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Protein

Interleukin-1 receptor-associated kinase 3

Gene

Irak3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.1 Publication2 Publications

Caution

Asn-306 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in PubMed:12054681, while other authors describe this as an inactive kinase.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei205ATPPROSITE-ProRule annotationBy similarity1
Binding sitei324ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi184 – 192ATPPROSITE-ProRule annotationBy similarity9
Nucleotide bindingi308 – 311ATPPROSITE-ProRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase 3 (EC:2.7.11.1)
Short name:
IRAK-3
Alternative name(s):
IL-1 receptor-associated kinase M
Short name:
IRAK-M
Gene namesi
Name:Irak3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1921164 Irak3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860341 – 609Interleukin-1 receptor-associated kinase 3Add BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei480PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K4B2
PaxDbiQ8K4B2
PRIDEiQ8K4B2

PTM databases

iPTMnetiQ8K4B2
PhosphoSitePlusiQ8K4B2

Expressioni

Tissue specificityi

Highly expressed in liver and thymus and at lower levels in heart, brain, spleen and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000020227 Expressed in 95 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_IRAK3
ExpressionAtlasiQ8K4B2 baseline and differential
GenevisibleiQ8K4B2 MM

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216351, 2 interactors
IntActiQ8K4B2, 6 interactors
MINTiQ8K4B2
STRINGi10090.ENSMUSP00000020448

Structurei

3D structure databases

ProteinModelPortaliQ8K4B2
SMRiQ8K4B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 106DeathPROSITE-ProRule annotationAdd BLAST66
Domaini178 – 463Protein kinasePROSITE-ProRule annotationAdd BLAST286

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063073
HOGENOMiHOG000060319
HOVERGENiHBG052146
InParanoidiQ8K4B2
KOiK04732
OMAiYMPEEYI
OrthoDBiEOG091G0YKT
PhylomeDBiQ8K4B2
TreeFamiTF328924

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR033610 IRAK3
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PANTHERiPTHR24419:SF7 PTHR24419:SF7, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8K4B2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGRCGARGA LSPQLLLFDL PPALLGELCG ILDSCDGPLG WRGLAERLSN
60 70 80 90 100
SWLDVRHIEK YVNQGKSGTR ELLWSWAQKN KTIGDLLEVL QDMGHQRAIH
110 120 130 140 150
LIINYGVSWT PSVQTHHELP FPSFPPEVKH ACRENDPGPL EPANVTVDNV
160 170 180 190 200
LVPEHNEKGT LQKTPISFQS ILEGTKHFHK DFLIGEGEIF EVYRVDIRNQ
210 220 230 240 250
AYAVKLFKQE KKMQLKKHWK RFLSELEVLL LFRHPHILEL AAYFTETEKL
260 270 280 290 300
CLVYPYMSNG TLFDRLQCTN GTTPLSWHVR ISVLIGIAKA IQYLHNTQPC
310 320 330 340 350
AVICGNVSSA NILLDDQLQP KLTDFAAAHF RPNLEQQSST INMTGGGRKH
360 370 380 390 400
LWYMPEEYIR QGRLSVKTDV YSFGIVIMEV LTGCKVVLDD PKHVQLRDLL
410 420 430 440 450
MELMEKRGLD SCLSFLDRKI PPCPRNFSAK LFSLAGRCVA TKAKLRPTMD
460 470 480 490 500
EVLSSLESTQ PSLYFAEDPP TSLKSFRCPS PLFLDNVPSI PVEDDENQNN
510 520 530 540 550
HSVPPKEVLG TDRVTQKTPF ECSQSEVTFL GLDRNRGNRG SEADCNVPSS
560 570 580 590 600
SHEECWSPEL VAPSQDLSPT VISLGSSWEV PGHSYGSKPM EKRCSSGLFC

SEHEQSKKQ
Length:609
Mass (Da):68,455
Last modified:October 25, 2004 - v2
Checksum:iA63E010C9F29D856
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCU1D6RCU1_MOUSE
Interleukin-1 receptor-associated k...
Irak3
309Annotation score:
D3Z007D3Z007_MOUSE
Interleukin-1 receptor-associated k...
Irak3
517Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35C → W in AAM83393 (PubMed:12150927).Curated1
Sequence conflicti42R → W in AAM83393 (PubMed:12150927).Curated1
Sequence conflicti62V → L in AAM83393 (PubMed:12150927).Curated1
Sequence conflicti126P → L in AAM83393 (PubMed:12150927).Curated1
Sequence conflicti147V → M in AAM83393 (PubMed:12150927).Curated1
Sequence conflicti282S → G in BAC33612 (PubMed:16141072).Curated1
Sequence conflicti282S → N in AAM83393 (PubMed:12150927).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461763 mRNA Translation: AAM83393.1
AJ440757 mRNA Translation: CAD29448.2
AK029057 mRNA Translation: BAC26270.1
AK049210 mRNA Translation: BAC33612.1
CCDSiCCDS24204.1
RefSeqiNP_082955.2, NM_028679.3
UniGeneiMm.146194

Genome annotation databases

EnsembliENSMUST00000020448; ENSMUSP00000020448; ENSMUSG00000020227
GeneIDi73914
KEGGimmu:73914
UCSCiuc007het.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461763 mRNA Translation: AAM83393.1
AJ440757 mRNA Translation: CAD29448.2
AK029057 mRNA Translation: BAC26270.1
AK049210 mRNA Translation: BAC33612.1
CCDSiCCDS24204.1
RefSeqiNP_082955.2, NM_028679.3
UniGeneiMm.146194

3D structure databases

ProteinModelPortaliQ8K4B2
SMRiQ8K4B2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216351, 2 interactors
IntActiQ8K4B2, 6 interactors
MINTiQ8K4B2
STRINGi10090.ENSMUSP00000020448

PTM databases

iPTMnetiQ8K4B2
PhosphoSitePlusiQ8K4B2

Proteomic databases

MaxQBiQ8K4B2
PaxDbiQ8K4B2
PRIDEiQ8K4B2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020448; ENSMUSP00000020448; ENSMUSG00000020227
GeneIDi73914
KEGGimmu:73914
UCSCiuc007het.1 mouse

Organism-specific databases

CTDi11213
MGIiMGI:1921164 Irak3

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063073
HOGENOMiHOG000060319
HOVERGENiHBG052146
InParanoidiQ8K4B2
KOiK04732
OMAiYMPEEYI
OrthoDBiEOG091G0YKT
PhylomeDBiQ8K4B2
TreeFamiTF328924

Enzyme and pathway databases

ReactomeiR-MMU-9020702 Interleukin-1 signaling

Miscellaneous databases

PROiPR:Q8K4B2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020227 Expressed in 95 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_IRAK3
ExpressionAtlasiQ8K4B2 baseline and differential
GenevisibleiQ8K4B2 MM

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR033610 IRAK3
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PANTHERiPTHR24419:SF7 PTHR24419:SF7, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRAK3_MOUSE
AccessioniPrimary (citable) accession number: Q8K4B2
Secondary accession number(s): Q8C7U8, Q8CE40, Q8K1S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: October 25, 2004
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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