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Protein

pre-mRNA 3' end processing protein WDR33

Gene

Wdr33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.By similarity

GO - Biological processi

  • mRNA polyadenylation Source: GO_Central

Keywordsi

Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
pre-mRNA 3' end processing protein WDR33
Alternative name(s):
WD repeat-containing protein 33
WD repeat-containing protein of 146 kDa1 Publication
Gene namesi
Name:Wdr33
Synonyms:Wdc1461 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1921570 Wdr33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004152912 – 1330pre-mRNA 3' end processing protein WDR33Add BLAST1329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei46N6-acetyllysineCombined sources1
Cross-linki526Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki530Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei776Omega-N-methylarginineBy similarity1
Modified residuei909Asymmetric dimethylarginineCombined sources1
Modified residuei981Omega-N-methylarginineCombined sources1
Modified residuei1028Omega-N-methylarginineCombined sources1
Modified residuei1204PhosphoserineBy similarity1
Modified residuei1256Omega-N-methylarginineCombined sources1
Modified residuei1309Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei1309Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K4P0
MaxQBiQ8K4P0
PaxDbiQ8K4P0
PeptideAtlasiQ8K4P0
PRIDEiQ8K4P0

PTM databases

iPTMnetiQ8K4P0
PhosphoSitePlusiQ8K4P0

Expressioni

Tissue specificityi

Most highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000024400 Expressed in 273 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ8K4P0 baseline and differential
GenevisibleiQ8K4P0 MM

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) module of the pre-mRNA 3'-end processing complex. Interacts with CPSF3/CPSF73 (By similarity).By similarity

Protein-protein interaction databases

BioGridi216664, 3 interactors
IntActiQ8K4P0, 4 interactors
MINTiQ8K4P0
STRINGi10090.ENSMUSP00000025264

Structurei

3D structure databases

ProteinModelPortaliQ8K4P0
SMRiQ8K4P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati117 – 156WD 1Add BLAST40
Repeati159 – 198WD 2Add BLAST40
Repeati200 – 239WD 3Add BLAST40
Repeati242 – 283WD 4Add BLAST42
Repeati286 – 325WD 5Add BLAST40
Repeati329 – 369WD 6Add BLAST41
Repeati373 – 412WD 7Add BLAST40
Domaini617 – 769Collagen-likeAdd BLAST153

Keywords - Domaini

Collagen, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0284 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00730000111130
HOGENOMiHOG000148601
HOVERGENiHBG054623
InParanoidiQ8K4P0
KOiK15542
OMAiNQEGQSA
OrthoDBiEOG091G048U
PhylomeDBiQ8K4P0
TreeFamiTF317659

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8K4P0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEIGSPPR FFHMPRFQHQ APRQLFYKRP DFAQQQAMQQ LTFDGKRMRK
60 70 80 90 100
AVNRKTIDYN PSVIKYLENR IWQRDQRDMR AIQPDAGYYN DLVPPIGMLN
110 120 130 140 150
NPMNAVTTKF VRTSTNKVKC PVFVVRWTPE GRRLVTGASS GEFTLWNGLT
160 170 180 190 200
FNFETILQAH DSPVRAMTWS HNDMWMLTAD HGGYVKYWQS NMNNVKMFQA
210 220 230 240 250
HKEAIREASF SPTDNKFATC SDDGTVRIWD FLRCHEERIL RGHGADVKCV
260 270 280 290 300
DWHPTKGLVV SGSKDSQQPI KFWDPKTGQS LATLHAHKNT VMEVKLNLNG
310 320 330 340 350
NWLLTASRDH LCKLFDIRNL KEELQVFRGH KKEATAVAWH PVHEGLFASG
360 370 380 390 400
GSDGSLLFWH VGVEKEVGGM EMAHEGMIWS LAWHPLGHIL CSGSNDHTSK
410 420 430 440 450
FWTRNRPGDK MRDRYNLNLL PGMSEDGVEY DDLEPNSLAV IPGMGIPEQL
460 470 480 490 500
KLAMEQEQMG KDESSEIEMT IPGLDWGMEE VMQKDQKKVP QKKVPYAKPI
510 520 530 540 550
PAQFQQAWMQ NKVPIPAPNE VLNDRKEDIK LEEKKKTQAE IEQEMATLQY
560 570 580 590 600
TNPQLLEQLK IERLAQKQAD QIQPPPSSGT PLLGPQPFSG QGPISQIPQG
610 620 630 640 650
FQQPHPSQQM PLVPQMGPPG PQGQFRAPGP QGQMGPQGPP MHQGGGGPQG
660 670 680 690 700
FMGPQGPQGP PQGLPRPQDM HGPQGMQRHP GPHGPLGPQG PPGPQGSSGP
710 720 730 740 750
QGHMGPQGPP GPQGHIGPQG PPASQGHMGP QGPPGTQGMQ GPPGPRGMQG
760 770 780 790 800
PPHPHGIQGG PASQGIQGPL MGLNPRGMQG PPGPRENQGP APQGLMIGHP
810 820 830 840 850
PQEMRGPHPP SGLLGHGPQE MRGPQEMRGM QGPPPQGSML GPPQELRGPS
860 870 880 890 900
GSQGQQGPPQ GSLGPPPQGG MQGPPGPQGQ QNPARGPHPS QGPIPFQQQK
910 920 930 940 950
APLLGDGPRA PFNQEGQSTG PPPLIPGLGQ QGAQGRIPPL NPGQGPGPNK
960 970 980 990 1000
GDTRGPPNHH LGPMSERRHE QSGGPEHGPD RGPFRGGQDC RGPPDRRGSH
1010 1020 1030 1040 1050
PDFPDDFRPD DFHPDKRFGH RLREFEGRGG PLPQEEKWRR GGPGPPFPPD
1060 1070 1080 1090 1100
HREFNEGDGR GAARGPPGAW EGRRPGDDRF PRDPDDPRFR GRREESFRRG
1110 1120 1130 1140 1150
APPRHEGRAP PRGRDNFPGP DDFGPEEGFD ASDEAARGRD LRGRGRGTPR
1160 1170 1180 1190 1200
GGSRKCLLPT PDEFPRFEGG RKPDSWDGNR EPGPGHEHFR DAPRPDHPPH
1210 1220 1230 1240 1250
DGHSPASRER SSSLQGMDMA SLPPRKRPWH DGSGTSEHRE MEAQGGPSED
1260 1270 1280 1290 1300
RGSKGRGGPG PSQRVPKSGR SSSLDGDHHD GYHRDEPFGG PPGSSSSSRG
1310 1320 1330
ARSGSNWGRG SNMNSGPPRR GTSRGSGRGR
Length:1,330
Mass (Da):145,267
Last modified:October 1, 2002 - v1
Checksum:i5175B5DEB49F9A03
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YX80D3YX80_MOUSE
pre-mRNA 3' end-processing protein ...
Wdr33
271Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086191 mRNA Translation: BAC00776.1
AK031786 mRNA Translation: BAC27549.1
AK050653 mRNA Translation: BAC34364.1
AC124393 Genomic DNA No translation available.
AC131761 Genomic DNA No translation available.
AC161511 Genomic DNA No translation available.
CCDSiCCDS29112.1
RefSeqiNP_083142.2, NM_028866.3
UniGeneiMm.277705

Genome annotation databases

EnsembliENSMUST00000025264; ENSMUSP00000025264; ENSMUSG00000024400
GeneIDi74320
KEGGimmu:74320
UCSCiuc008eis.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086191 mRNA Translation: BAC00776.1
AK031786 mRNA Translation: BAC27549.1
AK050653 mRNA Translation: BAC34364.1
AC124393 Genomic DNA No translation available.
AC131761 Genomic DNA No translation available.
AC161511 Genomic DNA No translation available.
CCDSiCCDS29112.1
RefSeqiNP_083142.2, NM_028866.3
UniGeneiMm.277705

3D structure databases

ProteinModelPortaliQ8K4P0
SMRiQ8K4P0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216664, 3 interactors
IntActiQ8K4P0, 4 interactors
MINTiQ8K4P0
STRINGi10090.ENSMUSP00000025264

PTM databases

iPTMnetiQ8K4P0
PhosphoSitePlusiQ8K4P0

Proteomic databases

EPDiQ8K4P0
MaxQBiQ8K4P0
PaxDbiQ8K4P0
PeptideAtlasiQ8K4P0
PRIDEiQ8K4P0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025264; ENSMUSP00000025264; ENSMUSG00000024400
GeneIDi74320
KEGGimmu:74320
UCSCiuc008eis.2 mouse

Organism-specific databases

CTDi55339
MGIiMGI:1921570 Wdr33

Phylogenomic databases

eggNOGiKOG0284 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00730000111130
HOGENOMiHOG000148601
HOVERGENiHBG054623
InParanoidiQ8K4P0
KOiK15542
OMAiNQEGQSA
OrthoDBiEOG091G048U
PhylomeDBiQ8K4P0
TreeFamiTF317659

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Miscellaneous databases

ChiTaRSiWdr33 mouse
PROiPR:Q8K4P0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024400 Expressed in 273 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ8K4P0 baseline and differential
GenevisibleiQ8K4P0 MM

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR33_MOUSE
AccessioniPrimary (citable) accession number: Q8K4P0
Secondary accession number(s): Q8C7C6, Q8CD02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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