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Protein

ATP-binding cassette sub-family A member 6

Gene

Abca6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transporter which may play a role in macrophage lipid homeostasis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi514 – 521ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1320 – 1327ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369062 ABC transporters in lipid homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 6
Gene namesi
Name:Abca6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923434 Abca6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei854 – 874HelicalSequence analysisAdd BLAST21
Transmembranei971 – 991HelicalSequence analysisAdd BLAST21
Transmembranei1005 – 1025HelicalSequence analysisAdd BLAST21
Transmembranei1058 – 1078HelicalSequence analysisAdd BLAST21
Transmembranei1094 – 1114HelicalSequence analysisAdd BLAST21
Transmembranei1130 – 1150HelicalSequence analysisAdd BLAST21
Transmembranei1154 – 1174HelicalSequence analysisAdd BLAST21
Transmembranei1194 – 1214HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002506731 – 1624ATP-binding cassette sub-family A member 6Add BLAST1624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi576N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K441
PeptideAtlasiQ8K441
PRIDEiQ8K441

PTM databases

iPTMnetiQ8K441
PhosphoSitePlusiQ8K441
SwissPalmiQ8K441

Expressioni

Tissue specificityi

Widely expressed with higher expression in heart, lung, brain, spleen and testis.1 Publication

Developmental stagei

Expressed during embryogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000044749
GenevisibleiQ8K441 MM

Interactioni

Protein-protein interaction databases

BioGridi218010, 1 interactor
IntActiQ8K441, 1 interactor
MINTiQ8K441
STRINGi10090.ENSMUSP00000035458

Structurei

3D structure databases

ProteinModelPortaliQ8K441
SMRiQ8K441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini478 – 713ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1282 – 1520ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00760000118965
HOGENOMiHOG000231057
HOVERGENiHBG079884
InParanoidiQ8K441
KOiK05649
OMAiCFQHQRT
OrthoDBiEOG091G00AG
TreeFamiTF105192

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR026082 ABCA
IPR030368 ABCA6
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PTHR19229:SF13 PTHR19229:SF13, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K441-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL
60 70 80 90 100
ARNIQVLEVP PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK
110 120 130 140 150
GTRIIGVPSI EDLDEVLLHN IPDALGVIFN DSFSYQLKVL RMYGNPFLKE
160 170 180 190 200
DLLAHCWDTH SQAFCSLSKY WERGFVALQT AINAGIIEVT TNHSVMEELM
210 220 230 240 250
SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS NVTKERKQCK
260 270 280 290 300
EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI
310 320 330 340 350
FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE
360 370 380 390 400
LPPSLEWVLS IFSPFAFTSG MAKVIFQDYN LNGVVFPDPS GESYVMIAVF
410 420 430 440 450
FILAFDSLLY LVLALYFDKI LLYGAEHRSA PLFFLNPTSC FRKTANRNKV
460 470 480 490 500
IERDLDPELP SDEYFEPVDP EYQGKEAIRI RNIKKEYKGK SGKVKALKGL
510 520 530 540 550
FLDIYESQIT AILGHSGAGK SSLLNILSGL YVPTAGSVTV YNKNLSDMQD
560 570 580 590 600
LKEIRKAIGV CPQHNVQFDA LTVKENLTLF AKIKGILPQD VEQEVQQILS
610 620 630 640 650
ELDMQNIRDD LAEHLSEGQK RKLTFGIATV GDPQILLLDE PTVGLDPFSR
660 670 680 690 700
QRIWGFLKER RADHVILFST QFMDEADILA DRKVLIANGA LKCTGSSVFL
710 720 730 740 750
KRKWGLGYHL SLFMDETCDS ERLTSFINHH IPYAKLKAKT KEKLVYILPL
760 770 780 790 800
ERTSEFPEFF SDLDKYSGQG LMSYEVSMST LNDVFLNLEG EPSTKQDFEK
810 820 830 840 850
RETATDSESL NDMEVAYPSL SQVQETVSTM SLWRMQVCAI ARLRILKLKR
860 870 880 890 900
ERKAFLIILL LLGIALLPLV IEYVANALLE VKNNWEFKTD LYFLSPGQLP
910 920 930 940 950
QGLRTSLLVI NNTESNIEDF LQSLKHQNIV LEVDDFENRN ATNSLSYNGA
960 970 980 990 1000
IIVSGRQKDY RFSAVCNTKR LHCFPILMNV ISNGILHMLN HTQYIRIKED
1010 1020 1030 1040 1050
IFSPFIVLVW TGIQETCLFI LCVICSLSPH IAMSSVSDYK KKADSQLWIS
1060 1070 1080 1090 1100
GLYPSAYWCG QAVVDISLFS GMLLTSYFTS YTSKLLNIDM TSEIVFSVIV
1110 1120 1130 1140 1150
LALGCAASLV FLTYVISFVF GKRKKNSTLW SICFLLVIAI TFEKVANGPF
1160 1170 1180 1190 1200
NEALVISATM LVPSFALNGL LVVLEMRAYQ YYIEFEEIKH GLSAVDLLLC
1210 1220 1230 1240 1250
LIPYIHTLLF IFVLRCLELK YGKNVVRRDP IFRIAPQSLK AQPNPEEPID
1260 1270 1280 1290 1300
EDENVQAERL RTSDALSTPN LDEKPVIIAS CLHKEYAGQK KHCCSRRTRN
1310 1320 1330 1340 1350
MAVRNVSFCV NKGEILGLLG PDGAGKSSSI RMIAGITKPT AGQVELKRLS
1360 1370 1380 1390 1400
SAVGHQGDSR AEFGYCPQEN GLWPNLTVKE HLELYAAVKG LRKEDAVVAI
1410 1420 1430 1440 1450
SRLVNALKLH DQLNVQVQNL VAGATRKLCF VLSILGNSPV LILDEPSTGL
1460 1470 1480 1490 1500
DVSGKHQVWQ AIQAVVKDNE KGVLLSTHDL AEAEALCDRA AIMVSGRLRC
1510 1520 1530 1540 1550
IGPIQHLKRK FGQDYVLELR VKDVSQEPLV HREILKLFPQ AARQDRCFSL
1560 1570 1580 1590 1600
LTYKLPVTDV HPLSQAFHKL EAVKHGFDLE DYSLSQCTLD RVILELSKEQ
1610 1620
ELGTVYEEAD MTLGRKLLPP SDEL
Length:1,624
Mass (Da):183,283
Last modified:June 28, 2011 - v2
Checksum:i90C077C465B5F79C
GO
Isoform 2 (identifier: Q8K441-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-388: IFQDYNLNGVVFPD → NTEVITDASNGINP
     389-1624: Missing.

Show »
Length:388
Mass (Da):44,092
Checksum:i9AAFD1942A53EB1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti331I → V in BAC35372 (PubMed:19468303).Curated1
Sequence conflicti1020I → T in AAM90907 (PubMed:12532264).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020699375 – 388IFQDY…VVFPD → NTEVITDASNGINP in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_020700389 – 1624Missing in isoform 2. 1 PublicationAdd BLAST1236

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498361 mRNA Translation: AAM90907.1
AK040652 mRNA Translation: BAC30657.1
AK042934 mRNA Translation: BAC31409.1
AK053384 mRNA Translation: BAC35372.1
AL603792 Genomic DNA No translation available.
BC132417 mRNA Translation: AAI32418.1
BC132419 mRNA Translation: AAI32420.1
CCDSiCCDS25590.1 [Q8K441-1]
RefSeqiNP_001160028.1, NM_001166556.1 [Q8K441-2]
NP_001160029.1, NM_001166557.1
NP_671751.2, NM_147218.2 [Q8K441-1]
XP_006534476.1, XM_006534413.1 [Q8K441-1]
XP_006534477.1, XM_006534414.2 [Q8K441-1]
UniGeneiMm.159704

Genome annotation databases

EnsembliENSMUST00000044003; ENSMUSP00000035458; ENSMUSG00000044749 [Q8K441-1]
GeneIDi76184
KEGGimmu:76184
UCSCiuc007mdj.3 mouse [Q8K441-1]
uc007mdk.2 mouse [Q8K441-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABCA6_MOUSE
AccessioniPrimary (citable) accession number: Q8K441
Secondary accession number(s): A2A6R3, Q8BGH0, Q8BPT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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