Jouberin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: MGI

GO - Biological processⁱ

• cellular protein localization Source: UniProtKB <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis."
    Louie C.M., Caridi G., Lopes V.S., Brancati F., Kispert A., Lancaster M.A., Schlossman A.M., Otto E.A., Leitges M., Grone H.J., Lopez I., Gudiseva H.V., O'Toole J.F., Vallespin E., Ayyagari R., Ayuso C., Cremers F.P., den Hollander A.I.

    , Koenekoop R.K., Dallapiccola B., Ghiggeri G.M., Hildebrandt F., Valente E.M., Williams D.S., Gleeson J.G.
    Nat Genet 42:175-180(2010) [PubMed] [Europe PMC] [Abstract]
• central nervous system development Source: UniProtKBInferred from genetic interactionⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• cilium assembly Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.6

    "Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking."
    Hsiao Y.C., Tong Z.J., Westfall J.E., Ault J.G., Page-McCaw P.S., Ferland R.J.
    Hum. Mol. Genet. 18:3926-3941(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH RAB8A, SUBCELLULAR LOCATION.
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• cloaca development Source: UniProtKBInferred from genetic interactionⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• eye photoreceptor cell development Source: CACAO <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis."
    Louie C.M., Caridi G., Lopes V.S., Brancati F., Kispert A., Lancaster M.A., Schlossman A.M., Otto E.A., Leitges M., Grone H.J., Lopez I., Gudiseva H.V., O'Toole J.F., Vallespin E., Ayyagari R., Ayuso C., Cremers F.P., den Hollander A.I.

    , Koenekoop R.K., Dallapiccola B., Ghiggeri G.M., Hildebrandt F., Valente E.M., Williams D.S., Gleeson J.G.
    Nat Genet 42:175-180(2010) [PubMed] [Europe PMC] [Abstract]
• heart looping Source: UniProtKBInferred from genetic interactionⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• hindbrain development Source: UniProtKBInferred from genetic interactionⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• Kupffer's vesicle development Source: UniProtKB
• left/right axis specification Source: UniProtKB
• morphogenesis of a polarized epithelium Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis."
    Louie C.M., Caridi G., Lopes V.S., Brancati F., Kispert A., Lancaster M.A., Schlossman A.M., Otto E.A., Leitges M., Grone H.J., Lopez I., Gudiseva H.V., O'Toole J.F., Vallespin E., Ayyagari R., Ayuso C., Cremers F.P., den Hollander A.I.

    , Koenekoop R.K., Dallapiccola B., Ghiggeri G.M., Hildebrandt F., Valente E.M., Williams D.S., Gleeson J.G.
    Nat Genet 42:175-180(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of glucose import Source: MGI
• non-motile cilium assembly Source: MGIInferred from mutant phenotypeⁱ
  • Ref.6

    "Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking."
    Hsiao Y.C., Tong Z.J., Westfall J.E., Ault J.G., Page-McCaw P.S., Ferland R.J.
    Hum. Mol. Genet. 18:3926-3941(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH RAB8A, SUBCELLULAR LOCATION.
• otic vesicle development Source: UniProtKBInferred from genetic interactionⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• photoreceptor cell outer segment organization Source: MGIInferred from mutant phenotypeⁱ
  • "Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1."
    Westfall J.E., Hoyt C., Liu Q., Hsiao Y.C., Pierce E.A., Page-McCaw P.S., Ferland R.J.
    J Neurosci 30:8759-8768(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1."
    Westfall J.E., Hoyt C., Liu Q., Hsiao Y.C., Pierce E.A., Page-McCaw P.S., Ferland R.J.
    J Neurosci 30:8759-8768(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of growth Source: CACAOInferred from direct assayⁱ
  • "AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells."
    Zhou L.L., Zhao Y., Ringrose A., DeGeer D., Kennah E., Lin A.E., Sheng G., Li X.J., Turhan A., Jiang X.
    J Exp Med 205:2657-2671(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron projection development Source: CACAOInferred from mutant phenotypeⁱ
  • "Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice."
    Sheng G., Xu X., Lin Y.F., Wang C.E., Rong J., Cheng D., Peng J., Jiang X., Li S.H., Li X.J.
    J. Clin. Invest. 118:2785-2795(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of polarized epithelial cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of receptor internalization Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype."
    Xu X., Yang H., Lin Y.F., Li X., Cape A., Ressler K.J., Li S., Li X.J.
    Proc Natl Acad Sci U S A 107:19126-19131(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype."
    Xu X., Yang H., Lin Y.F., Li X., Cape A., Ressler K.J., Li S., Li X.J.
    Proc Natl Acad Sci U S A 107:19126-19131(2010) [PubMed] [Europe PMC] [Abstract]
• pronephric duct morphogenesis Source: UniProtKB
• pronephric nephron tubule morphogenesis Source: UniProtKBInferred from genetic interactionⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• protein localization to organelle Source: MGIInferred from mutant phenotypeⁱ
  • Ref.6

    "Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking."
    Hsiao Y.C., Tong Z.J., Westfall J.E., Ault J.G., Page-McCaw P.S., Ferland R.J.
    Hum. Mol. Genet. 18:3926-3941(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH RAB8A, SUBCELLULAR LOCATION.
• regulation of behavior Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype."
    Xu X., Yang H., Lin Y.F., Li X., Cape A., Ressler K.J., Li S., Li X.J.
    Proc Natl Acad Sci U S A 107:19126-19131(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of protein secretion Source: CACAOInferred from mutant phenotypeⁱ
  • "Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice."
    Sheng G., Xu X., Lin Y.F., Wang C.E., Rong J., Cheng D., Peng J., Jiang X., Li S.H., Li X.J.
    J. Clin. Invest. 118:2785-2795(2008) [PubMed] [Europe PMC] [Abstract]
• retina development in camera-type eye Source: MGIInferred from mutant phenotypeⁱ
  • "Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1."
    Westfall J.E., Hoyt C., Liu Q., Hsiao Y.C., Pierce E.A., Page-McCaw P.S., Ferland R.J.
    J Neurosci 30:8759-8768(2010) [PubMed] [Europe PMC] [Abstract]
• retina layer formation Source: UniProtKBInferred from genetic interactionⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• retinal cone cell development Source: CACAOInferred from mutant phenotypeⁱ
  • "AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis."
    Louie C.M., Caridi G., Lopes V.S., Brancati F., Kispert A., Lancaster M.A., Schlossman A.M., Otto E.A., Leitges M., Grone H.J., Lopez I., Gudiseva H.V., O'Toole J.F., Vallespin E., Ayyagari R., Ayuso C., Cremers F.P., den Hollander A.I.

    , Koenekoop R.K., Dallapiccola B., Ghiggeri G.M., Hildebrandt F., Valente E.M., Williams D.S., Gleeson J.G.
    Nat Genet 42:175-180(2010) [PubMed] [Europe PMC] [Abstract]
• retinal rod cell development Source: CACAOInferred from mutant phenotypeⁱ
  • "AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis."
    Louie C.M., Caridi G., Lopes V.S., Brancati F., Kispert A., Lancaster M.A., Schlossman A.M., Otto E.A., Leitges M., Grone H.J., Lopez I., Gudiseva H.V., O'Toole J.F., Vallespin E., Ayyagari R., Ayuso C., Cremers F.P., den Hollander A.I.

    , Koenekoop R.K., Dallapiccola B., Ghiggeri G.M., Hildebrandt F., Valente E.M., Williams D.S., Gleeson J.G.
    Nat Genet 42:175-180(2010) [PubMed] [Europe PMC] [Abstract]
• specification of axis polarity Source: UniProtKBInferred from genetic interactionⁱ
  • "Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development."
    Simms R.J., Hynes A.M., Eley L., Inglis D., Chaudhry B., Dawe H.R., Sayer J.A.
    Cell Mol Life Sci 69:993-1009(2012) [PubMed] [Europe PMC] [Abstract]
• transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype."
    Xu X., Yang H., Lin Y.F., Li X., Cape A., Ressler K.J., Li S., Li X.J.
    Proc Natl Acad Sci U S A 107:19126-19131(2010) [PubMed] [Europe PMC] [Abstract]
• vesicle-mediated transport Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking."
    Hsiao Y.C., Tong Z.J., Westfall J.E., Ault J.G., Page-McCaw P.S., Ferland R.J.
    Hum. Mol. Genet. 18:3926-3941(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH RAB8A, SUBCELLULAR LOCATION.
• vesicle targeting Source: MGIInferred from mutant phenotypeⁱ
  • "Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1."
    Westfall J.E., Hoyt C., Liu Q., Hsiao Y.C., Pierce E.A., Page-McCaw P.S., Ferland R.J.
    J Neurosci 30:8759-8768(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEPETPEKVD SAQEKVRGKT PTADDSDDSR EKTGIEEKGE LTDAYQLQVA 
        60         70         80         90        100
EEMAKEIKKK IRKKLKEQLT YFPPDTLLHD DKLASEKRKK KKKKVPVPTK 
       110        120        130        140        150
PESSPSDVCD SAVEGEQKKE GTPEDSQHME GICSREQDVD ATVPENAKPK 
       160        170        180        190        200
PKKTKKKTKA VSNDNEDTNG DGVHEITSRD SPVHPKCLLD DDLVMGVYIH 
       210        220        230        240        250
RTDRLKSDFM ISHPMVKIHV VDEHTGQYVK KDDSERPVSS YYEKDNVDYI 
       260        270        280        290        300
LPIMTQPYDF KKLKSRLPEW EEQVIFNENF PYLLREFEEC PKVILFFEIL 
       310        320        330        340        350
DFLSMDEIKN NSEVQNQECG FRKIAWAFLK LLGANGNANI NSKLRLQLYY 
       360        370        380        390        400
PPTKPRSQLN VVEVFEWWSK CPRNRYPSTL YVTVRGLKVP DCIKPSYRSM 
       410        420        430        440        450
MALQEERGTP VYCERHRETS SVDTEPGLED SKEEVKWKRL PGQACRIPNK 
       460        470        480        490        500
HLFSLNAGER GCFCLDFSHN GRILAAACAS RDGYPIILYE IPSGRFMREL 
       510        520        530        540        550
CGHLNIIYDL DWSKDDRYLV TSSSDGTARV WKNEINSTST FRVLPHPSFV 
       560        570        580        590        600
YTAKFHPATR ELVVTGCYDS MIRIWKIDAR EDAAILVRQL DVHKSFVNSI 
       610        620        630        640        650
CFDDEGHHMY SGDCIGVIVV WDTYVKVNDV QTSVRHWTIN KEIKETEFRG 
       660        670        680        690        700
VPISYLEVHP NGKRLLIHTK DSTLRIMDLR ILAARKFVGA ANYREKIHST 
       710        720        730        740        750
LTPCGTLLFS GSEDGIVYVW NPETGEQVAM YSDLPFKSTI RDISYHPLEN 
       760        770        780        790        800
MVAFCAFGQS EPILLYIYDF QVAQQEAEML KRYSGTLPLP GIHQSEDALC 
       810        820        830        840        850
TCPKLPQQGS FQIDEFVNTE NSSSRKIQLV KQRLETVTEV IRSCAAKVNK 
       860        870        880        890        900
NLSMTSPPPG PAKKPRVKQS FVLTTDEIIH QFGLPQTAFI SIERGPFVRH 
       910        920        930        940        950
VDPPPMVVAL YDYTASRSDE LTIHRGDIIR VYFKDNEDWW YGSVRKGQEG 
       960        970        980        990       1000
FFPANHVASE TLYRDSPPKV KERSPPLTPK EKTKPEKPLA SQKQSLSKGR 
      1010       1020       1030       1040 
PLDPRLGPQP VGHSEKGKDQ NVEDRGHKVD METKKSEPVV RKVTLIE    

        10         20         30         40         50
MEPETPEKVD SAQEKVRGKT PTADDSDDSR EKTGIEEKGE LTDAYQLQVA 
        60         70         80         90        100
EEMAKEIKKK IRKKLKEQLT YFPPDTLLHD DKLASEKRKK KKKKVPVPTK 
       110        120        130        140        150
PESSPSDVCD SAVEGEQKKE GTPEDSQHME GICSREQDVD ATVPENAKPK 
       160        170        180        190        200
PKKTKKKTKA VSNDNEDTNG DGVHEITSRD SPVHPKCLLD DDLVMGVYIH 
       210        220        230        240        250
RTDRLKSDFM ISHPMVKIHV VDEHTGQYVK KDDSERPVSS YYEKDNVDYI 
       260        270        280        290        300
LPIMTQPYDF KKLKSRLPEW EEQVIFNENF PYLLREFEEC PKVILFFEIL 
       310        320        330        340        350
DFLSMDEIKN NSEVQNQECG FRKIAWAFLK LLGANGNANI NSKLRLQLYY 
       360        370        380        390        400
PPTKPRSQLN VVEVFEWWSK CPRNRYPSTL YVTVRGLKVP DCIKPSYRSM 
       410        420        430        440        450
MALQEERGTP VYCERHRETS SVDTEPGLED SKEEVKWKRL PGQACRIPNK 
       460        470        480        490        500
HLFSLNAGER GCFCLDFSHN GRILAAACAS RDGYPIILYE IPSGRFMREL 
       510        520        530        540        550
CGHLNIIYDL DWSKDDRYLV TSSSDGTARV WKNEINSTST FRVLPHPSFV 
       560        570        580        590        600
YTAKFHPATR ELVVTGCYDS MIRIWKIDAR EDAAILVRQL DVHKSFVNSI 
       610        620        630        640        650
CFDDEGHHMY SGDCIGVIVV WDTYVKVNDV QTSVRHWTIN KEIKETEFRG 
       660        670        680        690        700
VPISYLEVHP NGKRLLIHTK DSTLRIMDLR ILAARKFVGA ANYREKIHST 
       710        720        730        740        750
LTPCGTLLFS GSEDGIVYVW NPETGEQVAM YSDLPFKSTI RDISYHPLEN 
       760        770        780        790        800
MVAFCAFGQS EPILLYIYDF QVAQQEAEML KRYSGTLPLP GIHQSEDALC 
       810        820        830        840        850
TCPKLPQQGS FQIDEFVNTE NSSSRKIQLV KQRLETVTEV IRSCAAKVNK 
       860        870        880        890        900
NLSMTSPPPG PAKKPRVKQS FVLTTDEIIH QFGLPQTAFI SIERGPFVRH 
       910        920        930        940        950
VDPPPMVVAL YDYTASRSDE LTIHRGDIIR VYFKDNEDWW YGSVRKGQEG 
       960        970        980        990       1000
FFPANHVASE TLYRDSPPKV KERSPPLTPK EKTKPEKPLA SQKGGHEEET 

KSQTN                                                  

Experimental Info

Alternative sequence

Sequence databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot