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Protein

Regulator of G-protein signaling 13

Gene

Rgs13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha.

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: MGI
  • negative regulation of G protein-coupled receptor signaling pathway Source: MGI

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 13
Short name:
RGS13
Gene namesi
Name:Rgs13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2180585 Rgs13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042161 – 158Regulator of G-protein signaling 13Add BLAST158

Proteomic databases

PaxDbiQ8K443
PRIDEiQ8K443

PTM databases

iPTMnetiQ8K443
PhosphoSitePlusiQ8K443

Expressioni

Gene expression databases

BgeeiENSMUSG00000051079 Expressed in 60 organ(s), highest expression level in cumulus cell
CleanExiMM_RGS13
GenevisibleiQ8K443 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Tomm70Q9CZW512EBI-645999,EBI-642469

Protein-protein interaction databases

BioGridi232932, 2 interactors
IntActiQ8K443, 1 interactor
STRINGi10090.ENSMUSP00000058813

Structurei

3D structure databases

ProteinModelPortaliQ8K443
SMRiQ8K443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 150RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ8K443
KOiK16449
OMAiIKNIQEP
OrthoDBiEOG091G0BDG
PhylomeDBiQ8K443
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034954 RGS13
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF32 PTHR10845:SF32, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRHICWICK LCRDESKRLP SNLTLDEVLK WAQSLESLMA TKYGPIVYTA
60 70 80 90 100
YLKLEHSDEN IKFWMACETY KKIASRRGRI SRAKKLYNIY IQPQSPREIN
110 120 130 140 150
IDSTTREAII KSIREPTQTC FEEAQKIVYM HMEMDSYPRF LKSEMYQQLL

KTVQSQSS
Length:158
Mass (Da):18,729
Last modified:October 1, 2002 - v1
Checksum:iAC5DD876F4020C1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498319 mRNA Translation: AAM74139.1
AK043268 mRNA Translation: BAC31511.1
BC049624 mRNA Translation: AAH49624.1
CCDSiCCDS15348.1
RefSeqiNP_694811.1, NM_153171.4
XP_006529676.1, XM_006529613.2
UniGeneiMm.38271

Genome annotation databases

EnsembliENSMUST00000052375; ENSMUSP00000058813; ENSMUSG00000051079
ENSMUST00000111941; ENSMUSP00000107572; ENSMUSG00000051079
GeneIDi246709
KEGGimmu:246709
UCSCiuc007cxh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498319 mRNA Translation: AAM74139.1
AK043268 mRNA Translation: BAC31511.1
BC049624 mRNA Translation: AAH49624.1
CCDSiCCDS15348.1
RefSeqiNP_694811.1, NM_153171.4
XP_006529676.1, XM_006529613.2
UniGeneiMm.38271

3D structure databases

ProteinModelPortaliQ8K443
SMRiQ8K443
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232932, 2 interactors
IntActiQ8K443, 1 interactor
STRINGi10090.ENSMUSP00000058813

PTM databases

iPTMnetiQ8K443
PhosphoSitePlusiQ8K443

Proteomic databases

PaxDbiQ8K443
PRIDEiQ8K443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052375; ENSMUSP00000058813; ENSMUSG00000051079
ENSMUST00000111941; ENSMUSP00000107572; ENSMUSG00000051079
GeneIDi246709
KEGGimmu:246709
UCSCiuc007cxh.1 mouse

Organism-specific databases

CTDi6003
MGIiMGI:2180585 Rgs13

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ8K443
KOiK16449
OMAiIKNIQEP
OrthoDBiEOG091G0BDG
PhylomeDBiQ8K443
TreeFamiTF315837

Miscellaneous databases

PROiPR:Q8K443
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051079 Expressed in 60 organ(s), highest expression level in cumulus cell
CleanExiMM_RGS13
GenevisibleiQ8K443 MM

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034954 RGS13
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF32 PTHR10845:SF32, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS13_MOUSE
AccessioniPrimary (citable) accession number: Q8K443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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