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Protein

Presequence protease, mitochondrial

Gene

Pitrm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently.By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Mainly exists in a closed and catalytically competent conformation but a closed-to-open switch allows substrate entry into the catalytic chamber. Substrate binding induces closure and dimerization. A disulfide bond may lock the enzyme in a closed conformation preventing substrate entry into the catalytic chamber, participating in redox regulation of the enzyme. Inhibited by metal-chelating agents. Inhibited by nickel and zinc excess, and slightly activated by manganese.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi104Zinc; via tele nitrogen; catalyticBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei107Proton acceptorBy similarity1
Metal bindingi108Zinc; via tele nitrogen; catalyticBy similarity1
Metal bindingi205Zinc; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1268020 Mitochondrial protein import

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Presequence protease, mitochondrialCurated (EC:3.4.24.-By similarity)
Alternative name(s):
Pitrilysin metalloproteinase 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pitrm1Imported
Synonyms:Kiaa1104Imported, Ntup1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916867 Pitrm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 15MitochondrionBy similarityAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024993216 – 1036Presequence protease, mitochondrialAdd BLAST1021

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi119 ↔ 556By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei759N6-acetyllysineCombined sources1
Modified residuei770N6-acetyllysine; alternateCombined sources1
Modified residuei770N6-succinyllysine; alternateCombined sources1
Modified residuei848N6-succinyllysineCombined sources1
Modified residuei883N6-acetyllysineCombined sources1
Modified residuei945N6-succinyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A disulfide bond locks the enzyme in the closed conformation preventing substrate entry into the catalytic chamber.By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K411

PeptideAtlas

More...
PeptideAtlasi
Q8K411

PRoteomics IDEntifications database

More...
PRIDEi
Q8K411

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K411

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K411

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8K411

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated transplantes nuclei derived from embryonic stem (ES) cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000021193 Expressed in 310 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
MM_PITRM1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K411 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K411 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer; homodimerization is induced by binding of the substrate.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
213572, 1 interactor

Protein interaction database and analysis system

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IntActi
Q8K411, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8K411

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000021611

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8K411

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8K411

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M16 family. PreP subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2019 Eukaryota
COG1026 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000018381

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG082167

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8K411

KEGG Orthology (KO)

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KOi
K06972

Identification of Orthologs from Complete Genome Data

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OMAi
FTYGNFP

Database of Orthologous Groups

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OrthoDBi
EOG091G0108

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8K411

TreeFam database of animal gene trees

More...
TreeFami
TF300333

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
IPR013578 Peptidase_M16C_assoc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08367 M16C_assoc, 1 hit
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01264 M16C_associated, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63411 SSF63411, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K411-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRFSGRRGL CAVQRLSCGR VHHRVWREKS DQACERALQY KVGEKIHGFT
60 70 80 90 100
VNQVTPVPEL FLTAVKLSHD NTGARYLHLA REDKNNLFSV QFRTTPMDST
110 120 130 140 150
GVPHVLEHTV LCGSQKYPCR DPFFKMLNRS LSTFMNAMTA SDYTIYPFST
160 170 180 190 200
QNPKDFQNLL SVYLDATFFP CLRELDFWQE GWRLEHENPR DPQTPLIFKG
210 220 230 240 250
VVFNEMKGAF TDNERIFSQH LQNKLLPDHT YSVVSGGDPL CIPELTWEQL
260 270 280 290 300
KQFHATHYHP SNARFFTYGN FQLEGHLKQI HEEALSKFQR LEQSTAVPAQ
310 320 330 340 350
PHWDKPREFH ITCGPDSLAT ETAKQTTVSV SFLLPDITDT FEAFTLSLLS
360 370 380 390 400
SLLIAGPNSP FYKALIESGL GTDFSPDVGY NGYTREAYFS VGLQGIAEKD
410 420 430 440 450
VKTVRELVDR TIEEVIEKGF EDDRIEALLH KIEIQTKHQS ASFGLTLTSY
460 470 480 490 500
IASCWNHDGD PVELLQIGSQ LTRFRKCLKE NPKFLQEKVE QYFKNNQHKL
510 520 530 540 550
TLSMKPDDKY YEKQTQMETE KLEQKVNSLS PADKQQIYEK GLELQTQQSK
560 570 580 590 600
HQDASCLPAL KVSDIEPSMP FTKLDIGLAA GDIPVQYCPQ PTNGMVYFRA
610 620 630 640 650
FSSLNTLPED LRPIVPLFCS VLTKLGCGIL NYREQAQQIE LKTGGMSVTP
660 670 680 690 700
HVLPDDSQLD TYEQGVLFSS LCLERNLPDM MHLWSEIFNN PCFEEEEHFK
710 720 730 740 750
VLVKMTAQEL SNGISDSGHL YAALRASKTL TPSGDLQETF SGMDQVKVMK
760 770 780 790 800
RIAEMTDIKP ILRKLPRIKK YLLNCDNMRC SVNATPQQMP QAEKEVENFL
810 820 830 840 850
RNVGRSKKER KPVRPHIVEK PTPSGPSGAA HVSGSQIVRK LVTDPTFKPC
860 870 880 890 900
QMKTHFVLPF PVNYIGECVR TVPYADPDHA SLKILARLMT AKFLHTEIRE
910 920 930 940 950
KGGAYGGGAK LTHSGIFTLY SYRDPNSIET LQSFGKAVDW AKSGKFTQQD
960 970 980 990 1000
IDEAKLSVFS TVDSPVAPSD KGMDHFLYGL SDEMKQAYRE QLFAVNHDKL
1010 1020 1030
TSVSHKYLGI GKSTHGLAIL GPENSKIAKD PSWIIK
Length:1,036
Mass (Da):117,372
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD397879609881BF1
GO
Isoform 2 (identifier: Q8K411-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Missing.

Note: No experimental confirmation available.
Show »
Length:1,035
Mass (Da):117,216
Checksum:i421F1DFBE0699DF7
GO
Isoform 3 (identifier: Q8K411-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Missing.
     380-417: Missing.

Note: No experimental confirmation available.
Show »
Length:997
Mass (Da):112,842
Checksum:iF7624584E14AB86E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VMS3A0A1Y7VMS3_MOUSE
Presequence protease, mitochondrial
Pitrm1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VIW4A0A1Y7VIW4_MOUSE
Presequence protease, mitochondrial
Pitrm1
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VN02A0A1Y7VN02_MOUSE
Presequence protease, mitochondrial
Pitrm1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH06917 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7R → G in BAE37695 (PubMed:16141072).Curated1
Sequence conflicti283E → D in BAE39514 (PubMed:16141072).Curated1
Sequence conflicti388Y → C in BAE24630 (PubMed:16141072).Curated1
Sequence conflicti394Q → P in AAX11356 (PubMed:15919810).Curated1
Sequence conflicti475R → M in BAE40273 (PubMed:16141072).Curated1
Sequence conflicti652V → L in BAC98102 (PubMed:14621295).Curated1
Sequence conflicti830A → T in BAE40273 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti15R → Q in strain: LG/J and SM/J. 1 Publication1
Natural varianti17S → I in strain: LG/J and SM/J. 1 Publication1
Natural varianti19G → C in strain: LG/J and SM/J. 1 Publication1
Natural varianti462V → M in strain: LG/J and SM/J. 1 Publication1
Natural varianti546T → K in strain: LG/J and SM/J. 1 Publication1
Natural varianti583I → V in strain: LG/J and SM/J. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02059820Missing in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_020599380 – 417Missing in isoform 3. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF513714 mRNA Translation: AAM49783.1
AY779273 mRNA Translation: AAX11355.1
AY779274 mRNA Translation: AAX11356.1
AK009313 mRNA Translation: BAB26211.1
AK141277 mRNA Translation: BAE24630.1
AK147837 mRNA Translation: BAE28172.1
AK164235 mRNA Translation: BAE37695.1
AK167426 mRNA Translation: BAE39514.1
AK168335 mRNA Translation: BAE40273.1
AK129292 mRNA Translation: BAC98102.1
BC006917 mRNA Translation: AAH06917.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36585.1 [Q8K411-1]

NCBI Reference Sequences

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RefSeqi
NP_660113.1, NM_145131.1 [Q8K411-1]
XP_006516571.1, XM_006516508.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.41933

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000021611; ENSMUSP00000021611; ENSMUSG00000021193 [Q8K411-3]
ENSMUST00000222485; ENSMUSP00000152229; ENSMUSG00000021193 [Q8K411-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
69617

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:69617

UCSC genome browser

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UCSCi
uc007pjx.1 mouse [Q8K411-1]
uc007pjy.1 mouse [Q8K411-2]
uc011ywa.1 mouse [Q8K411-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513714 mRNA Translation: AAM49783.1
AY779273 mRNA Translation: AAX11355.1
AY779274 mRNA Translation: AAX11356.1
AK009313 mRNA Translation: BAB26211.1
AK141277 mRNA Translation: BAE24630.1
AK147837 mRNA Translation: BAE28172.1
AK164235 mRNA Translation: BAE37695.1
AK167426 mRNA Translation: BAE39514.1
AK168335 mRNA Translation: BAE40273.1
AK129292 mRNA Translation: BAC98102.1
BC006917 mRNA Translation: AAH06917.1 Different initiation.
CCDSiCCDS36585.1 [Q8K411-1]
RefSeqiNP_660113.1, NM_145131.1 [Q8K411-1]
XP_006516571.1, XM_006516508.1
UniGeneiMm.41933

3D structure databases

ProteinModelPortaliQ8K411
SMRiQ8K411
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213572, 1 interactor
IntActiQ8K411, 2 interactors
MINTiQ8K411
STRINGi10090.ENSMUSP00000021611

PTM databases

iPTMnetiQ8K411
PhosphoSitePlusiQ8K411
SwissPalmiQ8K411

Proteomic databases

PaxDbiQ8K411
PeptideAtlasiQ8K411
PRIDEiQ8K411

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
69617
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021611; ENSMUSP00000021611; ENSMUSG00000021193 [Q8K411-3]
ENSMUST00000222485; ENSMUSP00000152229; ENSMUSG00000021193 [Q8K411-1]
GeneIDi69617
KEGGimmu:69617
UCSCiuc007pjx.1 mouse [Q8K411-1]
uc007pjy.1 mouse [Q8K411-2]
uc011ywa.1 mouse [Q8K411-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10531
MGIiMGI:1916867 Pitrm1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG2019 Eukaryota
COG1026 LUCA
GeneTreeiENSGT00390000018381
HOVERGENiHBG082167
InParanoidiQ8K411
KOiK06972
OMAiFTYGNFP
OrthoDBiEOG091G0108
PhylomeDBiQ8K411
TreeFamiTF300333

Enzyme and pathway databases

ReactomeiR-MMU-1268020 Mitochondrial protein import

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8K411

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021193 Expressed in 310 organ(s), highest expression level in blood
CleanExiMM_PITRM1
ExpressionAtlasiQ8K411 baseline and differential
GenevisibleiQ8K411 MM

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
IPR013578 Peptidase_M16C_assoc
PfamiView protein in Pfam
PF08367 M16C_assoc, 1 hit
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 2 hits
SMARTiView protein in SMART
SM01264 M16C_associated, 1 hit
SUPFAMiSSF63411 SSF63411, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPREP_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K411
Secondary accession number(s): Q3THC4
, Q3TJI1, Q3TPP0, Q3URQ8, Q4KUG2, Q4KUG3, Q6ZPX6, Q922N1, Q9CV63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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