UniProtKB - Q8K3J9 (GPC5C_MOUSE)
Protein
G-protein coupled receptor family C group 5 member C
Gene
Gprc5c
Organism
Mus musculus (Mouse)
Status
Functioni
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- protein kinase activator activity Source: GO_Central
- sevenless binding Source: InterPro
GO - Biological processi
- visual perception Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor family C group 5 member CAlternative name(s): Retinoic acid-induced gene 3 protein Short name: RAIG-3 |
Gene namesi | Name:Gprc5c Synonyms:Raig3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917605, Gprc5c |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- extracellular exosome Source: GO_Central
Mitochondrion
- mitochondrion Source: MGI
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: GO_Central
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 49 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 50 – 70 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 71 – 84 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 85 – 105 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 106 – 119 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 120 – 140 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 141 – 155 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 156 – 176 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 207 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 208 – 228 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 229 – 240 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 241 – 261 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 278 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 279 – 299 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 300 – 440 | CytoplasmicSequence analysisAdd BLAST | 141 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000012968 | 23 – 440 | G-protein coupled receptor family C group 5 member CAdd BLAST | 418 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 190 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 343 | PhosphoserineBy similarity | 1 | |
Modified residuei | 382 | PhosphoserineBy similarity | 1 | |
Modified residuei | 402 | PhosphoserineCombined sources | 1 | |
Modified residuei | 405 | PhosphoserineCombined sources | 1 | |
Modified residuei | 413 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 422 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q8K3J9 |
MaxQBi | Q8K3J9 |
PaxDbi | Q8K3J9 |
PRIDEi | Q8K3J9 |
PTM databases
GlyGeni | Q8K3J9, 1 site |
iPTMneti | Q8K3J9 |
PhosphoSitePlusi | Q8K3J9 |
Interactioni
GO - Molecular functioni
- sevenless binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000061760 |
Miscellaneous databases
RNActi | Q8K3J9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQEH, Eukaryota |
InParanoidi | Q8K3J9 |
Family and domain databases
InterProi | View protein in InterPro IPR002956, Bride_of_7less IPR017978, GPCR_3_C |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PRINTSi | PR01223, BRIDEOF7LESS |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q8K3J9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATHRTLLMC LGLPLFFPGA LAQNHAPPGC SPDLDPLYYN LCDRSGAWGI
60 70 80 90 100
VSEAVAGAGI ITTFVLTIIL VASLPFVQDT KKRSLLGTQV FFLLGTLGLF
110 120 130 140 150
CLVFACVVKP DFSTCASRRF LFGVLFAICF SCLVAHVLSL NFLTRKNHGP
160 170 180 190 200
RGWVIFTVAL LLTLVEVIIN TEWLIITLVR GGGQVSPLGN VSADSTMTSP
210 220 230 240 250
CAIANMDFVM ALIYVMLLLL TAFLGAWPTL CGRFKRWRKH GVFVLLTTVI
260 270 280 290 300
SIAIWVVWIV MYTYGNEQHH SPTWDDPTLA IALAANAWTF VLFYVIPEVS
310 320 330 340 350
QVTKPSPEQS YQGDMYPTRG VGYETILKEQ TGQSMFVENK AFSMDEPASA
360 370 380 390 400
KRPVSPYSGY NGQLLTSVYQ PTEMALMHKG PSEGAYDVIL PRATANSQVM
410 420 430 440
GSANSTLRAE DMYMVQSHQV ATPPKDGKIS QVFRNPYVWD
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI7HPW4 | I7HPW4_MOUSE | G protein-coupled receptor, family ... | Gprc5c RP23-254J18.2-001 | 441 | Annotation score: | ||
J3JS84 | J3JS84_MOUSE | G protein-coupled receptor, family ... | Gprc5c RP23-254J18.2-003 | 440 | Annotation score: | ||
B7FAT7 | B7FAT7_MOUSE | G protein-coupled receptor, family ... | Gprc5c RP23-254J18.2-007 | 133 | Annotation score: | ||
B7FAT8 | B7FAT8_MOUSE | G protein-coupled receptor, family ... | Gprc5c RP23-254J18.2-005 | 283 | Annotation score: | ||
E9PZP1 | E9PZP1_MOUSE | G-protein-coupled receptor family C... | Gprc5c | 104 | Annotation score: | ||
B7FAU0 | B7FAU0_MOUSE | G protein-coupled receptor, family ... | Gprc5c RP23-254J18.2-004 | 78 | Annotation score: | ||
B7FAT9 | B7FAT9_MOUSE | G protein-coupled receptor, family ... | Gprc5c RP23-254J18.2-006 | 109 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | S → L in AAL87525 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY079516 mRNA Translation: AAL87525.1 BC031439 mRNA Translation: AAH31439.1 |
CCDSi | CCDS25612.1 |
RefSeqi | NP_001103808.1, NM_001110338.1 NP_671750.2, NM_147217.3 XP_006534228.1, XM_006534165.1 |
Genome annotation databases
GeneIDi | 70355 |
KEGGi | mmu:70355 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY079516 mRNA Translation: AAL87525.1 BC031439 mRNA Translation: AAH31439.1 |
CCDSi | CCDS25612.1 |
RefSeqi | NP_001103808.1, NM_001110338.1 NP_671750.2, NM_147217.3 XP_006534228.1, XM_006534165.1 |
3D structure databases
SMRi | Q8K3J9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000061760 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8K3J9, 1 site |
iPTMneti | Q8K3J9 |
PhosphoSitePlusi | Q8K3J9 |
Proteomic databases
jPOSTi | Q8K3J9 |
MaxQBi | Q8K3J9 |
PaxDbi | Q8K3J9 |
PRIDEi | Q8K3J9 |
Genome annotation databases
GeneIDi | 70355 |
KEGGi | mmu:70355 |
Organism-specific databases
CTDi | 55890 |
MGIi | MGI:1917605, Gprc5c |
Phylogenomic databases
eggNOGi | ENOG502QQEH, Eukaryota |
InParanoidi | Q8K3J9 |
Miscellaneous databases
BioGRID-ORCSi | 70355, 1 hit in 17 CRISPR screens |
ChiTaRSi | Gprc5c, mouse |
PROi | PR:Q8K3J9 |
RNActi | Q8K3J9, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR002956, Bride_of_7less IPR017978, GPCR_3_C |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PRINTSi | PR01223, BRIDEOF7LESS |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPC5C_MOUSE | |
Accessioni | Q8K3J9Primary (citable) accession number: Q8K3J9 Secondary accession number(s): Q8K0H0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries