Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 114 (10 Feb 2021)
Sequence version 3 (16 Mar 2016)
Previous versions | rss
Add a publicationFeedback
Protein

Interleukin-17 receptor C

Gene

Il17rc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:27923703, PubMed:19144317). Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:17911633, PubMed:20554964). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (By similarity). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (By similarity). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:28813677). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:20554964). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:27923703). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processInflammatory response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-17 receptor C
Short name:
IL-17 receptor C
Short name:
IL-17RC
Alternative name(s):
Interleukin-17 receptor-like protein
Short name:
IL-17RL
ZcytoR14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Il17rc
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2159336, Il17rc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 464ExtracellularSequence analysisAdd BLAST443
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 698CytoplasmicSequence analysisAdd BLAST213

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001103522 – 698Interleukin-17 receptor CAdd BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi190 ↔ 202By similarity
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi266 ↔ 316By similarity
Disulfide bondi268 ↔ 284By similarity
Disulfide bondi325 ↔ 334By similarity
Disulfide bondi364 ↔ 378By similarity
Disulfide bondi406 ↔ 413By similarity
Disulfide bondi440 ↔ 455By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K4C2

PRoteomics IDEntifications database

More...
PRIDEi
Q8K4C2

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8K4C2, 5 sites

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K4C2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in colonic epithelial cells (PubMed:19144317). Expressed in lung epithelial cells (PubMed:28813677). Expressed in macrophages (PubMed:19144317). Highly expressed in B-1a B cells and at a lower extent in B-1b and B-2 B cells (at protein level) (PubMed:26735852).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in lung epithelial cells upon bacterial and fungal infection. Up-regulated in lung epithelial cells by IL17F; this might account for a persistent activation via a positive feedback loop.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030281, Expressed in zone of skin and 66 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K4C2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K4C2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (By similarity). Heterodimer with IL17RA (PubMed:20554964). Heterodimerization with IL17RA is independent of the cytoplasmic tail. Associates with non-glycosylated IL17RA constitutively. Binding of IL17A and IL17F induces association with glycosylated IL17RA (PubMed:20554964). Forms complexes with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (By similarity). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex, whereas IL17F homodimer forms predominantly complexes with IL17RC homodimer (By similarity). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (By similarity). IL17RC chain can not distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity).

Interacts (through SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated) (PubMed:20554964).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
228481, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8K4C2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000055343

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K4C2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K4C2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini496 – 645SEFIRPROSITE-ProRule annotationAdd BLAST150

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWQ3, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111286

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026893_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K4C2

TreeFam database of animal gene trees

More...
TreeFami
TF335852

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039465, IL-17_rcpt-like
IPR027841, IL-17_rcpt_C/E_N
IPR013568, SEFIR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15583, PTHR15583, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15037, IL17_R_N, 1 hit
PF08357, SEFIR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51534, SEFIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K4C2-3) [UniParc]FASTAAdd to basket
Also known as: IL17RC1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVSWFLLSL ALGRNPVVVS LERLMEPQDT ARCSLGLSCH LWDGDVLCLP
60 70 80 90 100
GSLQSAPGPV LVPTRLQTEL VLRCPQKTDC ALCVRVVVHL AVHGHWAEPE
110 120 130 140 150
EAGKSDSELQ ESRNASLQAQ VVLSFQAYPI ARCALLEVQV PADLVQPGQS
160 170 180 190 200
VGSAVFDCFE ASLGAEVQIW SYTKPRYQKE LNLTQQLPDC RGLEVRDSIQ
210 220 230 240 250
SCWVLPWLNV STDGDNVLLT LDVSEEQDFS FLLYLRPVPD ALKSLWYKNL
260 270 280 290 300
TGPQNITLNH TDLVPCLCIQ VWSLEPDSER VEFCPFREDP GAHRNLWHIA
310 320 330 340 350
RLRVLSPGVW QLDAPCCLPG KVTLCWQAPD QSPCQPLVPP VPQKNATVNE
360 370 380 390 400
PQDFQLVAGH PNLCVQVSTW EKVQLQACLW ADSLGPFKDD MLLVEMKTGL
410 420 430 440 450
NNTSVCALEP SGCTPLPSMA STRAARLGEE LLQDFRSHQC MQLWNDDNMG
460 470 480 490 500
SLWACPMDKY IHRRWVLVWL ACLLLAAALF FFLLLKKDRR KAARGSRTAL
510 520 530 540 550
LLHSADGAGY ERLVGALASA LSQMPLRVAV DLWSRRELSA HGALAWFHHQ
560 570 580 590 600
RRRILQEGGV VILLFSPAAV AQCQQWLQLQ TVEPGPHDAL AAWLSCVLPD
610 620 630 640 650
FLQGRATGRY VGVYFDGLLH PDSVPSPFRV APLFSLPSQL PAFLDALQGG
660 670 680 690
CSTSAGRPAD RVERVTQALR SALDSCTSSS EAPGCCEEWD LGPCTTLE
Length:698
Mass (Da):77,148
Last modified:March 16, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24EC9DA8B3A144E7
GO
Isoform 2 (identifier: Q8K4C2-4) [UniParc]FASTAAdd to basket
Also known as: IL17RC-delta71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     189-203: Missing.

Show »
Length:683
Mass (Da):75,399
Checksum:i495E0785DAEACFFA
GO
Isoform 3 (identifier: Q8K4C2-1) [UniParc]FASTAAdd to basket
Also known as: IL17RC-delta7,81 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     189-212: Missing.

Show »
Length:674
Mass (Da):74,389
Checksum:i131EF5CE5C8E09E6
GO
Isoform 4 (identifier: Q8K4C2-5) [UniParc]FASTAAdd to basket
Also known as: IL17RC-delta81 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     204-212: Missing.

Show »
Length:689
Mass (Da):76,138
Checksum:i0062B44FE6CB4851
GO
Isoform 5 (identifier: Q8K4C2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     490-698: RKAARGSRTA...WDLGPCTTLE → MTPSPPGSAA...RGDPRTGWNE

Show »
Length:567
Mass (Da):62,798
Checksum:iC1AAAB79E2006B1D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7AR97F7AR97_MOUSE
Interleukin-17 receptor C
Il17rc
579Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SW88A0A0N4SW88_MOUSE
Interleukin-17 receptor C
Il17rc
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZF00F6ZF00_MOUSE
Interleukin-17 receptor C
Il17rc
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83C → R in AAM77570 (Ref. 1) Curated1
Sequence conflicti83C → R in CAD23359 (Ref. 3) Curated1
Sequence conflicti83C → R in CAD23360 (Ref. 3) Curated1
Sequence conflicti379L → S in AAM77570 (Ref. 1) Curated1
Sequence conflicti379L → S in CAD23359 (Ref. 3) Curated1
Sequence conflicti379L → S in CAD23360 (Ref. 3) Curated1
Sequence conflicti638S → T in AAM77570 (Ref. 1) Curated1
Sequence conflicti638S → T in CAD23359 (Ref. 3) Curated1
Sequence conflicti638S → T in CAD23360 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058140189 – 212Missing in isoform 3. Add BLAST24
Alternative sequenceiVSP_058139189 – 203Missing in isoform 2. Add BLAST15
Alternative sequenceiVSP_058141204 – 212Missing in isoform 4. 9
Alternative sequenceiVSP_058142490 – 698RKAAR…CTTLE → MTPSPPGSAACYPISCKAGR PAATSGSTSTGCCTQTLCPP RSASPRSSPCPRSCRLSWMH CREAAPLPRGDPRTGWNE in isoform 5. 1 PublicationAdd BLAST209

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF458066 mRNA Translation: AAM77570.1
CS251263 Unassigned DNA No translation available.
CS251267 Unassigned DNA No translation available.
AX360307 Unassigned DNA Translation: CAD23359.1
AX360310 Unassigned DNA Translation: CAD23360.1
AC153910 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99478.1
BC004759 mRNA Translation: AAH04759.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20422.1 [Q8K4C2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_598920.3, NM_134159.4 [Q8K4C2-1]
NP_849273.1, NM_178942.1 [Q8K4C2-3]
XP_006505728.1, XM_006505665.1 [Q8K4C2-5]
XP_006505729.1, XM_006505666.1 [Q8K4C2-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000058300; ENSMUSP00000055343; ENSMUSG00000030281 [Q8K4C2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
171095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:171095

UCSC genome browser

More...
UCSCi
uc009dgl.3, mouse [Q8K4C2-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458066 mRNA Translation: AAM77570.1
CS251263 Unassigned DNA No translation available.
CS251267 Unassigned DNA No translation available.
AX360307 Unassigned DNA Translation: CAD23359.1
AX360310 Unassigned DNA Translation: CAD23360.1
AC153910 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99478.1
BC004759 mRNA Translation: AAH04759.1
CCDSiCCDS20422.1 [Q8K4C2-1]
RefSeqiNP_598920.3, NM_134159.4 [Q8K4C2-1]
NP_849273.1, NM_178942.1 [Q8K4C2-3]
XP_006505728.1, XM_006505665.1 [Q8K4C2-5]
XP_006505729.1, XM_006505666.1 [Q8K4C2-4]

3D structure databases

SMRiQ8K4C2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi228481, 2 interactors
IntActiQ8K4C2, 2 interactors
STRINGi10090.ENSMUSP00000055343

PTM databases

GlyGeniQ8K4C2, 5 sites
PhosphoSitePlusiQ8K4C2

Proteomic databases

PaxDbiQ8K4C2
PRIDEiQ8K4C2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10412, 315 antibodies

Genome annotation databases

EnsembliENSMUST00000058300; ENSMUSP00000055343; ENSMUSG00000030281 [Q8K4C2-1]
GeneIDi171095
KEGGimmu:171095
UCSCiuc009dgl.3, mouse [Q8K4C2-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84818
MGIiMGI:2159336, Il17rc

Phylogenomic databases

eggNOGiENOG502QWQ3, Eukaryota
GeneTreeiENSGT00730000111286
HOGENOMiCLU_026893_1_0_1
InParanoidiQ8K4C2
TreeFamiTF335852

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
171095, 0 hits in 17 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8K4C2
RNActiQ8K4C2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030281, Expressed in zone of skin and 66 other tissues
ExpressionAtlasiQ8K4C2, baseline and differential
GenevisibleiQ8K4C2, MM

Family and domain databases

InterProiView protein in InterPro
IPR039465, IL-17_rcpt-like
IPR027841, IL-17_rcpt_C/E_N
IPR013568, SEFIR_dom
PANTHERiPTHR15583, PTHR15583, 1 hit
PfamiView protein in Pfam
PF15037, IL17_R_N, 1 hit
PF08357, SEFIR, 1 hit
PROSITEiView protein in PROSITE
PS51534, SEFIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI17RC_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K4C2
Secondary accession number(s): G3X9C0, Q99J43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 16, 2016
Last modified: February 10, 2021
This is version 114 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again