UniProtKB - Q8K3E5 (AHI1_MOUSE)

BLAST

>sp|Q8K3E5|AHI1_MOUSE Jouberin OS=Mus musculus OX=10090 GN=Ahi1 PE=1 SV=2
MEPETPEKVDSAQEKVRGKTPTADDSDDSREKTGIEEKGELTDAYQLQVAEEMAKEIKKK
IRKKLKEQLTYFPPDTLLHDDKLASEKRKKKKKKVPVPTKPESSPSDVCDSAVEGEQKKE
GTPEDSQHMEGICSREQDVDATVPENAKPKPKKTKKKTKAVSNDNEDTNGDGVHEITSRD
SPVHPKCLLDDDLVMGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSERPVSS
YYEKDNVDYILPIMTQPYDFKKLKSRLPEWEEQVIFNENFPYLLREFEECPKVILFFEIL
DFLSMDEIKNNSEVQNQECGFRKIAWAFLKLLGANGNANINSKLRLQLYYPPTKPRSQLN
VVEVFEWWSKCPRNRYPSTLYVTVRGLKVPDCIKPSYRSMMALQEERGTPVYCERHRETS
SVDTEPGLEDSKEEVKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACAS
RDGYPIILYEIPSGRFMRELCGHLNIIYDLDWSKDDRYLVTSSSDGTARVWKNEINSTST
FRVLPHPSFVYTAKFHPATRELVVTGCYDSMIRIWKIDAREDAAILVRQLDVHKSFVNSI
CFDDEGHHMYSGDCIGVIVVWDTYVKVNDVQTSVRHWTINKEIKETEFRGVPISYLEVHP
NGKRLLIHTKDSTLRIMDLRILAARKFVGAANYREKIHSTLTPCGTLLFSGSEDGIVYVW
NPETGEQVAMYSDLPFKSTIRDISYHPLENMVAFCAFGQSEPILLYIYDFQVAQQEAEML
KRYSGTLPLPGIHQSEDALCTCPKLPQQGSFQIDEFVNTENSSSRKIQLVKQRLETVTEV
IRSCAAKVNKNLSMTSPPPGPAKKPRVKQSFVLTTDEIIHQFGLPQTAFISIERGPFVRH
VDPPPMVVALYDYTASRSDELTIHRGDIIRVYFKDNEDWWYGSVRKGQEGFFPANHVASE
TLYRDSPPKVKERSPPLTPKEKTKPEKPLASQKQSLSKGRPLDPRLGPQPVGHSEKGKDQ
NVEDRGHKVDMETKKSEPVVRKVTLIE

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History
Entry version 134 (12 Sep 2018)
Sequence version 2 (30 Aug 2005)
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Protein

Jouberin

Gene

Ahi1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium (PubMed:19625297). Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (PubMed:22179047). Involved in neuronal differentiation (PubMed:23658157). As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382).4 Publications

Miscellaneous

Is targeted by provirus integrations. This deregulation contributes to tumor development.

GO - Molecular functionⁱ

identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein localization
Source: UniProtKB
Inferred from genetic interactionⁱ
- 20081859
central nervous system development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21959375
cilium assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19625297
- 21959375
cloaca development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21959375
eye photoreceptor cell development
Source: CACAO
Inferred from direct assayⁱ
- 20081859
heart looping
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21959375
hindbrain development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21959375
Kupffer's vesicle development Source: UniProtKB
left/right axis specification Source: UniProtKB
morphogenesis of a polarized epithelium
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21959375
negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20081859
negative regulation of glucose import Source: MGI
non-motile cilium assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- 19625297
otic vesicle development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21959375
photoreceptor cell outer segment organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 20592197
positive regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 20592197
positive regulation of growth
Source: CACAO
Inferred from direct assayⁱ
- 18936234
positive regulation of neuron projection development
Source: CACAO
Inferred from mutant phenotypeⁱ
- 18636121
positive regulation of polarized epithelial cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21959375
positive regulation of receptor internalization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20956301
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20956301
pronephric duct morphogenesis Source: UniProtKB
pronephric nephron tubule morphogenesis
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21959375
protein localization to organelle
Source: MGI
Inferred from mutant phenotypeⁱ
- 19625297
regulation of behavior
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20956301
regulation of protein secretion
Source: CACAO
Inferred from mutant phenotypeⁱ
- 18636121
retina development in camera-type eye
Source: MGI
Inferred from mutant phenotypeⁱ
- 20592197
retina layer formation
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21959375
retinal cone cell development
Source: CACAO
Inferred from mutant phenotypeⁱ
- 20081859
retinal rod cell development
Source: CACAO
Inferred from mutant phenotypeⁱ
- 20081859
specification of axis polarity
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21959375
transmembrane receptor protein tyrosine kinase signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20956301
vesicle-mediated transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19625297
vesicle targeting
Source: MGI
Inferred from mutant phenotypeⁱ
- 20592197

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Cilium biogenesis/degradation, Differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Jouberin Alternative name(s): Abelson helper integration site 1 protein Short name: AHI-1
Gene namesⁱ	Name:Ahi1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:87971 Ahi1

Keywords - Cellular componentⁱ

Cell junction, Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mutant mice, when surviving after birth, show retarded growth during the postnatal period, but do not develop severe cerebellar vermis hypoplasia or ataxia associated with cerebellar dysfunction (PubMed:23658157). Adult homozygous knockout mice have a small body size, with slightly reduced brain size compared with wild-type and heterozygous littermates. The overall brain morphology appears normal except for a smaller cerebellum and underdeveloped vermis with a mildly defective foliation pattern. Vermian lobules VI and VII appear fused, whereas lobule V appears smaller and underdeveloped at 3 weeks of age. Overall, the cerebellum is slightly hypoplastic (PubMed:21623382).2 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050839	1 – 1047	JouberinAdd BLAST		1047

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	853	PhosphoserineBy similarity		1
Modified residueⁱ	974	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8K3E5
PRIDEⁱ	Q8K3E5

PTM databases

iPTMnetⁱ	Q8K3E5
PhosphoSitePlusⁱ	Q8K3E5

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the brain and testis. Weakly expressed in the liver. Strongly expressed during periods of both cortical and cerebellar development.2 Publications

Developmental stageⁱ

First detected at embryonic days 7 (E7) and is also present at E11, E15 and E17 with the most high level at E15. Expression in whole brain is detected from E14 to adult. Expression in cerebellum appears maximal at E18 and postnatal days 5 (P5), whereas expression in cerebral cortex appears maximal at E16 and E18.1 Publication

Gene expression databases

CleanExⁱ	MM_AHI1

CleanExⁱ

MM_AHI1

Interactionⁱ

Subunit structureⁱ

Self-associates (By similarity). Part of the tectonic-like complex (also named B9 complex) (PubMed:22179047). Interacts with MKS1 (PubMed:21565611). Interacts with NPHP1; probably as heterodimers and/or AHI1₂:NPHP1₂ heterotetramers (PubMed:18633336). Interacts (via SH3 domain) with the dynamin GTPase DNM2 (By similarity). Interacts with HAP1; probably as AHI1₂:HAP1₂ heterotetramers (By similarity) (PubMed:23658157). Interacts with RAB8A (PubMed:19625297). Interacts with CEND1 (PubMed:23658157).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Hap1	O35668	3	EBI-4280729,EBI-473704

With

Entry

#Exp.

IntAct

Notes

Hap1

O35668

EBI-4280729,EBI-473704

GO - Molecular functionⁱ

identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	206874, 30 interactors
CORUMⁱ	Q8K3E5
IntActⁱ	Q8K3E5, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q8K3E5
STRINGⁱ	10090.ENSMUSP00000101164

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8K3E5
SMRⁱ	Q8K3E5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	457 – 499	WD 1Add BLAST	43
Repeatⁱ	502 – 541	WD 2Add BLAST	40
Repeatⁱ	545 – 585	WD 3Add BLAST	41
Repeatⁱ	592 – 631	WD 4Add BLAST	40
Repeatⁱ	648 – 687	WD 5Add BLAST	40
Repeatⁱ	691 – 730	WD 6Add BLAST	40
Repeatⁱ	735 – 776	WD 7Add BLAST	42
Domainⁱ	902 – 962	SH3PROSITE-ProRule annotationAdd BLAST	61

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 284	Interaction with HAP1By similarityAdd BLAST		284

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	87 – 94	Poly-Lys		8

Keywords - Domainⁱ

Repeat, SH3 domain, WD repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IQ0Z Eukaryota ENOG410XVKN LUCA
HOGENOMⁱ	HOG000033864
HOVERGENⁱ	HBG080824
InParanoidⁱ	Q8K3E5
PhylomeDBⁱ	Q8K3E5

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11812 SH3_AHI-1, 1 hit
Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR035832 AHI1_SH3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00018 SH3_1, 1 hit PF00400 WD40, 2 hits
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00326 SH3, 1 hit SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002 SH3, 1 hit PS50082 WD_REPEATS_2, 4 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8K3E5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPETPEKVD SAQEKVRGKT PTADDSDDSR EKTGIEEKGE LTDAYQLQVA 
        60         70         80         90        100
EEMAKEIKKK IRKKLKEQLT YFPPDTLLHD DKLASEKRKK KKKKVPVPTK 
       110        120        130        140        150
PESSPSDVCD SAVEGEQKKE GTPEDSQHME GICSREQDVD ATVPENAKPK 
       160        170        180        190        200
PKKTKKKTKA VSNDNEDTNG DGVHEITSRD SPVHPKCLLD DDLVMGVYIH 
       210        220        230        240        250
RTDRLKSDFM ISHPMVKIHV VDEHTGQYVK KDDSERPVSS YYEKDNVDYI 
       260        270        280        290        300
LPIMTQPYDF KKLKSRLPEW EEQVIFNENF PYLLREFEEC PKVILFFEIL 
       310        320        330        340        350
DFLSMDEIKN NSEVQNQECG FRKIAWAFLK LLGANGNANI NSKLRLQLYY 
       360        370        380        390        400
PPTKPRSQLN VVEVFEWWSK CPRNRYPSTL YVTVRGLKVP DCIKPSYRSM 
       410        420        430        440        450
MALQEERGTP VYCERHRETS SVDTEPGLED SKEEVKWKRL PGQACRIPNK 
       460        470        480        490        500
HLFSLNAGER GCFCLDFSHN GRILAAACAS RDGYPIILYE IPSGRFMREL 
       510        520        530        540        550
CGHLNIIYDL DWSKDDRYLV TSSSDGTARV WKNEINSTST FRVLPHPSFV 
       560        570        580        590        600
YTAKFHPATR ELVVTGCYDS MIRIWKIDAR EDAAILVRQL DVHKSFVNSI 
       610        620        630        640        650
CFDDEGHHMY SGDCIGVIVV WDTYVKVNDV QTSVRHWTIN KEIKETEFRG 
       660        670        680        690        700
VPISYLEVHP NGKRLLIHTK DSTLRIMDLR ILAARKFVGA ANYREKIHST 
       710        720        730        740        750
LTPCGTLLFS GSEDGIVYVW NPETGEQVAM YSDLPFKSTI RDISYHPLEN 
       760        770        780        790        800
MVAFCAFGQS EPILLYIYDF QVAQQEAEML KRYSGTLPLP GIHQSEDALC 
       810        820        830        840        850
TCPKLPQQGS FQIDEFVNTE NSSSRKIQLV KQRLETVTEV IRSCAAKVNK 
       860        870        880        890        900
NLSMTSPPPG PAKKPRVKQS FVLTTDEIIH QFGLPQTAFI SIERGPFVRH 
       910        920        930        940        950
VDPPPMVVAL YDYTASRSDE LTIHRGDIIR VYFKDNEDWW YGSVRKGQEG 
       960        970        980        990       1000
FFPANHVASE TLYRDSPPKV KERSPPLTPK EKTKPEKPLA SQKQSLSKGR 
      1010       1020       1030       1040 
PLDPRLGPQP VGHSEKGKDQ NVEDRGHKVD METKKSEPVV RKVTLIE

Length:1,047

Mass (Da):119,650

Last modified:August 30, 2005 - v2

Checksum:ⁱ91908C847218D4C0

Isoform 2 (identifier: Q8K3E5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
994-1005: QSLSKGRPLDPR → GGHEEETKSQTN
1006-1047: Missing.

« Hide

        10         20         30         40         50
MEPETPEKVD SAQEKVRGKT PTADDSDDSR EKTGIEEKGE LTDAYQLQVA 
        60         70         80         90        100
EEMAKEIKKK IRKKLKEQLT YFPPDTLLHD DKLASEKRKK KKKKVPVPTK 
       110        120        130        140        150
PESSPSDVCD SAVEGEQKKE GTPEDSQHME GICSREQDVD ATVPENAKPK 
       160        170        180        190        200
PKKTKKKTKA VSNDNEDTNG DGVHEITSRD SPVHPKCLLD DDLVMGVYIH 
       210        220        230        240        250
RTDRLKSDFM ISHPMVKIHV VDEHTGQYVK KDDSERPVSS YYEKDNVDYI 
       260        270        280        290        300
LPIMTQPYDF KKLKSRLPEW EEQVIFNENF PYLLREFEEC PKVILFFEIL 
       310        320        330        340        350
DFLSMDEIKN NSEVQNQECG FRKIAWAFLK LLGANGNANI NSKLRLQLYY 
       360        370        380        390        400
PPTKPRSQLN VVEVFEWWSK CPRNRYPSTL YVTVRGLKVP DCIKPSYRSM 
       410        420        430        440        450
MALQEERGTP VYCERHRETS SVDTEPGLED SKEEVKWKRL PGQACRIPNK 
       460        470        480        490        500
HLFSLNAGER GCFCLDFSHN GRILAAACAS RDGYPIILYE IPSGRFMREL 
       510        520        530        540        550
CGHLNIIYDL DWSKDDRYLV TSSSDGTARV WKNEINSTST FRVLPHPSFV 
       560        570        580        590        600
YTAKFHPATR ELVVTGCYDS MIRIWKIDAR EDAAILVRQL DVHKSFVNSI 
       610        620        630        640        650
CFDDEGHHMY SGDCIGVIVV WDTYVKVNDV QTSVRHWTIN KEIKETEFRG 
       660        670        680        690        700
VPISYLEVHP NGKRLLIHTK DSTLRIMDLR ILAARKFVGA ANYREKIHST 
       710        720        730        740        750
LTPCGTLLFS GSEDGIVYVW NPETGEQVAM YSDLPFKSTI RDISYHPLEN 
       760        770        780        790        800
MVAFCAFGQS EPILLYIYDF QVAQQEAEML KRYSGTLPLP GIHQSEDALC 
       810        820        830        840        850
TCPKLPQQGS FQIDEFVNTE NSSSRKIQLV KQRLETVTEV IRSCAAKVNK 
       860        870        880        890        900
NLSMTSPPPG PAKKPRVKQS FVLTTDEIIH QFGLPQTAFI SIERGPFVRH 
       910        920        930        940        950
VDPPPMVVAL YDYTASRSDE LTIHRGDIIR VYFKDNEDWW YGSVRKGQEG 
       960        970        980        990       1000
FFPANHVASE TLYRDSPPKV KERSPPLTPK EKTKPEKPLA SQKGGHEEET 

KSQTN

Note: No experimental confirmation available.

Show »

Length:1,005

Mass (Da):114,935

Checksum:ⁱ63388F7CA53AE454

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9QP54	E9QP54_MOUSE	Jouberin Jouberin	Ahi1	1,047	Annotation score:
A0A1L1SQE2	A0A1L1SQE2_MOUSE	Jouberin Jouberin	Ahi1	1,005	Annotation score:
E9Q552	E9Q552_MOUSE	Jouberin Jouberin	Ahi1	142	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	48	Q → T in AAM94175 (PubMed:12186888).Curated	1
Sequence conflictⁱ	194	V → L in AAM94175 (PubMed:12186888).Curated	1
Sequence conflictⁱ	227 – 234	QYVKKDDS → H in BAB24355 (PubMed:16141072).Curated	8
Sequence conflictⁱ	632	T → H in AAH55400 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015357	994 – 1005	QSLSK…PLDPR → GGHEEETKSQTN in isoform 2. 1 PublicationAdd BLAST		12
Alternative sequenceⁱVSP_015358	1006 – 1047	Missing in isoform 2. 1 PublicationAdd BLAST		42

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY133241 mRNA Translation: AAM94175.1 BC055400 mRNA Translation: AAH55400.1 AK005991 mRNA Translation: BAB24355.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35860.1 [Q8K3E5-1]
UniGeneⁱ	Mm.253280 Mm.486431

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8K3E5	Jouberin		MOUSE		142	UniRef100_Q8K3E5
Uncharacterized protein (Fragment)		MOUSE		49

Protein	Similar proteins		Species	Score	Length	Source
Q8K3E5	Jouberin		RAT		1047	UniRef90_Q8K3E5
Jouberin		MOUSE		142
UPI000A31280E		MUSPA		1047
UPI000A314C73		MUSCR		1047
Uncharacterized protein (Fragment)		MOUSE		49
+7

Protein	Similar proteins		Species	Score	Length	Source
Q8K3E5	Jouberin		RAT		1047	UniRef50_Q8K3E5
Jouberin		MOUSE		142
UPI000A31280E		MUSPA		1047
UPI000A314C73		MUSCR		1047
UPI0003AB6898		MACFA		1145
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY133241 mRNA Translation: AAM94175.1 BC055400 mRNA Translation: AAH55400.1 AK005991 mRNA Translation: BAB24355.1
CCDSⁱ	CCDS35860.1 [Q8K3E5-1]
UniGeneⁱ	Mm.253280 Mm.486431

3D structure databases

ProteinModelPortalⁱ	Q8K3E5
SMRⁱ	Q8K3E5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	206874, 30 interactors
CORUMⁱ	Q8K3E5
IntActⁱ	Q8K3E5, 18 interactors
MINTⁱ	Q8K3E5
STRINGⁱ	10090.ENSMUSP00000101164

PTM databases

iPTMnetⁱ	Q8K3E5
PhosphoSitePlusⁱ	Q8K3E5

Proteomic databases

PaxDbⁱ	Q8K3E5
PRIDEⁱ	Q8K3E5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

MGIⁱ	MGI:87971 Ahi1

Phylogenomic databases

eggNOGⁱ	ENOG410IQ0Z Eukaryota ENOG410XVKN LUCA
HOGENOMⁱ	HOG000033864
HOVERGENⁱ	HBG080824
InParanoidⁱ	Q8K3E5
PhylomeDBⁱ	Q8K3E5

Miscellaneous databases

ChiTaRSⁱ	Ahi1 mouse
Protein Ontology More...PROⁱ	PR:Q8K3E5
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_AHI1

CleanExⁱ

MM_AHI1

Family and domain databases

CDDⁱ	cd11812 SH3_AHI-1, 1 hit
Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR035832 AHI1_SH3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF00018 SH3_1, 1 hit PF00400 WD40, 2 hits
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00326 SH3, 1 hit SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002 SH3, 1 hit PS50082 WD_REPEATS_2, 4 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AHI1_MOUSE
Accessionⁱ	Q8K3E5Primary (citable) accession number: Q8K3E5 Secondary accession number(s): Q7TNV2, Q9CVY1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	August 30, 2005
	Last modified:	September 12, 2018
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8K3E5 (AHI1_MOUSE)

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Jouberin

Ahi1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ