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Entry version 130 (08 May 2019)
Sequence version 2 (01 Mar 2003)
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Protein

P2X purinoceptor 2

Gene

P2rx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K+ recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel
Biological processHearing, Ion transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2X purinoceptor 2
Short name:
P2X2
Alternative name(s):
ATP receptor
Purinergic receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2rx2
Synonyms:P2x2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2665170 P2rx2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 339ExtracellularSequence analysisAdd BLAST275
Transmembranei340 – 360Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini361 – 485CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show small differences in body weight, but are visibly and histopathologically normal for up to 1 year of age. Simultaneous knockout of P2rx2 and P2rx3 results in reduced pain-related behaviors in response to intraplantar injection of formalin and reduced urinary bladder reflexes and decreased pelvic afferent nerve activity in response to bladder distension. Neurons have minimal to no response to ATP (PubMed:15961431). P2rx2 null mice show impaired peristalsis in ileal segments of small intestine (PubMed:12937291). P2rx2 null mice show disorganized neuromuscular junctions (NMJ) with misapposition of nerve terminals and post-synaptic AChR expression localization, reduction of the density of post-synaptic and increased end-plate fragmentation. These changes in NMJ structure are associated with muscle fiber atrophy and an increase in the proportion of fast type muscle fibers (PubMed:17706883). P2rx2 null mice display age-related hearing loss: in the absence of exposure to noise, auditory thresholds are normal until at least age 19-23 week. Then, mice develop severe progressive hearing loss, and their early exposure to continuous moderate noise leads to high-frequency hearing loss as young adults (PubMed:23345450). Simultaneous knockout of P2rx2 and P2rx3 results in defects in taste responses in the taste nerves and reduced behavioral responses to sweeteners, glutamate and bitter substances (PubMed:16322458).6 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004259051 – 485P2X purinoceptor 2Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi22 ↔ 443By similarity
Disulfide bondi126 ↔ 177By similarity
Disulfide bondi137 ↔ 160By similarity
Disulfide bondi143 ↔ 171By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi227 ↔ 237By similarity
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi271 ↔ 280By similarity
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K3P1

PRoteomics IDEntifications database

More...
PRIDEi
Q8K3P1

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K3P1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In skeletal muscle, strongly expressed in postnatal day 3 (P3), P7 and P15 muscles. Expression is not maintained in P21 in adult skeletal muscle (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029503 Expressed in 64 organ(s), highest expression level in utricle of membranous labyrinth

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K3P1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer and heterotrimer; functional P2XRs are organized as homomeric and heteromeric trimers.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000054233

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K3P1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni322 – 335Pore-forming motifSequence analysisAdd BLAST14

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJK Eukaryota
ENOG410ZQ3M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232042

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K3P1

KEGG Orthology (KO)

More...
KOi
K05216

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRFAKYY

Database of Orthologous Groups

More...
OrthoDBi
1128763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K3P1

TreeFam database of animal gene trees

More...
TreeFami
TF328633

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003045 P2X2_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005713 P2X_purinoceptor, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01309 P2X2RECEPTOR
PR01307 P2XRECEPTOR

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00863 P2X, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8K3P1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAQPRLPA GAAMVRRLAR GCWSAFWDYE TPKVIVVRNR RLGFVHRMVQ
60 70 80 90 100
LLILLYFVWY VFIVQKSYQD SETGPESSII TKVKGITMSE HKVWDVEEYV
110 120 130 140 150
KPPEGGSVVS IITRIEVTPS QTLGTCPESM RVHSSTCHLD DDCVAGQLDM
160 170 180 190 200
QGNGIRTGRC VPYYHGDSKT CEVSAWCPVE DGTSENHFLG KMAPNFTILI
210 220 230 240 250
KNSIHYPKFK FSKGNIASQK SDYLKHCTFD QDSDPYCPIF RLGFIVEQAG
260 270 280 290 300
ENFTELAHKG GVIGVIINWN CDLDLSESEC NPKYSFRRLD PKYDPASSGY
310 320 330 340 350
NFRFAKYYKI NGTTTTRTLI KAYGIRIDVI VHGQAGKFSL IPTIINLATA
360 370 380 390 400
LTSIGVGSFL CDWILLTFMN KNKLYSHKKF DKVRTPRHPS SRWPVTLALV
410 420 430 440 450
LGQIPPPPSH YSQDQPPSLP SGEGPALGEG AELPLAVQPP RSCSSSALTE
460 470 480
QVVDTLDQHM GQRPPVPEPS QQDSTSTDPK GLAQL
Length:485
Mass (Da):53,937
Last modified:March 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABDE08727CA66B70
GO
Isoform 2 (identifier: Q8K3P1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-451: Missing.

Show »
Length:416
Mass (Da):46,724
Checksum:iE456A506ED5A44E3
GO
Isoform 3 (identifier: Q8K3P1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-472: Missing.

Show »
Length:395
Mass (Da):44,383
Checksum:i5A7A55EA44F73C86
GO
Isoform 4 (identifier: Q8K3P1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: No experimental confirmation available.
Show »
Length:398
Mass (Da):43,952
Checksum:i508A56932A77AA68
GO
Isoform 5 (identifier: Q8K3P1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-59: W → WVASGAGTALSHR

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):55,045
Checksum:iC5122D8673811897
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti341I → T in BAE34462 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0538871 – 87Missing in isoform 4. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_05388859W → WVASGAGTALSHR in isoform 5. 1 Publication1
Alternative sequenceiVSP_053889383 – 472Missing in isoform 3. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_053890383 – 451Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY044240 mRNA Translation: AAK95327.2
AB094663 mRNA Translation: BAC55013.1
AB094664 mRNA Translation: BAC55014.1
AK141196 mRNA Translation: BAE24579.1
AK158334 mRNA Translation: BAE34462.1
AC123699 Genomic DNA No translation available.
CH466529 Genomic DNA Translation: EDL20025.1
BC106964 mRNA Translation: AAI06965.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51607.1 [Q8K3P1-1]
CCDS51608.1 [Q8K3P1-2]
CCDS80361.1 [Q8K3P1-4]
CCDS80362.1 [Q8K3P1-3]
CCDS80363.1 [Q8K3P1-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001158305.1, NM_001164833.1 [Q8K3P1-2]
NP_001158306.1, NM_001164834.1 [Q8K3P1-3]
NP_001297629.1, NM_001310700.1 [Q8K3P1-5]
NP_001297630.1, NM_001310701.1 [Q8K3P1-4]
NP_700449.2, NM_153400.4 [Q8K3P1-1]
XP_011247750.1, XM_011249448.2 [Q8K3P1-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000058016; ENSMUSP00000054233; ENSMUSG00000029503 [Q8K3P1-5]
ENSMUST00000112478; ENSMUSP00000108097; ENSMUSG00000029503 [Q8K3P1-2]
ENSMUST00000195985; ENSMUSP00000143047; ENSMUSG00000029503 [Q8K3P1-1]
ENSMUST00000200037; ENSMUSP00000143554; ENSMUSG00000029503 [Q8K3P1-3]
ENSMUST00000200214; ENSMUSP00000142567; ENSMUSG00000029503 [Q8K3P1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
231602

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:231602

UCSC genome browser

More...
UCSCi
uc008yqq.1 mouse [Q8K3P1-1]
uc008yqs.2 mouse [Q8K3P1-3]
uc008yqt.2 mouse [Q8K3P1-5]
uc008yqu.2 mouse [Q8K3P1-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044240 mRNA Translation: AAK95327.2
AB094663 mRNA Translation: BAC55013.1
AB094664 mRNA Translation: BAC55014.1
AK141196 mRNA Translation: BAE24579.1
AK158334 mRNA Translation: BAE34462.1
AC123699 Genomic DNA No translation available.
CH466529 Genomic DNA Translation: EDL20025.1
BC106964 mRNA Translation: AAI06965.1
CCDSiCCDS51607.1 [Q8K3P1-1]
CCDS51608.1 [Q8K3P1-2]
CCDS80361.1 [Q8K3P1-4]
CCDS80362.1 [Q8K3P1-3]
CCDS80363.1 [Q8K3P1-5]
RefSeqiNP_001158305.1, NM_001164833.1 [Q8K3P1-2]
NP_001158306.1, NM_001164834.1 [Q8K3P1-3]
NP_001297629.1, NM_001310700.1 [Q8K3P1-5]
NP_001297630.1, NM_001310701.1 [Q8K3P1-4]
NP_700449.2, NM_153400.4 [Q8K3P1-1]
XP_011247750.1, XM_011249448.2 [Q8K3P1-4]

3D structure databases

SMRiQ8K3P1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054233

PTM databases

PhosphoSitePlusiQ8K3P1

Proteomic databases

PaxDbiQ8K3P1
PRIDEiQ8K3P1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058016; ENSMUSP00000054233; ENSMUSG00000029503 [Q8K3P1-5]
ENSMUST00000112478; ENSMUSP00000108097; ENSMUSG00000029503 [Q8K3P1-2]
ENSMUST00000195985; ENSMUSP00000143047; ENSMUSG00000029503 [Q8K3P1-1]
ENSMUST00000200037; ENSMUSP00000143554; ENSMUSG00000029503 [Q8K3P1-3]
ENSMUST00000200214; ENSMUSP00000142567; ENSMUSG00000029503 [Q8K3P1-4]
GeneIDi231602
KEGGimmu:231602
UCSCiuc008yqq.1 mouse [Q8K3P1-1]
uc008yqs.2 mouse [Q8K3P1-3]
uc008yqt.2 mouse [Q8K3P1-5]
uc008yqu.2 mouse [Q8K3P1-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22953
MGIiMGI:2665170 P2rx2

Phylogenomic databases

eggNOGiENOG410IGJK Eukaryota
ENOG410ZQ3M LUCA
GeneTreeiENSGT00950000182706
HOGENOMiHOG000232042
InParanoidiQ8K3P1
KOiK05216
OMAiYRFAKYY
OrthoDBi1128763at2759
PhylomeDBiQ8K3P1
TreeFamiTF328633

Enzyme and pathway databases

ReactomeiR-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8K3P1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000029503 Expressed in 64 organ(s), highest expression level in utricle of membranous labyrinth
GenevisibleiQ8K3P1 MM

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003045 P2X2_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01309 P2X2RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RX2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K3P1
Secondary accession number(s): Q3KP15
, Q3TYV0, Q812E6, Q812E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: March 1, 2003
Last modified: May 8, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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