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Protein

Interferon regulatory factor 2-binding protein-like

Gene

Irf2bpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to the control of female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri694 – 741RING-type; degenerateAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein-like
Alternative name(s):
Enhanced at puberty protein 1
Gene namesi
Name:Irf2bpl
Synonyms:Eap1, Kiaa1865
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2442463 Irf2bpl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564121 – 775Interferon regulatory factor 2-binding protein-likeAdd BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineBy similarity1
Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei195PhosphoserineCombined sources1
Modified residuei498PhosphoserineBy similarity1
Modified residuei526PhosphoserineCombined sources1
Modified residuei618PhosphoserineBy similarity1
Modified residuei636PhosphoserineCombined sources1
Modified residuei637PhosphoserineBy similarity1
Modified residuei638PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K3X4
MaxQBiQ8K3X4
PaxDbiQ8K3X4
PeptideAtlasiQ8K3X4
PRIDEiQ8K3X4

PTM databases

iPTMnetiQ8K3X4
PhosphoSitePlusiQ8K3X4

Miscellaneous databases

PMAP-CutDBiQ8K3X4

Expressioni

Gene expression databases

BgeeiENSMUSG00000034168 Expressed in 243 organ(s), highest expression level in dorsal pancreas
CleanExiMM_6430527G18RIK
GenevisibleiQ8K3X4 MM

Interactioni

Protein-protein interaction databases

BioGridi231970, 2 interactors
IntActiQ8K3X4, 1 interactor
MINTiQ8K3X4
STRINGi10090.ENSMUSP00000041070

Structurei

3D structure databases

ProteinModelPortaliQ8K3X4
SMRiQ8K3X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili83 – 113Sequence analysisAdd BLAST31
Coiled coili314 – 350Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 95Poly-Ala8
Compositional biasi96 – 108Poly-GlnAdd BLAST13
Compositional biasi134 – 144Poly-AlaAdd BLAST11
Compositional biasi154 – 282Pro-richAdd BLAST129
Compositional biasi575 – 602Pro-richAdd BLAST28

Sequence similaritiesi

Belongs to the IRF2BP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri694 – 741RING-type; degenerateAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3579 Eukaryota
ENOG410Z1AW LUCA
GeneTreeiENSGT00390000005089
HOVERGENiHBG108364
InParanoidiQ8K3X4
KOiK22383
OMAiPSTHPGM
OrthoDBiEOG091G040R
PhylomeDBiQ8K3X4
TreeFamiTF317075

Family and domain databases

InterProiView protein in InterPro
IPR022750 Interferon_reg_fac2-bd1_2_Znf
PfamiView protein in Pfam
PF11261 IRF-2BP1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K3X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAQVSSSR RQSCYLCDLP RMPWAMIWDF SEPVCRGCVN YEGADRIEFV
60 70 80 90 100
IETARQLKRA HGCFQDGRSP GPPPPVGVKT VALSAKEAAA AAAAAQQQQQ
110 120 130 140 150
QQQQQQQQLN HVDGSTKPAV LAAPSGLERY GLSAAAAAAA AAAAVEQRSR
160 170 180 190 200
FEYPPPPVSL GSSSHAARLP NGLGGPNGFP KPAPEEGPPE LNRQSPNSSS
210 220 230 240 250
AATSVASRRG THSGLVTGLP NPGGGGGPQL TVPPNLLPQT LLNGPASAAV
260 270 280 290 300
LPPPHGLGGS RGPPTPAPPG APGGPACLGG PPGVSATVSS APSSTSSTVA
310 320 330 340 350
EVGVGAAGKR PGSVSSTDQE RELKEKQRNA EALAELSESL RNRAEEWANK
360 370 380 390 400
PKMVRDTLLT LAGCTPYEVR FKKDHSLLGR VFAFDAVSKP GMDYELKLFI
410 420 430 440 450
EYPTGSGNVY SSASGVAKQM YQDCMKDFGR GLSSGFKYLE YEKKHGSGDW
460 470 480 490 500
RLLGDLLPEA VRFFKEGVPG ADMLPQPYLD ASCPMLPTAL VSLSRAPSAP
510 520 530 540 550
PGTGALPPAA PTGRGAASSL RKRKASPEPP DSAESALKLG EEQQRQQWMA
560 570 580 590 600
NQSEALKLTM SAGGFAAPGH SAGGPPPPPP PLGPHSNRTT PPESAPQNGP
610 620 630 640 650
SPMAALMSVA DTLGTAHSPK DGSSVHSTTA SARRNSSSPV SPASVPGQRR
660 670 680 690 700
LASRNGDLNL QVAPPPPSAH PGMDQVHPQN IPDSPMANSG PLCCTICHER
710 720 730 740 750
LEDTHFVQCP SVPSHKFCFP CSRESIKAQG ATGEVYCPSG EKCPLVGSNV
760 770
PWAFMQGEIA TILAGDVKVK KERDP
Length:775
Mass (Da):80,565
Last modified:October 1, 2002 - v1
Checksum:iECB11652F2F7C2AB
GO

Sequence cautioni

The sequence BAD32560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226G → E in BAC38621 (PubMed:16141072).Curated1
Sequence conflicti227G → E in BAE32550 (PubMed:16141072).Curated1
Sequence conflicti330A → P in BAC27955 (PubMed:16141072).Curated1
Sequence conflicti442E → G in BAC27955 (PubMed:16141072).Curated1
Sequence conflicti619P → S in BAE33226 (PubMed:16141072).Curated1
Sequence conflicti619P → S in BAE42208 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525300 mRNA Translation: AAM82165.1
AK173282 mRNA Translation: BAD32560.1 Different initiation.
AK032366 mRNA Translation: BAC27837.1
AK032622 mRNA Translation: BAC27955.1
AK082791 mRNA Translation: BAC38621.1
AK140441 mRNA Translation: BAE24388.1
AK154383 mRNA Translation: BAE32550.1
AK155373 mRNA Translation: BAE33226.1
AK171043 mRNA Translation: BAE42208.1
BC057128 mRNA Translation: AAH57128.1
BC063253 mRNA Translation: AAH63253.1
CCDSiCCDS26068.1
RefSeqiNP_665835.1, NM_145836.2
UniGeneiMm.248358

Genome annotation databases

EnsembliENSMUST00000038422; ENSMUSP00000041070; ENSMUSG00000034168
GeneIDi238330
KEGGimmu:238330
UCSCiuc007oia.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525300 mRNA Translation: AAM82165.1
AK173282 mRNA Translation: BAD32560.1 Different initiation.
AK032366 mRNA Translation: BAC27837.1
AK032622 mRNA Translation: BAC27955.1
AK082791 mRNA Translation: BAC38621.1
AK140441 mRNA Translation: BAE24388.1
AK154383 mRNA Translation: BAE32550.1
AK155373 mRNA Translation: BAE33226.1
AK171043 mRNA Translation: BAE42208.1
BC057128 mRNA Translation: AAH57128.1
BC063253 mRNA Translation: AAH63253.1
CCDSiCCDS26068.1
RefSeqiNP_665835.1, NM_145836.2
UniGeneiMm.248358

3D structure databases

ProteinModelPortaliQ8K3X4
SMRiQ8K3X4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231970, 2 interactors
IntActiQ8K3X4, 1 interactor
MINTiQ8K3X4
STRINGi10090.ENSMUSP00000041070

PTM databases

iPTMnetiQ8K3X4
PhosphoSitePlusiQ8K3X4

Proteomic databases

EPDiQ8K3X4
MaxQBiQ8K3X4
PaxDbiQ8K3X4
PeptideAtlasiQ8K3X4
PRIDEiQ8K3X4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038422; ENSMUSP00000041070; ENSMUSG00000034168
GeneIDi238330
KEGGimmu:238330
UCSCiuc007oia.2 mouse

Organism-specific databases

CTDi64207
MGIiMGI:2442463 Irf2bpl
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3579 Eukaryota
ENOG410Z1AW LUCA
GeneTreeiENSGT00390000005089
HOVERGENiHBG108364
InParanoidiQ8K3X4
KOiK22383
OMAiPSTHPGM
OrthoDBiEOG091G040R
PhylomeDBiQ8K3X4
TreeFamiTF317075

Miscellaneous databases

ChiTaRSiIrf2bpl mouse
PMAP-CutDBiQ8K3X4
PROiPR:Q8K3X4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034168 Expressed in 243 organ(s), highest expression level in dorsal pancreas
CleanExiMM_6430527G18RIK
GenevisibleiQ8K3X4 MM

Family and domain databases

InterProiView protein in InterPro
IPR022750 Interferon_reg_fac2-bd1_2_Znf
PfamiView protein in Pfam
PF11261 IRF-2BP1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI2BPL_MOUSE
AccessioniPrimary (citable) accession number: Q8K3X4
Secondary accession number(s): Q3TBU9
, Q3U483, Q3USE5, Q69Z84, Q8BUS1, Q8C011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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