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Protein

CDK5 regulatory subunit-associated protein 2

Gene

Cdk5rap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion (PubMed:20627074). Involved in regulation of mitotic spindle orientation (PubMed:20460369). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis (PubMed:20471352). Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear (PubMed:19553473).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 2
Alternative name(s):
CDK5 activator-binding protein C48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cdk5rap2
Synonyms:Kiaa1633
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2384875 Cdk5rap2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898371 – 1822CDK5 regulatory subunit-associated protein 2Add BLAST1822

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei485PhosphoserineCombined sources1
Modified residuei544PhosphoserineBy similarity1
Modified residuei1195PhosphothreonineCombined sources1
Modified residuei1243PhosphoserineBy similarity1
Modified residuei1245PhosphoserineCombined sources1
Modified residuei1497PhosphoserineCombined sources1
Modified residuei1592PhosphoserineBy similarity1
Modified residuei1595PhosphoserineBy similarity1
Modified residuei1822PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by CDK5.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8K389

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8K389

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K389

PRoteomics IDEntifications database

More...
PRIDEi
Q8K389

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K389

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K389

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis, thymus, heart and brain.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in the developing cortex at 9.5 dpc. Expression peaks between 10.5 and 13.5 dpc, remains robust at 15.5 dpc and declines thereafter. This peak corresponds to periods of active neurogenesis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039298 Expressed in 201 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
MM_CDK5RAP2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K389 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K389 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK5R1 (p35 form) (By similarity). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. May form a complex with CDK5R1 and CDK5 (By similarity). Interacts (via C-terminus) with PCNT; the interaction is leading to centrosomal localization of CDK5RAP2 and PCNT. Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9 (By similarity). Interacts with TUBG1; the interaction is leading to the centrosomal localization of CDK5RAP2 and TUBG1 (By similarity). Interacts with TUBGCP3 (By similarity). Interacts with CALM1 (By similarity). Interacts with CDC20 (By similarity). Interacts with CEP68; degradation of CEP68 in early mitosis leads to removal of CDK5RAP2 from the centrosome which promotes centriole disengagement and subsequent centriole separation (By similarity). Interacts with NCKAP5L (By similarity). Interacts with LGALS3BP; this interaction may connect the pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (By similarity). Contrary to human, chimpanzee, bovine and dog orthologous proteins, does not interact with EB1/MAPRE1, possibly due to a divergence at the level of the critical residue 940, which is a proline in MAPRE1-binding orthologs and a leucine in mouse and rat (PubMed:19553473).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
229527, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q8K389, 20 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000119891

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K389

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 195Interaction with NCKAP5LBy similarityAdd BLAST139
Regioni1201 – 1822Interaction with PCNT and AKAP91 PublicationAdd BLAST622
Regioni1655 – 1822Required for centrosomal attachment, Golgi targeting and CALM1 interactionBy similarityAdd BLAST168
Regioni1655 – 1697Interaction with CDK5R1By similarityAdd BLAST43
Regioni1688 – 1822Interaction with PCNT1 PublicationAdd BLAST135
Regioni1790 – 1799Required for centrosomal attachment, Golgi localization and CALM1 interactionBy similarity10

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2NR Eukaryota
ENOG411281S LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063845

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050976

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8K389

KEGG Orthology (KO)

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KOi
K16542

Identification of Orthologs from Complete Genome Data

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OMAi
TYQHILP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G008W

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K389

TreeFam database of animal gene trees

More...
TreeFami
TF329233

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8K389-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSGMEEEGA LPGTLSGCSG LHPVLPSDLD VISDTSGLGN GVLPSMSEEK
60 70 80 90 100
VSPTRARNMK DFENQITELK KENFNLKLRI YFLEERIQQE FAGPTEHIYK
110 120 130 140 150
TNIELKVEVE SLKRELQEKD QLLVKASKAV ESLAERGGSE VQRVKEDARK
160 170 180 190 200
KVQQVEDLLT KRIHLLEEDV KAAQAELEKA FAGTETEKAL RLSLESKLSA
210 220 230 240 250
MKKMQEGDLE MTLALEEKDR LIEELKLSLK SKEALIQCLK EEKSQMASPD
260 270 280 290 300
ENVSSGELRG LSATLREEKE RDAEEWQKER NHFEERIQAL QEDLREKERE
310 320 330 340 350
IATEKKNNLK SYKAIQGLTM ALKSKEREVE ELDSKIKEVT TDSTKGREDP
360 370 380 390 400
LKTQIPRFQL REGSEDCEAA LVEKEALLAK LHSENVTKST ENHRLLRNVK
410 420 430 440 450
KVTQELNDLK KEKLRLEQAL EEAHQEGNRG ARTIHDLRNE VEKLRKEVSE
460 470 480 490 500
REKAVEKHYK SLPGESKTKF HTQEQVVRSL TGSGSQEDLL LQKSNEKDLE
510 520 530 540 550
AIQQNCYLMT AEELKFGSDG LITEKCSQQS PDSKLIFSKE KQQSEYEGLT
560 570 580 590 600
GDLKAEQNIY AHLAKTQDTD SVSNLQAELK EVLALRKQLE QDVLAYRNLQ
610 620 630 640 650
KALQEQLSEI RSREEEPFSF YSDQTSYLSI CLEEHNQFQL EHFSQEELKK
660 670 680 690 700
KVSDLIQLVK DLHTDNQHLK KTIFDLSSVG FQGSDRLELT KQEELVASKE
710 720 730 740 750
DEDTLKFEAD VETPFQSDQH LEQSREIMED YAEGGCKSGY GRHMDSNILG
760 770 780 790 800
HDGAQTPGAS EEHTLEDELL GLLATLFSKK ATPLLESRPD LLKALGALLL
810 820 830 840 850
ERICLAEQGR PGDHLDSKTE KALQQVAVQL RDELGHSFPA NSFSKSYNEV
860 870 880 890 900
KSMWGNWLVK TGDEDTVELK SVSVQTMAIE DTPHGFKPQS KRDAWAEKQE
910 920 930 940 950
EAIFSTELES EALGEMPGQQ ATHLSFPSAI NPDAEKTGLL IQLKTPELLE
960 970 980 990 1000
NLYNLPASPE VVVAQLQGQV LELQRELKEF KTRNKQLHEK LILAEAMMEG
1010 1020 1030 1040 1050
LPVPNSALVN VPAAQAVVRT AFQDNPGEQE GPETTQSAGR DKDMDSDQYT
1060 1070 1080 1090 1100
SFEIDSEICP PDDLALLPAC KENLEDLLGP SSIATYLDSK SQLSVKVSVN
1110 1120 1130 1140 1150
GTDQSENINI PDDTEDLKQK IHDLQTELEG YRNIIVQLLK HSQCSEAIIT
1160 1170 1180 1190 1200
VLCGTEGAQD GLNKPKGHID EEEMTFSSLH QVRYVKHMKI LRPLTPEMID
1210 1220 1230 1240 1250
GKMLESLKQQ LVDQEQELQK EQDLNLELFG EIHDLQNKFQ DLSPSRYDSL
1260 1270 1280 1290 1300
VQSQARELSL QRQQIKDSHG ICVIYRQHMS TMIKAFEELL QASDVDSCVA
1310 1320 1330 1340 1350
EGFREQLTQC AGLLEQLERL FLHGKSARVE PHPQNELLKG LRTVEGNLPY
1360 1370 1380 1390 1400
HHLLPESPEP SASHALSDDE MSEKSFLSRD PKPDSDTEKY PAMASHFPQD
1410 1420 1430 1440 1450
LLMEHIQEIR TLRKHLEESI KTNEKLRKQL ERQGSETDQG SRNVSACGLA
1460 1470 1480 1490 1500
LHSSLTSEIH FLRKQNEALS MMLEKGSKDK QKESEKLRES LARKAESLEQ
1510 1520 1530 1540 1550
LQLEYTSVRE ENERLQRDII EKERHNQELT EEVCSSRQEL SRVQEEAKSR
1560 1570 1580 1590 1600
QQLLSQKDKL LQSLQMELKV YEKLAEEHPR LQQDGSKCPE ASDNSFDLFE
1610 1620 1630 1640 1650
STQAMAPKSA SETPLLSGTD VDSLSCDSTS SATSPTSMPC LVAGHHMWAS
1660 1670 1680 1690 1700
KSGHHMLGLI EDYDALYKQI SWGQTLLAKM DVQTQEALSP TSHKLGPKGS
1710 1720 1730 1740 1750
SSVPLSKFLS SMNTAKLVLE KASRLLKLFW RVSVPTNGQC SLHCEQIGEM
1760 1770 1780 1790 1800
KAENTKLHKK LFEQEKKLQN TAKLLQQSKH QEKVIFDQLV ITHQVLRKAR
1810 1820
GNLELRPGAT RPGASSPSRP GS
Length:1,822
Mass (Da):205,945
Last modified:December 20, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDD6CD7B8CFC8DA9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SP75Q5SP75_MOUSE
CDK5 regulatory subunit-associated ...
Cdk5rap2
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6R2K5F6R2K5_MOUSE
CDK5 regulatory subunit-associated ...
Cdk5rap2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX43H7BX43_MOUSE
CDK5 regulatory subunit-associated ...
Cdk5rap2
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129411 mRNA Translation: BAC98221.1 Different initiation.
AL929409, AL845502 Genomic DNA Translation: CAM23429.1
BC059253 mRNA Translation: AAH59253.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38779.1

NCBI Reference Sequences

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RefSeqi
NP_666102.2, NM_145990.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.370777
Mm.379344

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000144099; ENSMUSP00000119891; ENSMUSG00000039298

Database of genes from NCBI RefSeq genomes

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GeneIDi
214444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:214444

UCSC genome browser

More...
UCSCi
uc008thy.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129411 mRNA Translation: BAC98221.1 Different initiation.
AL929409, AL845502 Genomic DNA Translation: CAM23429.1
BC059253 mRNA Translation: AAH59253.1
CCDSiCCDS38779.1
RefSeqiNP_666102.2, NM_145990.4
UniGeneiMm.370777
Mm.379344

3D structure databases

SMRiQ8K389
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229527, 20 interactors
IntActiQ8K389, 20 interactors
STRINGi10090.ENSMUSP00000119891

PTM databases

iPTMnetiQ8K389
PhosphoSitePlusiQ8K389

Proteomic databases

EPDiQ8K389
MaxQBiQ8K389
PaxDbiQ8K389
PRIDEiQ8K389

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000144099; ENSMUSP00000119891; ENSMUSG00000039298
GeneIDi214444
KEGGimmu:214444
UCSCiuc008thy.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55755
MGIiMGI:2384875 Cdk5rap2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410J2NR Eukaryota
ENOG411281S LUCA
GeneTreeiENSGT00530000063845
HOVERGENiHBG050976
InParanoidiQ8K389
KOiK16542
OMAiTYQHILP
OrthoDBiEOG091G008W
PhylomeDBiQ8K389
TreeFamiTF329233

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cdk5rap2 mouse

Protein Ontology

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PROi
PR:Q8K389

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000039298 Expressed in 201 organ(s), highest expression level in testis
CleanExiMM_CDK5RAP2
ExpressionAtlasiQ8K389 baseline and differential
GenevisibleiQ8K389 MM

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCK5P2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K389
Secondary accession number(s): A2AVA1, Q6PCN1, Q6ZPL0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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