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Protein

Major intrinsically disordered Notch2-binding receptor 1

Gene

Minar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth (By similarity). Negatively regulates neurite outgrowth in hippocampal neurons (By similarity).By similarity

Caution

MINAR1 topology is a matter of debate, some authors think the N-terminus is extracellular, while preliminary experimental results suggest a cytosolic location.By similarity

GO - Biological processi

Keywordsi

Biological processAngiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Major intrinsically disordered Notch2-binding receptor 1
Alternative name(s):
Membrane integral NOTCH2-associated receptor 1
Protein DD1
Ubiquitination and mTOR signaling protein
Gene namesi
Name:Minar1
Synonyms:Ubtor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2667167 AF529169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 892CytoplasmicCuratedAdd BLAST892
Transmembranei893 – 913HelicalSequence analysisAdd BLAST21
Topological domaini914 – 917ExtracellularCurated4

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001571341 – 917Major intrinsically disordered Notch2-binding receptor 1Add BLAST917

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei712PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K3V7
PRIDEiQ8K3V7

PTM databases

iPTMnetiQ8K3V7
PhosphoSitePlusiQ8K3V7

Expressioni

Tissue specificityi

Expressed in brain and in islets of Langerhans.

Gene expression databases

BgeeiENSMUSG00000039313 Expressed in 108 organ(s), highest expression level in habenula
CleanExiMM_AF529169
ExpressionAtlasiQ8K3V7 baseline and differential
GenevisibleiQ8K3V7 MM

Interactioni

Subunit structurei

Interacts with NOTCH2; this interaction increases MINAR1 stability. Interacts (via N-terminus) with DEPTOR (via PDZ domain); this interaction may stabilize DEPTOR protein by impairing its ubiquitination.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046111

Structurei

3D structure databases

ProteinModelPortaliQ8K3V7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MINAR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFF3 Eukaryota
ENOG410ZD1X LUCA
GeneTreeiENSGT00530000063851
HOGENOMiHOG000004865
HOVERGENiHBG052193
InParanoidiQ8K3V7
OMAiPEHNLTK
OrthoDBiEOG091G014I
PhylomeDBiQ8K3V7
TreeFamiTF350677

Family and domain databases

InterProiView protein in InterPro
IPR009626 MINAR1-like_C
PfamiView protein in Pfam
PF06789 UPF0258, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K3V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEANQEASLF LVKILEELDS KQNTVSYQDL CKSLCAQFDL SQLAKLRSVL
60 70 80 90 100
FYTACLDPNF PATLFKDKMK CSVNNQQSKK IMVAADIVTI FNLIQMNGGT
110 120 130 140 150
AKEKLPMSCH KVRKKEASFE SCRSDTEVCS PTVCEPLNCE LSERPFSRGY
160 170 180 190 200
PTRQSSKCRK MDCKECPQFV PASEPNFLLG VSKEVKNRAA SLDRLQALSP
210 220 230 240 250
YSVASPQPCE MQRTYFPMNI ENEPMSDQDS LPISQGIKET FISSEEPFVV
260 270 280 290 300
QSCVQKRNIF KEDFHNLMTV SPSLVGTTNK AEEGHGEPQS QKELHKPPFF
310 320 330 340 350
NHSFEMPYHN QYLNPVYSPI PDKRRAKHES LDDLQASTYF GPTPVMGTQD
360 370 380 390 400
TRRCPGRSSK QTPWPAKSWS LNTEEVPDFE RSFFNRNPSE EKLRYPNSGS
410 420 430 440 450
QTPNFSGPDR HPVYLVPKDQ QKVLPAGYAV KPNGLKSKEI SSPVDLEKHE
460 470 480 490 500
AVKKFKDKSI SCTSGQHSSD TSSVGTQTEQ HVLDPPKCKD LCTSGQAKYG
510 520 530 540 550
DRHAMKQSDD DSEIVSDDIS DIFRFLDDMS ISGSTGVIQS SCYNSTGSLS
560 570 580 590 600
QLHKSDCDSS PEHHLAKITN GVSSGKGDKC NRPENVHHSE EELKSSVCKL
610 620 630 640 650
VLRIGEIERK LESLSGVREE ISQVLGKLNK LDQKIQQPEK VNVQIDLNSL
660 670 680 690 700
TSEAPSDDSA SPRVFRAHSG SHGPKLENSP DWCCSDASGS NSESLRVKAL
710 720 730 740 750
KKSLFTRPSS RSLTEENSAT ESKIASISNS PRDWRTITYT NRMSLNEEEI
760 770 780 790 800
KDAGPANNKD WHRKSKEADR QYDIPPQHRL PKQPKDGFLV EQVFSPHPYP
810 820 830 840 850
TSLKGHMKSN PLYTDMRLTE LAEVKRGQPS WTIEEYARNS GDKGKLTALD
860 870 880 890 900
LQTQESLNPN NLEYWMEDIY TPGYDSLLKR KEAEFRRAKV CKIAALITAA
910
ACTVILVIVV PICTMKS
Length:917
Mass (Da):102,792
Last modified:October 1, 2002 - v1
Checksum:i065DCB22C917E493
GO
Isoform 2 (identifier: Q8K3V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-382: Missing.

Note: No experimental confirmation available.
Show »
Length:907
Mass (Da):101,602
Checksum:i798FBBD69E1C3512
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WS88A0A087WS88_MOUSE
cDNA sequence AF529169
AF529169 mCG_7769
855Annotation score:

Sequence cautioni

The sequence BAD32367 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013706373 – 382Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529169 mRNA Translation: AAM93262.1
AK035830 mRNA Translation: BAC29204.1
AK173089 Transcribed RNA Translation: BAD32367.1 Different initiation.
CH466560 Genomic DNA Translation: EDL20893.1
BC113792 mRNA Translation: AAI13793.1
CCDSiCCDS23395.1 [Q8K3V7-1]
RefSeqiNP_705729.1, NM_153509.2 [Q8K3V7-1]
XP_006511020.1, XM_006510957.3 [Q8K3V7-1]
XP_017168754.1, XM_017313265.1 [Q8K3V7-1]
UniGeneiMm.242899
Mm.458520

Genome annotation databases

EnsembliENSMUST00000044491; ENSMUSP00000046111; ENSMUSG00000039313 [Q8K3V7-1]
GeneIDi209743
KEGGimmu:209743
UCSCiuc009qzn.2 mouse [Q8K3V7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529169 mRNA Translation: AAM93262.1
AK035830 mRNA Translation: BAC29204.1
AK173089 Transcribed RNA Translation: BAD32367.1 Different initiation.
CH466560 Genomic DNA Translation: EDL20893.1
BC113792 mRNA Translation: AAI13793.1
CCDSiCCDS23395.1 [Q8K3V7-1]
RefSeqiNP_705729.1, NM_153509.2 [Q8K3V7-1]
XP_006511020.1, XM_006510957.3 [Q8K3V7-1]
XP_017168754.1, XM_017313265.1 [Q8K3V7-1]
UniGeneiMm.242899
Mm.458520

3D structure databases

ProteinModelPortaliQ8K3V7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046111

PTM databases

iPTMnetiQ8K3V7
PhosphoSitePlusiQ8K3V7

Proteomic databases

PaxDbiQ8K3V7
PRIDEiQ8K3V7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044491; ENSMUSP00000046111; ENSMUSG00000039313 [Q8K3V7-1]
GeneIDi209743
KEGGimmu:209743
UCSCiuc009qzn.2 mouse [Q8K3V7-1]

Organism-specific databases

CTDi209743
MGIiMGI:2667167 AF529169

Phylogenomic databases

eggNOGiENOG410IFF3 Eukaryota
ENOG410ZD1X LUCA
GeneTreeiENSGT00530000063851
HOGENOMiHOG000004865
HOVERGENiHBG052193
InParanoidiQ8K3V7
OMAiPEHNLTK
OrthoDBiEOG091G014I
PhylomeDBiQ8K3V7
TreeFamiTF350677

Miscellaneous databases

PROiPR:Q8K3V7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039313 Expressed in 108 organ(s), highest expression level in habenula
CleanExiMM_AF529169
ExpressionAtlasiQ8K3V7 baseline and differential
GenevisibleiQ8K3V7 MM

Family and domain databases

InterProiView protein in InterPro
IPR009626 MINAR1-like_C
PfamiView protein in Pfam
PF06789 UPF0258, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMNAR1_MOUSE
AccessioniPrimary (citable) accession number: Q8K3V7
Secondary accession number(s): Q14CG5, Q69ZS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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