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Protein

Protein chibby homolog 1

Gene

Cby1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.By similarity

Miscellaneous

'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Differentiation

Enzyme and pathway databases

ReactomeiR-RNO-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Protein chibby homolog 1
Alternative name(s):
Cytosolic leucine-rich protein
PIGEA-14
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
Gene namesi
Name:Cby1
Synonyms:Cby, Pgea1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi708481 Cby1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583561 – 127Protein chibby homolog 1Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K4I6
PRIDEiQ8K4I6

PTM databases

iPTMnetiQ8K4I6
PhosphoSitePlusiQ8K4I6

Expressioni

Gene expression databases

BgeeiENSRNOG00000013892 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiQ8K4I6 RN

Interactioni

Subunit structurei

Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of CTNNB1. Interacts (C-terminus) with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1. Interacts with FAM92A; this interaction facilites targeting of FAM92A to cilium basal body.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018787

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 112Minimal region for the interaction with PKD2By similarityAdd BLAST53

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili68 – 110Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the chibby family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWV4 Eukaryota
ENOG4111NU6 LUCA
GeneTreeiENSGT00510000047043
HOGENOMiHOG000006694
HOVERGENiHBG050816
InParanoidiQ8K4I6
OMAiMPLFSNK
OrthoDBiEOG091G12BK
PhylomeDBiQ8K4I6
TreeFamiTF324419

Family and domain databases

CDDicd07429 Cby_like, 1 hit
InterProiView protein in InterPro
IPR028118 Chibby_fam
PfamiView protein in Pfam
PF14645 Chibby, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K4I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ
60 70 80 90 100
SLKFENGQWV ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD
110 120
MLSETTAESH LKDKELDELK ITNRRRK
Length:127
Mass (Da):14,549
Last modified:October 1, 2002 - v1
Checksum:i7CE38A48D045DE57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393211 mRNA Translation: AAM73679.1
RefSeqiNP_663709.1, NM_145676.1
XP_006242029.1, XM_006241967.3
UniGeneiRn.229691

Genome annotation databases

EnsembliENSRNOT00000018787; ENSRNOP00000018787; ENSRNOG00000013892
GeneIDi246768
KEGGirno:246768
UCSCiRGD:708481 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393211 mRNA Translation: AAM73679.1
RefSeqiNP_663709.1, NM_145676.1
XP_006242029.1, XM_006241967.3
UniGeneiRn.229691

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018787

PTM databases

iPTMnetiQ8K4I6
PhosphoSitePlusiQ8K4I6

Proteomic databases

PaxDbiQ8K4I6
PRIDEiQ8K4I6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018787; ENSRNOP00000018787; ENSRNOG00000013892
GeneIDi246768
KEGGirno:246768
UCSCiRGD:708481 rat

Organism-specific databases

CTDi25776
RGDi708481 Cby1

Phylogenomic databases

eggNOGiENOG410IWV4 Eukaryota
ENOG4111NU6 LUCA
GeneTreeiENSGT00510000047043
HOGENOMiHOG000006694
HOVERGENiHBG050816
InParanoidiQ8K4I6
OMAiMPLFSNK
OrthoDBiEOG091G12BK
PhylomeDBiQ8K4I6
TreeFamiTF324419

Enzyme and pathway databases

ReactomeiR-RNO-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

PROiPR:Q8K4I6

Gene expression databases

BgeeiENSRNOG00000013892 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiQ8K4I6 RN

Family and domain databases

CDDicd07429 Cby_like, 1 hit
InterProiView protein in InterPro
IPR028118 Chibby_fam
PfamiView protein in Pfam
PF14645 Chibby, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBY1_RAT
AccessioniPrimary (citable) accession number: Q8K4I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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