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Protein

Gap junction alpha-8 protein

Gene

Gja8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

  • cell-cell signaling Source: RGD
  • lens development in camera-type eye Source: Ensembl
  • protein homooligomerization Source: RGD
  • transmembrane transport Source: GOC

Enzyme and pathway databases

ReactomeiR-RNO-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-8 protein
Alternative name(s):
Connexin-50
Short name:
Cx50
Gene namesi
Name:Gja8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi628890 Gja8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 46HelicalSequence analysisAdd BLAST23
Topological domaini47 – 76ExtracellularSequence analysisAdd BLAST30
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Topological domaini100 – 157CytoplasmicSequence analysisAdd BLAST58
Transmembranei158 – 180HelicalSequence analysisAdd BLAST23
Topological domaini181 – 209ExtracellularSequence analysisAdd BLAST29
Transmembranei210 – 229HelicalSequence analysisAdd BLAST20
Topological domaini230 – 440CytoplasmicSequence analysisAdd BLAST211

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Gja8 are the cause of cataract.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130051 – 440Gap junction alpha-8 proteinAdd BLAST440

Proteomic databases

PaxDbiQ8K4Q9

Expressioni

Gene expression databases

BgeeiENSRNOG00000046703
ExpressionAtlasiQ8K4Q9 differential

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066975

Structurei

3D structure databases

SMRiQ8K4Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
GeneTreeiENSGT00910000143998
HOVERGENiHBG009576
InParanoidiQ8K4Q9
OMAiLRTYICH
OrthoDBiEOG091G0FKH
PhylomeDBiQ8K4Q9

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002266 Connexin50
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF19 PTHR11984:SF19, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF03509 Connexin50, 1 hit
PRINTSiPR00206 CONNEXIN
PR01137 CONNEXINA8
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K4Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS
60 70 80 90 100
DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL MYVGHAVHHV
110 120 130 140 150
RMEEKRKDRE AEELCQQSRS NGGERVPIAP DQASIRKSSS SSKGTKKFRL
160 170 180 190 200
EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY GFRILPLYRC SRWPCPNVVD
210 220 230 240 250
CFVSRPTEKT IFILFMLSVA FVSLFLNIME MSHLGMKGIR SAFKRPAEQP
260 270 280 290 300
LGEIAEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVETSPLS
310 320 330 340 350
AKPFSQFEEK IGTGPLADMS RGYQETLPSY AQVGAQEVER EEQPVEEAVE
360 370 380 390 400
PEVGEKKQEA EKVAPEGQET VAVPDGEKVE TPGVGKDDEK EELQAEKVTK
410 420 430 440
QGLSAEKAPT LCPELTTDDN RPLSRLSKAS SRARSDDLTI
Length:440
Mass (Da):49,401
Last modified:October 1, 2002 - v1
Checksum:iDDF57B9D6E1016AF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti340R → W in cataract. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078344 Genomic DNA Translation: BAC06574.1
UniGeneiRn.86658

Genome annotation databases

EnsembliENSRNOT00000071622; ENSRNOP00000066975; ENSRNOG00000046703

Similar proteinsi

Entry informationi

Entry nameiCXA8_RAT
AccessioniPrimary (citable) accession number: Q8K4Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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