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Protein

Actin-binding LIM protein 1

Gene

Ablim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.By similarity2 Publications

Miscellaneous

Isoform 1 is not necessary for normal axon guidance.

GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding LIM protein 1
Short name:
abLIM-1
Alternative name(s):
Actin-binding LIM protein family member 1
Gene namesi
Name:Ablim1
Synonyms:Ablim, Kiaa0059
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1194500 Ablim1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000756981 – 861Actin-binding LIM protein 1Add BLAST861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei417PhosphotyrosineBy similarity1
Modified residuei440PhosphotyrosineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei477PhosphothreonineBy similarity1
Modified residuei479PhosphoserineCombined sources1
Modified residuei483PhosphotyrosineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei499PhosphoserineCombined sources1
Modified residuei502PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei723PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1
Modified residuei760PhosphoserineCombined sources1
Modified residuei789PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8K4G5
PeptideAtlasiQ8K4G5
PRIDEiQ8K4G5

PTM databases

iPTMnetiQ8K4G5
PhosphoSitePlusiQ8K4G5

Expressioni

Tissue specificityi

Isoform 1 is detected in adult retina, where it is highly expressed in the ganglion layer. Detected in rod inner segment. Isoform 2 is highly expressed in adult retina, brain, kidney and heart. Isoform 3 is highly expressed in adult retina, brain, kidney, liver, skeletal muscle, spleen and heart. Detected in embryonic retina, brain, spinal cord, peripheral sensory ganglia and thymus.3 Publications

Developmental stagei

Isoform 1 is detected at low levels starting from E12 and remains constant until birth. After this levels increase strongly and expression remains high in adults. Isoform 2 and isoform 3 are expressed at a constant high level throughout development.2 Publications

Gene expression databases

BgeeiENSMUSG00000025085 Expressed in 301 organ(s), highest expression level in blood
CleanExiMM_ABLIM1
ExpressionAtlasiQ8K4G5 baseline and differential
GenevisibleiQ8K4G5 MM

Interactioni

Subunit structurei

Binds F-actin. Interacts with ABRA (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621085EBI-2307994,EBI-300895

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230492, 6 interactors
IntActiQ8K4G5, 6 interactors
MINTiQ8K4G5
STRINGi10090.ENSMUSP00000078336

Structurei

3D structure databases

ProteinModelPortaliQ8K4G5
SMRiQ8K4G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 156LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini156 – 216LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini224 – 283LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini283 – 343LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61
Domaini793 – 861HPPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili673 – 723Sequence analysisAdd BLAST51

Keywords - Domaini

Coiled coil, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1044 Eukaryota
ENOG410XRPY LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000285997
HOVERGENiHBG031499
InParanoidiQ8K4G5
KOiK07520
OMAiWHTECEP
PhylomeDBiQ8K4G5

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR028448 ABLIM1
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM
PANTHERiPTHR24213:SF18 PTHR24213:SF18, 1 hit
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 1 hit
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K4G5-1) [UniParc]FASTAAdd to basket
Also known as: AbLIM-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSLLGLKCL GKLCSSEIGK VPSPERASLR NSHRRLLIED LSVPETPDPA
60 70 80 90 100
HRRRGTVIHL VYLYSAGCGP PELRFSSYDP SVAHPQDPHH SSEKPVIHCH
110 120 130 140 150
KCGEPCKGEV LRVQTKHFHI KCFTCKVCGC DLAQGGFFIK NGDYLCTLDY
160 170 180 190 200
QRMYGTRCHG CGEFVEGEVV TALGKTYHPN CFACTICKRP FPPGDRVTFN
210 220 230 240 250
GRDCLCQLCA QPMSSSPKEA SCSSNCAGCG RDIKNGQALL ALDKQWHLGC
260 270 280 290 300
FKCKSCGKVL TGEYISKDGS PYCEKDYQGL FGVKCEACHQ FITGKVLEAG
310 320 330 340 350
DKHYHPSCAR CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRPPN
360 370 380 390 400
IPRSSSDFFY PKSLIRRTGR SPALQLLSPP CLTNSNKNPR QPTRTSSESI
410 420 430 440 450
YSRPGSSIPG SPGHTIYAKV DNEILDYKDL AAIPKVKAIY DIERPDLITY
460 470 480 490 500
EPFYTSGYED KQERQSLGES PRTLSPTPSA EGYQDVRDRM IHRSTSQGSI
510 520 530 540 550
NSPVYSRHSY TPTTSRSPQH FHRPELLSPG VHRWSPLRTS SFSSTHSDSR
560 570 580 590 600
PNPPFRHHFL PHVKGNEPSS GRNSPLPYRP DSRPLTPTYA QAPKHFHVPD
610 620 630 640 650
QGINIYRKPP IYKQHAALAA QSKASEDIIK FSKFPAAQAP DPNEIPKIET
660 670 680 690 700
DHWPGPPSLA AVGTDPRRRS SGREEDEEEL LRRRQLQEEQ LMKLNSGLGQ
710 720 730 740 750
LILKEEMEKE SRERASLASR YDSPLHSASH APSSKTSSLP GYGKNGLHRP
760 770 780 790 800
VSTDFAQYNS YGDISGGVRD YQTLPDGHMP AVRMDRGVSM PNMLEPKIFP
810 820 830 840 850
YEMLMVTNRG RNKILRDVDR TRLERHLAPE VFWEIFGMSI QEFDKLPLWR
860
RNDMKKKAKL F
Length:861
Mass (Da):96,805
Last modified:October 1, 2002 - v1
Checksum:i5E045F7CEF1D91EF
GO
Isoform 2 (identifier: Q8K4G5-2) [UniParc]FASTAAdd to basket
Also known as: AbLIM-M

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPSLLGLKCL...ELRFSSYDPS → MVKEK
     348-391: Missing.
     525-564: Missing.

Show »
Length:701
Mass (Da):78,960
Checksum:i5B5B038DC13E8335
GO
Isoform 3 (identifier: Q8K4G5-3) [UniParc]FASTAAdd to basket
Also known as: AbLIM-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.

Show »
Length:545
Mass (Da):62,004
Checksum:i4AC77999CAE0228B
GO
Isoform 4 (identifier: Q8K4G5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPSLLGLKCL...ELRFSSYDPS → MVKEK
     348-391: Missing.
     525-564: Missing.
     616-662: Missing.

Note: No experimental confirmation available.
Show »
Length:654
Mass (Da):74,052
Checksum:i90BFFB081F2BF1D2
GO
Isoform 5 (identifier: Q8K4G5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-81: YDPS → MSTR
     301-345: DKHYHPSCAR...CKQSTKTEEK → VTEASRTWSH...SAREWFALSA
     346-861: Missing.

Note: No experimental confirmation available.
Show »
Length:268
Mass (Da):29,911
Checksum:i08A6BFFDC99BB56B
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QK41E9QK41_MOUSE
Actin-binding LIM protein 1
Ablim1
861Annotation score:
E9Q9C7E9Q9C7_MOUSE
Actin-binding LIM protein 1
Ablim1
668Annotation score:
E9Q9C0E9Q9C0_MOUSE
Actin-binding LIM protein 1
Ablim1
714Annotation score:
E9Q9C1E9Q9C1_MOUSE
Actin-binding LIM protein 1
Ablim1
744Annotation score:
E9Q9C4E9Q9C4_MOUSE
Actin-binding LIM protein 1
Ablim1
682Annotation score:
E9Q9C2E9Q9C2_MOUSE
Actin-binding LIM protein 1
Ablim1
777Annotation score:
E9Q030E9Q030_MOUSE
Actin-binding LIM protein 1
Ablim1
545Annotation score:
E9Q9D1E9Q9D1_MOUSE
Actin-binding LIM protein 1
Ablim1
426Annotation score:
E9Q9D2E9Q9D2_MOUSE
Actin-binding LIM protein 1
Ablim1
454Annotation score:
E9Q9Q7E9Q9Q7_MOUSE
Actin-binding LIM protein 1
Ablim1
400Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence BAC65478 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0121031 – 316Missing in isoform 3. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_0121041 – 81MPSLL…SYDPS → MVKEK in isoform 2 and isoform 4. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_0121051 – 77Missing in isoform 5. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_01210678 – 81YDPS → MSTR in isoform 5. 1 Publication4
Alternative sequenceiVSP_012107301 – 345DKHYH…KTEEK → VTEASRTWSHIDLRWQGRSE ELRAWRHSIQSLRHQSAREW FALSA in isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_012109346 – 861Missing in isoform 5. 1 PublicationAdd BLAST516
Alternative sequenceiVSP_012108348 – 391Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_012110525 – 564Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_012111616 – 662Missing in isoform 4. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404774 mRNA Translation: AAM73705.1
AF404775 mRNA Translation: AAM73706.1
AF404776 mRNA Translation: AAM73707.1
AK122196 mRNA Translation: BAC65478.1 Different initiation.
AK029371 mRNA Translation: BAC26424.1
CCDSiCCDS38027.1 [Q8K4G5-1]
CCDS50478.1 [Q8K4G5-3]
CCDS50479.1 [Q8K4G5-2]
CCDS70964.1 [Q8K4G5-4]
RefSeqiNP_001096647.1, NM_001103177.2 [Q8K4G5-2]
NP_001096648.1, NM_001103178.2
NP_001277742.1, NM_001290813.1
NP_001277744.1, NM_001290815.1 [Q8K4G5-4]
NP_848803.3, NM_178688.3
UniGeneiMm.217161
Mm.446592

Genome annotation databases

EnsembliENSMUST00000099294; ENSMUSP00000096897; ENSMUSG00000025085 [Q8K4G5-4]
ENSMUST00000111524; ENSMUSP00000107149; ENSMUSG00000025085 [Q8K4G5-5]
ENSMUST00000111546; ENSMUSP00000107172; ENSMUSG00000025085 [Q8K4G5-2]
GeneIDi226251
KEGGimmu:226251
UCSCiuc008hzz.1 mouse [Q8K4G5-5]
uc033hkz.2 mouse [Q8K4G5-2]
uc033hld.2 mouse [Q8K4G5-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404774 mRNA Translation: AAM73705.1
AF404775 mRNA Translation: AAM73706.1
AF404776 mRNA Translation: AAM73707.1
AK122196 mRNA Translation: BAC65478.1 Different initiation.
AK029371 mRNA Translation: BAC26424.1
CCDSiCCDS38027.1 [Q8K4G5-1]
CCDS50478.1 [Q8K4G5-3]
CCDS50479.1 [Q8K4G5-2]
CCDS70964.1 [Q8K4G5-4]
RefSeqiNP_001096647.1, NM_001103177.2 [Q8K4G5-2]
NP_001096648.1, NM_001103178.2
NP_001277742.1, NM_001290813.1
NP_001277744.1, NM_001290815.1 [Q8K4G5-4]
NP_848803.3, NM_178688.3
UniGeneiMm.217161
Mm.446592

3D structure databases

ProteinModelPortaliQ8K4G5
SMRiQ8K4G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230492, 6 interactors
IntActiQ8K4G5, 6 interactors
MINTiQ8K4G5
STRINGi10090.ENSMUSP00000078336

PTM databases

iPTMnetiQ8K4G5
PhosphoSitePlusiQ8K4G5

Proteomic databases

PaxDbiQ8K4G5
PeptideAtlasiQ8K4G5
PRIDEiQ8K4G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099294; ENSMUSP00000096897; ENSMUSG00000025085 [Q8K4G5-4]
ENSMUST00000111524; ENSMUSP00000107149; ENSMUSG00000025085 [Q8K4G5-5]
ENSMUST00000111546; ENSMUSP00000107172; ENSMUSG00000025085 [Q8K4G5-2]
GeneIDi226251
KEGGimmu:226251
UCSCiuc008hzz.1 mouse [Q8K4G5-5]
uc033hkz.2 mouse [Q8K4G5-2]
uc033hld.2 mouse [Q8K4G5-4]

Organism-specific databases

CTDi3983
MGIiMGI:1194500 Ablim1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1044 Eukaryota
ENOG410XRPY LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000285997
HOVERGENiHBG031499
InParanoidiQ8K4G5
KOiK07520
OMAiWHTECEP
PhylomeDBiQ8K4G5

Miscellaneous databases

PROiPR:Q8K4G5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025085 Expressed in 301 organ(s), highest expression level in blood
CleanExiMM_ABLIM1
ExpressionAtlasiQ8K4G5 baseline and differential
GenevisibleiQ8K4G5 MM

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR028448 ABLIM1
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM
PANTHERiPTHR24213:SF18 PTHR24213:SF18, 1 hit
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 1 hit
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiABLM1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4G5
Secondary accession number(s): Q80U86
, Q8BIR9, Q8K4G3, Q8K4G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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