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Entry version 134 (02 Jun 2021)
Sequence version 2 (03 Oct 2006)
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Protein

ABC-type organic anion transporter ABCA8B

Gene

Abca8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates cholesterol and taurocholate efflux (PubMed:28882873).

Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Cholesterol efflux is increased by extracellularly applied taurocholate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi515 – 522ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1321 – 1328ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-382556, ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC-type organic anion transporter ABCA8BCurated (EC:7.6.2.-By similarity)
Alternative name(s):
ATP-binding cassette sub-family A member 8BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abca8bImported
Synonyms:Abca8, Kiaa0822
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1351668, Abca8b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei860 – 880HelicalSequence analysisAdd BLAST21
Transmembranei979 – 999HelicalSequence analysisAdd BLAST21
Transmembranei1023 – 1043HelicalSequence analysisAdd BLAST21
Transmembranei1069 – 1089HelicalSequence analysisAdd BLAST21
Transmembranei1105 – 1125HelicalSequence analysisAdd BLAST21
Transmembranei1135 – 1155HelicalSequence analysisAdd BLAST21
Transmembranei1164 – 1184HelicalSequence analysisAdd BLAST21
Transmembranei1194 – 1214HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002506791 – 1620ABC-type organic anion transporter ABCA8BAdd BLAST1620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi723N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K440

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K440

PRoteomics IDEntifications database

More...
PRIDEi
Q8K440

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
285897 [Q8K440-1]
285898 [Q8K440-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8K440, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K440

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K440

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8K440

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, lung, liver and skeletal muscle (PubMed:12532264). Highly expressed in the liver, and is also abundant in heart and skeletal muscle (PubMed:28882873). Highly expressed in liver (PubMed:29300488).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during embryogenesis.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020620, Expressed in liver and 142 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K440, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K440, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
205211, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q8K440, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8K440

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020948

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K440, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K440

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini479 – 714ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1283 – 1516ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K440

Identification of Orthologs from Complete Genome Data

More...
OMAi
LQLACMF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K440

TreeFam database of animal gene trees

More...
TreeFami
TF105192

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR030372, ABCA8
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229, PTHR19229, 1 hit
PTHR19229:SF148, PTHR19229:SF148, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8K440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIKREISVRQ QTCALLQKNL LKKWRLKRES LMEWVSSLLL LLFLYWYPHG
60 70 80 90 100
HGATDLSSVP TKDLGRVDSF RQSGFMIGYT PVTSMTQQIM EKVAATPFMA
110 120 130 140 150
DKKVLGLLDE ENIKELTESH AEIIRVIFSD TFSYHLKFQF DQRIPTSREL
160 170 180 190 200
RDHNAHCDGL YEDVNCLIAI FWKEGFVALQ AAINAAIIET TTNHSVMEEL
210 220 230 240 250
LSVSGKFMKI HPFVRQEGIL TDFFIFTCII SFSPITYYVS INVARERKRM
260 270 280 290 300
KGLMMMMGLR DPAFWLSWGL LYAGFVFIMA LSLALVIKSV QFFILTSFMV
310 320 330 340 350
VFSLFLLYGL SMITLAFLMS ALVRKSVLTG LSVFLLTIFW GSLGFTSLYR
360 370 380 390 400
YLPAPVEWTL SLFSPFAFTL GMAQLLRVDY DLNSNAPPDP ASGSNLIIAT
410 420 430 440 450
NFMLVFDAFL YLALMMYFEK VLPNEYGHQH SPLFFLKSSF WLQTRKPAHV
460 470 480 490 500
ILEDGIDPVP SSGDSFEPVS PEFHGKESIR IRNISKEYKG KPNKIEALKD
510 520 530 540 550
LTLDIYEGQI TAVLGHSGAG KSTLLNILSG LSVPTKGSVT IYNNNLSEMA
560 570 580 590 600
DLENILRIAG VCPQANVQFD FLTVRENLRL FAKIRGIPPQ DVEKEVQRVL
610 620 630 640 650
LELEMKNIQN ILAQNLSGGQ KRKLTFGIAI LGDSQIFLLD EPTAGLDPFS
660 670 680 690 700
RHRVWNLLKE RRADRVVLFS TQFMDEADIL ADRKVFISNG RLKCAGSSLF
710 720 730 740 750
LKKKWGVGYH LSLQLKEVCV PENITSLVKQ HIPAAKLSAE GEGKLLYTLP
760 770 780 790 800
LETTYRFPEL CQSLDSCPGL GIENYGVSMT TLNEVFLKLE GKASIDEPEV
810 820 830 840 850
DIVGEGQTER SGDTERLMEM EQTLSSLRET EKTDGMALWR QQTCAIAKVR
860 870 880 890 900
LLKLKHERKT LLSVLLILVV GICPFLFENI STKIRQSSYT WELSPHDYFL
910 920 930 940 950
APGQQPQGML TQLLIINKTE ASIDDFIHSV ERQNIALEVD ASGTRDGTDD
960 970 980 990 1000
PSYNGALIVS GNEKNHSFSF ACNTKRLNCF PVLMDILSNG LLGMVKPSAR
1010 1020 1030 1040 1050
IQTDRSTYLM DETIHPLEDL WKTAFWLILT SACPPYIAMS SVTDYKNRAW
1060 1070 1080 1090 1100
FQLRVSGLFP SAYWVGQAMV DIPLYCFVFL FMSLMDYLFR FPDTMFSIIS
1110 1120 1130 1140 1150
HVIQIPCSVG YAISLIFLTY VISFISRKGK KNSGIWSLSF YIITVFSVAV
1160 1170 1180 1190 1200
ILLAFDVDGT QYYIIFLIPP STLVGCLILS LHLFIGQIFE EGQVIEPFLV
1210 1220 1230 1240 1250
FLIPFLHVFI FIFTLRCLEW KFGKKTMRKD PIFRISPRNN DVYQNPEEPE
1260 1270 1280 1290 1300
DEDEDVQMER MRTANALVST SFDEKPVIIA SCLRKEYAGK QKHCLSKKKA
1310 1320 1330 1340 1350
KIATRNVSFC VRKGEILGLL GHNGAGKSTS LKMISGDTKV TAGQVLLKGS
1360 1370 1380 1390 1400
REGDTPGFLG YCPQENALWP NLTVKEHLEI FAAVRGLRKS HAAVAITRLA
1410 1420 1430 1440 1450
DALKLQDQLK SPVKTLSEGV KRKLCFVLSI LGNPSILLLD EPSTGLDPEG
1460 1470 1480 1490 1500
QQQIWQAIRA IIKNTDRGAL LTTHYMAEAE ALCDRVAILV SGRLRCIGSI
1510 1520 1530 1540 1550
QHLKSKFGKD YLLEMKVKTL EQVEPLNTEI LRLFPQASRQ ERYSSLMAYK
1560 1570 1580 1590 1600
LPVEAVQPLS QAFFKLEKVK QTFDLEEYSL SQSTLEQVFL ELSKEQELDG
1610 1620
LELEELDSSI KWKLLPQEEA
Length:1,620
Mass (Da):183,039
Last modified:October 3, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4330378E6D820B62
GO
Isoform 2 (identifier: Q8K440-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-374: Missing.

Show »
Length:1,558
Mass (Da):176,165
Checksum:i7BFE98326CD9F38B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32312 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti985D → G in AAM90908 (PubMed:12532264).Curated1
Sequence conflicti1447D → V in AAF31432 (PubMed:10708515).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020704313 – 374Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF498362 mRNA Translation: AAM90908.1
AK173034 mRNA Translation: BAD32312.1 Different initiation.
AL807245 Genomic DNA No translation available.
AK043744 mRNA Translation: BAC31640.1
AF213393 mRNA Translation: AAF31432.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25587.1 [Q8K440-1]
CCDS88278.1 [Q8K440-2]

NCBI Reference Sequences

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RefSeqi
NP_038879.2, NM_013851.2 [Q8K440-1]
XP_006533522.1, XM_006533459.3 [Q8K440-1]
XP_006533525.1, XM_006533462.3
XP_006533526.1, XM_006533463.3 [Q8K440-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020948; ENSMUSP00000020948; ENSMUSG00000020620 [Q8K440-1]
ENSMUST00000106669; ENSMUSP00000102280; ENSMUSG00000020620 [Q8K440-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27404

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:27404

UCSC genome browser

More...
UCSCi
uc007mdb.2, mouse [Q8K440-1]
uc007mdc.2, mouse [Q8K440-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498362 mRNA Translation: AAM90908.1
AK173034 mRNA Translation: BAD32312.1 Different initiation.
AL807245 Genomic DNA No translation available.
AK043744 mRNA Translation: BAC31640.1
AF213393 mRNA Translation: AAF31432.1
CCDSiCCDS25587.1 [Q8K440-1]
CCDS88278.1 [Q8K440-2]
RefSeqiNP_038879.2, NM_013851.2 [Q8K440-1]
XP_006533522.1, XM_006533459.3 [Q8K440-1]
XP_006533525.1, XM_006533462.3
XP_006533526.1, XM_006533463.3 [Q8K440-2]

3D structure databases

SMRiQ8K440
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205211, 8 interactors
IntActiQ8K440, 2 interactors
MINTiQ8K440
STRINGi10090.ENSMUSP00000020948

PTM databases

GlyGeniQ8K440, 1 site
iPTMnetiQ8K440
PhosphoSitePlusiQ8K440
SwissPalmiQ8K440

Proteomic databases

jPOSTiQ8K440
PaxDbiQ8K440
PRIDEiQ8K440
ProteomicsDBi285897 [Q8K440-1]
285898 [Q8K440-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31802, 133 antibodies

The DNASU plasmid repository

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DNASUi
27404

Genome annotation databases

EnsembliENSMUST00000020948; ENSMUSP00000020948; ENSMUSG00000020620 [Q8K440-1]
ENSMUST00000106669; ENSMUSP00000102280; ENSMUSG00000020620 [Q8K440-2]
GeneIDi27404
KEGGimmu:27404
UCSCiuc007mdb.2, mouse [Q8K440-1]
uc007mdc.2, mouse [Q8K440-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27404
MGIiMGI:1351668, Abca8b

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0059, Eukaryota
GeneTreeiENSGT00940000162012
HOGENOMiCLU_000604_19_1_1
InParanoidiQ8K440
OMAiLQLACMF
PhylomeDBiQ8K440
TreeFamiTF105192

Enzyme and pathway databases

ReactomeiR-MMU-382556, ABC-family proteins mediated transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
27404, 1 hit in 52 CRISPR screens

Protein Ontology

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PROi
PR:Q8K440
RNActiQ8K440, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020620, Expressed in liver and 142 other tissues
ExpressionAtlasiQ8K440, baseline and differential
GenevisibleiQ8K440, MM

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR030372, ABCA8
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PTHR19229:SF148, PTHR19229:SF148, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABC8B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K440
Secondary accession number(s): A2AM55
, Q69ZY4, Q8BRQ1, Q9JL38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 2, 2021
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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