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Entry version 122 (08 May 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Transcription factor COE4

Gene

Ebf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to weakly activate transcription. Binds an Olf-1 consensus site in vitro.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri152 – 171C5-typeSequence analysisAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor COE4
Alternative name(s):
Early B-cell factor 4
Short name:
EBF-4
Olf-1/EBF-like 4
Short name:
O/E-4
Short name:
OE-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ebf4
Synonyms:Coe4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385972 Ebf4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001078361 – 599Transcription factor COE4Add BLAST599

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K4J2

PRoteomics IDEntifications database

More...
PRIDEi
Q8K4J2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K4J2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K4J2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the neuronal and basal cell layers of olfactory epithelium. Absent in the vomeronasal organ.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053552 Expressed in 154 organ(s), highest expression level in olfactory epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K4J2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K4J2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms either a homodimer or a heterodimer with a related family member.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei164Interaction with DNABy similarity1
Sitei173Interaction with DNABy similarity1

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230746, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K4J2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini256 – 339IPT/TIGAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 67Interaction with DNABy similarity4
Regioni198 – 205Interaction with DNABy similarity8
Regioni237 – 240Interaction with DNABy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 171C5-typeSequence analysisAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3836 Eukaryota
ENOG410XQ9Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182859

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K4J2

KEGG Orthology (KO)

More...
KOi
K09103

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMLVWSE

Database of Orthologous Groups

More...
OrthoDBi
817293at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313391

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11606 COE_DBD, 1 hit
cd01175 IPT_COE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.3180, 1 hit
4.10.280.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032200 COE_DBD
IPR038173 COE_DBD_sf
IPR032201 COE_HLH
IPR038006 COE_IPT
IPR036638 HLH_DNA-bd_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR003523 Transcription_factor_COE
IPR018350 Transcription_factor_COE_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10747 PTHR10747, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16422 COE1_DBD, 1 hit
PF16423 COE1_HLH, 1 hit
PF01833 TIG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01345 COE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q8K4J2-1) [UniParc]FASTAAdd to basket
Also known as: 4-23

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPAQDALPR GGLHLKEEPL LPSSLGSVRS WMQSAGILDS NTAAQSGVGL
60 70 80 90 100
ARAHFEKQPP SNLRKSNFFH FVLAMYDRQG QPVEVERTAF IDFVEKDREP
110 120 130 140 150
GTEKTNNGIH YRLRLVYNNG LRTEQDLYVR LIDSMSKQAI IYEGQDKNPE
160 170 180 190 200
MCRVLLTHEI MCSRCCDRKS CGNRNETPSD PVIIDRFFLK FFLKCNQNCL
210 220 230 240 250
KNAGNPRDMR RFQVVVSTTV SVDGHVLAVS DNMFVHNNSK HGRRARRLDP
260 270 280 290 300
SEAATPCIKA ISPGEGWTTG GATVIIIGDN FFDGLQVVFG NVLLWSELIT
310 320 330 340 350
PHAIRVQTPP RHIPGVVEVT LSYKSKQFCK GAPGRFVYTA LNEPTIDYGF
360 370 380 390 400
QRLQKVIPRH PGDPERLPKE VLLKRAADLA EALYGVPSSN QELLLKRAAD
410 420 430 440 450
VAEALYSAPR APAPLGPLAP SHPHPAVVGI NAFSSPLAIA VGDTTPEPGY
460 470 480 490 500
ARSCGSASPR FAPSPGSQQS SYGSGLGAGL GSYGAPGVTG LGVPGSPSFL
510 520 530 540 550
NGSTATSPFA IMPSSPPLAA ASSMSLPAAA PTTSVFSFSP VNMICAVKQR
560 570 580 590
SAFAPVLRPP SSPSQACPRA HREGLPDQPF EDTDKFHSAA RGLQGLAYS
Length:599
Mass (Da):64,624
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76748B3E04D42260
GO
Isoform 1 (identifier: Q8K4J2-2) [UniParc]FASTAAdd to basket
Also known as: 4-11

The sequence of this isoform differs from the canonical sequence as follows:
     577-582: DQPFED → AQRTGR
     583-599: Missing.

Show »
Length:582
Mass (Da):62,758
Checksum:i22EEC610A093175F
GO
Isoform 2 (identifier: Q8K4J2-3) [UniParc]FASTAAdd to basket
Also known as: 4-14

The sequence of this isoform differs from the canonical sequence as follows:
     481-508: GSYGAPGVTGLGVPGSPSFLNGSTATSP → APRWRLPPPCPFRPPPPPPASSPSRLST
     509-599: Missing.

Show »
Length:508
Mass (Da):55,639
Checksum:iAC940A674C5DE872
GO
Isoform 4 (identifier: Q8K4J2-4) [UniParc]FASTAAdd to basket
Also known as: 4-132

The sequence of this isoform differs from the canonical sequence as follows:
     511-541: IMPSSPPLAAASSMSLPAAAPTTSVFSFSPV → KERLRPCAAPTQFPIAGLPQSPQRGASRPAF
     542-599: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:541
Mass (Da):58,661
Checksum:i18915B375F4C5E1A
GO
Isoform 5 (identifier: Q8K4J2-5) [UniParc]FASTAAdd to basket
Also known as: 4S

The sequence of this isoform differs from the canonical sequence as follows:
     392-426: ELLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPA → VWRLCPPPSARGRGSDPAPAAAPAVPRSCLRRSSS
     427-599: Missing.

Show »
Length:426
Mass (Da):47,445
Checksum:i28C18C1A9B677A2B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2BI80A2BI80_MOUSE
Transcription factor COE4
Ebf4
696Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2BI84A2BI84_MOUSE
Transcription factor COE4
Ebf4
569Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001119392 – 426ELLLK…HPHPA → VWRLCPPPSARGRGSDPAPA AAPAVPRSCLRRSSS in isoform 5. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_001120427 – 599Missing in isoform 5. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_001121481 – 508GSYGA…TATSP → APRWRLPPPCPFRPPPPPPA SSPSRLST in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_001122509 – 599Missing in isoform 2. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_001123511 – 541IMPSS…SFSPV → KERLRPCAAPTQFPIAGLPQ SPQRGASRPAF in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_001124542 – 599Missing in isoform 4. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_001125577 – 582DQPFED → AQRTGR in isoform 1. 1 Publication6
Alternative sequenceiVSP_001126583 – 599Missing in isoform 1. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF387630 mRNA Translation: AAM97580.1
AF387631 mRNA Translation: AAM97581.1
AF387632 mRNA Translation: AAM97582.1
AF387633 mRNA Translation: AAM97583.1
AF387634 mRNA Translation: AAM97584.1
BX890605 Genomic DNA No translation available.
BX936285 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50709.1 [Q8K4J2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001103983.1, NM_001110513.1 [Q8K4J2-1]
XP_011237773.1, XM_011239471.2 [Q8K4J2-2]
XP_011237774.1, XM_011239472.2 [Q8K4J2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000110286; ENSMUSP00000105915; ENSMUSG00000053552 [Q8K4J2-1]
ENSMUST00000126740; ENSMUSP00000133528; ENSMUSG00000053552 [Q8K4J2-2]
ENSMUST00000140169; ENSMUSP00000134520; ENSMUSG00000053552 [Q8K4J2-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
228598

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:228598

UCSC genome browser

More...
UCSCi
uc008miq.2 mouse [Q8K4J2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387630 mRNA Translation: AAM97580.1
AF387631 mRNA Translation: AAM97581.1
AF387632 mRNA Translation: AAM97582.1
AF387633 mRNA Translation: AAM97583.1
AF387634 mRNA Translation: AAM97584.1
BX890605 Genomic DNA No translation available.
BX936285 Genomic DNA No translation available.
CCDSiCCDS50709.1 [Q8K4J2-1]
RefSeqiNP_001103983.1, NM_001110513.1 [Q8K4J2-1]
XP_011237773.1, XM_011239471.2 [Q8K4J2-2]
XP_011237774.1, XM_011239472.2 [Q8K4J2-3]

3D structure databases

SMRiQ8K4J2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi230746, 2 interactors
STRINGi10090.ENSMUSP00000105915

PTM databases

iPTMnetiQ8K4J2
PhosphoSitePlusiQ8K4J2

Proteomic databases

PaxDbiQ8K4J2
PRIDEiQ8K4J2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110286; ENSMUSP00000105915; ENSMUSG00000053552 [Q8K4J2-1]
ENSMUST00000126740; ENSMUSP00000133528; ENSMUSG00000053552 [Q8K4J2-2]
ENSMUST00000140169; ENSMUSP00000134520; ENSMUSG00000053552 [Q8K4J2-4]
GeneIDi228598
KEGGimmu:228598
UCSCiuc008miq.2 mouse [Q8K4J2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57593
MGIiMGI:2385972 Ebf4

Phylogenomic databases

eggNOGiKOG3836 Eukaryota
ENOG410XQ9Z LUCA
GeneTreeiENSGT00950000182859
InParanoidiQ8K4J2
KOiK09103
OMAiNMLVWSE
OrthoDBi817293at2759
TreeFamiTF313391

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8K4J2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000053552 Expressed in 154 organ(s), highest expression level in olfactory epithelium
ExpressionAtlasiQ8K4J2 baseline and differential
GenevisibleiQ8K4J2 MM

Family and domain databases

CDDicd11606 COE_DBD, 1 hit
cd01175 IPT_COE, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.3180, 1 hit
4.10.280.10, 2 hits
InterProiView protein in InterPro
IPR032200 COE_DBD
IPR038173 COE_DBD_sf
IPR032201 COE_HLH
IPR038006 COE_IPT
IPR036638 HLH_DNA-bd_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR003523 Transcription_factor_COE
IPR018350 Transcription_factor_COE_CS
PANTHERiPTHR10747 PTHR10747, 1 hit
PfamiView protein in Pfam
PF16422 COE1_DBD, 1 hit
PF16423 COE1_HLH, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01345 COE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOE4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K4J2
Secondary accession number(s): A2BI82
, A2BI83, Q8K4J1, Q8K4J3, Q8K4J4, Q8K4J5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 1, 2002
Last modified: May 8, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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