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Protein

Transmembrane inner ear expressed protein

Gene

Tmie

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain.

GO - Biological processi

  • inner ear morphogenesis Source: MGI
  • sensory perception of sound Source: MGI

Protein family/group databases

TCDBi9.A.30.1.1 the putative tmie gentamiein uptake mechanosensitive channel (tmie) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane inner ear expressed protein
Gene namesi
Name:Tmie
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2159400 Tmie

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 58ExtracellularSequence analysisAdd BLAST30
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 153CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Tmie are the cause of the spinner mutant strain phenotype (sr). This disorder results in hearing loss and vestibular dysfunction due to neuroepithelial defects in the inner ear. It is recognized by behavioral dysfunction, including bidirectional circling and head shaking. Auditory function in spinner mice is found to be reduced, based upon the lack of a startle reflex to sound at any age. Breeding experiments indicated that these defects are inherited in an autosomal recessive fashion. The postnatal defects present in the cochleae of sr/sr mice suggest a requirement for Tmie during maturation of sensory cells, including the normal development or maintenance of stereocilia bundles.1 Publication

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002255629 – 153Transmembrane inner ear expressed proteinAdd BLAST125

Proteomic databases

PaxDbiQ8K467
PRIDEiQ8K467

PTM databases

iPTMnetiQ8K467
PhosphoSitePlusiQ8K467

Expressioni

Tissue specificityi

Expressed in brain, kidney, liver, lung and cochlea.1 Publication

Developmental stagei

Required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles.

Gene expression databases

BgeeiENSMUSG00000049555 Expressed in 140 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_TMIE
ExpressionAtlasiQ8K467 baseline and differential
GenevisibleiQ8K467 MM

Interactioni

Subunit structurei

Interacts with TOMT.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060148

Structurei

3D structure databases

ProteinModelPortaliQ8K467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 153Lys-richAdd BLAST30

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYQZ Eukaryota
ENOG4111RFP LUCA
GeneTreeiENSGT00390000005082
HOGENOMiHOG000060175
HOVERGENiHBG079268
InParanoidiQ8K467
OMAiETVVIWG
OrthoDBiEOG091G188E
PhylomeDBiQ8K467
TreeFamiTF332314

Family and domain databases

InterProiView protein in InterPro
IPR032006 TMIE
PANTHERiPTHR28635 PTHR28635, 1 hit
PfamiView protein in Pfam
PF16038 TMIE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGRQHGSGR LWALGGAALG ACLAGVATQL VEPSTAPPKP KPPPLTKETV
60 70 80 90 100
VFWDMRLWHV VGIFSLFVLS IIITLCCVFN CRVPRTRKEI EARYLQRKAA
110 120 130 140 150
KMYTDKLETV PPLNELTEIP GEDKKKKKKD SVDTVAIKVE EDEKNEAKKK

GEK
Length:153
Mass (Da):17,027
Last modified:October 1, 2002 - v1
Checksum:i2B22474B275CBBD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481143 mRNA Translation: AAM89222.1
CCDSiCCDS23578.1
RefSeqiNP_666372.1, NM_146260.2
XP_006512070.1, XM_006512007.3
XP_006512071.1, XM_006512008.3
XP_006512072.1, XM_006512009.3
XP_006512073.1, XM_006512010.3
XP_006512076.1, XM_006512013.3
XP_011241246.1, XM_011242944.2
XP_011241247.1, XM_011242945.2
UniGeneiMm.390229

Genome annotation databases

EnsembliENSMUST00000050958; ENSMUSP00000060148; ENSMUSG00000049555
GeneIDi20776
KEGGimmu:20776
UCSCiuc009rvb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481143 mRNA Translation: AAM89222.1
CCDSiCCDS23578.1
RefSeqiNP_666372.1, NM_146260.2
XP_006512070.1, XM_006512007.3
XP_006512071.1, XM_006512008.3
XP_006512072.1, XM_006512009.3
XP_006512073.1, XM_006512010.3
XP_006512076.1, XM_006512013.3
XP_011241246.1, XM_011242944.2
XP_011241247.1, XM_011242945.2
UniGeneiMm.390229

3D structure databases

ProteinModelPortaliQ8K467
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060148

Protein family/group databases

TCDBi9.A.30.1.1 the putative tmie gentamiein uptake mechanosensitive channel (tmie) family

PTM databases

iPTMnetiQ8K467
PhosphoSitePlusiQ8K467

Proteomic databases

PaxDbiQ8K467
PRIDEiQ8K467

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050958; ENSMUSP00000060148; ENSMUSG00000049555
GeneIDi20776
KEGGimmu:20776
UCSCiuc009rvb.1 mouse

Organism-specific databases

CTDi259236
MGIiMGI:2159400 Tmie

Phylogenomic databases

eggNOGiENOG410IYQZ Eukaryota
ENOG4111RFP LUCA
GeneTreeiENSGT00390000005082
HOGENOMiHOG000060175
HOVERGENiHBG079268
InParanoidiQ8K467
OMAiETVVIWG
OrthoDBiEOG091G188E
PhylomeDBiQ8K467
TreeFamiTF332314

Miscellaneous databases

PROiPR:Q8K467
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049555 Expressed in 140 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_TMIE
ExpressionAtlasiQ8K467 baseline and differential
GenevisibleiQ8K467 MM

Family and domain databases

InterProiView protein in InterPro
IPR032006 TMIE
PANTHERiPTHR28635 PTHR28635, 1 hit
PfamiView protein in Pfam
PF16038 TMIE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMIE_MOUSE
AccessioniPrimary (citable) accession number: Q8K467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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