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Protein

Leucine-rich repeat-containing protein 10

Gene

Lrrc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play important roles in cardiac development and/or cardiac function.

GO - Molecular functioni

  • actin binding Source: MGI
  • alpha-actinin binding Source: MGI

GO - Biological processi

  • cardiac muscle cell development Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 10
Alternative name(s):
Heart-restricted leucine-rich repeat protein
Gene namesi
Name:Lrrc10
Synonyms:Hrlrrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2448063 Lrrc10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844711 – 274Leucine-rich repeat-containing protein 10Add BLAST274

Proteomic databases

PaxDbiQ8K3W2
PRIDEiQ8K3W2

PTM databases

iPTMnetiQ8K3W2
PhosphoSitePlusiQ8K3W2

Expressioni

Tissue specificityi

Detected specifically in the heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000060187 Expressed in 15 organ(s), highest expression level in heart
CleanExiMM_LRRC10

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8K3W2, 2 interactors
STRINGi10090.ENSMUSP00000073502

Structurei

3D structure databases

ProteinModelPortaliQ8K3W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 51LRR 1Add BLAST22
Repeati52 – 74LRR 2Add BLAST23
Repeati76 – 97LRR 3Add BLAST22
Repeati98 – 120LRR 4Add BLAST23
Repeati121 – 143LRR 5Add BLAST23
Repeati145 – 166LRR 6Add BLAST22
Repeati167 – 189LRR 7Add BLAST23
Repeati191 – 213LRR 8Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi265 – 268Poly-Pro4

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150841
HOGENOMiHOG000113359
HOVERGENiHBG055066
InParanoidiQ8K3W2
OMAiDFPPVLL
OrthoDBiEOG091G0HMZ
PhylomeDBiQ8K3W2
TreeFamiTF332853

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits

Sequencei

Sequence statusi: Complete.

Q8K3W2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNTIRAFVA FIPTDRCQSY VVGDLREMPL DRMVDLSGSQ LRRFPLHVCS
60 70 80 90 100
FTELVKLYLS DNHLHSLPPD LAQLQNLQIL ALDFNNFKAL PRVVCTLKQL
110 120 130 140 150
CILYLGNNKL CDLPDELSLL QNLRTLWLES NCLTRLPDVV CELSLLKTLH
160 170 180 190 200
AGSNALRLLP GQLRRLRELR TIWLSGNQLA DFPSVLLRMP FLEVIDVDRN
210 220 230 240 250
SIRYFPSLAH LTNLKLVIYD HNPCRNAPKV GKGVRRVGRW AEETPEPDPR
260 270
KARRYALAKE ENQEPPPPLL PSSS
Length:274
Mass (Da):31,263
Last modified:October 1, 2002 - v1
Checksum:i826B76D4FA4EDDD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26R → Q in BAC39192 (PubMed:16141072).Curated1
Sequence conflicti75Q → R in BAC39192 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527781 mRNA Translation: AAM89260.1
AB091100 mRNA Translation: BAC57985.1
AK084466 mRNA Translation: BAC39192.1
AK085779 mRNA Translation: BAC39536.1
BC086911 mRNA Translation: AAH86911.1
CCDSiCCDS24189.1
RefSeqiNP_666354.1, NM_146242.2
UniGeneiMm.37320

Genome annotation databases

EnsembliENSMUST00000073834; ENSMUSP00000073502; ENSMUSG00000060187
GeneIDi237560
KEGGimmu:237560
UCSCiuc007hcr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527781 mRNA Translation: AAM89260.1
AB091100 mRNA Translation: BAC57985.1
AK084466 mRNA Translation: BAC39192.1
AK085779 mRNA Translation: BAC39536.1
BC086911 mRNA Translation: AAH86911.1
CCDSiCCDS24189.1
RefSeqiNP_666354.1, NM_146242.2
UniGeneiMm.37320

3D structure databases

ProteinModelPortaliQ8K3W2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K3W2, 2 interactors
STRINGi10090.ENSMUSP00000073502

PTM databases

iPTMnetiQ8K3W2
PhosphoSitePlusiQ8K3W2

Proteomic databases

PaxDbiQ8K3W2
PRIDEiQ8K3W2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073834; ENSMUSP00000073502; ENSMUSG00000060187
GeneIDi237560
KEGGimmu:237560
UCSCiuc007hcr.1 mouse

Organism-specific databases

CTDi376132
MGIiMGI:2448063 Lrrc10

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150841
HOGENOMiHOG000113359
HOVERGENiHBG055066
InParanoidiQ8K3W2
OMAiDFPPVLL
OrthoDBiEOG091G0HMZ
PhylomeDBiQ8K3W2
TreeFamiTF332853

Miscellaneous databases

PROiPR:Q8K3W2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060187 Expressed in 15 organ(s), highest expression level in heart
CleanExiMM_LRRC10

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC10_MOUSE
AccessioniPrimary (citable) accession number: Q8K3W2
Secondary accession number(s): Q8BUL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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