UniProtKB - Q8K443 (RGS13_MOUSE)
Protein
Regulator of G-protein signaling 13
Gene
Rgs13
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha.
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: MGI
- negative regulation of G protein-coupled receptor signaling pathway Source: MGI
Keywordsi
Molecular function | Signal transduction inhibitor |
Enzyme and pathway databases
Reactomei | R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 13Short name: RGS13 |
Gene namesi | Name:Rgs13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2180585, Rgs13 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204216 | 1 – 158 | Regulator of G-protein signaling 13Add BLAST | 158 |
Proteomic databases
PaxDbi | Q8K443 |
PRIDEi | Q8K443 |
PTM databases
iPTMneti | Q8K443 |
PhosphoSitePlusi | Q8K443 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000051079, Expressed in cumulus cell and 80 other tissues |
Genevisiblei | Q8K443, MM |
Interactioni
Binary interactionsi
Q8K443
With | #Exp. | IntAct |
---|---|---|
Tomm70 [Q9CZW5] | 12 | EBI-645999,EBI-642469 |
Protein-protein interaction databases
BioGRIDi | 232932, 2 interactors |
IntActi | Q8K443, 1 interactor |
STRINGi | 10090.ENSMUSP00000058813 |
Miscellaneous databases
RNActi | Q8K443, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 150 | RGSPROSITE-ProRule annotationAdd BLAST | 117 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000158520 |
HOGENOMi | CLU_059863_1_5_1 |
InParanoidi | Q8K443 |
OMAi | HMEMDSY |
OrthoDBi | 1416350at2759 |
PhylomeDBi | Q8K443 |
TreeFami | TF315837 |
Family and domain databases
Gene3Di | 1.10.196.10, 2 hits |
InterProi | View protein in InterPro IPR016137, RGS IPR034954, RGS13 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF32, PTHR10845:SF32, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8K443-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRHICWICK LCRDESKRLP SNLTLDEVLK WAQSLESLMA TKYGPIVYTA
60 70 80 90 100
YLKLEHSDEN IKFWMACETY KKIASRRGRI SRAKKLYNIY IQPQSPREIN
110 120 130 140 150
IDSTTREAII KSIREPTQTC FEEAQKIVYM HMEMDSYPRF LKSEMYQQLL
KTVQSQSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF498319 mRNA Translation: AAM74139.1 AK043268 mRNA Translation: BAC31511.1 BC049624 mRNA Translation: AAH49624.1 |
CCDSi | CCDS15348.1 |
RefSeqi | NP_694811.1, NM_153171.4 XP_006529676.1, XM_006529613.2 |
Genome annotation databases
Ensembli | ENSMUST00000052375; ENSMUSP00000058813; ENSMUSG00000051079 ENSMUST00000111941; ENSMUSP00000107572; ENSMUSG00000051079 |
GeneIDi | 246709 |
KEGGi | mmu:246709 |
UCSCi | uc007cxh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF498319 mRNA Translation: AAM74139.1 AK043268 mRNA Translation: BAC31511.1 BC049624 mRNA Translation: AAH49624.1 |
CCDSi | CCDS15348.1 |
RefSeqi | NP_694811.1, NM_153171.4 XP_006529676.1, XM_006529613.2 |
3D structure databases
SMRi | Q8K443 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 232932, 2 interactors |
IntActi | Q8K443, 1 interactor |
STRINGi | 10090.ENSMUSP00000058813 |
PTM databases
iPTMneti | Q8K443 |
PhosphoSitePlusi | Q8K443 |
Proteomic databases
PaxDbi | Q8K443 |
PRIDEi | Q8K443 |
Protocols and materials databases
Antibodypediai | 20618, 232 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000052375; ENSMUSP00000058813; ENSMUSG00000051079 ENSMUST00000111941; ENSMUSP00000107572; ENSMUSG00000051079 |
GeneIDi | 246709 |
KEGGi | mmu:246709 |
UCSCi | uc007cxh.1, mouse |
Organism-specific databases
CTDi | 6003 |
MGIi | MGI:2180585, Rgs13 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000158520 |
HOGENOMi | CLU_059863_1_5_1 |
InParanoidi | Q8K443 |
OMAi | HMEMDSY |
OrthoDBi | 1416350at2759 |
PhylomeDBi | Q8K443 |
TreeFami | TF315837 |
Enzyme and pathway databases
Reactomei | R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 246709, 0 hits in 17 CRISPR screens |
ChiTaRSi | Rgs13, mouse |
PROi | PR:Q8K443 |
RNActi | Q8K443, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000051079, Expressed in cumulus cell and 80 other tissues |
Genevisiblei | Q8K443, MM |
Family and domain databases
Gene3Di | 1.10.196.10, 2 hits |
InterProi | View protein in InterPro IPR016137, RGS IPR034954, RGS13 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF32, PTHR10845:SF32, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS13_MOUSE | |
Accessioni | Q8K443Primary (citable) accession number: Q8K443 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot