSRSQV
410 420 430 440 450
PIILQWNKSS KKFVPHGDIP NMEDVLAVKS FRMQNTLYLS LTRFIGDSRV
460 470 480 490 500
MRWNSKQFVE VQALPSRGAM TLQPFSFKDN HYLALGSDYT FSQIYQWDKE
510 520 530 540 550
KQQFKKFKEI YVQAPRSFTA VSTDRRDFFF ASSFKGKTKI FEHIIVDLSL
Sequence cautioni
The sequence BAC65852 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007680 | 135 | L → LSLANNHIKALPRDVFSDLD SLIEL in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_007681 | 192 – 223 | Missing in isoform 2. CuratedAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ487515 mRNA Translation: CAD31783.1 AK122570 mRNA Translation: BAC65852.1 Different initiation. |
CCDSi | CCDS19285.1 [Q8K4Z0-1] CCDS80281.1 [Q8K4Z0-2] |
RefSeqi | NP_001297533.1, NM_001310604.1 [Q8K4Z0-2] NP_659194.1, NM_144945.3 [Q8K4Z0-1] |
Genome annotation databases
Ensembli | ENSMUST00000039750; ENSMUSP00000040436; ENSMUSG00000039252 [Q8K4Z0-1] ENSMUST00000199942; ENSMUSP00000143707; ENSMUSG00000039252 [Q8K4Z0-2] |
GeneIDi | 246316 |
KEGGi | mmu:246316 |
UCSCi | uc008xkm.1, mouse [Q8K4Z0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ487515 mRNA Translation: CAD31783.1 AK122570 mRNA Translation: BAC65852.1 Different initiation. |
CCDSi | CCDS19285.1 [Q8K4Z0-1] CCDS80281.1 [Q8K4Z0-2] |
RefSeqi | NP_001297533.1, NM_001310604.1 [Q8K4Z0-2] NP_659194.1, NM_144945.3 [Q8K4Z0-1] |
3D structure databases
SMRi | Q8K4Z0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000040436 |
PTM databases
GlyConnecti | 2425, 2 N-Linked glycans (1 site) [Q8K4Z0-2] |
GlyGeni | Q8K4Z0, 4 sites |
PhosphoSitePlusi | Q8K4Z0 |
Proteomic databases
MaxQBi | Q8K4Z0 |
PaxDbi | Q8K4Z0 |
PeptideAtlasi | Q8K4Z0 |
PRIDEi | Q8K4Z0 |
ProteomicsDBi | 265066 [Q8K4Z0-1] 265067 [Q8K4Z0-2] |
Protocols and materials databases
Antibodypediai | 2543, 149 antibodies from 31 providers |
DNASUi | 246316 |
Genome annotation databases
Ensembli | ENSMUST00000039750; ENSMUSP00000040436; ENSMUSG00000039252 [Q8K4Z0-1] ENSMUST00000199942; ENSMUSP00000143707; ENSMUSG00000039252 [Q8K4Z0-2] |
GeneIDi | 246316 |
KEGGi | mmu:246316 |
UCSCi | uc008xkm.1, mouse [Q8K4Z0-1] |
Organism-specific databases
CTDi | 55203 |
MGIi | MGI:2180196, Lgi2 |
VEuPathDBi | HostDB:ENSMUSG00000039252 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR53, Eukaryota |
GeneTreei | ENSGT00940000157294 |
InParanoidi | Q8K4Z0 |
OMAi | EAMFSHM |
OrthoDBi | 365688at2759 |
PhylomeDBi | Q8K4Z0 |
TreeFami | TF333155 |
Enzyme and pathway databases
Reactomei | R-MMU-5682910, LGI-ADAM interactions |
Miscellaneous databases
BioGRID-ORCSi | 246316, 0 hits in 49 CRISPR screens |
ChiTaRSi | Lgi2, mouse |
PROi | PR:Q8K4Z0 |
RNActi | Q8K4Z0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039252, Expressed in conjunctival fornix and 241 other tissues |
Genevisiblei | Q8K4Z0, MM |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR009039, EAR IPR005492, EPTP IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF03736, EPTP, 6 hits PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 2 hits SM00082, LRRCT, 1 hit |
PROSITEi | View protein in PROSITE PS50912, EAR, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LGI2_MOUSE | |
Accessioni | Q8K4Z0Primary (citable) accession number: Q8K4Z0 Secondary accession number(s): Q80T76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 3, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot