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Entry version 147 (08 May 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Actin-binding LIM protein 1

Gene

Ablim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.By similarity2 Publications

Miscellaneous

Isoform 1 is not necessary for normal axon guidance.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin-binding LIM protein 1
Short name:
abLIM-1
Alternative name(s):
Actin-binding LIM protein family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ablim1
Synonyms:Ablim, Kiaa0059
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1194500 Ablim1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000756981 – 861Actin-binding LIM protein 1Add BLAST861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei216PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei417PhosphotyrosineBy similarity1
Modified residuei440PhosphotyrosineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei477PhosphothreonineBy similarity1
Modified residuei479PhosphoserineCombined sources1
Modified residuei483PhosphotyrosineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei499PhosphoserineCombined sources1
Modified residuei502PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei723PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1
Modified residuei760PhosphoserineCombined sources1
Modified residuei789PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K4G5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K4G5

PeptideAtlas

More...
PeptideAtlasi
Q8K4G5

PRoteomics IDEntifications database

More...
PRIDEi
Q8K4G5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K4G5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K4G5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is detected in adult retina, where it is highly expressed in the ganglion layer. Detected in rod inner segment. Isoform 2 is highly expressed in adult retina, brain, kidney and heart. Isoform 3 is highly expressed in adult retina, brain, kidney, liver, skeletal muscle, spleen and heart. Detected in embryonic retina, brain, spinal cord, peripheral sensory ganglia and thymus.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 is detected at low levels starting from 12 dpc and remains constant until birth. After this levels increase strongly and expression remains high in adults. Isoform 2 and isoform 3 are expressed at a constant high level throughout development.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025085 Expressed in 301 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K4G5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K4G5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds F-actin. Interacts with ABRA (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621085EBI-2307994,EBI-300895

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230492, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8K4G5, 6 interactors

Molecular INTeraction database

More...
MINTi
Q8K4G5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000078336

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K4G5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 156LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini156 – 216LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini224 – 283LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini283 – 343LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61
Domaini793 – 861HPPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili673 – 723Sequence analysisAdd BLAST51

Keywords - Domaini

Coiled coil, LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1044 Eukaryota
ENOG410XRPY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182850

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285997

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K4G5

KEGG Orthology (KO)

More...
KOi
K07520

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKERICQ

Database of Orthologous Groups

More...
OrthoDBi
192350at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K4G5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.950.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028448 ABLIM1
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24213:SF18 PTHR24213:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16182 AbLIM_anchor, 1 hit
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47050 SSF47050, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K4G5-1) [UniParc]FASTAAdd to basket
Also known as: AbLIM-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSLLGLKCL GKLCSSEIGK VPSPERASLR NSHRRLLIED LSVPETPDPA
60 70 80 90 100
HRRRGTVIHL VYLYSAGCGP PELRFSSYDP SVAHPQDPHH SSEKPVIHCH
110 120 130 140 150
KCGEPCKGEV LRVQTKHFHI KCFTCKVCGC DLAQGGFFIK NGDYLCTLDY
160 170 180 190 200
QRMYGTRCHG CGEFVEGEVV TALGKTYHPN CFACTICKRP FPPGDRVTFN
210 220 230 240 250
GRDCLCQLCA QPMSSSPKEA SCSSNCAGCG RDIKNGQALL ALDKQWHLGC
260 270 280 290 300
FKCKSCGKVL TGEYISKDGS PYCEKDYQGL FGVKCEACHQ FITGKVLEAG
310 320 330 340 350
DKHYHPSCAR CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRPPN
360 370 380 390 400
IPRSSSDFFY PKSLIRRTGR SPALQLLSPP CLTNSNKNPR QPTRTSSESI
410 420 430 440 450
YSRPGSSIPG SPGHTIYAKV DNEILDYKDL AAIPKVKAIY DIERPDLITY
460 470 480 490 500
EPFYTSGYED KQERQSLGES PRTLSPTPSA EGYQDVRDRM IHRSTSQGSI
510 520 530 540 550
NSPVYSRHSY TPTTSRSPQH FHRPELLSPG VHRWSPLRTS SFSSTHSDSR
560 570 580 590 600
PNPPFRHHFL PHVKGNEPSS GRNSPLPYRP DSRPLTPTYA QAPKHFHVPD
610 620 630 640 650
QGINIYRKPP IYKQHAALAA QSKASEDIIK FSKFPAAQAP DPNEIPKIET
660 670 680 690 700
DHWPGPPSLA AVGTDPRRRS SGREEDEEEL LRRRQLQEEQ LMKLNSGLGQ
710 720 730 740 750
LILKEEMEKE SRERASLASR YDSPLHSASH APSSKTSSLP GYGKNGLHRP
760 770 780 790 800
VSTDFAQYNS YGDISGGVRD YQTLPDGHMP AVRMDRGVSM PNMLEPKIFP
810 820 830 840 850
YEMLMVTNRG RNKILRDVDR TRLERHLAPE VFWEIFGMSI QEFDKLPLWR
860
RNDMKKKAKL F
Length:861
Mass (Da):96,805
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E045F7CEF1D91EF
GO
Isoform 2 (identifier: Q8K4G5-2) [UniParc]FASTAAdd to basket
Also known as: AbLIM-M

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPSLLGLKCL...ELRFSSYDPS → MVKEK
     348-391: Missing.
     525-564: Missing.

Show »
Length:701
Mass (Da):78,960
Checksum:i5B5B038DC13E8335
GO
Isoform 3 (identifier: Q8K4G5-3) [UniParc]FASTAAdd to basket
Also known as: AbLIM-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.

Show »
Length:545
Mass (Da):62,004
Checksum:i4AC77999CAE0228B
GO
Isoform 4 (identifier: Q8K4G5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPSLLGLKCL...ELRFSSYDPS → MVKEK
     348-391: Missing.
     525-564: Missing.
     616-662: Missing.

Note: No experimental confirmation available.
Show »
Length:654
Mass (Da):74,052
Checksum:i90BFFB081F2BF1D2
GO
Isoform 5 (identifier: Q8K4G5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-81: YDPS → MSTR
     301-345: DKHYHPSCAR...CKQSTKTEEK → VTEASRTWSH...SAREWFALSA
     346-861: Missing.

Note: No experimental confirmation available.
Show »
Length:268
Mass (Da):29,911
Checksum:i08A6BFFDC99BB56B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QK41E9QK41_MOUSE
Actin-binding LIM protein 1
Ablim1
861Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9C7E9Q9C7_MOUSE
Actin-binding LIM protein 1
Ablim1
668Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9C0E9Q9C0_MOUSE
Actin-binding LIM protein 1
Ablim1
714Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9C1E9Q9C1_MOUSE
Actin-binding LIM protein 1
Ablim1
744Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9C4E9Q9C4_MOUSE
Actin-binding LIM protein 1
Ablim1
682Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9C2E9Q9C2_MOUSE
Actin-binding LIM protein 1
Ablim1
777Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q030E9Q030_MOUSE
Actin-binding LIM protein 1
Ablim1
545Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9D1E9Q9D1_MOUSE
Actin-binding LIM protein 1
Ablim1
426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9D2E9Q9D2_MOUSE
Actin-binding LIM protein 1
Ablim1
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9Q7E9Q9Q7_MOUSE
Actin-binding LIM protein 1
Ablim1
400Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65478 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0121031 – 316Missing in isoform 3. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_0121041 – 81MPSLL…SYDPS → MVKEK in isoform 2 and isoform 4. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_0121051 – 77Missing in isoform 5. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_01210678 – 81YDPS → MSTR in isoform 5. 1 Publication4
Alternative sequenceiVSP_012107301 – 345DKHYH…KTEEK → VTEASRTWSHIDLRWQGRSE ELRAWRHSIQSLRHQSAREW FALSA in isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_012109346 – 861Missing in isoform 5. 1 PublicationAdd BLAST516
Alternative sequenceiVSP_012108348 – 391Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_012110525 – 564Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_012111616 – 662Missing in isoform 4. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF404774 mRNA Translation: AAM73705.1
AF404775 mRNA Translation: AAM73706.1
AF404776 mRNA Translation: AAM73707.1
AK122196 mRNA Translation: BAC65478.1 Different initiation.
AK029371 mRNA Translation: BAC26424.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38027.1 [Q8K4G5-1]
CCDS50478.1 [Q8K4G5-3]
CCDS50479.1 [Q8K4G5-2]
CCDS70964.1 [Q8K4G5-4]

NCBI Reference Sequences

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RefSeqi
NP_001096647.1, NM_001103177.2 [Q8K4G5-2]
NP_001096648.1, NM_001103178.2
NP_001277742.1, NM_001290813.1
NP_001277744.1, NM_001290815.1 [Q8K4G5-4]
NP_848803.3, NM_178688.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000099294; ENSMUSP00000096897; ENSMUSG00000025085 [Q8K4G5-4]
ENSMUST00000111524; ENSMUSP00000107149; ENSMUSG00000025085 [Q8K4G5-5]
ENSMUST00000111546; ENSMUSP00000107172; ENSMUSG00000025085 [Q8K4G5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
226251

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:226251

UCSC genome browser

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UCSCi
uc008hzz.1 mouse [Q8K4G5-5]
uc033hkz.2 mouse [Q8K4G5-2]
uc033hld.2 mouse [Q8K4G5-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404774 mRNA Translation: AAM73705.1
AF404775 mRNA Translation: AAM73706.1
AF404776 mRNA Translation: AAM73707.1
AK122196 mRNA Translation: BAC65478.1 Different initiation.
AK029371 mRNA Translation: BAC26424.1
CCDSiCCDS38027.1 [Q8K4G5-1]
CCDS50478.1 [Q8K4G5-3]
CCDS50479.1 [Q8K4G5-2]
CCDS70964.1 [Q8K4G5-4]
RefSeqiNP_001096647.1, NM_001103177.2 [Q8K4G5-2]
NP_001096648.1, NM_001103178.2
NP_001277742.1, NM_001290813.1
NP_001277744.1, NM_001290815.1 [Q8K4G5-4]
NP_848803.3, NM_178688.3

3D structure databases

SMRiQ8K4G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230492, 6 interactors
IntActiQ8K4G5, 6 interactors
MINTiQ8K4G5
STRINGi10090.ENSMUSP00000078336

PTM databases

iPTMnetiQ8K4G5
PhosphoSitePlusiQ8K4G5

Proteomic databases

jPOSTiQ8K4G5
PaxDbiQ8K4G5
PeptideAtlasiQ8K4G5
PRIDEiQ8K4G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099294; ENSMUSP00000096897; ENSMUSG00000025085 [Q8K4G5-4]
ENSMUST00000111524; ENSMUSP00000107149; ENSMUSG00000025085 [Q8K4G5-5]
ENSMUST00000111546; ENSMUSP00000107172; ENSMUSG00000025085 [Q8K4G5-2]
GeneIDi226251
KEGGimmu:226251
UCSCiuc008hzz.1 mouse [Q8K4G5-5]
uc033hkz.2 mouse [Q8K4G5-2]
uc033hld.2 mouse [Q8K4G5-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3983
MGIiMGI:1194500 Ablim1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1044 Eukaryota
ENOG410XRPY LUCA
GeneTreeiENSGT00950000182850
HOGENOMiHOG000285997
InParanoidiQ8K4G5
KOiK07520
OMAiGKERICQ
OrthoDBi192350at2759
PhylomeDBiQ8K4G5

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8K4G5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025085 Expressed in 301 organ(s), highest expression level in blood
ExpressionAtlasiQ8K4G5 baseline and differential
GenevisibleiQ8K4G5 MM

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR028448 ABLIM1
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM
PANTHERiPTHR24213:SF18 PTHR24213:SF18, 1 hit
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 1 hit
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABLM1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K4G5
Secondary accession number(s): Q80U86
, Q8BIR9, Q8K4G3, Q8K4G4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2002
Last modified: May 8, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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