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Entry version 131 (12 Aug 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Probable E3 ubiquitin-protein ligase IRF2BPL

Gene

Irf2bpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri694 – 741RING-type; degenerateAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase IRF2BPLBy similarity (EC:2.3.2.27By similarity)
Alternative name(s):
Enhanced at puberty protein 1
Interferon regulatory factor 2-binding protein-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Irf2bpl
Synonyms:Eap1, Kiaa1865
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442463, Irf2bpl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000564121 – 775Probable E3 ubiquitin-protein ligase IRF2BPLAdd BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei69PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei195PhosphoserineCombined sources1
Modified residuei498PhosphoserineBy similarity1
Modified residuei526PhosphoserineCombined sources1
Modified residuei618PhosphoserineBy similarity1
Modified residuei636PhosphoserineCombined sources1
Modified residuei637PhosphoserineBy similarity1
Modified residuei638PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8K3X4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K3X4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8K3X4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K3X4

PeptideAtlas

More...
PeptideAtlasi
Q8K3X4

PRoteomics IDEntifications database

More...
PRIDEi
Q8K3X4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K3X4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K3X4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034168, Expressed in dorsal pancreas and 259 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K3X4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNB1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231970, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q8K3X4, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8K3X4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041070

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K3X4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K3X4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili83 – 113Sequence analysisAdd BLAST31
Coiled coili314 – 350Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi88 – 95Poly-Ala8
Compositional biasi96 – 108Poly-GlnAdd BLAST13
Compositional biasi134 – 144Poly-AlaAdd BLAST11
Compositional biasi154 – 282Pro-richAdd BLAST129
Compositional biasi575 – 602Pro-richAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IRF2BP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri694 – 741RING-type; degenerateAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3579, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019307_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K3X4

KEGG Orthology (KO)

More...
KOi
K22383

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMLPQPH

Database of Orthologous Groups

More...
OrthoDBi
1156771at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K3X4

TreeFam database of animal gene trees

More...
TreeFami
TF317075

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022750, Interferon_reg_fac2-bd1_2_Znf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11261, IRF-2BP1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8K3X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAQVSSSR RQSCYLCDLP RMPWAMIWDF SEPVCRGCVN YEGADRIEFV
60 70 80 90 100
IETARQLKRA HGCFQDGRSP GPPPPVGVKT VALSAKEAAA AAAAAQQQQQ
110 120 130 140 150
QQQQQQQQLN HVDGSTKPAV LAAPSGLERY GLSAAAAAAA AAAAVEQRSR
160 170 180 190 200
FEYPPPPVSL GSSSHAARLP NGLGGPNGFP KPAPEEGPPE LNRQSPNSSS
210 220 230 240 250
AATSVASRRG THSGLVTGLP NPGGGGGPQL TVPPNLLPQT LLNGPASAAV
260 270 280 290 300
LPPPHGLGGS RGPPTPAPPG APGGPACLGG PPGVSATVSS APSSTSSTVA
310 320 330 340 350
EVGVGAAGKR PGSVSSTDQE RELKEKQRNA EALAELSESL RNRAEEWANK
360 370 380 390 400
PKMVRDTLLT LAGCTPYEVR FKKDHSLLGR VFAFDAVSKP GMDYELKLFI
410 420 430 440 450
EYPTGSGNVY SSASGVAKQM YQDCMKDFGR GLSSGFKYLE YEKKHGSGDW
460 470 480 490 500
RLLGDLLPEA VRFFKEGVPG ADMLPQPYLD ASCPMLPTAL VSLSRAPSAP
510 520 530 540 550
PGTGALPPAA PTGRGAASSL RKRKASPEPP DSAESALKLG EEQQRQQWMA
560 570 580 590 600
NQSEALKLTM SAGGFAAPGH SAGGPPPPPP PLGPHSNRTT PPESAPQNGP
610 620 630 640 650
SPMAALMSVA DTLGTAHSPK DGSSVHSTTA SARRNSSSPV SPASVPGQRR
660 670 680 690 700
LASRNGDLNL QVAPPPPSAH PGMDQVHPQN IPDSPMANSG PLCCTICHER
710 720 730 740 750
LEDTHFVQCP SVPSHKFCFP CSRESIKAQG ATGEVYCPSG EKCPLVGSNV
760 770
PWAFMQGEIA TILAGDVKVK KERDP
Length:775
Mass (Da):80,565
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECB11652F2F7C2AB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32560 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti226G → E in BAC38621 (PubMed:16141072).Curated1
Sequence conflicti227G → E in BAE32550 (PubMed:16141072).Curated1
Sequence conflicti330A → P in BAC27955 (PubMed:16141072).Curated1
Sequence conflicti442E → G in BAC27955 (PubMed:16141072).Curated1
Sequence conflicti619P → S in BAE33226 (PubMed:16141072).Curated1
Sequence conflicti619P → S in BAE42208 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF525300 mRNA Translation: AAM82165.1
AK173282 mRNA Translation: BAD32560.1 Different initiation.
AK032366 mRNA Translation: BAC27837.1
AK032622 mRNA Translation: BAC27955.1
AK082791 mRNA Translation: BAC38621.1
AK140441 mRNA Translation: BAE24388.1
AK154383 mRNA Translation: BAE32550.1
AK155373 mRNA Translation: BAE33226.1
AK171043 mRNA Translation: BAE42208.1
BC057128 mRNA Translation: AAH57128.1
BC063253 mRNA Translation: AAH63253.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26068.1

NCBI Reference Sequences

More...
RefSeqi
NP_665835.1, NM_145836.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038422; ENSMUSP00000041070; ENSMUSG00000034168

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
238330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:238330

UCSC genome browser

More...
UCSCi
uc007oia.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525300 mRNA Translation: AAM82165.1
AK173282 mRNA Translation: BAD32560.1 Different initiation.
AK032366 mRNA Translation: BAC27837.1
AK032622 mRNA Translation: BAC27955.1
AK082791 mRNA Translation: BAC38621.1
AK140441 mRNA Translation: BAE24388.1
AK154383 mRNA Translation: BAE32550.1
AK155373 mRNA Translation: BAE33226.1
AK171043 mRNA Translation: BAE42208.1
BC057128 mRNA Translation: AAH57128.1
BC063253 mRNA Translation: AAH63253.1
CCDSiCCDS26068.1
RefSeqiNP_665835.1, NM_145836.2

3D structure databases

SMRiQ8K3X4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231970, 8 interactors
IntActiQ8K3X4, 1 interactor
MINTiQ8K3X4
STRINGi10090.ENSMUSP00000041070

PTM databases

iPTMnetiQ8K3X4
PhosphoSitePlusiQ8K3X4

Proteomic databases

EPDiQ8K3X4
jPOSTiQ8K3X4
MaxQBiQ8K3X4
PaxDbiQ8K3X4
PeptideAtlasiQ8K3X4
PRIDEiQ8K3X4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
54435, 15 antibodies

Genome annotation databases

EnsembliENSMUST00000038422; ENSMUSP00000041070; ENSMUSG00000034168
GeneIDi238330
KEGGimmu:238330
UCSCiuc007oia.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64207
MGIiMGI:2442463, Irf2bpl

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG3579, Eukaryota
GeneTreeiENSGT00940000162596
HOGENOMiCLU_019307_1_0_1
InParanoidiQ8K3X4
KOiK22383
OMAiDMLPQPH
OrthoDBi1156771at2759
PhylomeDBiQ8K3X4
TreeFamiTF317075

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
238330, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Irf2bpl, mouse

Protein Ontology

More...
PROi
PR:Q8K3X4
RNActiQ8K3X4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034168, Expressed in dorsal pancreas and 259 other tissues
GenevisibleiQ8K3X4, MM

Family and domain databases

InterProiView protein in InterPro
IPR022750, Interferon_reg_fac2-bd1_2_Znf
PfamiView protein in Pfam
PF11261, IRF-2BP1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI2BPL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K3X4
Secondary accession number(s): Q3TBU9
, Q3U483, Q3USE5, Q69Z84, Q8BUS1, Q8C011
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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