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Protein

Leucine-rich repeat LGI family member 2

Gene

Lgi2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-5682910 LGI-ADAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat LGI family member 2
Alternative name(s):
Leucine-rich glioma-inactivated protein 2
Gene namesi
Name:Lgi2
Synonyms:Kiaa1916
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2180196 Lgi2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001770926 – 550Leucine-rich repeat LGI family member 2Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K4Z0
PeptideAtlasiQ8K4Z0
PRIDEiQ8K4Z0

PTM databases

PhosphoSitePlusiQ8K4Z0

Expressioni

Gene expression databases

BgeeiENSMUSG00000039252 Expressed in 215 organ(s), highest expression level in conjunctival fornix
CleanExiMM_LGI2
ExpressionAtlasiQ8K4Z0 baseline and differential
GenevisibleiQ8K4Z0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040436

Structurei

3D structure databases

ProteinModelPortaliQ8K4Z0
SMRiQ8K4Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 62LRRNTAdd BLAST37
Repeati83 – 104LRR 1Add BLAST22
Repeati107 – 128LRR 2Add BLAST22
Domaini140 – 190LRRCTAdd BLAST51
Repeati224 – 266EAR 1PROSITE-ProRule annotationAdd BLAST43
Repeati270 – 312EAR 2PROSITE-ProRule annotationAdd BLAST43
Repeati316 – 363EAR 3PROSITE-ProRule annotationAdd BLAST48
Repeati365 – 408EAR 4PROSITE-ProRule annotationAdd BLAST44
Repeati412 – 455EAR 5PROSITE-ProRule annotationAdd BLAST44
Repeati457 – 499EAR 6PROSITE-ProRule annotationAdd BLAST43
Repeati503 – 545EAR 7PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIXR Eukaryota
ENOG410XSZV LUCA
GeneTreeiENSGT00930000150915
HOGENOMiHOG000286015
HOVERGENiHBG036744
InParanoidiQ8K4Z0
OMAiNTQIFEH
OrthoDBiEOG091G03ZX
PhylomeDBiQ8K4Z0
TreeFamiTF333155

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03736 EPTP, 6 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 2 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 7 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8K4Z0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALWRGGGAL GLLLLSAACL IPPSAQVRRL ARCPATCSCT KESIICVGSS
60 70 80 90 100
WVPRIVPGDI SSLSLVNGTF LEIKDRMFSH LPSLQLLLLN SNSFTVIRDD
110 120 130 140 150
AFAGLFHLEY LFIEGNKIET ISRNAFRGLR DLTHLDLRGN KFECDCKAKW
160 170 180 190 200
LYLWLKMTNS TVSDVLCIGP PEYQEKKLNE VTSFDYECTT TGPQTDEAKQ
210 220 230 240 250
RGWQLELSLG FCELIFVFQH PLSDFVVHQT LPYQSVSVDT FNSKNDVYVA
260 270 280 290 300
IAQPSMENCM VLEWDHIEMN FRSYDNITGQ SIVGCKAILI DDQVFVVVAQ
310 320 330 340 350
LFGGSHIYKY DESWTKFVKF QDIEVSRISK PNDIELFEID DETFFIIADS
360 370 380 390 400
SKAGLSTVYK WNSKGFYSYQ SLHEWFRDTD AEFVDIDGKS HLILSSRSQV
410 420 430 440 450
PIILQWNKSS KKFVPHGDIP NMEDVLAVKS FRMQNTLYLS LTRFIGDSRV
460 470 480 490 500
MRWNSKQFVE VQALPSRGAM TLQPFSFKDN HYLALGSDYT FSQIYQWDKE
510 520 530 540 550
KQQFKKFKEI YVQAPRSFTA VSTDRRDFFF ASSFKGKTKI FEHIIVDLSL
Length:550
Mass (Da):63,006
Last modified:October 1, 2002 - v1
Checksum:i56974B9DE663CCD1
GO
Isoform 2 (identifier: Q8K4Z0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: L → LSLANNHIKALPRDVFSDLDSLIEL
     192-223: Missing.

Show »
Length:542
Mass (Da):62,012
Checksum:iAE6FF7E087E652C2
GO

Sequence cautioni

The sequence BAC65852 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007680135L → LSLANNHIKALPRDVFSDLD SLIEL in isoform 2. Curated1
Alternative sequenceiVSP_007681192 – 223Missing in isoform 2. CuratedAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487515 mRNA Translation: CAD31783.1
AK122570 mRNA Translation: BAC65852.1 Different initiation.
CCDSiCCDS19285.1 [Q8K4Z0-1]
CCDS80281.1 [Q8K4Z0-2]
RefSeqiNP_001297533.1, NM_001310604.1 [Q8K4Z0-2]
NP_659194.1, NM_144945.3 [Q8K4Z0-1]
UniGeneiMm.44721

Genome annotation databases

EnsembliENSMUST00000039750; ENSMUSP00000040436; ENSMUSG00000039252 [Q8K4Z0-1]
ENSMUST00000199942; ENSMUSP00000143707; ENSMUSG00000039252 [Q8K4Z0-2]
GeneIDi246316
KEGGimmu:246316
UCSCiuc008xkm.1 mouse [Q8K4Z0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487515 mRNA Translation: CAD31783.1
AK122570 mRNA Translation: BAC65852.1 Different initiation.
CCDSiCCDS19285.1 [Q8K4Z0-1]
CCDS80281.1 [Q8K4Z0-2]
RefSeqiNP_001297533.1, NM_001310604.1 [Q8K4Z0-2]
NP_659194.1, NM_144945.3 [Q8K4Z0-1]
UniGeneiMm.44721

3D structure databases

ProteinModelPortaliQ8K4Z0
SMRiQ8K4Z0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040436

PTM databases

PhosphoSitePlusiQ8K4Z0

Proteomic databases

PaxDbiQ8K4Z0
PeptideAtlasiQ8K4Z0
PRIDEiQ8K4Z0

Protocols and materials databases

DNASUi246316
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039750; ENSMUSP00000040436; ENSMUSG00000039252 [Q8K4Z0-1]
ENSMUST00000199942; ENSMUSP00000143707; ENSMUSG00000039252 [Q8K4Z0-2]
GeneIDi246316
KEGGimmu:246316
UCSCiuc008xkm.1 mouse [Q8K4Z0-1]

Organism-specific databases

CTDi55203
MGIiMGI:2180196 Lgi2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IIXR Eukaryota
ENOG410XSZV LUCA
GeneTreeiENSGT00930000150915
HOGENOMiHOG000286015
HOVERGENiHBG036744
InParanoidiQ8K4Z0
OMAiNTQIFEH
OrthoDBiEOG091G03ZX
PhylomeDBiQ8K4Z0
TreeFamiTF333155

Enzyme and pathway databases

ReactomeiR-MMU-5682910 LGI-ADAM interactions

Miscellaneous databases

PROiPR:Q8K4Z0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039252 Expressed in 215 organ(s), highest expression level in conjunctival fornix
CleanExiMM_LGI2
ExpressionAtlasiQ8K4Z0 baseline and differential
GenevisibleiQ8K4Z0 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03736 EPTP, 6 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 2 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLGI2_MOUSE
AccessioniPrimary (citable) accession number: Q8K4Z0
Secondary accession number(s): Q80T76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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