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Protein

Potassium voltage-gated channel subfamily KQT member 3

Gene

Kcnq3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.By similarity

GO - Molecular functioni

  • calmodulin binding Source: MGI
  • delayed rectifier potassium channel activity Source: GO_Central
  • ion channel binding Source: MGI
  • potassium channel activity Source: MGI
  • protein kinase binding Source: MGI
  • ubiquitin protein ligase binding Source: MGI
  • voltage-gated ion channel activity Source: MGI
  • voltage-gated potassium channel activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 3Curated
Alternative name(s):
KQT-like 3
Potassium channel subunit alpha KvLQT3
Voltage-gated potassium channel subunit Kv7.3
Gene namesi
Name:Kcnq3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1336181 Kcnq3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
Transmembranei123 – 143Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini144 – 153ExtracellularSequence analysis10
Transmembranei154 – 174Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini175 – 197CytoplasmicSequence analysisAdd BLAST23
Transmembranei198 – 218Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini219 – 226ExtracellularSequence analysis8
Transmembranei227 – 248Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST22
Topological domaini249 – 262CytoplasmicSequence analysisAdd BLAST14
Transmembranei263 – 283Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini284 – 304ExtracellularSequence analysisAdd BLAST21
Intramembranei305 – 325Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini326 – 331ExtracellularSequence analysis6
Transmembranei332 – 352Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini353 – 873CytoplasmicSequence analysisAdd BLAST521

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540351 – 873Potassium voltage-gated channel subfamily KQT member 3Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphothreonineBy similarity1

Post-translational modificationi

KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation. Degradation induced by NEDD4L is inhibited by USP36.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8K3F6
PRIDEiQ8K3F6

PTM databases

iPTMnetiQ8K3F6
PhosphoSitePlusiQ8K3F6
SwissPalmiQ8K3F6

Expressioni

Gene expression databases

BgeeiENSMUSG00000056258 Expressed in 140 organ(s), highest expression level in CA1 field of hippocampus
GenevisibleiQ8K3F6 MM

Interactioni

Subunit structurei

Heterotetramer with KCNQ2; form the heterotetrameric M potassium channel. Interacts with calmodulin; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel. Heteromultimer with KCNQ5. May associate with KCNE2. Interacts with IQCJ-SCHIP1 (PubMed:27979964).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi225968, 1 interactor
IntActiQ8K3F6, 1 interactor
STRINGi10090.ENSMUSP00000063380

Structurei

3D structure databases

ProteinModelPortaliQ8K3F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni357 – 538Mediates interaction with calmodulinBy similarityAdd BLAST182

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi317 – 322Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 25Poly-GlyAdd BLAST13

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1419 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00550000074513
HOGENOMiHOG000220839
HOVERGENiHBG059014
InParanoidiQ8K3F6
KOiK04928
OMAiHVTEYYP
OrthoDBiEOG091G02ZT
TreeFamiTF315186

Family and domain databases

InterProiView protein in InterPro
IPR020969 Ankyrin-G_BS
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR003948 K_chnl_volt-dep_KCNQ3
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF5 PTHR11537:SF5, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 1 hit
PF11956 KCNQC3-Ank-G_bd, 1 hit
PRINTSiPR00169 KCHANNEL
PR01462 KCNQ3CHANNEL
PR01459 KCNQCHANNEL

Sequencei

Sequence statusi: Complete.

Q8K3F6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLKARRAAG AAGGGGGEGG GGGGGAANPA GGDSAVAGDE ERKVGLAPGD
60 70 80 90 100
VEQVTLALGA GADKDGTLLL EGGGREEGQR RTPQGIGLLA KTPLSRPVKR
110 120 130 140 150
NNAKYRRIQT LIYDALERPR GWALLYHALV FLIVLGCLIL AVLTTFKEYE
160 170 180 190 200
TVSGDWLLLL ETFAIFIFGA EFALRIWAAG CCCRYKGWRG RLKFARKPLC
210 220 230 240 250
MLDIFVLIAS VPVVAVGNQG NVLATSLRSL RFLQILRMLR MDRRGGTWKL
260 270 280 290 300
LGSAICAHSK ELITAWYIGF LTLILSSFLV YLVEKDVPEM DAQGEEMKEE
310 320 330 340 350
FETYADALWW GLITLATIGY GDKTPKTWEG RLIAATFSLI GVSFFALPAG
360 370 380 390 400
ILGSGLALKV QEQHRQKHFE KRRKPAAELI QAAWRYYATN PNRLDLVATW
410 420 430 440 450
RFYESVVSFP FFRKEQLEAA ASQKLGLLDR VRLSNPRGSN TKGKLFTPLN
460 470 480 490 500
VDAIEESPSK EPKPVGLNNK ERFRTAFRMK AYAFWQSSED AGTGDPMAED
510 520 530 540 550
RGYGNDFLIE DMIPTLKAAI RAVRILQFRL YKKKFKETLR PYDVKDVIEQ
560 570 580 590 600
YSAGHLDMLS RIKYLQTRID MIFTPGPPST PKHKKSQKGS AFTYPSQQSP
610 620 630 640 650
RNEPYVARAA TSETEDQSMM GKFVKVERQV HDMGKKLDFL VDMHMQHMER
660 670 680 690 700
LQVHVTEYYP TKGASSPAEG EKKEDNRYSD LKTIICNYSE TGPPDPPYSF
710 720 730 740 750
HQVPIDRVGP YGFFAHDPVK LTRGGPSSTK AQANLPSSGS TYAERPTVLP
760 770 780 790 800
ILTLLDSCVS YHSQTELQGP YSDHISPRQR RSITRDSDTP LSLMSVNHEE
810 820 830 840 850
LERSPSGFSI SQDRDDYVFG PSGGSSWMRE KRYLAEGETD TDTDPFTPSG
860 870
SMPMSSTGDG ISDSIWTPSN KPT
Length:873
Mass (Da):96,852
Last modified:July 27, 2011 - v2
Checksum:iEB98ABA9BE87E3A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → T in AAM81579 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY118171 mRNA Translation: AAM81579.1
AC091276 Genomic DNA No translation available.
AC102633 Genomic DNA No translation available.
AC110897 Genomic DNA No translation available.
AC125054 Genomic DNA No translation available.
CCDSiCCDS49619.1
RefSeqiNP_690887.2, NM_152923.2
UniGeneiMm.255585

Genome annotation databases

EnsembliENSMUST00000070256; ENSMUSP00000063380; ENSMUSG00000056258
GeneIDi110862
KEGGimmu:110862
UCSCiuc007wab.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY118171 mRNA Translation: AAM81579.1
AC091276 Genomic DNA No translation available.
AC102633 Genomic DNA No translation available.
AC110897 Genomic DNA No translation available.
AC125054 Genomic DNA No translation available.
CCDSiCCDS49619.1
RefSeqiNP_690887.2, NM_152923.2
UniGeneiMm.255585

3D structure databases

ProteinModelPortaliQ8K3F6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225968, 1 interactor
IntActiQ8K3F6, 1 interactor
STRINGi10090.ENSMUSP00000063380

PTM databases

iPTMnetiQ8K3F6
PhosphoSitePlusiQ8K3F6
SwissPalmiQ8K3F6

Proteomic databases

PaxDbiQ8K3F6
PRIDEiQ8K3F6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070256; ENSMUSP00000063380; ENSMUSG00000056258
GeneIDi110862
KEGGimmu:110862
UCSCiuc007wab.2 mouse

Organism-specific databases

CTDi3786
MGIiMGI:1336181 Kcnq3

Phylogenomic databases

eggNOGiKOG1419 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00550000074513
HOGENOMiHOG000220839
HOVERGENiHBG059014
InParanoidiQ8K3F6
KOiK04928
OMAiHVTEYYP
OrthoDBiEOG091G02ZT
TreeFamiTF315186

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

PROiPR:Q8K3F6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056258 Expressed in 140 organ(s), highest expression level in CA1 field of hippocampus
GenevisibleiQ8K3F6 MM

Family and domain databases

InterProiView protein in InterPro
IPR020969 Ankyrin-G_BS
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR003948 K_chnl_volt-dep_KCNQ3
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF5 PTHR11537:SF5, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 1 hit
PF11956 KCNQC3-Ank-G_bd, 1 hit
PRINTSiPR00169 KCHANNEL
PR01462 KCNQ3CHANNEL
PR01459 KCNQCHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNQ3_MOUSE
AccessioniPrimary (citable) accession number: Q8K3F6
Secondary accession number(s): E9QJY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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