Rgs13

Functionⁱ

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha.

GO - Biological processⁱ

G protein-coupled receptor signaling pathway
Source: MGI
Inferred from physical interactionⁱ
- 12193720
negative regulation of G protein-coupled receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 12193720

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor

Molecular function

Signal transduction inhibitor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 13 Short name: RGS13
Gene namesⁱ	Name:Rgs13
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:2180585 Rgs13

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204216	1 – 158	Regulator of G-protein signaling 13Add BLAST		158

Proteomic databases

PaxDbⁱ	Q8K443
PRIDEⁱ	Q8K443

PTM databases

iPTMnetⁱ	Q8K443
PhosphoSitePlusⁱ	Q8K443

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000051079 Expressed in 60 organ(s), highest expression level in cumulus cell
CleanExⁱ	MM_RGS13
Genevisibleⁱ	Q8K443 MM

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Tomm70	Q9CZW5	12	EBI-645999,EBI-642469

With

Entry

#Exp.

IntAct

Notes

Tomm70

Q9CZW5

12

EBI-645999,EBI-642469

Protein-protein interaction databases

BioGridⁱ	232932, 2 interactors
IntActⁱ	Q8K443, 1 interactor
STRINGⁱ	10090.ENSMUSP00000058813

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8K443
SMRⁱ	Q8K443
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	34 – 150	RGSPROSITE-ProRule annotationAdd BLAST		117

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233513
HOVERGENⁱ	HBG013233
InParanoidⁱ	Q8K443
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	IKNIQEP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	Q8K443
TreeFamⁱ	TF315837

Family and domain databases

Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR034954 RGS13 IPR036305 RGS_sf IPR024066 RGS_subdom1/3
PANTHERⁱ	PTHR10845:SF32 PTHR10845:SF32, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8K443-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRHICWICK LCRDESKRLP SNLTLDEVLK WAQSLESLMA TKYGPIVYTA 
        60         70         80         90        100
YLKLEHSDEN IKFWMACETY KKIASRRGRI SRAKKLYNIY IQPQSPREIN 
       110        120        130        140        150
IDSTTREAII KSIREPTQTC FEEAQKIVYM HMEMDSYPRF LKSEMYQQLL 

KTVQSQSS

Length:158

Mass (Da):18,729

Last modified:October 1, 2002 - v1

Checksum:ⁱAC5DD876F4020C1A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF498319 mRNA Translation: AAM74139.1 AK043268 mRNA Translation: BAC31511.1 BC049624 mRNA Translation: AAH49624.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15348.1
NCBI Reference Sequences More...RefSeqⁱ	NP_694811.1, NM_153171.4 XP_006529676.1, XM_006529613.2
UniGeneⁱ	Mm.38271

Genome annotation databases

Ensemblⁱ	ENSMUST00000052375; ENSMUSP00000058813; ENSMUSG00000051079 ENSMUST00000111941; ENSMUSP00000107572; ENSMUSG00000051079
GeneIDⁱ	246709
KEGGⁱ	mmu:246709
UCSC genome browser More...UCSCⁱ	uc007cxh.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q8K443	Regulator of G-protein-signaling 13		RAT		158	UniRef90_Q8K443
UPI00022F3FEA		CRIGR		158
UPI000A30DB50		MUSPA		158
UPI000A31AD35		MUSCR		158
UPI00042AE868		PERMB		158
+3

Protein	Similar proteins		Species	Score	Length	Source
Q8K443	Regulator of G-protein signaling 13		HUMAN		159	UniRef50_Q8K443
Regulator of G-protein-signaling 13		RAT		158
Uncharacterized protein		FELCA		180
regulator of G-protein signaling 13 isoform X1		URSMA		159
Uncharacterized protein		PROCO		159
+58

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF498319 mRNA Translation: AAM74139.1 AK043268 mRNA Translation: BAC31511.1 BC049624 mRNA Translation: AAH49624.1
CCDSⁱ	CCDS15348.1
RefSeqⁱ	NP_694811.1, NM_153171.4 XP_006529676.1, XM_006529613.2
UniGeneⁱ	Mm.38271

3D structure databases

ProteinModelPortalⁱ	Q8K443
SMRⁱ	Q8K443
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	232932, 2 interactors
IntActⁱ	Q8K443, 1 interactor
STRINGⁱ	10090.ENSMUSP00000058813

PTM databases

iPTMnetⁱ	Q8K443
PhosphoSitePlusⁱ	Q8K443

Proteomic databases

PaxDbⁱ	Q8K443
PRIDEⁱ	Q8K443

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000052375; ENSMUSP00000058813; ENSMUSG00000051079 ENSMUST00000111941; ENSMUSP00000107572; ENSMUSG00000051079
GeneIDⁱ	246709
KEGGⁱ	mmu:246709
UCSCⁱ	uc007cxh.1 mouse

Organism-specific databases

CTDⁱ	6003
MGIⁱ	MGI:2180585 Rgs13

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233513
HOVERGENⁱ	HBG013233
InParanoidⁱ	Q8K443
KOⁱ	K16449
OMAⁱ	IKNIQEP
OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	Q8K443
TreeFamⁱ	TF315837

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8K443
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000051079 Expressed in 60 organ(s), highest expression level in cumulus cell
CleanExⁱ	MM_RGS13
Genevisibleⁱ	Q8K443 MM

Family and domain databases

Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR034954 RGS13 IPR036305 RGS_sf IPR024066 RGS_subdom1/3
PANTHERⁱ	PTHR10845:SF32 PTHR10845:SF32, 1 hit
Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS13_MOUSE
Accessionⁱ	Q8K443Primary (citable) accession number: Q8K443
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8K443 (RGS13_MOUSE)

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Regulator of G-protein signaling 13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ