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Entry version 123 (03 Jul 2019)
Sequence version 2 (28 Jun 2011)
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Protein

ATP-binding cassette sub-family A member 8-A

Gene

Abca8a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent lipophilic drug transporter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi514 – 521ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1322 – 1329ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 8-A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abca8a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2386846 Abca8a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Transmembranei861 – 881HelicalSequence analysisAdd BLAST21
Transmembranei979 – 999HelicalSequence analysisAdd BLAST21
Transmembranei1019 – 1039HelicalSequence analysisAdd BLAST21
Transmembranei1068 – 1088HelicalSequence analysisAdd BLAST21
Transmembranei1105 – 1125HelicalSequence analysisAdd BLAST21
Transmembranei1133 – 1153HelicalSequence analysisAdd BLAST21
Transmembranei1159 – 1179HelicalSequence analysisAdd BLAST21
Transmembranei1196 – 1216HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002506781 – 1620ATP-binding cassette sub-family A member 8-AAdd BLAST1620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi482N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi967N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8K442

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K442

PRoteomics IDEntifications database

More...
PRIDEi
Q8K442

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K442

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K442

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8K442

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung, heart, liver, skeletal muscle and testis.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is first detected at 17 dpc.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041828 Expressed in 172 organ(s), highest expression level in sciatic nerve

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K442 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K442 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
229875, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097860

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K442

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini478 – 713ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1284 – 1517ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059 Eukaryota
COG1131 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231057

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K442

KEGG Orthology (KO)

More...
KOi
K05650

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105192

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8K442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKREINVCQ QTWALLCKNL LRKKRLKRDT FLEFLYTALI LLSLILFLQL
60 70 80 90 100
HEVYDFSSLP DVDLGRIDSF NDSTFMIVYT PITPTTQRIM DRVSLVSYMT
110 120 130 140 150
GRKILASPNE ENMTELISMR FSDVVGVIFT NAYSYNLKFI KGARIPTIKE
160 170 180 190 200
HQDHTAHCHS YGEIIYCGLS EFWRDGFVAL QAAINAAIIE VTTNHSVMEE
210 220 230 240 250
MMSLTGKYIK IDSFVGQEGT TTDCFLFFCI IRFSPLTYYI SAGVTRERKK
260 270 280 290 300
MKGLMAVMGL RDSAFWLSWG LLYGVIVFVV TLLSTTIVKL VQFVFLTGFM
310 320 330 340 350
VIFSLFFFYG LSLISLSFLM SVLLKKSFLT DLVVFLLTVS CGSLGFTALY
360 370 380 390 400
RYLPVSLEWL LSLLSPFAFM LGMVQLLRLD YDVNSNADPM GNPNEVIGTI
410 420 430 440 450
FMLFFDGVFY LLLTFYFEKV LPSKSFHDKT YWHACKSHFF LIDYSFYIRT
460 470 480 490 500
ALDNETDYEF SDDSFEPVSM EFHGKEAIRI RNLTKDYIQK SKRTEALKDL
510 520 530 540 550
TLDVYKGQIT AILGHSGAGK STLLNVLSGL CVPTKGWVTI HNNKLSEMTD
560 570 580 590 600
LENISKLTGV CPQCNVQFDF LTVRENLRLF AKIKGIQAHE VDNEVQRVLL
610 620 630 640 650
ELDMKNTQNI LVQNLSGGQK RKLTFGIAIL GDPQIFLLDE PTAGLDPFSR
660 670 680 690 700
HRVWNFLKER RADRVVLFST QFMDEADILA DRKVFISKGK LKCAGSSLFL
710 720 730 740 750
KKKWGIGYHL SLQLSETCVH ERITSLVKQH IPDSKLSAES EGKLSYILPL
760 770 780 790 800
ERTNKFPDLY RDLERSPDLG IENYGVSITT LTEVFLKLEG KSSIDQSDIG
810 820 830 840 850
MTEDVQAGGA RSPERFAEVE QLVSLLNGRC KMKGGMALWW QQLCAVTRLR
860 870 880 890 900
FLKLKHERKS IVILILVLGI GLLHILSANI YRMVRQSDYC WELAPHMYFL
910 920 930 940 950
TPGQQPQPPL TNLLIVNKTG AKIDDFIHSL EQQNIALEVD AFGTRNGTED
960 970 980 990 1000
SQYNGAIILS GDEKNYNFTL ACNTKRLNCF PVLVDIVSNG LLGLFAPSAH
1010 1020 1030 1040 1050
IQTDRSTFPE ENDHRKFDYL AYFFLWVLLM ACVPPYISMT SIDDYKNRAQ
1060 1070 1080 1090 1100
FQLWISGLSP SAYWFGQALF EVPVYCALIL SIFIAFYASA PPESKFTVGD
1110 1120 1130 1140 1150
LFIQILYVGG YAMSVIFMTY VISFIYRKGR KNSGLWSLCF YIVSFFSMCF
1160 1170 1180 1190 1200
MLIDYFRDIS LFVLIALVPP ATLGGCTLLH FENREFSEII FEPEREYSYL
1210 1220 1230 1240 1250
FFLAPLLHFA IFVVILRCME RKFGMKTMRT DPVFRISPRS DRVFNNPEDP
1260 1270 1280 1290 1300
DGEDEDVSQE RVWTANALTS ADFQEKPAII ASCLRKEYKG KKKCFVLKSK
1310 1320 1330 1340 1350
KKIATRNISF CVRKGEVVGL LGHNGAGKST SIKMITGETK PSAGQVLLKG
1360 1370 1380 1390 1400
SSTGDTPGFL GYCPQENALW LNLTVREHLE IFAAIKGMRK SDANVAIERL
1410 1420 1430 1440 1450
ADALKLQDQL KSPVKTLSEG VKRKLCFVLS ILGNPSVVLL DEPSTGMDPE
1460 1470 1480 1490 1500
GQQQMWQAIQ ATFSNTERGA LLTTHYMAEA EAVCDRVAIM VSGRLRCIGS
1510 1520 1530 1540 1550
IQHLKSKFGK EYLLEMKVKT PSQVEPLNTE IMRLFPQAAR QERYSSLMVY
1560 1570 1580 1590 1600
KLPREDVQPL SQAFFKLETV KQSFDLEEYS LSQSTLEQVF LELSKEQELD
1610 1620
GFEEELDPSV KWKLLPQEEA
Length:1,620
Mass (Da):184,180
Last modified:June 28, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED455820ACB6D7B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WGE3F8WGE3_MOUSE
ATP-binding cassette sub-family A m...
Abca8a
1,619Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YSZ8F6YSZ8_MOUSE
ATP-binding cassette sub-family A m...
Abca8a
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6R7A2A6R7_MOUSE
ATP-binding cassette sub-family A m...
Abca8a
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC27576 differs from that shown. Reason: Frameshift at position 1620.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti449R → S in AAM90906 (PubMed:12532264).Curated1
Sequence conflicti449R → S in AAU81985 (PubMed:16445568).Curated1
Sequence conflicti901T → A in BAC27576 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF498360 mRNA Translation: AAM90906.1
AY732492 mRNA Translation: AAU81985.1
AL603792 Genomic DNA No translation available.
AL662821 Genomic DNA No translation available.
BC026496 mRNA Translation: AAH26496.1
BC060032 mRNA Translation: AAH60032.1
AK031843 mRNA Translation: BAC27576.1 Frameshift.

NCBI Reference Sequences

More...
RefSeqi
NP_694785.3, NM_153145.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000100287; ENSMUSP00000097860; ENSMUSG00000041828
ENSMUST00000106664; ENSMUSP00000102275; ENSMUSG00000041828

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217258

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:217258

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498360 mRNA Translation: AAM90906.1
AY732492 mRNA Translation: AAU81985.1
AL603792 Genomic DNA No translation available.
AL662821 Genomic DNA No translation available.
BC026496 mRNA Translation: AAH26496.1
BC060032 mRNA Translation: AAH60032.1
AK031843 mRNA Translation: BAC27576.1 Frameshift.
RefSeqiNP_694785.3, NM_153145.4

3D structure databases

SMRiQ8K442
ModBaseiSearch...

Protein-protein interaction databases

BioGridi229875, 1 interactor
STRINGi10090.ENSMUSP00000097860

PTM databases

iPTMnetiQ8K442
PhosphoSitePlusiQ8K442
SwissPalmiQ8K442

Proteomic databases

MaxQBiQ8K442
PaxDbiQ8K442
PRIDEiQ8K442

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100287; ENSMUSP00000097860; ENSMUSG00000041828
ENSMUST00000106664; ENSMUSP00000102275; ENSMUSG00000041828
GeneIDi217258
KEGGimmu:217258

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
217258
MGIiMGI:2386846 Abca8a

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00940000162012
HOGENOMiHOG000231057
InParanoidiQ8K442
KOiK05650
OrthoDBi131191at2759
TreeFamiTF105192

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8K442

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041828 Expressed in 172 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiQ8K442 baseline and differential
GenevisibleiQ8K442 MM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABC8A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K442
Secondary accession number(s): A2AB96
, Q6PAV3, Q8C0A9, Q8R0R4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 28, 2011
Last modified: July 3, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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