UniProtKB - Q8K4S3 (S45A1_RAT)
Protein
Proton-associated sugar transporter A
Gene
Slc45a1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Proton-associated glucose transporter in the brain.1 Publication
GO - Molecular functioni
- glucose transmembrane transporter activity Source: RGD
- sucrose:proton symporter activity Source: GO_Central
GO - Biological processi
- glucose transmembrane transport Source: RGD
Keywordsi
Biological process | Sugar transport, Symport, Transport |
Protein family/group databases
TCDBi | 2.A.2.4.4, the glycoside-pentoside-hexuronide (gph):cation symporter family |
Names & Taxonomyi
Protein namesi | Recommended name: Proton-associated sugar transporter A1 PublicationShort name: PAST-A1 Publication Alternative name(s): Solute carrier family 45 member 1 |
Gene namesi | Name:Slc45a1 Synonyms:Dnb5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708502, Slc45a1 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 233 – 253 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 536 – 556 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 576 – 596 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 606 – 626 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 630 – 650 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 688 – 708 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 710 – 730 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122516 | 1 – 751 | Proton-associated sugar transporter AAdd BLAST | 751 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 500 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q8K4S3 |
PRIDEi | Q8K4S3 |
Expressioni
Tissue specificityi
Predominantly expressed in brain.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0637, Eukaryota |
InParanoidi | Q8K4S3 |
PhylomeDBi | Q8K4S3 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8K4S3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIPPAGSTPP GEALIPSVAP QDFWRSPISG YSGSVTRHIS HRANNFKRHP
60 70 80 90 100
KRRKYIRPSP PPPPNTPCPI ELVDFEDLHP QRSFWELLFN GCILFGIEFS
110 120 130 140 150
YAMETAYVTP VLLQMGLPDQ LYSLVWFISP ILGFLLQPLL GAWSDRCTSR
160 170 180 190 200
FGRRRPFILV LAIGALLGLS LLLNGRDIGM ALADTATNHK WGILLTVCGV
210 220 230 240 250
VLMDFSADSA DNPSHAYMMD VCGPVDQDRG LNIHALMAGL GGGFGYVVGG
260 270 280 290 300
IHWDKTSFGR ALGGQLRVIY IFTAITLSVT TVFTLVSIPE RPLRPLGEKR
310 320 330 340 350
TAMKSPSLPL PPSPPVLLEE GAGDTLPSTT ATSLYASFSS PISPPSPLTP
360 370 380 390 400
KYGSFISRDS SLTGINEFAS SFGTSNIDSV LIDCFTAGHD NYLALPSSVP
410 420 430 440 450
RQAISVSFPR APDGFYCQER GLERREGPLT LGLDGDVLRV GSLDTSKPRA
460 470 480 490 500
SGILKRPQTL ALPDVAGGNG PETSRRRNVT FSQQVANILL NGVKYESELT
510 520 530 540 550
GSSEQSEQPL SLRRLCSTIY NMPRPVRNLC VNHFLGWLSF EGMLLFYTDF
560 570 580 590 600
MGEVVFQGDP KAPHASEAYQ KYNSGVTMGC WGMCIYAFSA AFYSAILEKL
610 620 630 640 650
EECLSVRTLY FIAYLLFGLG TGLATLSRNL YVVLSLCTHY GILFSTLCTL
660 670 680 690 700
PYSLLCDYYQ SKKFAGSSAD GTRRGMGVDI SLLSCQYFLA QILVSLVLGP
710 720 730 740 750
LTSAVGSANG VMYFASLVSF LGCLYSSLCV TYEIPSADAA DEERQPLLLN
V
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2QC36 | A0A0G2QC36_RAT | Proton-associated sugar transporter... | Slc45a1 rCG_30837 | 752 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075229 mRNA Translation: BAB97313.1 |
Genome annotation databases
UCSCi | RGD:708502, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075229 mRNA Translation: BAB97313.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024581 |
Protein family/group databases
TCDBi | 2.A.2.4.4, the glycoside-pentoside-hexuronide (gph):cation symporter family |
Proteomic databases
PaxDbi | Q8K4S3 |
PRIDEi | Q8K4S3 |
Genome annotation databases
UCSCi | RGD:708502, rat |
Organism-specific databases
RGDi | 708502, Slc45a1 |
Phylogenomic databases
eggNOGi | KOG0637, Eukaryota |
InParanoidi | Q8K4S3 |
PhylomeDBi | Q8K4S3 |
Miscellaneous databases
PROi | PR:Q8K4S3 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S45A1_RAT | |
Accessioni | Q8K4S3Primary (citable) accession number: Q8K4S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | August 12, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families