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Protein

Zinc finger protein 131

Gene

Znf131

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling (By similarity). Plays a role during development and organogenesis as well as in the function of the adult central nervous system.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 381C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 443C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3899300 SUMOylation of transcription cofactors

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 131
Gene namesi
Name:Znf131
Synonyms:Zfp131
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1919715 Zfp131

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474141 – 619Zinc finger protein 131Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineCombined sources1
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki598Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Monosumoylated at Lys-598 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination (By similarity).By similarity
Ubiquitinated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PeptideAtlasiQ8K3J5
PRIDEiQ8K3J5

PTM databases

iPTMnetiQ8K3J5
PhosphoSitePlusiQ8K3J5

Expressioni

Tissue specificityi

Ubiquitously expressed. Predominant expression is found in the developing central nervous system with strongest signals in the forebrain, midbrain, and hindbrain areas and in the neural tube.1 Publication

Developmental stagei

Expression found as early as 8.5 dpc. High expression is found in the developing limb buds of embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000094870 Expressed in 288 organ(s), highest expression level in cleaving embryo
CleanExiMM_ZFP131
GenevisibleiQ8K3J5 MM

Structurei

3D structure databases

ProteinModelPortaliQ8K3J5
SMRiQ8K3J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 98BTBPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi137 – 148Nuclear localization signal 1By similarityAdd BLAST12
Motifi317 – 328Nuclear localization signal 2By similarityAdd BLAST12

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 381C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 443C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00920000149040
HOGENOMiHOG000294225
HOVERGENiHBG057353
InParanoidiQ8K3J5
OMAiDLFHCEK
OrthoDBiEOG091G03OI
PhylomeDBiQ8K3J5
TreeFamiTF331428

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR027758 Zfp131
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44722 PTHR44722, 1 hit
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8K3J5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAEETMECL QEFPEHHKMI LDRLNEQREQ DRFTDITLIV DGHHFKAHKA
60 70 80 90 100
VLAACSKFFY KFFQEFTQEP LVEIEGVSKM AFRHLIEFTY TAKLMIQGEE
110 120 130 140 150
EANDVWKAAE FLQMLEAIKA LEVRNKENSA PLEENTTGKN EAKKRKIAET
160 170 180 190 200
SNVITESLPS AESEPVEIEV EIAEGTIEVE DEGIEALEEM ASAKQSIKYI
210 220 230 240 250
QSTGSSDDSA LALLADITSK YRQGESKGQI SEDDCASDPI SKQVEGIEIV
260 270 280 290 300
ELQLSHVKDL FHCEKCNRSF KLFYHFKEHM KSHSTESFKC EICNKRYLRE
310 320 330 340 350
SAWKQHLNCY HLEEGGVSKK QRTGKKIHIC QYCDKQFDHF GHFKEHLRKH
360 370 380 390 400
TGEKPFECSN CHERFARNST LKCHLTACQT GVGAKKGRKK LYECQVCNSV
410 420 430 440 450
FNSWDQFKDH LVIHTGDKPN HCTLCDLWFM QGNELRRHLS DAHNISERIV
460 470 480 490 500
TEEVLSVETH LQTEPVTSMT IIEQVGKVHV LPLLQVQVDS AQVTVEQVHP
510 520 530 540 550
DLLQDSQVHD SQMTGLPEQV QVSYLEVGRI QTEEGTEVHV EELHVERVNQ
560 570 580 590 600
MPVEVQTELL EADLDHMTPE IMSQEEREPN HADAAMEEHE DAEGLETKPS
610
EYSQARKTEN DRTSLPVLE
Length:619
Mass (Da):71,022
Last modified:October 1, 2002 - v1
Checksum:i932A6B9EF62AE5DB
GO
Isoform 2 (identifier: Q8K3J5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-277: Missing.

Show »
Length:585
Mass (Da):66,902
Checksum:iAF2D43EEA73A676D
GO
Isoform 3 (identifier: Q8K3J5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: E → N
     354-619: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):40,719
Checksum:iED27C86BC6B99ACA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCJ2A0A286YCJ2_MOUSE
Zinc finger protein 131
Zfp131
103Annotation score:
A0A286YDW0A0A286YDW0_MOUSE
Zinc finger protein 131
Zfp131
112Annotation score:
A0A286YDU7A0A286YDU7_MOUSE
Zinc finger protein 131
Zfp131
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80M → V in BAE22067 (PubMed:16141072).Curated1
Sequence conflicti105V → E in BAE22067 (PubMed:16141072).Curated1
Sequence conflicti218T → A in BAE22067 (PubMed:16141072).Curated1
Sequence conflicti404W → R in AAH48839 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016924244 – 277Missing in isoform 2. 3 PublicationsAdd BLAST34
Alternative sequenceiVSP_016925353E → N in isoform 3. 1 Publication1
Alternative sequenceiVSP_016926354 – 619Missing in isoform 3. 1 PublicationAdd BLAST266

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY092766 mRNA Translation: AAM18207.1
AK011832 mRNA Translation: BAB27867.1
AK030398 mRNA Translation: BAC26943.1
AK047429 mRNA Translation: BAC33056.1
AK134257 mRNA Translation: BAE22067.1
AK135723 mRNA Translation: BAE22629.1
AK162903 mRNA Translation: BAE37106.1
BC048839 mRNA Translation: AAH48839.1
BC057991 mRNA Translation: AAH57991.1
CCDSiCCDS56903.1 [Q8K3J5-2]
CCDS79245.1 [Q8K3J5-1]
RefSeqiNP_001289476.1, NM_001302547.1 [Q8K3J5-1]
NP_001289477.1, NM_001302548.1 [Q8K3J5-2]
NP_001289478.1, NM_001302549.1 [Q8K3J5-1]
NP_001289479.1, NM_001302550.1 [Q8K3J5-1]
NP_082521.1, NM_028245.4 [Q8K3J5-2]
XP_006517829.1, XM_006517766.1 [Q8K3J5-1]
XP_006517832.1, XM_006517769.3 [Q8K3J5-1]
XP_017171099.1, XM_017315610.1 [Q8K3J5-2]
UniGeneiMm.139115
Mm.446549

Genome annotation databases

EnsembliENSMUST00000177916; ENSMUSP00000136867; ENSMUSG00000094870 [Q8K3J5-1]
ENSMUST00000178271; ENSMUSP00000136019; ENSMUSG00000094870 [Q8K3J5-2]
ENSMUST00000223722; ENSMUSP00000153044; ENSMUSG00000094870 [Q8K3J5-1]
ENSMUST00000223813; ENSMUSP00000152941; ENSMUSG00000094870 [Q8K3J5-2]
ENSMUST00000224946; ENSMUSP00000153517; ENSMUSG00000094870 [Q8K3J5-3]
GeneIDi72465
KEGGimmu:72465
UCSCiuc007rzn.2 mouse [Q8K3J5-1]
uc007rzo.2 mouse [Q8K3J5-2]
uc007rzq.2 mouse [Q8K3J5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN131_MOUSE
AccessioniPrimary (citable) accession number: Q8K3J5
Secondary accession number(s): Q3UYZ4
, Q80UU7, Q8C8D0, Q9D042
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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