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Protein

Transient receptor potential cation channel subfamily V member 3

Gene

Trpv3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calcium channel activity Source: GO_Central
  • cation channel activity Source: MGI
  • ion channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 3
Short name:
TrpV3
Gene namesi
Name:Trpv3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2181407 Trpv3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 439CytoplasmicSequence analysisAdd BLAST439
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 487ExtracellularSequence analysisAdd BLAST27
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 523CytoplasmicSequence analysisAdd BLAST15
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545ExtracellularSequence analysis1
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 589CytoplasmicSequence analysisAdd BLAST23
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21
Intramembranei621 – 637Pore-formingSequence analysisAdd BLAST17
Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Topological domaini671 – 791CytoplasmicSequence analysisAdd BLAST121

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3879838
GuidetoPHARMACOLOGYi509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153461 – 791Transient receptor potential cation channel subfamily V member 3Add BLAST791

Proteomic databases

PaxDbiQ8K424
PRIDEiQ8K424

PTM databases

iPTMnetiQ8K424
PhosphoSitePlusiQ8K424

Expressioni

Tissue specificityi

Expressed in keratinocytes and hair follicles.1 Publication

Gene expression databases

BgeeiENSMUSG00000043029 Expressed in 30 organ(s), highest expression level in spinal cord

Interactioni

Subunit structurei

May form a heteromeric channel with TRPV1. Interacts with TRPV1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2650739,EBI-297353From Homo sapiens.

Protein-protein interaction databases

IntActiQ8K424, 1 interactor
STRINGi10090.ENSMUSP00000053755

Structurei

Secondary structure

1791
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8K424
SMRiQ8K424
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati214 – 243ANK 1Add BLAST30
Repeati261 – 291ANK 2Add BLAST31
Repeati340 – 369ANK 3Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
GeneTreeiENSGT00550000074425
HOGENOMiHOG000234630
HOVERGENiHBG054085
InParanoidiQ8K424
KOiK04972
OMAiKHEGFYF
OrthoDBiEOG091G020O
PhylomeDBiQ8K424
TreeFamiTF314711

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR024862 TRPV
IPR008347 TRPV1-4_channel
IPR024866 TRPV3_channel
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF6 PTHR10582:SF6, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01768 TRPVRECEPTOR
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q8K424-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAHSKEMAP LMGKRTTAPG GNPVVLTEKR PADLTPTKKS AHFFLEIEGF
60 70 80 90 100
EPNPTVTKTS PPIFSKPMDS NIRQCLSGNC DDMDSPQSPQ DDVTETPSNP
110 120 130 140 150
NSPSANLAKE EQRQKKKRLK KRIFAAVSEG CVEELRELLQ DLQDLCRRRR
160 170 180 190 200
GLDVPDFLMH KLTASDTGKT CLMKALLNIN PNTKEIVRIL LAFAEENDIL
210 220 230 240 250
DRFINAEYTE EAYEGQTALN IAIERRQGDI TAVLIAAGAD VNAHAKGVFF
260 270 280 290 300
NPKYQHEGFY FGETPLALAA CTNQPEIVQL LMENEQTDIT SQDSRGNNIL
310 320 330 340 350
HALVTVAEDF KTQNDFVKRM YDMILLRSGN WELETMRNND GLTPLQLAAK
360 370 380 390 400
MGKAEILKYI LSREIKEKPL RSLSRKFTDW AYGPVSSSLY DLTNVDTTTD
410 420 430 440 450
NSVLEIIVYN TNIDNRHEML TLEPLHTLLH TKWKKFAKYM FFLSFCFYFF
460 470 480 490 500
YNITLTLVSY YRPREDEDLP HPLALTHKMS WLQLLGRMFV LIWATCISVK
510 520 530 540 550
EGIAIFLLRP SDLQSILSDA WFHFVFFVQA VLVILSVFLY LFAYKEYLAC
560 570 580 590 600
LVLAMALGWA NMLYYTRGFQ SMGMYSVMIQ KVILHDVLKF LFVYILFLLG
610 620 630 640 650
FGVALASLIE KCSKDKKDCS SYGSFSDAVL ELFKLTIGLG DLNIQQNSTY
660 670 680 690 700
PILFLFLLIT YVILTFVLLL NMLIALMGET VENVSKESER IWRLQRARTI
710 720 730 740 750
LEFEKMLPEW LRSRFRMGEL CKVADEDFRL CLRINEVKWT EWKTHVSFLN
760 770 780 790
EDPGPIRRTA DLNKIQDSSR SNSKTTLYAF DELDEFPETS V
Length:791
Mass (Da):90,663
Last modified:April 26, 2005 - v2
Checksum:i76A244781D223C6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → V in AAM33069 (PubMed:12016205).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510316 mRNA Translation: AAM33069.1
AL645739 Genomic DNA No translation available.
CCDSiCCDS25004.1
RefSeqiNP_659567.2, NM_145099.2
UniGeneiMm.347652
Mm.75196

Genome annotation databases

EnsembliENSMUST00000049676; ENSMUSP00000053755; ENSMUSG00000043029
GeneIDi246788
KEGGimmu:246788
UCSCiuc007kaj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTRPV3_MOUSE
AccessioniPrimary (citable) accession number: Q8K424
Secondary accession number(s): Q5SV08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 12, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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