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Protein

Protein ABHD11

Gene

Abhd11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Charge relay systemBy similarity1
Active sitei229Charge relay systemBy similarity1
Active sitei288Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERimouse-Abhd11 ABHD11-Acetyl_transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD11Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 11Curated
Short name:
Abhydrolase domain-containing protein 11Imported
Williams-Beuren syndrome chromosomal region 21 protein homolog
Gene namesi
Name:Abhd11Imported
Synonyms:Wbscr21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916008 Abhd11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795090

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002810041 – 307Protein ABHD11Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79N6-succinyllysineCombined sources1
Modified residuei196N6-succinyllysineCombined sources1

Proteomic databases

EPDiQ8K4F5
MaxQBiQ8K4F5
PaxDbiQ8K4F5
PeptideAtlasiQ8K4F5
PRIDEiQ8K4F5

PTM databases

iPTMnetiQ8K4F5
PhosphoSitePlusiQ8K4F5

Expressioni

Tissue specificityi

Expressed in white adipose tissues.1 Publication

Inductioni

Up-regulated by rosiglitazone and down-regulated by high fat feeding.1 Publication

Gene expression databases

BgeeiENSMUSG00000040532
CleanExiMM_ABHD11
ExpressionAtlasiQ8K4F5 baseline and differential
GenevisibleiQ8K4F5 MM

Interactioni

Protein-protein interaction databases

IntActiQ8K4F5, 1 interactor
MINTiQ8K4F5
STRINGi10090.ENSMUSP00000043041

Structurei

3D structure databases

ProteinModelPortaliQ8K4F5
SMRiQ8K4F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2382 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00390000015880
HOGENOMiHOG000028067
HOVERGENiHBG080815
InParanoidiQ8K4F5
KOiK13703
OMAiHWLHAEN
OrthoDBiEOG091G0EP1
PhylomeDBiQ8K4F5
TreeFamiTF314071

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K4F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWARAWRV PRGVLGASSP RRLAVPVTFC SSRSSGQENA DLRPLPLSYN
60 70 80 90 100
LLDGDATLPA IVFLHGLFGS KTNFNSLAKA MVQRTGRRVL TVDARNHGDS
110 120 130 140 150
PHSPDASYEA MSQDLQGLLP QLGLVPCVLV GHSMGGKTAM LLALQRPDVV
160 170 180 190 200
ERLVVVDISP VGTTPGSHIG AFIAAMKAVE IPEKVPHSQA RKLADKQLSS
210 220 230 240 250
VVKEAGIRQF LLTNLVEVGG RFSWRLNLDT LAQHLDKIMT FPQQREPYSG
260 270 280 290 300
PTLFLLGGNS TYVQPSHHSE IRRLFPQAQI QTVPNAGHWV HSDKPQDFMD

AVTSFLA
Length:307
Mass (Da):33,561
Last modified:October 1, 2002 - v1
Checksum:iB1FAB20B83545B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412033 mRNA Translation: AAM62315.1
BC069866 mRNA Translation: AAH69866.1
CCDSiCCDS19730.1
RefSeqiNP_660250.1, NM_145215.2
UniGeneiMm.389700

Genome annotation databases

EnsembliENSMUST00000046999; ENSMUSP00000043041; ENSMUSG00000040532
GeneIDi68758
KEGGimmu:68758
UCSCiuc008zxg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiABHDB_MOUSE
AccessioniPrimary (citable) accession number: Q8K4F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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