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Protein

Beta-defensin 19

Gene

Defb19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 19
Short name:
BD-19
Short name:
mBD-19
Alternative name(s):
Defensin, beta 19
Testis-specific beta-defensin-like protein
Gene namesi
Name:Defb19
Synonyms:Defb24, Tdl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385955 Defb19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PeptideiPRO_000000694420 – 83Beta-defensin 19Add BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 54By similarity
Disulfide bondi34 ↔ 48By similarity
Disulfide bondi38 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8K3I8
PRIDEiQ8K3I8

Expressioni

Tissue specificityi

Specifically expressed in male gonads (Sertoli cells).1 Publication

Developmental stagei

Not detected at 11.5 dpc. Specific signals are observed within seminiferous cords in male gonads at 12.5, 13.5, 14.5, and 16.5 dpc and in newborn testes. In 16.5 and newborn testes, its expression is also found in epididymis. No specific signal is found in female gonads.1 Publication

Gene expression databases

BgeeiENSMUSG00000050645 Expressed in 37 organ(s), highest expression level in testis
CleanExiMM_DEFB19
GenevisibleiQ8K3I8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059585

Structurei

3D structure databases

ProteinModelPortaliQ8K3I8
SMRiQ8K3I8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEX6 Eukaryota
ENOG41118Y9 LUCA
GeneTreeiENSGT00510000050451
HOGENOMiHOG000112157
HOVERGENiHBG107794
InParanoidiQ8K3I8
OMAiNYQPCCL
OrthoDBiEOG091G153Z
PhylomeDBiQ8K3I8

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
IPR028060 Defensin_big
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF14862 Defensin_big, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254 PD866254, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K3I8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLALLLLAI LVATELVVSG KNPILQCMGN RGFCRSSCKK SEQAYFYCRT
60 70 80
FQMCCLQSYV RISLTGVDDN TNWSYEKHWP RIP
Length:83
Mass (Da):9,568
Last modified:October 1, 2002 - v1
Checksum:i9D7B69BD9AA30B98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY098993 mRNA Translation: AAM28243.1
AF532614 mRNA Translation: AAO27571.1
DQ012035 mRNA Translation: AAY59771.1
AK133049 mRNA Translation: BAE21487.1
AL845162 Genomic DNA No translation available.
BC049701 mRNA Translation: AAH49701.1
CCDSiCCDS38277.1
RefSeqiNP_660139.1, NM_145157.3
UniGeneiMm.82820

Genome annotation databases

EnsembliENSMUST00000053180; ENSMUSP00000059585; ENSMUSG00000050645
GeneIDi246700
KEGGimmu:246700
UCSCiuc008nfs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY098993 mRNA Translation: AAM28243.1
AF532614 mRNA Translation: AAO27571.1
DQ012035 mRNA Translation: AAY59771.1
AK133049 mRNA Translation: BAE21487.1
AL845162 Genomic DNA No translation available.
BC049701 mRNA Translation: AAH49701.1
CCDSiCCDS38277.1
RefSeqiNP_660139.1, NM_145157.3
UniGeneiMm.82820

3D structure databases

ProteinModelPortaliQ8K3I8
SMRiQ8K3I8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059585

Proteomic databases

PaxDbiQ8K3I8
PRIDEiQ8K3I8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053180; ENSMUSP00000059585; ENSMUSG00000050645
GeneIDi246700
KEGGimmu:246700
UCSCiuc008nfs.1 mouse

Organism-specific databases

CTDi246700
MGIiMGI:2385955 Defb19

Phylogenomic databases

eggNOGiENOG410JEX6 Eukaryota
ENOG41118Y9 LUCA
GeneTreeiENSGT00510000050451
HOGENOMiHOG000112157
HOVERGENiHBG107794
InParanoidiQ8K3I8
OMAiNYQPCCL
OrthoDBiEOG091G153Z
PhylomeDBiQ8K3I8

Miscellaneous databases

PROiPR:Q8K3I8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050645 Expressed in 37 organ(s), highest expression level in testis
CleanExiMM_DEFB19
GenevisibleiQ8K3I8 MM

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
IPR028060 Defensin_big
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF14862 Defensin_big, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254 PD866254, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDFB19_MOUSE
AccessioniPrimary (citable) accession number: Q8K3I8
Secondary accession number(s): Q3V0L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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