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Protein

Neuropeptide B

Gene

Npb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of feeding, neuroendocrine system, memory and learning. May be involved in the afferent pain pathway (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide B
Alternative name(s):
Preproprotein L7
Short name:
rPPL7
Cleaved into the following chain:
Neuropeptide B-29
Short name:
NPB29
Alternative name(s):
L7C
Gene namesi
Name:Npb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi708513 Npb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PeptideiPRO_000001984122 – 50Neuropeptide B-29Add BLAST29
PropeptideiPRO_000001984253 – 119Sequence analysisAdd BLAST67

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8K4P2

Expressioni

Tissue specificityi

Detected in a variety of tissues. High levels are found in the lymphoid organs, central nervous system, mammary gland and uterus.

Gene expression databases

BgeeiENSRNOG00000036685

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051836

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J07G Eukaryota
ENOG41120QH LUCA
GeneTreeiENSGT00390000013683
HOGENOMiHOG000231239
HOVERGENiHBG039578
InParanoidiQ8K4P2
KOiK05267
OMAiWYKPAAG
OrthoDBiEOG091G0VSK
PhylomeDBiQ8K4P2
TreeFamiTF333179

Family and domain databases

InterProiView protein in InterPro
IPR013298 Neuropept_B_pre
IPR013297 Neuropept_BW_pre
PANTHERiPTHR28553 PTHR28553, 1 hit
PfamiView protein in Pfam
PF15180 NPBW, 1 hit
PRINTSiPR01888 NROPEPTIDEBW
PR01889 PPNRPEPTIDEB
ProDomiView protein in ProDom or Entries sharing at least one domain
PD685249 PD685249, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRCRTLVAA ALALLLTPAL AWYKPAAGSH HYSVGRAAGL LSSFHRFPST
60 70 80 90 100
RRSESPALRV GTVPLRNLEM RPSVRSLALC VKDVTPNLQS CQRQLNSRGT
110
FQCKADVFLS LHKAECQSA
Length:119
Mass (Da):13,019
Last modified:October 1, 2002 - v1
Checksum:i6C2F5B9E6251CAC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085944 mRNA Translation: BAC07177.1
RefSeqiNP_695205.1, NM_153293.1
UniGeneiRn.66426

Genome annotation databases

EnsembliENSRNOT00000054953; ENSRNOP00000051836; ENSRNOG00000036685
GeneIDi259222
KEGGirno:259222

Similar proteinsi

Entry informationi

Entry nameiNPB_RAT
AccessioniPrimary (citable) accession number: Q8K4P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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