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Protein

ATP-binding cassette sub-family A member 5

Gene

Abca5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the processing of autolysosomes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi514 – 521ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1333 – 1340ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • cholesterol efflux Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • lipid transport Source: GO_Central
  • negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • reverse cholesterol transport Source: BHF-UCL

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369062 ABC transporters in lipid homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 5
Gene namesi
Name:Abca5
Synonyms:Kiaa1888
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2386607 Abca5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei864 – 884HelicalSequence analysisAdd BLAST21
Transmembranei967 – 987HelicalSequence analysisAdd BLAST21
Transmembranei1021 – 1041HelicalSequence analysisAdd BLAST21
Transmembranei1071 – 1091HelicalSequence analysisAdd BLAST21
Transmembranei1102 – 1122HelicalSequence analysisAdd BLAST21
Transmembranei1138 – 1158HelicalSequence analysisAdd BLAST21
Transmembranei1164 – 1184HelicalSequence analysisAdd BLAST21
Transmembranei1207 – 1227HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display hypothyroidism and lethal heart abnormalities that may be due to altered autolysosomes processing.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002506701 – 1642ATP-binding cassette sub-family A member 5Add BLAST1642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi919N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi996N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K448
PaxDbiQ8K448
PeptideAtlasiQ8K448
PRIDEiQ8K448

PTM databases

iPTMnetiQ8K448
PhosphoSitePlusiQ8K448

Expressioni

Tissue specificityi

Expressed in cardiomyocytes, oligodendrocytes and astrocytes in brain, alveolar type 2 cells in lung and follicular cells in the thyroid gland (at protein level). Detected in brain, testis, lung, heart, liver, kidney, skeletal muscle and placenta.2 Publications

Developmental stagei

Expressed during embryogenesis.1 Publication

Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

BgeeiENSMUSG00000018800 Expressed in 198 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiQ8K448 baseline and differential
GenevisibleiQ8K448 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047927

Structurei

3D structure databases

ProteinModelPortaliQ8K448
SMRiQ8K448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini478 – 713ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1290 – 1533ABC transporter 2PROSITE-ProRule annotationAdd BLAST244

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00760000118965
HOVERGENiHBG079884
InParanoidiQ8K448
KOiK05648
OMAiCLICFIK
OrthoDBiEOG091G00AG
PhylomeDBiQ8K448
TreeFamiTF105192

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030367 ABCA5
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PTHR19229:SF100 PTHR19229:SF100, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8K448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAIRDVGV WRQTRTLLLK NYLIKCRTKK SSVQEILFPL FFLFWLILVS
60 70 80 90 100
MMHPNKKYEE VSDIELSPMD KFSLSNVILG YTPVTNITSS IMQRVSTDHL
110 120 130 140 150
PKVIVTEEYA NEKELVAASL SKSSNFVGVV FKDTMSYELR FFPEMIPVSS
160 170 180 190 200
IYMNSREGCS KTCDAAQYWS LGFTVLQASI DAAIIQLKTN VSVWSELEST
210 220 230 240 250
KAVIMGEAAV VEIDTFPRGV ILIYLVIAFS PFGYFLAIHI VAEKEKKLKE
260 270 280 290 300
FLKIMGLHDT AFWLSWVLLY ASLIFLMSLL MAVIATASSL FPQSSSIVIF
310 320 330 340 350
LLFFLYGLSS VFFALMLTPL FKKSKHVGVV EFFVTVVFGF VGLLIVLIES
360 370 380 390 400
FPRSLVWLFS PLCQCAFLIG IAQVMHLEDF NEGALFSNLT EGPYPLIITI
410 420 430 440 450
IMLALDSVFY VLLAVYLDQV IPGEFGLRRS SLYFLKPSYW SKNKRNYKEL
460 470 480 490 500
SEGNINGNIS LNEIVEPVSS EFIGKEAIRI SGIQKSYRKK TENVEALRNL
510 520 530 540 550
SFDIYEGQIT ALLGHSGTGK STLMNILCGL CPPSDGFASI YGHRVSEIDE
560 570 580 590 600
MFEARKMIGI CPQSDINFDV LTVEENLSIL ASIKGIPANN IIQEVQKVLL
610 620 630 640 650
DLDMQAIKDN QAKKLSGGQK RKLSVGIAVL GNPKILLLDE PTAGMDPCSR
660 670 680 690 700
HIVWNLLKYR KANRVTVFST HFMDEADILA DRKAVISQGM LKCVGSSIFL
710 720 730 740 750
KSKWGIGYRL SMYIDRYCAT ESLSSLVRQH IPAAALLQQN DQQLVYSLPF
760 770 780 790 800
KDMDKFSGLF SALDIHSNLG VISYGVSMTT LEDVFLKLEV EAEIDQADYS
810 820 830 840 850
VFTQQPREEE TDSKSFDEME QSLLILSETK ASSVSTMSLW KQQVSTIAKF
860 870 880 890 900
HFLSLKRESK SVRAVLLLLL IFFAVQIFMF FLHHSFKNAV VPIKLVPDLY
910 920 930 940 950
FLKPGDKPHK YKTSLLLQNS TDSDINGLIE FFAHQNIMVA MFNDSDYVSA
960 970 980 990 1000
APHSAALNVV RSEKDYVFSA VFNSTMVYCL PVMMNIISNY YLYHLNVTEA
1010 1020 1030 1040 1050
IQTWSTPFIQ EITDIVFKIE LYFQAALLGI IVTAMPPYFA MENAENHKIK
1060 1070 1080 1090 1100
AYTQLKLSGL LPSAYWVGQA VVDIPLFFVV LILMLGSLFA FHHGLYFYPA
1110 1120 1130 1140 1150
KFLAVVFCLI AYVPSVILFT YIASFTFKKI LNTKEFWSFI YSVTALACVA
1160 1170 1180 1190 1200
ITETTFFLQY AVTAVFHYTF CIAIPIYPLL GCLISFIKGS WKNMPKNENT
1210 1220 1230 1240 1250
YNPWDRLLVA VIMPYLQCIL WIFLLQHYEK IHGGRSIRKD PFFRALSQKA
1260 1270 1280 1290 1300
KNKKFPEPPI NEDEDEDVKA ERLKVKELMG CQCCEEKPAI MVCNLHKEYD
1310 1320 1330 1340 1350
DKKDFLHSRK TTKVATKYIS FCVKKGEILG LLGPNGAGKS TVINTLVGDV
1360 1370 1380 1390 1400
EPTSGKIFLG DYGSHSSEDD ESIKCMGYCP QTNPLWPDLT LQEHFEIYGA
1410 1420 1430 1440 1450
VKGMSPGDMK EVISRITKAL DLKEHLQKTV KKLPAGIKRK LCFALSMLGN
1460 1470 1480 1490 1500
PQVTLLDEPS TGMDPRAKQH MWRAIRTAFK NKKRAALLTT HYMEEAEAVC
1510 1520 1530 1540 1550
DRVAIMVSGQ LRCIGTVQHL KSKFGKGYFL EIKLKDWIEN LEIDRLQREI
1560 1570 1580 1590 1600
QYIFPNASRQ ESFSSILAFK IPKEDVQSLS QSFAKLEEAK RTFAIEEYSF
1610 1620 1630 1640
SQATLEQVFV ELTKEQEEED NSCGTLASTL WWERTQEDRV VF
Length:1,642
Mass (Da):185,895
Last modified:October 3, 2006 - v2
Checksum:i177A5FC0B075DFC5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AEP5A2AEP5_MOUSE
ATP-binding cassette sub-family A m...
Abca5
1,194Annotation score:
A2AEP6A2AEP6_MOUSE
ATP-binding cassette sub-family A m...
Abca5
181Annotation score:

Sequence cautioni

The sequence BAC28896 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96S → C in BAC32984 (PubMed:16141072).Curated1
Sequence conflicti113K → E in BAE41431 (PubMed:16141072).Curated1
Sequence conflicti132K → E in BAC32984 (PubMed:16141072).Curated1
Sequence conflicti188K → E in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti303F → V in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti384A → P in BAC32984 (PubMed:16141072).Curated1
Sequence conflicti530L → P in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti551M → I in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti809E → G in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti839L → P in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti856K → N in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti880F → V in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti1231I → K in AAH64823 (PubMed:15489334).Curated1
Sequence conflicti1503V → G in AAM90895 (PubMed:12532264).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491842 mRNA Translation: AAM90895.1
AB097675 mRNA Translation: BAC66658.1
AK034961 mRNA Translation: BAC28896.2 Different initiation.
AK047188 mRNA Translation: BAC32984.1
AK138604 mRNA Translation: BAE23713.1
AK169879 mRNA Translation: BAE41431.1
BC064823 mRNA Translation: AAH64823.1 Sequence problems.
AK129463 mRNA Translation: BAC98273.1
CCDSiCCDS25591.1
RefSeqiNP_671752.2, NM_147219.2
XP_006533128.1, XM_006533065.3
UniGeneiMm.41942

Genome annotation databases

EnsembliENSMUST00000043961; ENSMUSP00000047927; ENSMUSG00000018800
GeneIDi217265
KEGGimmu:217265
UCSCiuc007mdm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491842 mRNA Translation: AAM90895.1
AB097675 mRNA Translation: BAC66658.1
AK034961 mRNA Translation: BAC28896.2 Different initiation.
AK047188 mRNA Translation: BAC32984.1
AK138604 mRNA Translation: BAE23713.1
AK169879 mRNA Translation: BAE41431.1
BC064823 mRNA Translation: AAH64823.1 Sequence problems.
AK129463 mRNA Translation: BAC98273.1
CCDSiCCDS25591.1
RefSeqiNP_671752.2, NM_147219.2
XP_006533128.1, XM_006533065.3
UniGeneiMm.41942

3D structure databases

ProteinModelPortaliQ8K448
SMRiQ8K448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047927

PTM databases

iPTMnetiQ8K448
PhosphoSitePlusiQ8K448

Proteomic databases

MaxQBiQ8K448
PaxDbiQ8K448
PeptideAtlasiQ8K448
PRIDEiQ8K448

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043961; ENSMUSP00000047927; ENSMUSG00000018800
GeneIDi217265
KEGGimmu:217265
UCSCiuc007mdm.1 mouse

Organism-specific databases

CTDi23461
MGIiMGI:2386607 Abca5
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00760000118965
HOVERGENiHBG079884
InParanoidiQ8K448
KOiK05648
OMAiCLICFIK
OrthoDBiEOG091G00AG
PhylomeDBiQ8K448
TreeFamiTF105192

Enzyme and pathway databases

ReactomeiR-MMU-1369062 ABC transporters in lipid homeostasis

Miscellaneous databases

PROiPR:Q8K448
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018800 Expressed in 198 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiQ8K448 baseline and differential
GenevisibleiQ8K448 MM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030367 ABCA5
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PTHR19229:SF100 PTHR19229:SF100, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiABCA5_MOUSE
AccessioniPrimary (citable) accession number: Q8K448
Secondary accession number(s): Q3TE17
, Q3UUB4, Q6P1Y0, Q6ZPG4, Q810C7, Q8BM46, Q8BXG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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