UniProtKB - Q8K3W0 (BABA2_MOUSE)
BRISC and BRCA1-A complex member 2
Babam2
Functioni
GO - Molecular functioni
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: UniProtKB
- chromatin organization Source: UniProtKB-KW
- double-strand break repair Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of DNA repair Source: UniProtKB
- response to ionizing radiation Source: UniProtKB
- signal transduction involved in G2 DNA damage checkpoint Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Apoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-5689901, Metalloprotease DUBs R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-MMU-5693607, Processing of DNA double-strand break ends R-MMU-69473, G2/M DNA damage checkpoint |
Names & Taxonomyi
Protein namesi | Recommended name: BRISC and BRCA1-A complex member 2Alternative name(s): BRCA1-A complex subunit BRE BRCA1/BRCA2-containing complex subunit 45 Brain and reproductive organ-expressed protein |
Gene namesi | Name:Babam2 Synonyms:BreImported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333875, Babam2 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- BRCA1-A complex Source: UniProtKB
- BRISC complex Source: UniProtKB
- nuclear ubiquitin ligase complex Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000224190 | 1 – 383 | BRISC and BRCA1-A complex member 2Add BLAST | 383 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8K3W0 |
jPOSTi | Q8K3W0 |
MaxQBi | Q8K3W0 |
PeptideAtlasi | Q8K3W0 |
PRIDEi | Q8K3W0 |
PTM databases
iPTMneti | Q8K3W0 |
PhosphoSitePlusi | Q8K3W0 |
SwissPalmi | Q8K3W0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000052139, Expressed in lens of camera-type eye and 303 other tissues |
Genevisiblei | Q8K3W0, MM |
Interactioni
Subunit structurei
Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1.
Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin.
Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1.
Identified in a complex with SHMT2 and the other subunits of the BRISC complex.
Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A (PubMed:9737713).
By similarity1 PublicationGO - Molecular functioni
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 223733, 16 interactors |
ComplexPortali | CPX-4702, BRCA1-A complex CPX-972, BRCC ubiquitin ligase complex |
Miscellaneous databases
RNActi | Q8K3W0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 147 | UEV-like 1Add BLAST | 118 | |
Regioni | 275 – 364 | UEV-like 2Add BLAST | 90 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
GeneTreei | ENSGT00390000004208 |
HOGENOMi | CLU_1133268_0_0_1 |
InParanoidi | Q8K3W0 |
OMAi | LVQWDAG |
OrthoDBi | 831092at2759 |
PhylomeDBi | Q8K3W0 |
TreeFami | TF328507 |
Family and domain databases
InterProi | View protein in InterPro IPR010358, BRE |
PANTHERi | PTHR15189, PTHR15189, 1 hit |
Pfami | View protein in Pfam PF06113, BRE, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPEIALNRI SPMLSPFISS VVRNGKVGLD ATNCLRITDL KSGCTSLTPG
60 70 80 90 100
PNCDRFKLHI PYAGETLKWD IIFNAQYPEL PPDFIFGEDA EFLPDPSALH
110 120 130 140 150
NLASWNPSNP ECLLLVVKEL VQQYHQFQCG RLRESSRLMF EYQTLLEEPQ
160 170 180 190 200
YGENMEIYAG KKNNWTGEFS ARFLLKLPVD FSNIPTYLLK DVNEDPGEDV
210 220 230 240 250
ALLSVSFEDT EATQVYPKLY LSPRIEHALG GSSALHIPAF PGGGCLIDYV
260 270 280 290 300
PQVCHLLTNK VQYVIQGYHK RREYIAAFLS HFGTGVVEYD AEGFTKLTLL
310 320 330 340 350
LMWKDFCFLV HIDLPLFFPR DQPTLTFQSV YHFTNSGQLY SQAQKNYPYS
360 370 380
PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN GKL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z7P0 | D3Z7P0_MOUSE | BRCA1-A complex subunit BRE | Babam2 Bre | 385 | Annotation score: | ||
E9Q8Q1 | E9Q8Q1_MOUSE | BRCA1-A complex subunit BRE | Babam2 Bre | 43 | Annotation score: | ||
E9Q0U3 | E9Q0U3_MOUSE | BRCA1-A complex subunit BRE | Babam2 Bre | 205 | Annotation score: | ||
A0A0J9YV56 | A0A0J9YV56_MOUSE | BRCA1-A complex subunit BRE | Babam2 Bre | 63 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 105 | W → R in AAH61000 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051952 | 1 – 138 | Missing in isoform 3. 1 PublicationAdd BLAST | 138 | |
Alternative sequenceiVSP_037262 | 1 – 69 | MSPEI…ETLKW → MCACR in isoform 5. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_037263 | 1 – 43 | MSPEI…DLKSG → MCACNEWYGVPDLEKASYLW RKKENHLPLEKGQN in isoform 4. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_051953 | 27 – 43 | VGLDA…DLKSG → IHEKGPSQKLSFKSCSYHLP MCACNEWYGVPDLEKASYLW RKKENHLPLEKGQN in isoform 1. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF440752 mRNA Translation: AAL40809.1 AF527952 mRNA Translation: AAM92774.1 AF527953 mRNA Translation: AAM92775.1 AF527954 mRNA Translation: AAM92776.1 AF527955 mRNA Translation: AAM92777.1 AF538925 mRNA Translation: AAN15148.1 AK050695 mRNA Translation: BAC34385.1 Sequence problems. AK080991 mRNA Translation: BAC38108.1 AK156929 mRNA Translation: BAE33900.1 BC061000 mRNA Translation: AAH61000.1 BC100565 mRNA Translation: AAI00566.1 |
CCDSi | CCDS19188.1 [Q8K3W0-2] CCDS19189.1 [Q8K3W0-1] CCDS39058.1 [Q8K3W0-5] CCDS39059.1 [Q8K3W0-4] CCDS51461.1 [Q8K3W0-6] |
RefSeqi | NP_653124.1, NM_144541.1 [Q8K3W0-2] NP_851796.1, NM_181279.1 [Q8K3W0-1] NP_851797.1, NM_181280.1 [Q8K3W0-5] NP_851798.1, NM_181281.1 [Q8K3W0-6] NP_851799.1, NM_181282.1 [Q8K3W0-4] |
Genome annotation databases
Ensembli | ENSMUST00000063813; ENSMUSP00000069133; ENSMUSG00000052139 [Q8K3W0-1] ENSMUST00000071531; ENSMUSP00000071462; ENSMUSG00000052139 [Q8K3W0-5] ENSMUST00000114507; ENSMUSP00000110152; ENSMUSG00000052139 [Q8K3W0-6] ENSMUST00000131995; ENSMUSP00000128351; ENSMUSG00000052139 [Q8K3W0-4] ENSMUST00000201352; ENSMUSP00000144205; ENSMUSG00000052139 [Q8K3W0-2] |
GeneIDi | 107976 |
KEGGi | mmu:107976 |
UCSCi | uc008wza.1, mouse [Q8K3W0-2] uc008wzb.1, mouse [Q8K3W0-1] uc008wzc.1, mouse [Q8K3W0-5] uc008wze.1, mouse [Q8K3W0-6] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF440752 mRNA Translation: AAL40809.1 AF527952 mRNA Translation: AAM92774.1 AF527953 mRNA Translation: AAM92775.1 AF527954 mRNA Translation: AAM92776.1 AF527955 mRNA Translation: AAM92777.1 AF538925 mRNA Translation: AAN15148.1 AK050695 mRNA Translation: BAC34385.1 Sequence problems. AK080991 mRNA Translation: BAC38108.1 AK156929 mRNA Translation: BAE33900.1 BC061000 mRNA Translation: AAH61000.1 BC100565 mRNA Translation: AAI00566.1 |
CCDSi | CCDS19188.1 [Q8K3W0-2] CCDS19189.1 [Q8K3W0-1] CCDS39058.1 [Q8K3W0-5] CCDS39059.1 [Q8K3W0-4] CCDS51461.1 [Q8K3W0-6] |
RefSeqi | NP_653124.1, NM_144541.1 [Q8K3W0-2] NP_851796.1, NM_181279.1 [Q8K3W0-1] NP_851797.1, NM_181280.1 [Q8K3W0-5] NP_851798.1, NM_181281.1 [Q8K3W0-6] NP_851799.1, NM_181282.1 [Q8K3W0-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6GVW | X-ray | 3.75 | C/H | 1-383 | [»] | |
SMRi | Q8K3W0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 223733, 16 interactors |
ComplexPortali | CPX-4702, BRCA1-A complex CPX-972, BRCC ubiquitin ligase complex |
PTM databases
iPTMneti | Q8K3W0 |
PhosphoSitePlusi | Q8K3W0 |
SwissPalmi | Q8K3W0 |
Proteomic databases
EPDi | Q8K3W0 |
jPOSTi | Q8K3W0 |
MaxQBi | Q8K3W0 |
PeptideAtlasi | Q8K3W0 |
PRIDEi | Q8K3W0 |
Protocols and materials databases
Antibodypediai | 13903, 238 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000063813; ENSMUSP00000069133; ENSMUSG00000052139 [Q8K3W0-1] ENSMUST00000071531; ENSMUSP00000071462; ENSMUSG00000052139 [Q8K3W0-5] ENSMUST00000114507; ENSMUSP00000110152; ENSMUSG00000052139 [Q8K3W0-6] ENSMUST00000131995; ENSMUSP00000128351; ENSMUSG00000052139 [Q8K3W0-4] ENSMUST00000201352; ENSMUSP00000144205; ENSMUSG00000052139 [Q8K3W0-2] |
GeneIDi | 107976 |
KEGGi | mmu:107976 |
UCSCi | uc008wza.1, mouse [Q8K3W0-2] uc008wzb.1, mouse [Q8K3W0-1] uc008wzc.1, mouse [Q8K3W0-5] uc008wze.1, mouse [Q8K3W0-6] |
Organism-specific databases
CTDi | 9577 |
MGIi | MGI:1333875, Babam2 |
Phylogenomic databases
GeneTreei | ENSGT00390000004208 |
HOGENOMi | CLU_1133268_0_0_1 |
InParanoidi | Q8K3W0 |
OMAi | LVQWDAG |
OrthoDBi | 831092at2759 |
PhylomeDBi | Q8K3W0 |
TreeFami | TF328507 |
Enzyme and pathway databases
Reactomei | R-MMU-5689901, Metalloprotease DUBs R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-MMU-5693607, Processing of DNA double-strand break ends R-MMU-69473, G2/M DNA damage checkpoint |
Miscellaneous databases
BioGRID-ORCSi | 107976, 2 hits in 18 CRISPR screens |
ChiTaRSi | Bre, mouse |
PROi | PR:Q8K3W0 |
RNActi | Q8K3W0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052139, Expressed in lens of camera-type eye and 303 other tissues |
Genevisiblei | Q8K3W0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR010358, BRE |
PANTHERi | PTHR15189, PTHR15189, 1 hit |
Pfami | View protein in Pfam PF06113, BRE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BABA2_MOUSE | |
Accessioni | Q8K3W0Primary (citable) accession number: Q8K3W0 Secondary accession number(s): Q497G6 Q8VHN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families