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Protein

Angiomotin-like protein 2

Gene

Amotl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-2028269 Signaling by Hippo

Names & Taxonomyi

Protein namesi
Recommended name:
Angiomotin-like protein 2
Gene namesi
Name:Amotl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1929286 Amotl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001906731 – 772Angiomotin-like protein 2Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107Phosphotyrosine; by FGFR1By similarity1
Modified residuei752PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K371
PaxDbiQ8K371
PRIDEiQ8K371

PTM databases

iPTMnetiQ8K371
PhosphoSitePlusiQ8K371

Expressioni

Gene expression databases

BgeeiENSMUSG00000032531 Expressed in 282 organ(s), highest expression level in adipose tissue
CleanExiMM_AMOTL2
ExpressionAtlasiQ8K371 baseline and differential
GenevisibleiQ8K371 MM

Interactioni

Subunit structurei

Interacts with SRC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207908, 7 interactors
IntActiQ8K371, 1 interactor
STRINGi10090.ENSMUSP00000035121

Structurei

3D structure databases

ProteinModelPortaliQ8K371
SMRiQ8K371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili305 – 578Sequence analysisAdd BLAST274

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi769 – 772PDZ-binding4

Sequence similaritiesi

Belongs to the angiomotin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEF3 Eukaryota
ENOG410ZEXZ LUCA
GeneTreeiENSGT00530000063846
HOGENOMiHOG000233789
HOVERGENiHBG066485
InParanoidiQ8K371
KOiK06104
PhylomeDBiQ8K371
TreeFamiTF333368

Family and domain databases

InterProiView protein in InterPro
IPR009114 Angiomotin
IPR024646 Angiomotin_C
PfamiView protein in Pfam
PF12240 Angiomotin_C, 1 hit
PRINTSiPR01807 ANGIOMOTIN

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q8K371-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGAGGTGS
60 70 80 90 100
PQASLEIGAP EDSQVLQQAT RQEPQGQEHQ GGETHLAENR LYRLCPQPSK
110 120 130 140 150
GEELPTYEEA KAHSQYYAAQ QAGSRPHVGD RDPRGGVSGG GRRQDEALRE
160 170 180 190 200
LRHGHVRSLS ERLLQLSLER NGARVPSHMS SSHSFPQLAR SQQGPQPRGP
210 220 230 240 250
PAEGPEPRGP PPQYPHAVMA QETAAVTDPR YRPRSSPHFQ HAEVRILQAQ
260 270 280 290 300
VPPVFLQQQQ YQYLPQPQEH SPPLHPAALG HGPPSSFGPP AVEGPPSAQA
310 320 330 340 350
TLGSAHLAQM ETVLRENARL QRDNERLQRE LESTSEKAGR IEKLENEIQR
360 370 380 390 400
LSEAHESLMR TSSKREALEK TMRNKMDGEM RRLQDFNRDL RERLESANRH
410 420 430 440 450
LASKTQEAQA GSQDMVAKLL AQSYEQQQEQ EKLEREMALL RGAIEDQRRH
460 470 480 490 500
AELLEQALGN AQSRAARAEE ELRKKQAYVE KVERLQQALG QLQAACEKRE
510 520 530 540 550
QLELRLRTRL EQELKALRAQ QRQTGTLAGG GGSHGGSAEL SALRLSEQLR
560 570 580 590 600
EKEEQILALE ADMTKWEQKY LEERAMRQFA MDAAATAAAQ RDTTLIRHSP
610 620 630 640 650
QPSPSSSFNE GLLPGNHRHQ EMESRLKVLH AQILEKDAVI KVLQQRSRKD
660 670 680 690 700
PGKATQGTLR PAKSVPSIFA AAVGTQGWQG LVSSERQTDA RPAGDRVPAE
710 720 730 740 750
EPPATAPLPA HTKHGSRDGS TQTDGPADNT SACLASEPDG LLGCNSSQRT
760 770
PSLDSIAATR VQDLSDMVEI LI
Length:772
Mass (Da):85,278
Last modified:October 1, 2002 - v1
Checksum:i9979F5F4D2A54989
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8JK87B8JK87_MOUSE
Angiomotin-like protein 2
Amotl2
805Annotation score:
B8JK81B8JK81_MOUSE
Angiomotin-like protein 2
Amotl2
587Annotation score:
Q3TP05Q3TP05_MOUSE
Angiomotin-like protein 2
Amotl2
718Annotation score:
A0A087WRL8A0A087WRL8_MOUSE
Angiomotin-like protein 2
Amotl2
113Annotation score:
B8JK82B8JK82_MOUSE
Angiomotin-like protein 2
Amotl2
193Annotation score:
B8JK85B8JK85_MOUSE
Angiomotin-like protein 2
Amotl2
23Annotation score:
B8JK83B8JK83_MOUSE
Angiomotin-like protein 2
Amotl2
86Annotation score:
B8JK84B8JK84_MOUSE
Angiomotin-like protein 2
Amotl2
83Annotation score:
B8JK86B8JK86_MOUSE
Angiomotin-like protein 2
Amotl2
220Annotation score:

Sequence cautioni

The sequence BAC30740 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC36853 differs from that shown. Reason: Frameshift at position 171.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163 – 165LLQ → ILK in BAC36853 (PubMed:16141072).Curated3
Sequence conflicti187 – 197QLARSQQGPQP → EPPGFLGDRST in AAD56362 (PubMed:12406577).CuratedAdd BLAST11
Sequence conflicti257Q → H in AAD56362 (PubMed:12406577).Curated1
Sequence conflicti389D → N in BAC36853 (PubMed:16141072).Curated1
Sequence conflicti450H → N in BAC36853 (PubMed:16141072).Curated1
Sequence conflicti481K → R in AAD56362 (PubMed:12406577).Curated1
Sequence conflicti481K → R in AAD56363 (PubMed:12406577).Curated1
Sequence conflicti643L → P in AAD56362 (PubMed:12406577).Curated1
Sequence conflicti643L → P in AAD56363 (PubMed:12406577).Curated1
Sequence conflicti660R → W in AAD56362 (PubMed:12406577).Curated1
Sequence conflicti660R → W in AAD56363 (PubMed:12406577).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040912 mRNA Translation: BAC30740.1 Different initiation.
AK077535 mRNA Translation: BAC36853.1 Frameshift.
AK141348 mRNA Translation: BAE24658.1
AK164279 mRNA Translation: BAE37715.1
CT573150 Genomic DNA Translation: CAX15827.1
CH466560 Genomic DNA Translation: EDL21058.1
BC027824 mRNA Translation: AAH27824.1
AF175967 mRNA Translation: AAD56362.2
AF175968 mRNA Translation: AAD56363.1
CCDSiCCDS40745.1
RefSeqiNP_062738.2, NM_019764.2
XP_006511834.2, XM_006511771.3
XP_006511836.1, XM_006511773.2
UniGeneiMm.21145

Genome annotation databases

EnsembliENSMUST00000035121; ENSMUSP00000035121; ENSMUSG00000032531
GeneIDi56332
KEGGimmu:56332
UCSCiuc009rfx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040912 mRNA Translation: BAC30740.1 Different initiation.
AK077535 mRNA Translation: BAC36853.1 Frameshift.
AK141348 mRNA Translation: BAE24658.1
AK164279 mRNA Translation: BAE37715.1
CT573150 Genomic DNA Translation: CAX15827.1
CH466560 Genomic DNA Translation: EDL21058.1
BC027824 mRNA Translation: AAH27824.1
AF175967 mRNA Translation: AAD56362.2
AF175968 mRNA Translation: AAD56363.1
CCDSiCCDS40745.1
RefSeqiNP_062738.2, NM_019764.2
XP_006511834.2, XM_006511771.3
XP_006511836.1, XM_006511773.2
UniGeneiMm.21145

3D structure databases

ProteinModelPortaliQ8K371
SMRiQ8K371
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207908, 7 interactors
IntActiQ8K371, 1 interactor
STRINGi10090.ENSMUSP00000035121

PTM databases

iPTMnetiQ8K371
PhosphoSitePlusiQ8K371

Proteomic databases

MaxQBiQ8K371
PaxDbiQ8K371
PRIDEiQ8K371

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035121; ENSMUSP00000035121; ENSMUSG00000032531
GeneIDi56332
KEGGimmu:56332
UCSCiuc009rfx.1 mouse

Organism-specific databases

CTDi51421
MGIiMGI:1929286 Amotl2

Phylogenomic databases

eggNOGiENOG410IEF3 Eukaryota
ENOG410ZEXZ LUCA
GeneTreeiENSGT00530000063846
HOGENOMiHOG000233789
HOVERGENiHBG066485
InParanoidiQ8K371
KOiK06104
PhylomeDBiQ8K371
TreeFamiTF333368

Enzyme and pathway databases

ReactomeiR-MMU-2028269 Signaling by Hippo

Miscellaneous databases

PROiPR:Q8K371
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032531 Expressed in 282 organ(s), highest expression level in adipose tissue
CleanExiMM_AMOTL2
ExpressionAtlasiQ8K371 baseline and differential
GenevisibleiQ8K371 MM

Family and domain databases

InterProiView protein in InterPro
IPR009114 Angiomotin
IPR024646 Angiomotin_C
PfamiView protein in Pfam
PF12240 Angiomotin_C, 1 hit
PRINTSiPR01807 ANGIOMOTIN
ProtoNetiSearch...

Entry informationi

Entry nameiAMOL2_MOUSE
AccessioniPrimary (citable) accession number: Q8K371
Secondary accession number(s): B8JK80
, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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