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Protein

Leucine-rich glioma-inactivated protein 1

Gene

Lgi1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: Ensembl
  • positive regulation of cell growth Source: Ensembl
  • positive regulation of synaptic transmission Source: UniProtKB
  • protein homooligomerization Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-RNO-5682910 LGI-ADAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich glioma-inactivated protein 1
Gene namesi
Name:Lgi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628742 Lgi1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi383E → A: Fails to bind to ADAM22. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001770735 – 557Leucine-rich glioma-inactivated protein 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K4Y5
PRIDEiQ8K4Y5

PTM databases

iPTMnetiQ8K4Y5
PhosphoSitePlusiQ8K4Y5
SwissPalmiQ8K4Y5

Expressioni

Tissue specificityi

Expressed in brain. High levels found in hippocampus, thalamic nuclei, neocortex, and molecular and granule cell layers of the cerebellum.1 Publication

Gene expression databases

BgeeiENSRNOG00000014758
GenevisibleiQ8K4Y5 RN

Interactioni

Subunit structurei

Oligomer. Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1. Can bind to ADAM11 and ADAM23 (By similarity). Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2 (stargazin).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251653, 1 interactor
STRINGi10116.ENSRNOP00000020411

Structurei

3D structure databases

ProteinModelPortaliQ8K4Y5
SMRiQ8K4Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 72LRRNTAdd BLAST38
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 137LRR 2Add BLAST22
Repeati140 – 161LRR 3Add BLAST22
Domaini173 – 223LRRCTAdd BLAST51
Repeati225 – 267EAR 1PROSITE-ProRule annotationAdd BLAST43
Repeati271 – 313EAR 2PROSITE-ProRule annotationAdd BLAST43
Repeati317 – 364EAR 3PROSITE-ProRule annotationAdd BLAST48
Repeati366 – 415EAR 4PROSITE-ProRule annotationAdd BLAST50
Repeati419 – 462EAR 5PROSITE-ProRule annotationAdd BLAST44
Repeati464 – 506EAR 6PROSITE-ProRule annotationAdd BLAST43
Repeati510 – 552EAR 7PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIXR Eukaryota
ENOG410XSZV LUCA
GeneTreeiENSGT00920000148954
HOGENOMiHOG000286015
HOVERGENiHBG036744
InParanoidiQ8K4Y5
OMAiFTQVYRW
OrthoDBiEOG091G03ZX
PhylomeDBiQ8K4Y5
TreeFamiTF333155

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03736 EPTP, 7 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESESIRRMG NACIPLKRIA YFLCLFSVVL LTEGKKPAKP KCPAVCTCSK
60 70 80 90 100
DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS
110 120 130 140 150
NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN
160 170 180 190 200
LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK LKWLVEWLGH TNATVEDIYC
210 220 230 240 250
EGPPEYKKRK INSLSPKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV
260 270 280 290 300
VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IDTQLYVIVA
310 320 330 340 350
QLFGGSHIYK RDGFANKFIK IQDIEVLKIR KPNDIETFKI EDNWYFVVAD
360 370 380 390 400
SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIARP PLTLRTPHLI
410 420 430 440 450
LSSSSQRPVI YQWSKATQLF INQTDIPNME DVYAVKHFSV KGDVYICLTR
460 470 480 490 500
FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ
510 520 530 540 550
VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH

VIVDLSA
Length:557
Mass (Da):63,728
Last modified:October 1, 2002 - v1
Checksum:i2296F36B6C91C32B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487517 mRNA Translation: CAD31785.1
BC089222 mRNA Translation: AAH89222.1
RefSeqiNP_665712.1, NM_145769.3
UniGeneiRn.83615

Genome annotation databases

EnsembliENSRNOT00000020411; ENSRNOP00000020411; ENSRNOG00000014758
GeneIDi252892
KEGGirno:252892
UCSCiRGD:628742 rat

Similar proteinsi

Entry informationi

Entry nameiLGI1_RAT
AccessioniPrimary (citable) accession number: Q8K4Y5
Secondary accession number(s): Q5FWS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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