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Protein

Chloride channel protein

Gene

Clcn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processIon transportUniRule annotationSAAS annotation, Transport
LigandChlorideUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel proteinUniRule annotation
Gene namesi
Name:Clcn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88417 Clcn1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 109HelicalUniRule annotationAdd BLAST23
Transmembranei130 – 152HelicalUniRule annotationAdd BLAST23
Transmembranei172 – 192HelicalUniRule annotationAdd BLAST21
Transmembranei204 – 223HelicalUniRule annotationAdd BLAST20
Transmembranei235 – 259HelicalUniRule annotationAdd BLAST25
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21
Transmembranei317 – 339HelicalUniRule annotationAdd BLAST23
Transmembranei360 – 379HelicalUniRule annotationAdd BLAST20
Transmembranei495 – 516HelicalUniRule annotationAdd BLAST22
Transmembranei523 – 542HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ8K3N1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini578 – 637CBSInterPro annotationAdd BLAST60
Domaini796 – 851CBSInterPro annotationAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili626 – 646Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the chloride channel (TC 2.A.49) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotation, Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0476 Eukaryota
COG0038 LUCA
HOVERGENiHBG005332

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
InterProiView protein in InterPro
IPR000644 CBS_dom
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
IPR002243 Cl_channel-1
PfamiView protein in Pfam
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
PR01112 CLCHANNEL1
SUPFAMiSSF81340 SSF81340, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits

Sequencei

Sequence statusi: Fragment.

Q8K3N1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SYGLPSENGG LQHRPRKDMG PRHNAHPTQI YGHQKEQYSY KAQDGGMPKK
60 70 80 90 100
MGSSSTMDSL DEDHYSKCQD CVHRLGRVLR RKLGEDWIFL VLLGLLMALV
110 120 130 140 150
SWCMDYVSAK SLQAYKWTYA QMKPSLPLQY LAWVTFPLIL ILFSALFCQL
160 170 180 190 200
ISPQAVGSGI PEMKTILRGV VLKEYLTLKA FVAKVVALTA GLGSGIPVGK
210 220 230 240 250
EGPFVHIASI CAAVLSKFMS MFSGVYEQPY YYTDILTVGC AVGVGCCFGT
260 270 280 290 300
PLGGVLFSIE VTSTYFAVRN YWRGFFAATF SAFVFRVLAV WNKDAVTITA
310 320 330 340 350
LFRTNFRMDF PFDLKELPAF AVIGICCGFL GAVFVYLHRQ VMLGVRKHKC
360 370 380 390 400
LSQFLAKHRL LYPGIVTFVI ASLTFPPGMG QFMAGELMPR EAISTLFDNN
410 420 430 440 450
TWVKHIGDPQ SLGQSAVWLH PQVNVVIIIL LFFVMKFWMS IVATTMPIPC
460 470 480 490 500
GGFMPVFVLG AAFGRLVGEI MAMLFPEGIL FDDIIYKILP GGYAVIGAAA
510 520 530 540 550
LTGAVSHTVS TAVICFELTG QIAHILPMMV AVILANMVAQ SLQPSLYDSI
560 570 580 590 600
IQVKKLPYLP DLGWNQLSKF TIFVEDIMVR DVKFVSASCT YGELRNLLQA
610 620 630 640 650
TTVKTLPLVD SKDSMILLGS VERSELQSLL QRHLCAERRL KAAQDMARKL
660 670 680 690 700
SELPYNGKAQ LAGDWHPGGR PESFAFVDED EDEDLSRKME LPLTPAPPPP
710 720 730 740 750
SPPPPPSQFP IAPSHPEEPN GPLPSHKQPP EASDSADQRS STFQRLLHCL
760 770 780 790 800
LGKAHSKKKK ITQDSTDLVD NMSPEEIEAW EREQLSQPVC FDCCCIDQSP
810 820 830 840 850
FQLVEQTTLH KTHTLFSLLG LHLAYVTSMG KLRGVLALEE LQKAIEGHTK
860 870 880 890
SGVQLRPPLA SFRNTTSIRK TPGGPPPPAE GWNVPEDGDG
Length:890
Mass (Da):98,263
Last modified:October 1, 2002 - v1
Checksum:i7844C810A3743C38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei890Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046403 mRNA Translation: AAL05907.1
UniGeneiMm.386757

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046403 mRNA Translation: AAL05907.1
UniGeneiMm.386757

3D structure databases

ProteinModelPortaliQ8K3N1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88417 Clcn1

Phylogenomic databases

eggNOGiKOG0476 Eukaryota
COG0038 LUCA
HOVERGENiHBG005332

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
InterProiView protein in InterPro
IPR000644 CBS_dom
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
IPR002243 Cl_channel-1
PfamiView protein in Pfam
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
PR01112 CLCHANNEL1
SUPFAMiSSF81340 SSF81340, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ8K3N1_MOUSE
AccessioniPrimary (citable) accession number: Q8K3N1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: January 31, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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