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Protein

DCC-interacting protein 13-beta

Gene

Appl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell proliferation Source: UniProtKB
  • signaling Source: GO_Central

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
DCC-interacting protein 13-beta
Short name:
Dip13-beta
Alternative name(s):
Adapter protein containing PH domain, PTB domain and leucine zipper motif 2
Gene namesi
Name:Appl2
Synonyms:Dip13b, Dip3bImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384914 Appl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799881 – 662DCC-interacting protein 13-betaAdd BLAST662

Proteomic databases

EPDiQ8K3G9
MaxQBiQ8K3G9
PaxDbiQ8K3G9
PRIDEiQ8K3G9

PTM databases

iPTMnetiQ8K3G9
PhosphoSitePlusiQ8K3G9

Expressioni

Gene expression databases

BgeeiENSMUSG00000020263 Expressed in 289 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ8K3G9 baseline and differential
GenevisibleiQ8K3G9 MM

Interactioni

Subunit structurei

Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds subunits of the NuRD/MeCP1 complex (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229720, 1 interactor
IntActiQ8K3G9, 2 interactors
STRINGi10090.ENSMUSP00000020500

Structurei

3D structure databases

ProteinModelPortaliQ8K3G9
SMRiQ8K3G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 375PHPROSITE-ProRule annotationAdd BLAST99
Domaini486 – 635PIDPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 428Required for RAB5A bindingBy similarityAdd BLAST428

Phylogenomic databases

eggNOGiKOG0521 Eukaryota
KOG3536 Eukaryota
ENOG410ZISK LUCA
GeneTreeiENSGT00710000106752
HOGENOMiHOG000285988
HOVERGENiHBG051394
InParanoidiQ8K3G9
KOiK20132
OMAiKRVAMME
OrthoDBiEOG091G08AV
PhylomeDBiQ8K3G9
TreeFamiTF328669

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR006020 PTB/PI_dom
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00462 PTB, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01179 PID, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8K3G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAVDKLLLE EALQDSPQAR SLLSVFEEDA GTLTDYTNQL LQAMQRVYGA
60 70 80 90 100
QNEMCLATQQ LSRQLLAYEK QNFALGKGDE EVISTLHYFS KVMDELNGLH
110 120 130 140 150
TELAKQLADT MVLPVIQFRE KDLTEVSTLK DLFGLASSEH DLSMAKYSRL
160 170 180 190 200
PKKKENEKAK TEIVKEVAAA RRKQHLSSLQ YYCALNALQY RKRAAMMEPL
210 220 230 240 250
IGFAHGQINF FKRGAEMFSK SMDGFLSSVK DMVQSIQVEL EAEADKMRVS
260 270 280 290 300
QQELLSVSES VYTPDIDVAT AQINRNLIQK TGYLNLRNKT GLVTTTWERL
310 320 330 340 350
YFFTQGGNLM CQPRGAVAGG LIQDLDNCSV MAVDCEDRRY CFQISTPSGK
360 370 380 390 400
PGIILQAESR KEYEEWICAV NNISRQIYLT DNPEAVAIKL NQTALQAVTP
410 420 430 440 450
ITSFGKKQES SCSSQNIKNS DIEDDNIVPK ATASIPETEE LIAPGTPIQF
460 470 480 490 500
DIVLPATEFL DQNRGGRRTN PFGETEDGSF PEAEDSLLQQ MFIVRFLGSM
510 520 530 540 550
AVKTDSTAEV IYEAMRQVLA ARAIHNIFRM TESHLMVTSQ TLRLIDPQTQ
560 570 580 590 600
VSRACFELTS VTQFAAHQEN KRLVGFVIRV PESTGEESLS TYIFESNSEG
610 620 630 640 650
EKICYAINLG KEIIEVQKDP EALARLMLSV PLTNDGKYVL LNDQADDTGG
660
SPSENRGAES EA
Length:662
Mass (Da):73,854
Last modified:October 1, 2002 - v1
Checksum:i8917BDE1CF13FC3B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFR7D6RFR7_MOUSE
DCC-interacting protein 13-beta
Appl2
117Annotation score:
D3Z340D3Z340_MOUSE
DCC-interacting protein 13-beta
Appl2
209Annotation score:
H3BL43H3BL43_MOUSE
DCC-interacting protein 13-beta
Appl2
95Annotation score:
H3BJX0H3BJX0_MOUSE
DCC-interacting protein 13-beta
Appl2
67Annotation score:
H3BL67H3BL67_MOUSE
DCC-interacting protein 13-beta
Appl2
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428V → D in AAH02232 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY113706 mRNA Translation: AAM55532.1
BC002232 mRNA Translation: AAH02232.1
BC048906 mRNA Translation: AAH48906.1
CCDSiCCDS24078.1
RefSeqiNP_660255.1, NM_145220.2
UniGeneiMm.282985

Genome annotation databases

EnsembliENSMUST00000020500; ENSMUSP00000020500; ENSMUSG00000020263
GeneIDi216190
KEGGimmu:216190
UCSCiuc007gkk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY113706 mRNA Translation: AAM55532.1
BC002232 mRNA Translation: AAH02232.1
BC048906 mRNA Translation: AAH48906.1
CCDSiCCDS24078.1
RefSeqiNP_660255.1, NM_145220.2
UniGeneiMm.282985

3D structure databases

ProteinModelPortaliQ8K3G9
SMRiQ8K3G9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229720, 1 interactor
IntActiQ8K3G9, 2 interactors
STRINGi10090.ENSMUSP00000020500

PTM databases

iPTMnetiQ8K3G9
PhosphoSitePlusiQ8K3G9

Proteomic databases

EPDiQ8K3G9
MaxQBiQ8K3G9
PaxDbiQ8K3G9
PRIDEiQ8K3G9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020500; ENSMUSP00000020500; ENSMUSG00000020263
GeneIDi216190
KEGGimmu:216190
UCSCiuc007gkk.1 mouse

Organism-specific databases

CTDi55198
MGIiMGI:2384914 Appl2

Phylogenomic databases

eggNOGiKOG0521 Eukaryota
KOG3536 Eukaryota
ENOG410ZISK LUCA
GeneTreeiENSGT00710000106752
HOGENOMiHOG000285988
HOVERGENiHBG051394
InParanoidiQ8K3G9
KOiK20132
OMAiKRVAMME
OrthoDBiEOG091G08AV
PhylomeDBiQ8K3G9
TreeFamiTF328669

Miscellaneous databases

ChiTaRSiAppl2 mouse
PROiPR:Q8K3G9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020263 Expressed in 289 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ8K3G9 baseline and differential
GenevisibleiQ8K3G9 MM

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR006020 PTB/PI_dom
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00462 PTB, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01179 PID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDP13B_MOUSE
AccessioniPrimary (citable) accession number: Q8K3G9
Secondary accession number(s): Q99LT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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