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Entry version 127 (12 Aug 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Alstrom syndrome protein 1 homolog

Gene

Alms1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259, Loss of Nlp from mitotic centrosomes
R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320, Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912, Anchoring of the basal body to the plasma membrane
R-MMU-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alstrom syndrome protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Alms1
Synonyms:Kiaa0328
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1934606, Alms1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display obesity, hypogonadism, hyperinsulinemia, retinal dysfunction and hearing loss.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002255931 – 3251Alstrom syndrome protein 1 homologAdd BLAST3251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei401PhosphoserineBy similarity1
Modified residuei1305PhosphoserineBy similarity1
Modified residuei1623PhosphoserineBy similarity1
Modified residuei1788PhosphoserineBy similarity1
Modified residuei1916PhosphoserineCombined sources1
Modified residuei1958PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K4E0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K4E0

PeptideAtlas

More...
PeptideAtlasi
Q8K4E0

PRoteomics IDEntifications database

More...
PRIDEi
Q8K4E0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K4E0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K4E0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at 7.5 dpc. At 8.0 dpc expression is found in mesodermal- and ectodermal-derived layers. At 10.5 dpc mainly detected in midbrain, hindbrain, forelimb and hindlimb. Also expressed at 15.5 dpc and 18.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063810, Expressed in spermatid and 76 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K4E0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K4E0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231749, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8K4E0

Protein interaction database and analysis system

More...
IntActi
Q8K4E0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000071904

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K4E0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati440 – 4851Add BLAST46
Repeati486 – 5342Add BLAST49
Repeati540 – 5873Add BLAST48
Repeati588 – 6384Add BLAST51
Repeati639 – 6845Add BLAST46
Repeati685 – 7316Add BLAST47
Repeati732 – 7777Add BLAST46
Repeati778 – 8248Add BLAST47
Repeati825 – 8719Add BLAST47
Repeati872 – 91710Add BLAST46
Repeati918 – 95911Add BLAST42
Repeati960 – 100512Add BLAST46
Repeati1006 – 104813Add BLAST43
Repeati1115 – 116314Add BLAST49
Repeati1164 – 120815Add BLAST45
Repeati1269 – 131416Add BLAST46
Repeati1315 – 136217Add BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni440 – 136217 X 47 AA approximate tandem repeatAdd BLAST923
Regioni3129 – 3251ALMS motifAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 80Glu-richAdd BLAST79
Compositional biasi90 – 113Pro-richAdd BLAST24
Compositional biasi2582 – 2618His-richAdd BLAST37

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4613, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000177_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K4E0

KEGG Orthology (KO)

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KOi
K16741

Database of Orthologous Groups

More...
OrthoDBi
9342at2759

TreeFam database of animal gene trees

More...
TreeFami
TF335596

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028781, ALMS1
IPR029299, ALMS_motif
IPR040972, ALMS_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR21553:SF22, PTHR21553:SF22, 10 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15309, ALMS_motif, 1 hit
PF18727, ALMS_repeat, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K4E0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPEDLPWPD ELEEEEEEEE EEGEEEEGKK EVENASAAAT EEALTSEESG
60 70 80 90 100
RLEEFEEAGP DLDFNYESQR QESSDEEEDE LAKAWLQAHP DRPGSAFSLP
110 120 130 140 150
PPTPPPPPPP LSPRLRYTPV EHLGKTEVVP LTCRVWQQSS YQDNSRAQFS
160 170 180 190 200
NSSTMLLETG VRWGSEEDQR TESWHCLPQE RDSSQTLAMS QTEIGRVEGT
210 220 230 240 250
EVPDLPSQEG GLPAQSQCPG KKPKLNVLCS PLLVIQDNFA APDLPLLTCL
260 270 280 290 300
IQDQEEVEPD SLFQQSELEF APLRGIPDKS EDSEWLARPS EVSEALIQAT
310 320 330 340 350
SETSSDLANS CFSISQHPLT EGLQGKAESG VLTRCGDAKY SSLYENLGAQ
360 370 380 390 400
SERIAVLQRE VGCSNLGISQ ASPSSLPSFV PQEPTSEPEY HSSNLRMLRV
410 420 430 440 450
SPDTLLTTHT HSAGSADQKI GAAVVSSAYS QEIKPGSFHQ EELPDRHLNE
460 470 480 490 500
EIRKVSPALR TAGQKPEMLP VQSSSYSKGM KSIFYQHPVS HGHQGKEPLS
510 520 530 540 550
VSAVCGSAGN KAFHQLSTLS DSLLTEETWP VSVIPGLGNQ KTPLPSEFSL
560 570 580 590 600
SYSHRGKNLP EDVVKVSTDS GSAHKKADIL TASSRTYQHK MKPANIYHQE
610 620 630 640 650
LPDSRVPIGT RKVAFESGPA GQKSGVSHPY GEMPSVFYQQ GLPDRHSAKS
660 670 680 690 700
PTKTFIPGPA DQKTDLSPVP PTSSSHAEKP VSPYQLTLPG SHLPEDVFKA
710 720 730 740 750
SSVCKSSDEL SGITALTSAS YSYKGRPNSS YQQKFPDSHL NEEAQKILGT
760 770 780 790 800
TGTVDQKTVT PTMSSSFLQK EKPSIFYQQT LPDGGLSEED LQVSAVPWPA
810 820 830 840 850
DQNIAIPTVT SAAFSQREKP RIFYQQTLSV DRLPGEPLNV LGTSGPPDQN
860 870 880 890 900
TGAPTVTPSS YFPGEESIIF YQAGFPGNTL SAMSFKVPRI SGSTEQTNVT
910 920 930 940 950
TGSSSSYSVG EKSIIFYHQA LPDGRLPQEA SPAPADLNTG EPPMYLASCS
960 970 980 990 1000
VGVKPIIFYQ QPMSDSQRTK GHKESDVPGP TDQKTGIATV HSTSQSYIGR
1010 1020 1030 1040 1050
RTVSYQKEFP DLSEKALKVL GDVGSTEQKT QIPVVSSALL HKEGPSAYQE
1060 1070 1080 1090 1100
DLPDLTEEPL QILGVSEEVS SSSYQRKLPD HIEVFLKSVG SGSADRKTGA
1110 1120 1130 1140 1150
QIVSSSREKS SGFHQQELPN TGGDAVDAFH PEPVVQEVRK VQTPGAPAGP
1160 1170 1180 1190 1200
SSSHFHKEKL SDYQKASPHR DLTESSLKAS TVPGLSDQKK KPAVSSGFCL
1210 1220 1230 1240 1250
HKEKHEISAS ALLNCQTAEL LTVTQRSCLH REDPAISTVI KPDDQKIPLP
1260 1270 1280 1290 1300
TTFHGSSDQK VKPVIFVQKQ LRDRDQSEDI PKISTVSEPT VVNTVLPVLL
1310 1320 1330 1340 1350
PGSYSHREKS DSFYPQELPD GHLTEVDLKV SSGLGQADQI SGLPTGIPGT
1360 1370 1380 1390 1400
YSHSEKHQLI SEHVQELMDN LNSSESSCLS VDSMPLNSQI DDGVIICKPE
1410 1420 1430 1440 1450
SLGFANAGCE EMQNIDRGSK TLKEIQTLLM EAENMALKRC NFSVPLVPFR
1460 1470 1480 1490 1500
DVNDVSFIRS KKVVCFKESS TTDVCTQRES FVEEVPHIEY VQKDIGTQTN
1510 1520 1530 1540 1550
LKYQRGVGNW EFISSATFRS PLQEAEGTAR MAYDETFRQY KAARSVMRSE
1560 1570 1580 1590 1600
PEGCSTGIGN KMIIPMMTII KSDSSSDVSD GCCSWDNNLP ESLESVSDVF
1610 1620 1630 1640 1650
LNFFPYTSPK TSITDSREEE WLSESEDGYG STDSLAAHVK YLLQCETSLN
1660 1670 1680 1690 1700
QAKQILKNAE EEEYRVRTQA WNLKFNLGRD RGYSISELNE DDRRKVEEIK
1710 1720 1730 1740 1750
AKLFGHGRAT HMSEGLRSPQ GIGCLPEAVC SRIIIESHEK GCFRTLTAEQ
1760 1770 1780 1790 1800
PRPDSCHCAF RSVEPSDLIR GHRSPSSWRG RHINLSRSIE QSNPCFKVGS
1810 1820 1830 1840 1850
SFQLQSHPPF QKLLPDDIKI SKGVGMPVHA YMDPQPSELV EPTCVPAKEM
1860 1870 1880 1890 1900
DFPSSSQILP PEPKKQFTTA ITFSSHEHSE CISDSSGCKV GVTADSQCSG
1910 1920 1930 1940 1950
PSLGVFKPHI PEEQISPRDL KQKTSFQSSL ERHGSTPVTI LADGSRQRQK
1960 1970 1980 1990 2000
LPVDFEHSHQ KEKLLQRLGF KVSHSEPNVS TNVSNFKGVQ FSGKDTIVSQ
2010 2020 2030 2040 2050
DKLTSTVEVK EKNVTVTPDL PSCIFLEQPE LFEESHTPHT DLQMRKYPSP
2060 2070 2080 2090 2100
SCPEIASRIF LEQPKLSEQS KAPHVDREIR EDHSFFPKCQ DYIVADPSPD
2110 2120 2130 2140 2150
FPDQQQCKPP DVVGHTRKQN SLLSEGQDYE LEEVQHIPQS YFSNMVNVEA
2160 2170 2180 2190 2200
KVSDAISQSA PDHCTAASTP PSNRKALSCV RITLCPKTSS KLDSGTLGER
2210 2220 2230 2240 2250
FHSLDPASKT RINSEFNSDL RIISSRSLEP TSKLLTCKPV AQDQESLVFL
2260 2270 2280 2290 2300
GPKSPLDLQV AQSSLPDSKT IFQDLKTKPP QNSQIVTSRQ TQVNISHLEG
2310 2320 2330 2340 2350
YSKPEGTPVS ADGSQEQSKV SFTTSFGKLS SDAITQITTE SPEKTTFSSE
2360 2370 2380 2390 2400
IFIHADDRGQ GILDPMAQKP SRFASSSSVQ QIPASHGKDA QPVLLPYKPS
2410 2420 2430 2440 2450
GSSKMYYVPL LKRVPSYLDS KSDTTVESSH SGSNDAIAPD FPPQMLGTRD
2460 2470 2480 2490 2500
DDLSNTVNIK HKEGIYSKRA ATKGKNPSQK GDAAAPVQMP ITWDENVLDE
2510 2520 2530 2540 2550
NQEEVISRGV VIKMAGPEEM SSLEKDLAGP SDITVQDRKT ENLPDTKSIK
2560 2570 2580 2590 2600
QKEGSLEIES ECHSAFENTA HSVFRSAKFY FHHPVHLPHE QDFCHESLGR
2610 2620 2630 2640 2650
SVFMQHSWKD FFHHHSGHSC LPPPGPSSDK LDKTKMDYTR IKSLSINLNL
2660 2670 2680 2690 2700
GEHEKIHTIK NQARDPKGKR QANEQKKDQK VTPELTTECP VSLNELWNRY
2710 2720 2730 2740 2750
QERQKQQNPS GACDTKELSL VERLDRLAKL LQNPITHSLR ASESAQDDSR
2760 2770 2780 2790 2800
GGHRAREWTG RRQQKQKGKQ HRKWSKSLER GQSTGDFRKS KVFSPHQGGK
2810 2820 2830 2840 2850
SSQFKIEQIK LDKYILRKEP GFNNVSNTSL DSRPSEESVS LTDSPNIFSS
2860 2870 2880 2890 2900
TDSPVDSDVL TPTDRDMPLN ERSSSISTID TVRLIQAFGQ DRLSLSPRRI
2910 2920 2930 2940 2950
KLYSTVTSQR RRYLEQPCKH NRKALNTACP QMTSEHSRRR HIQVANHMTS
2960 2970 2980 2990 3000
SDSVSSPGSL LSLDSALSNE ETVRMVSKGV QAGNLEIVAG VKKYTQDVGV
3010 3020 3030 3040 3050
TFPTPSSSEA RLEEDSDVTS SSEEKAKEKK FLSNYLQTKN LRKNKPNPCA
3060 3070 3080 3090 3100
GVSWFVPVES GQSGSKKENL PKIYRPVISW FEPVTKTKPW REPLREQNWQ
3110 3120 3130 3140 3150
AQCMNSRGSL GGPGRDSGQV SLRPFVRATL QESLQLHRPD FISHSGERIK
3160 3170 3180 3190 3200
RLKLLVQERK LQSLFQSERE ALFHSARPLP RRVLLAVQKN KPIGKKEMIQ
3210 3220 3230 3240 3250
RTRRIYEQLP EVKKKREEEK RKSEYKSYWL RAQHYKMKVT NHLLGRKVPW

D
Length:3,251
Mass (Da):360,215
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i560D2B0650DDD0FB
GO
Isoform 2 (identifier: Q8K4E0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2947: Missing.

Show »
Length:304
Mass (Da):34,832
Checksum:iE844C8A038C87ECE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RMI8A0A1D5RMI8_MOUSE
Alstrom syndrome protein 1 homolog
Alms1
3,720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32212 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26E → Y in AAM62320 (PubMed:11941369).Curated1
Sequence conflicti2708 – 2710NPS → SPC in AAM62320 (PubMed:11941369).Curated3
Sequence conflicti3017D → G in BAD32212 (PubMed:15368895).Curated1
Sequence conflicti3060S → N in BAD32212 (PubMed:15368895).Curated1
Sequence conflicti3077V → G in BAD32212 (PubMed:15368895).Curated1
Sequence conflicti3229W → R in BAD32212 (PubMed:15368895).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173501 – 2947Missing in isoform 2. 1 PublicationAdd BLAST2947

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF425257 mRNA Translation: AAM62320.1
AK172934 mRNA Translation: BAD32212.1 Different initiation.
AC104743 Genomic DNA No translation available.
AC162313 Genomic DNA No translation available.
AK041679 mRNA Translation: BAC31030.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS20298.1 [Q8K4E0-1]

NCBI Reference Sequences

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RefSeqi
NP_660258.2, NM_145223.2 [Q8K4E0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000072018; ENSMUSP00000071904; ENSMUSG00000063810 [Q8K4E0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
236266

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:236266

UCSC genome browser

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UCSCi
uc009cpz.1, mouse [Q8K4E0-1]
uc009cqe.1, mouse [Q8K4E0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425257 mRNA Translation: AAM62320.1
AK172934 mRNA Translation: BAD32212.1 Different initiation.
AC104743 Genomic DNA No translation available.
AC162313 Genomic DNA No translation available.
AK041679 mRNA Translation: BAC31030.1
CCDSiCCDS20298.1 [Q8K4E0-1]
RefSeqiNP_660258.2, NM_145223.2 [Q8K4E0-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi231749, 6 interactors
CORUMiQ8K4E0
IntActiQ8K4E0, 1 interactor
STRINGi10090.ENSMUSP00000071904

PTM databases

iPTMnetiQ8K4E0
PhosphoSitePlusiQ8K4E0

Proteomic databases

jPOSTiQ8K4E0
PaxDbiQ8K4E0
PeptideAtlasiQ8K4E0
PRIDEiQ8K4E0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8144, 112 antibodies

Genome annotation databases

EnsembliENSMUST00000072018; ENSMUSP00000071904; ENSMUSG00000063810 [Q8K4E0-1]
GeneIDi236266
KEGGimmu:236266
UCSCiuc009cpz.1, mouse [Q8K4E0-1]
uc009cqe.1, mouse [Q8K4E0-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7840
MGIiMGI:1934606, Alms1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG4613, Eukaryota
GeneTreeiENSGT00940000153123
HOGENOMiCLU_000177_0_0_1
InParanoidiQ8K4E0
KOiK16741
OrthoDBi9342at2759
TreeFamiTF335596

Enzyme and pathway databases

ReactomeiR-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259, Loss of Nlp from mitotic centrosomes
R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320, Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912, Anchoring of the basal body to the plasma membrane
R-MMU-8854518, AURKA Activation by TPX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
236266, 1 hit in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Alms1, mouse

Protein Ontology

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PROi
PR:Q8K4E0
RNActiQ8K4E0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000063810, Expressed in spermatid and 76 other tissues
ExpressionAtlasiQ8K4E0, baseline and differential
GenevisibleiQ8K4E0, MM

Family and domain databases

InterProiView protein in InterPro
IPR028781, ALMS1
IPR029299, ALMS_motif
IPR040972, ALMS_repeat
PANTHERiPTHR21553:SF22, PTHR21553:SF22, 10 hits
PfamiView protein in Pfam
PF15309, ALMS_motif, 1 hit
PF18727, ALMS_repeat, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALMS1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K4E0
Secondary accession number(s): E9QKT8, Q6A084, Q8C9N9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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