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UniProtKB - Q8K4P8 (HECW1_MOUSE)

Entry version 138 (23 Feb 2022)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase HECW1

Gene

Hecw1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1.

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1572Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-4641258, Degradation of DVL

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HECW1 (EC:2.3.2.26)
Alternative name(s):
HECT, C2 and WW domain-containing protein 1
HECT-type E3 ubiquitin transferase HECW1
NEDD4-like E3 ubiquitin-protein ligase 1
Short name:
mNEDL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hecw1
Synonyms:Kiaa0322, Nedl1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2444115, Hecw1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000021301

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002776661 – 1604E3 ubiquitin-protein ligase HECW1Add BLAST1604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei871PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8K4P8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8K4P8

PeptideAtlas

More...PeptideAtlasi		Q8K4P8

PRoteomics IDEntifications database

More...PRIDEi		Q8K4P8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		269687 [Q8K4P8-1]
269688 [Q8K4P8-2]
269689 [Q8K4P8-3]
269690 [Q8K4P8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8K4P8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8K4P8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in neurons of the spinal cord.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000021301, Expressed in lumbar subsegment of spinal cord and 139 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8K4P8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DVL1 and SSR3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		220495, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q8K4P8, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000106145

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8K4P8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8K4P8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 318C2PROSITE-ProRule annotationAdd BLAST137
Domaini826 – 859WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini1016 – 1049WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini1269 – 1604HECTPROSITE-ProRule annotationAdd BLAST336

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni350 – 539DisorderedSequence analysisAdd BLAST190
Regioni570 – 604DisorderedSequence analysisAdd BLAST35
Regioni642 – 667DisorderedSequence analysisAdd BLAST26
Regioni727 – 826DisorderedSequence analysisAdd BLAST100
Regioni890 – 936DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili871 – 898Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi358 – 383Polar residuesSequence analysisAdd BLAST26
Compositional biasi398 – 413Polar residuesSequence analysisAdd BLAST16
Compositional biasi503 – 517Acidic residuesSequence analysisAdd BLAST15
Compositional biasi652 – 667Polar residuesSequence analysisAdd BLAST16
Compositional biasi744 – 758Polar residuesSequence analysisAdd BLAST15
Compositional biasi918 – 936Polar residuesSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0940, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158294

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002173_14_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8K4P8

Identification of Orthologs from Complete Genome Data

More...OMAi		GPWHDEL

Database of Orthologous Groups

More...OrthoDBi		117748at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8K4P8

TreeFam database of animal gene trees

More...TreeFami		TF313938

Family and domain databases

Conserved Domains Database

More...CDDi		cd08691, C2_NEDL1-like, 1 hit
cd00078, HECTc, 1 hit
cd00201, WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037795, C2_HECW
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR040524, HECW1_helix
IPR032348, HECW_N
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF00632, HECT, 1 hit
PF18436, HECW1_helix, 1 hit
PF16562, HECW_N, 1 hit
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00119, HECTc, 1 hit
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 1 hit
SSF51045, SSF51045, 2 hits
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS50237, HECT, 1 hit
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Named isoforms=2.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K4P8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN 
        60         70         80         90        100
IDIRNGAHDA ITIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW 
       110        120        130        140        150
DIKEEVDAGD WIGMYLIGEV SSENFLDYKN RGVNGSHRGQ IIWKIDASSY 
       160        170        180        190        200
FVESETKICF KYYHGVSGAL RATTPSVTVK NSAAPIFKGI GSEETAQSQG 
       210        220        230        240        250
SRRLISFSLS DFQAMGLKKG MFFNPDPYLK ISIQPGKHSI FPALPHHGQE 
       260        270        280        290        300
RRSTIIGNTV NPIWQAEHFS FVSLPTDVLE IEVKDKFAKS RPIIKRFLGK 
       310        320        330        340        350
LSMPVQRLLE RHAIGDRVVS YTLGRRLPTD HVSGQLQFRF EITSSIHADD 
       360        370        380        390        400
EEISLSAEPE SSAETQDSIM NSMVGNSNGE PSGDATEFCK DAKPESPSEG 
       410        420        430        440        450
NGVNSSENQN QEHAGPVEEA AGAMEARDGS NVSEAPEEPG ELQDPEQHDT 
       460        470        480        490        500
QPTLSAEEVA EGLPLDEDSP SSLLPEENTA LGSKVEEETV PENGAREEEM 
       510        520        530        540        550
QKGKDEEEEE EDVSTLEQGE PGLELRVSVR KKSRPCSLPV SELETVIASA 
       560        570        580        590        600
CGDAETPRTH YIRIHTLLHS MPSAQRGSTT EEEDGLEEES TLKESSEKDG 
       610        620        630        640        650
LSEVDTIAAD PQSMEDGESD GATLCMAPSD CSGGHFSSLS KGIGAGQDGE 
       660        670        680        690        700
AHPSTGSESD SSPQQGADHS CEGCDASCCS PSCYSTSCYS SSCYSSSCYS 
       710        720        730        740        750
SSCYNGNNRF ASHTRFSSVD SAKISESTVF SSQEDEEEEN SAFESVPDSV 
       760        770        780        790        800
QSPELDPEST NGAGPWQDEL AAPGGNAARS TEGLESPMAG PSNRREGECP 
       810        820        830        840        850
ILHNSQPISQ LPSLRPEHHH YPTIDEPLPP NWEARIDSHG RVFYVDHINR 
       860        870        880        890        900
TTTWQRPSMA PTPDGMIRSG SVHQMEQLNR RYQNIQRTMA TERAEEDSGN 
       910        920        930        940        950
QNSEQIPDGG GGGGGGSDSE AESSQSSLDL RREGSLSPVN SQKVTLLLQS 
       960        970        980        990       1000
PAVKFITNPE FFTVLHANYS AYRVFTSSTC LKHMILKVRR DARNFERYQH 
      1010       1020       1030       1040       1050
NRDLVNFINM FADTRLELPR GWEIKTDHQG KSFFVDHNSR ATTFIDPRIP 
      1060       1070       1080       1090       1100
LQNGRLPNHL THRQHLQRLR SYSAGEASEV SRNRGASLLA RPGHSLIAAI 
      1110       1120       1130       1140       1150
RSQHQHESLP LAYNDKIVAF LRQPNIFEML QERQPSLARN HTLREKIHYI 
      1160       1170       1180       1190       1200
RTEGNHGLDK LSCDADLVIL LSLFEEEIMS YVPLQSAFHP GYSFSPRCSP 
      1210       1220       1230       1240       1250
CSSPQNSPGL QRASARAPSP YRRDFEAKLR NFYRKLEAKG FGQGPGKIKL 
      1260       1270       1280       1290       1300
IIRRDHLLEG TFNQVMAYSR KELQRNKLYI TFVGEEGLDY SGPSREFFFL 
      1310       1320       1330       1340       1350
LSQELFNPYY GLFEYSANDT YTVQISPMSA FVENYLEWFR FSGRILGLAL 
      1360       1370       1380       1390       1400
IHQYLLDAFF TRPFYKGLLK LPCDLSDLEY LDEEFHQSLQ WMKDNNITDI 
      1410       1420       1430       1440       1450
LDLTFTVNEE VFGQVTEREL KSGGANTQVT EKNKKEYIER MVKWRVERGV 
      1460       1470       1480       1490       1500
VQQTEALLRG FYEVVDSRLV SVFDARELEL VIAGTAEIDL NDWRNNTEYR 
      1510       1520       1530       1540       1550
GGYHDGHLVI RWFWAAVERF NNEQRLRLLQ FVTGTSSVPY EGFAALRGSN 
      1560       1570       1580       1590       1600
GLRRFCIEKW GKITSLPRAH TCFNRLDLPP YPSYSMLYEK LLTAVEETST 

FGLE
Length:1,604
Mass (Da):179,467
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0643EE0129A08E0D
GO
Isoform 2 (identifier: Q8K4P8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     782-795: Missing.

Show »
Length:1,590
Mass (Da):177,984
Checksum:i51C7D0DA9432CED2
GO
Isoform 3 (identifier: Q8K4P8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MLLHLCSV → MICAQLEAA
     316-1604: Missing.

Show »
Length:316
Mass (Da):35,504
Checksum:iE3336039B30263B4
GO
Isoform 4 (identifier: Q8K4P8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-1604: Missing.

Show »
Length:315
Mass (Da):35,470
Checksum:i2D5E366B748ED3E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJ05A0A1Y7VJ05_MOUSE
HECT-type E3 ubiquitin transferase
Hecw1
1,177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJ41A0A1Y7VJ41_MOUSE
E3 ubiquitin-protein ligase HECW1
Hecw1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJB7A0A1Y7VJB7_MOUSE
E3 ubiquitin-protein ligase HECW1
Hecw1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VMF2A0A1Y7VMF2_MOUSE
E3 ubiquitin-protein ligase HECW1
Hecw1
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC28516 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167S → R in BAB97389 (PubMed:14684739).Curated1
Sequence conflicti823T → A in BAB97389 (PubMed:14684739).Curated1
Sequence conflicti1036D → G in BAB97389 (PubMed:14684739).Curated1
Sequence conflicti1248I → V in BAB97389 (PubMed:14684739).Curated1
Sequence conflicti1356L → P in BAB97389 (PubMed:14684739).Curated1
Sequence conflicti1538V → M in BAB97389 (PubMed:14684739).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0230741 – 8MLLHLCSV → MICAQLEAA in isoform 3. 1 Publication8
Alternative sequenceiVSP_023075316 – 1604Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST1289
Alternative sequenceiVSP_023076782 – 795Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK033922 mRNA Translation: BAC28516.1 Different initiation.
AK047678 mRNA Translation: BAC33122.1
AK051569 mRNA Translation: BAC34677.1
AK053694 mRNA Translation: BAC35477.1
AC092710 Genomic DNA No translation available.
AC154511 Genomic DNA No translation available.
AC154615 Genomic DNA No translation available.
AC161249 Genomic DNA No translation available.
CT025604 Genomic DNA No translation available.
AB083710 mRNA Translation: BAB97389.1
AK172932 mRNA Translation: BAD32210.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS49207.1 [Q8K4P8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001074817.3, NM_001081348.3 [Q8K4P8-1]
XP_006516873.1, XM_006516810.3 [Q8K4P8-1]
XP_006516874.1, XM_006516811.1 [Q8K4P8-1]
XP_006516875.1, XM_006516812.3 [Q8K4P8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000110516; ENSMUSP00000106145; ENSMUSG00000021301 [Q8K4P8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		94253

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:94253

UCSC genome browser

More...UCSCi		uc007pnd.2, mouse [Q8K4P8-1]
uc007png.2, mouse [Q8K4P8-4]
uc007pnh.2, mouse [Q8K4P8-3]
uc011ywk.1, mouse [Q8K4P8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033922 mRNA Translation: BAC28516.1 Different initiation.
AK047678 mRNA Translation: BAC33122.1
AK051569 mRNA Translation: BAC34677.1
AK053694 mRNA Translation: BAC35477.1
AC092710 Genomic DNA No translation available.
AC154511 Genomic DNA No translation available.
AC154615 Genomic DNA No translation available.
AC161249 Genomic DNA No translation available.
CT025604 Genomic DNA No translation available.
AB083710 mRNA Translation: BAB97389.1
AK172932 mRNA Translation: BAD32210.1
CCDSiCCDS49207.1 [Q8K4P8-1]
RefSeqiNP_001074817.3, NM_001081348.3 [Q8K4P8-1]
XP_006516873.1, XM_006516810.3 [Q8K4P8-1]
XP_006516874.1, XM_006516811.1 [Q8K4P8-1]
XP_006516875.1, XM_006516812.3 [Q8K4P8-1]

3D structure databases

SMRiQ8K4P8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi220495, 2 interactors
IntActiQ8K4P8, 1 interactor
STRINGi10090.ENSMUSP00000106145

PTM databases

iPTMnetiQ8K4P8
PhosphoSitePlusiQ8K4P8

Proteomic databases

MaxQBiQ8K4P8
PaxDbiQ8K4P8
PeptideAtlasiQ8K4P8
PRIDEiQ8K4P8
ProteomicsDBi269687 [Q8K4P8-1]
269688 [Q8K4P8-2]
269689 [Q8K4P8-3]
269690 [Q8K4P8-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1996, 51 antibodies from 16 providers

The DNASU plasmid repository

More...DNASUi		94253

Genome annotation databases

EnsembliENSMUST00000110516; ENSMUSP00000106145; ENSMUSG00000021301 [Q8K4P8-1]
GeneIDi94253
KEGGimmu:94253
UCSCiuc007pnd.2, mouse [Q8K4P8-1]
uc007png.2, mouse [Q8K4P8-4]
uc007pnh.2, mouse [Q8K4P8-3]
uc011ywk.1, mouse [Q8K4P8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23072
MGIiMGI:2444115, Hecw1
VEuPathDBiHostDB:ENSMUSG00000021301

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG0940, Eukaryota
GeneTreeiENSGT00940000158294
HOGENOMiCLU_002173_14_0_1
InParanoidiQ8K4P8
OMAiGPWHDEL
OrthoDBi117748at2759
PhylomeDBiQ8K4P8
TreeFamiTF313938

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-4641258, Degradation of DVL

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		94253, 1 hit in 63 CRISPR screens

Protein Ontology

More...PROi		PR:Q8K4P8
RNActiQ8K4P8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000021301, Expressed in lumbar subsegment of spinal cord and 139 other tissues
GenevisibleiQ8K4P8, MM

Family and domain databases

CDDicd08691, C2_NEDL1-like, 1 hit
cd00078, HECTc, 1 hit
cd00201, WW, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037795, C2_HECW
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR040524, HECW1_helix
IPR032348, HECW_N
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00632, HECT, 1 hit
PF18436, HECW1_helix, 1 hit
PF16562, HECW_N, 1 hit
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00119, HECTc, 1 hit
SM00456, WW, 2 hits
SUPFAMiSSF49562, SSF49562, 1 hit
SSF51045, SSF51045, 2 hits
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50237, HECT, 1 hit
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHECW1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K4P8
Secondary accession number(s): D3YZ67
, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 27, 2011
Last modified: February 23, 2022
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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