UniProtKB - Q8K459 (PXT1_MOUSE)
Protein
Peroxisomal testis-specific protein 1
Gene
Pxt1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- positive regulation of apoptotic process Source: MGI
- spermatogenesis Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisomal testis-specific protein 1Alternative name(s): Small testis-specific peroxisomal protein |
Gene namesi | Name:Pxt1 Synonyms:Stepp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916557, Pxt1 |
Subcellular locationi
Peroxisome
- Peroxisome 1 Publication
Nucleus
- nucleus Source: MGI
Peroxisome
- peroxisome Source: UniProtKB
Keywords - Cellular componenti
PeroxisomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 48 – 50 | NHL → WQK: Abolishes peroxisome localization. 1 Publication | 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324594 | 1 – 51 | Peroxisomal testis-specific protein 1Add BLAST | 51 |
Proteomic databases
PaxDbi | Q8K459 |
PRIDEi | Q8K459 |
PTM databases
PhosphoSitePlusi | Q8K459 |
Expressioni
Tissue specificityi
Testis-specific.1 Publication
Developmental stagei
During spermatogenesis, it is first detected in testis at 15 days postpartum (dpp). Expressed at higher level at 17 dpp, 20 dpp, 25 dpp and in adult testis. First expressed when primary spermatocytes are present in postnatal mouse testis.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000045378, Expressed in embryo and 59 other tissues |
ExpressionAtlasi | Q8K459, baseline and differential |
Genevisiblei | Q8K459, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000053366 |
Miscellaneous databases
RNActi | Q8K459, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 48 – 51 | Microbody targeting signal | 4 |
Phylogenomic databases
eggNOGi | ENOG502RU1V, Eukaryota |
GeneTreei | ENSGT00390000012893 |
HOGENOMi | CLU_211143_0_0_1 |
InParanoidi | Q8K459 |
OMAi | RMVQEDF |
OrthoDBi | 1461171at2759 |
PhylomeDBi | Q8K459 |
TreeFami | TF338547 |
Family and domain databases
InterProi | View protein in InterPro IPR029186, PXT1 |
PANTHERi | PTHR40381, PTHR40381, 1 hit |
Pfami | View protein in Pfam PF15214, PXT1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8K459-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQLRHIGDSV NHRVIQEHLA QEVGDVLAPF VALVFVRGQV LLRFFWNNHL
L
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B2WCX9 | A0A3B2WCX9_MOUSE | Peroxisomal testis-specific protein... | Pxt1 | 82 | Annotation score: | ||
A0A3B2W3G7 | A0A3B2W3G7_MOUSE | Peroxisomal testis-specific protein... | Pxt1 | 18 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF486826 mRNA Translation: AAN03788.1 BC100437 mRNA Translation: AAI00438.1 |
CCDSi | CCDS37534.1 |
RefSeqi | NP_700439.1, NM_153390.1 |
Genome annotation databases
Ensembli | ENSMUST00000051526; ENSMUSP00000053366; ENSMUSG00000045378 |
GeneIDi | 69307 |
KEGGi | mmu:69307 |
UCSCi | uc008brv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF486826 mRNA Translation: AAN03788.1 BC100437 mRNA Translation: AAI00438.1 |
CCDSi | CCDS37534.1 |
RefSeqi | NP_700439.1, NM_153390.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000053366 |
PTM databases
PhosphoSitePlusi | Q8K459 |
Proteomic databases
PaxDbi | Q8K459 |
PRIDEi | Q8K459 |
Protocols and materials databases
Antibodypediai | 29675, 29 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000051526; ENSMUSP00000053366; ENSMUSG00000045378 |
GeneIDi | 69307 |
KEGGi | mmu:69307 |
UCSCi | uc008brv.1, mouse |
Organism-specific databases
CTDi | 222659 |
MGIi | MGI:1916557, Pxt1 |
Phylogenomic databases
eggNOGi | ENOG502RU1V, Eukaryota |
GeneTreei | ENSGT00390000012893 |
HOGENOMi | CLU_211143_0_0_1 |
InParanoidi | Q8K459 |
OMAi | RMVQEDF |
OrthoDBi | 1461171at2759 |
PhylomeDBi | Q8K459 |
TreeFami | TF338547 |
Miscellaneous databases
BioGRID-ORCSi | 69307, 0 hits in 15 CRISPR screens |
ChiTaRSi | Pxt1, mouse |
PROi | PR:Q8K459 |
RNActi | Q8K459, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045378, Expressed in embryo and 59 other tissues |
ExpressionAtlasi | Q8K459, baseline and differential |
Genevisiblei | Q8K459, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029186, PXT1 |
PANTHERi | PTHR40381, PTHR40381, 1 hit |
Pfami | View protein in Pfam PF15214, PXT1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PXT1_MOUSE | |
Accessioni | Q8K459Primary (citable) accession number: Q8K459 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot