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Protein

Fibronectin type III domain-containing protein 5

Gene

Fndc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 5
Cleaved into the following chain:
Gene namesi
Name:Fndc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708525 Fndc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 149ExtracellularSequence analysisAdd BLAST121
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 209CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane, Peroxisome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000032897329 – 209Fibronectin type III domain-containing protein 5Add BLAST181
ChainiPRO_000041585929 – 140IrisinAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-Glycosylated.By similarity
The extracellular domain is cleaved and released from the cell membrane.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K3V5

PTM databases

iPTMnetiQ8K3V5
PhosphoSitePlusiQ8K3V5

Expressioni

Gene expression databases

BgeeiENSRNOG00000030238 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiQ8K3V5 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048830

Structurei

3D structure databases

ProteinModelPortaliQ8K3V5
SMRiQ8K3V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 124Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi207 – 209Microbody targeting signalSequence analysis3

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IESX Eukaryota
ENOG410YC2F LUCA
GeneTreeiENSGT00390000004923
HOGENOMiHOG000082536
HOVERGENiHBG067308
InParanoidiQ8K3V5
OMAiVTMKEMA
OrthoDBiEOG091G0HLN
PhylomeDBiQ8K3V5
TreeFamiTF325415

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K3V5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPGPCAWPP RAALRLWLGC VCFALVQADS PSAPVNVTVR HLKANSAVVS
60 70 80 90 100
WDVLEDEVVI GFAISQQKKD VRMLRFIQEV NTTTRSCALW DLEEDTEYIV
110 120 130 140 150
HVQAISIQGQ SPASEPVLFK TPREAEKMAS KNKDEVTMKE MGRNQQLRTG
160 170 180 190 200
EVLIIVVVLF MWAGVIALFC RQYDIIKDNE PNNNKEKTKS ASETSTPEHQ

GGGLLRSKI
Length:209
Mass (Da):23,321
Last modified:April 8, 2008 - v2
Checksum:i86A33DE8E4616507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03042295 Genomic DNA No translation available.
AABR03047757 Genomic DNA No translation available.
AF529211 mRNA Translation: AAM94408.1
RefSeqiNP_001257910.1, NM_001270981.1
UniGeneiRn.18757

Genome annotation databases

EnsembliENSRNOT00000047152; ENSRNOP00000048830; ENSRNOG00000030238
GeneIDi260327
KEGGirno:260327

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03042295 Genomic DNA No translation available.
AABR03047757 Genomic DNA No translation available.
AF529211 mRNA Translation: AAM94408.1
RefSeqiNP_001257910.1, NM_001270981.1
UniGeneiRn.18757

3D structure databases

ProteinModelPortaliQ8K3V5
SMRiQ8K3V5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048830

PTM databases

iPTMnetiQ8K3V5
PhosphoSitePlusiQ8K3V5

Proteomic databases

PaxDbiQ8K3V5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047152; ENSRNOP00000048830; ENSRNOG00000030238
GeneIDi260327
KEGGirno:260327

Organism-specific databases

CTDi252995
RGDi708525 Fndc5

Phylogenomic databases

eggNOGiENOG410IESX Eukaryota
ENOG410YC2F LUCA
GeneTreeiENSGT00390000004923
HOGENOMiHOG000082536
HOVERGENiHBG067308
InParanoidiQ8K3V5
OMAiVTMKEMA
OrthoDBiEOG091G0HLN
PhylomeDBiQ8K3V5
TreeFamiTF325415

Miscellaneous databases

PROiPR:Q8K3V5

Gene expression databases

BgeeiENSRNOG00000030238 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiQ8K3V5 RN

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFNDC5_RAT
AccessioniPrimary (citable) accession number: Q8K3V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 12, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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