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Entry version 140 (26 Feb 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Supervillin

Gene

Svil

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function.By similarity
May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Supervillin
Alternative name(s):
Archvillin
p205/p250
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Svil
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2147319 Svil

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187411 – 2170SupervillinAdd BLAST2170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineBy similarity1
Modified residuei220PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei666PhosphoserineBy similarity1
Modified residuei728PhosphoserineBy similarity1
Modified residuei761PhosphoserineCombined sources1
Modified residuei809PhosphotyrosineCombined sources1
Modified residuei811PhosphothreonineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei877PhosphoserineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei960PhosphoserineCombined sources1
Modified residuei1011PhosphoserineCombined sources1
Modified residuei1031PhosphoserineCombined sources1
Modified residuei1077PhosphoserineBy similarity1
Modified residuei1159Omega-N-methylarginineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1184PhosphoserineCombined sources1
Modified residuei1186PhosphothreonineCombined sources1
Modified residuei1190PhosphoserineCombined sources1
Modified residuei1278PhosphoserineBy similarity1
Modified residuei1361PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8K4L3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K4L3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K4L3

PeptideAtlas

More...
PeptideAtlasi
Q8K4L3

PRoteomics IDEntifications database

More...
PRIDEi
Q8K4L3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K4L3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K4L3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024236 Expressed in tracheobronchial tree and 286 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K4L3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K4L3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with F-actin (By similarity).

Interacts with NEB (By similarity).

Interacts with MYH9 (By similarity).

Interacts with MYLK (By similarity).

By similarity

Interacts with TRIP6 (By similarity).

Interacts with DYNLT1 (By similarity).

Interacts with KIF14; at midbody during cytokinesis (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230358, 2 interactors

Protein interaction database and analysis system

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IntActi
Q8K4L3, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8K4L3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000115078

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K4L3 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1397 – 1496Gelsolin-like 1Add BLAST100
Repeati1516 – 1638Gelsolin-like 2Add BLAST123
Repeati1708 – 1818Gelsolin-like 3Add BLAST111
Repeati1837 – 1938Gelsolin-like 4Add BLAST102
Repeati1971 – 2078Gelsolin-like 5Add BLAST108
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2107 – 2170HPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 167Interaction with MYLKBy similarityAdd BLAST167
Regioni1375 – 1643Interaction with NEBBy similarityAdd BLAST269

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0445 Eukaryota
ENOG410XPWY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154653

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K4L3

KEGG Orthology (KO)

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KOi
K10369

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8K4L3

TreeFam database of animal gene trees

More...
TreeFami
TF316081

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.950.10, 1 hit
3.40.20.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11977 PTHR11977, 1 hit
PTHR11977:SF86 PTHR11977:SF86, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00597 GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00262 GEL, 5 hits
SM00153 VHP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47050 SSF47050, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51089 HP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K4L3-1) [UniParc]FASTAAdd to basket
Also known as: ArchvillinBy similarity

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRKERIARR LEGIENDSQP ILLQSCTGLV THRLLEEDTP RYMRATDPAS
60 70 80 90 100
PHIGRSKEEE DTPGSSLEKQ TPSKYCIETS GIHSSGSMDT HSLESKAERI
110 120 130 140 150
ARYKAERRRQ LAEKYGLTLD PEADSEYLSR YAKSRKDPDV TERRGKSDKQ
160 170 180 190 200
EEQSKDANSR HSRTESGPRT SLVASQDCTP LGSNMSDQEQ LLNVENQRRV
210 220 230 240 250
QDPPLGEDGS SAFFSERSIS FPEVPRSPKQ IPSSPLQQPA SPNHPGDSPL
260 270 280 290 300
PTEARASTGK PTHEWFLQRD SEGDTPSLIN WPSRVKVREK LVKEESARSS
310 320 330 340 350
PELTSESLTQ RRQQPAPAHF LPIQSESSTF DRVTSKAVSS LQPSQSGVLP
360 370 380 390 400
TDPVHAIKLV TMDTPESTSE FSWVGSATPK VIKSTTLKIL EGGSRDAPVL
410 420 430 440 450
HICESKAEDW LSPEPLERSP KSLLTSEDDR LVRGHKDPSG NKDLDKAIIC
460 470 480 490 500
SIDVESERER QVQHLPTQRT GRSEMLLYVQ SGPVSQDATL TSHTKEASPK
510 520 530 540 550
KRKVLARSLS DYTGPPQLQV PRHKDEAPSQ ELELQSSRAE GPGAEASVLD
560 570 580 590 600
TRVSVAQLRN IFMESTRASK KPELQSRVER SAEGIGLPME RERGSRKPRR
610 620 630 640 650
YLSPGESRKT SERFRTQPIT SAERKESDRY PSGSEIPVVE DEEKVDERAK
660 670 680 690 700
LSVAAKRLLF REMEKSFDEH TVPKRHSRNA AVEQRLRRLQ DRSHTQPITT
710 720 730 740 750
EEVVIAATEP IPASCSGVTH PVTARLPSPT VARSSVQPAR LQASAHQKAL
760 770 780 790 800
ARDQANEGRE SAEPGEPDSS TLSLAEKLAL FNKLSQPVSK AISTRNRIDV
810 820 830 840 850
RQRRMNARYQ TQPVTLGEVE QVQSGKLISF SPTVNTSVSI MASAVAPTYA
860 870 880 890 900
GDLRKLSVDN NTSATDYKSP PAENSDSPVR SILKPQAWRP LVEHSGSKGM
910 920 930 940 950
PGESGKTESK NALTVAAEDS GVQTRGAFEE EEEPSYPILG RVREGDGQKE
960 970 980 990 1000
PKHVVLRRGS LELGNPSAAH LGDELKEVST AKSSLQENLD LKDKQASEEN
1010 1020 1030 1040 1050
TDVETVMRKF SLKEFGETTS EQTEVAARKA SVQMATPGAW KQQESSEQLA
1060 1070 1080 1090 1100
EKLFKNPCAM FASGEVKVPV GDSFLDSPSK TMSIKERLAL LKKSGEEDWK
1110 1120 1130 1140 1150
NRLIRKQEYG KATGGLHTQE VEQSLKKKRV TESRESQMTI EERKHLITVR
1160 1170 1180 1190 1200
EEAWKTKGRG AANDSTQFTV AGRMVKKGLA SPTSITPISS PLCSKSRGTT
1210 1220 1230 1240 1250
PVSKPLEDIE ARPDMQLESD LKLDRLETFL RRLNNKVAGI QETVLTVTGK
1260 1270 1280 1290 1300
SVKEVMKLDD DETFAKFYRS VDHSIPRSPV ELEEDFDVIF DPYAPKLTSS
1310 1320 1330 1340 1350
VAEHKRQVRP KRRVQASKNP LKLLAARDDL LQEYTEQRLN VAFMESKRMK
1360 1370 1380 1390 1400
VEKMSSNSNF SEVTLAGLAS RENFSNINLR SVNLMEQNSN NSAMPYKKLM
1410 1420 1430 1440 1450
LLQIKGRRHV QTRLVEPRAS SLNSGDCFLL LSPQYCFLWV GEFSNVIEKA
1460 1470 1480 1490 1500
KASELATLIQ TKRELGCRAT YIQTIEEGIN THTHAAKDFW KLLGGQTSYQ
1510 1520 1530 1540 1550
SAGDPKEDEL YETAIIETNC VYRLTDDKLV PDDDYWGKIP KCSLLQSKEV
1560 1570 1580 1590 1600
LVFDFGSEVY VWHGKEVTLA QRKIAFQLAK HLWNGTFDYE NCDINPLDPG
1610 1620 1630 1640 1650
ECNPLIPRKG QGRPDWAIFG RVTEHNETIL FKEKFLDWTE LKRPTEKNSG
1660 1670 1680 1690 1700
EVVQQKDDPR ADVKPYDVTR MVATPQITAG TILDGVNVGR GYGLVEGDDR
1710 1720 1730 1740 1750
RQFEIATVSV DVWHILEFDY SRLPRQSIGQ FHEGDAYVVK WKYMASTAVG
1760 1770 1780 1790 1800
SRQKGEHLVR VAGKEKCVYF FWQGRHSTVS EKGTSALMTV ELDEERGAQV
1810 1820 1830 1840 1850
QVLQGKEPPC FLQCFQGGMV VHSGRREEEE ENVQSEWRLY CVRGEVPMEG
1860 1870 1880 1890 1900
NLLEVACHCS SLRSRTSMVV LNINKALIYL WHGCKAQGHT KEVGRTAANK
1910 1920 1930 1940 1950
IKEECPLEAG LHSSSNVTIH ECDEGSEPLG FWDALGRRDR KAYDCMLQDP
1960 1970 1980 1990 2000
GSFNFAPRLF ILSSSSGDFS ATEFVYPAQA PSAVSSMPFL QEDLYSAPQP
2010 2020 2030 2040 2050
ALFLVDNHHE VYLWQGWWPT ENKITGSARI RWASDRKSAM ETVLQYCRGK
2060 2070 2080 2090 2100
NLKRPPPKSY LIHAGLEPLT FTNMFPSWEH REDIAEITEM DTEVSNQITL
2110 2120 2130 2140 2150
VEDVLAKLCK TIYPLADLLA RPLPEGVDPL KLEIYLTDED FEFALDMSRD
2160 2170
EFNALPTWKQ VNLKKSKGLF
Length:2,170
Mass (Da):243,162
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEAB710184FB71C6
GO
Isoform 2 (identifier: Q8K4L3-3) [UniParc]FASTAAdd to basket
Also known as: SupervillinBy similarity

The sequence of this isoform differs from the canonical sequence as follows:
     257-628: Missing.
     709-740: Missing.

Show »
Length:1,766
Mass (Da):198,529
Checksum:i3C2564892D30C2EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3Z5E9Q3Z5_MOUSE
Supervillin
Svil
2,056Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GS91A0A1B0GS91_MOUSE
Supervillin
Svil
2,257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8K4L2Q8K4L2_MOUSE
Archvillin
Svil
2,031Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6R6A4F6R6A4_MOUSE
Supervillin
Svil
749Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TBK9F6TBK9_MOUSE
Supervillin
Svil
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2X9D3Z2X9_MOUSE
Supervillin
Svil
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058333257 – 628Missing in isoform 2. Add BLAST372
Alternative sequenceiVSP_058334709 – 740Missing in isoform 2. Add BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF317422 mRNA Translation: AAM89518.1
AC115928 Genomic DNA No translation available.
AC124770 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS37720.1 [Q8K4L3-1]
CCDS84352.1 [Q8K4L3-3]

NCBI Reference Sequences

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RefSeqi
NP_001334378.1, NM_001347449.1 [Q8K4L3-3]
NP_694793.1, NM_153153.3 [Q8K4L3-1]
XP_011245180.1, XM_011246878.2 [Q8K4L3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000025079; ENSMUSP00000025079; ENSMUSG00000024236 [Q8K4L3-1]
ENSMUST00000126977; ENSMUSP00000115078; ENSMUSG00000024236 [Q8K4L3-1]
ENSMUST00000140448; ENSMUSP00000119803; ENSMUSG00000024236 [Q8K4L3-1]
ENSMUST00000143254; ENSMUSP00000119287; ENSMUSG00000024236 [Q8K4L3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
225115

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:225115

UCSC genome browser

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UCSCi
uc008dyr.2 mouse [Q8K4L3-1]
uc012aza.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317422 mRNA Translation: AAM89518.1
AC115928 Genomic DNA No translation available.
AC124770 Genomic DNA No translation available.
CCDSiCCDS37720.1 [Q8K4L3-1]
CCDS84352.1 [Q8K4L3-3]
RefSeqiNP_001334378.1, NM_001347449.1 [Q8K4L3-3]
NP_694793.1, NM_153153.3 [Q8K4L3-1]
XP_011245180.1, XM_011246878.2 [Q8K4L3-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi230358, 2 interactors
IntActiQ8K4L3, 3 interactors
MINTiQ8K4L3
STRINGi10090.ENSMUSP00000115078

PTM databases

iPTMnetiQ8K4L3
PhosphoSitePlusiQ8K4L3

Proteomic databases

EPDiQ8K4L3
jPOSTiQ8K4L3
PaxDbiQ8K4L3
PeptideAtlasiQ8K4L3
PRIDEiQ8K4L3

Genome annotation databases

EnsembliENSMUST00000025079; ENSMUSP00000025079; ENSMUSG00000024236 [Q8K4L3-1]
ENSMUST00000126977; ENSMUSP00000115078; ENSMUSG00000024236 [Q8K4L3-1]
ENSMUST00000140448; ENSMUSP00000119803; ENSMUSG00000024236 [Q8K4L3-1]
ENSMUST00000143254; ENSMUSP00000119287; ENSMUSG00000024236 [Q8K4L3-3]
GeneIDi225115
KEGGimmu:225115
UCSCiuc008dyr.2 mouse [Q8K4L3-1]
uc012aza.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6840
MGIiMGI:2147319 Svil

Phylogenomic databases

eggNOGiKOG0445 Eukaryota
ENOG410XPWY LUCA
GeneTreeiENSGT00940000154653
InParanoidiQ8K4L3
KOiK10369
PhylomeDBiQ8K4L3
TreeFamiTF316081

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Svil mouse

Protein Ontology

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PROi
PR:Q8K4L3
RNActiQ8K4L3 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024236 Expressed in tracheobronchial tree and 286 other tissues
ExpressionAtlasiQ8K4L3 baseline and differential
GenevisibleiQ8K4L3 MM

Family and domain databases

Gene3Di1.10.950.10, 1 hit
3.40.20.10, 5 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF86 PTHR11977:SF86, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 5 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVIL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K4L3
Secondary accession number(s): E9Q983
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2002
Last modified: February 26, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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