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Protein

Acyl-CoA dehydrogenase family member 10

Gene

Acad10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.By similarity

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei828FADBy similarity1
Binding sitei943FADBy similarity1
Binding sitei1013FADBy similarity1
Binding sitei1044FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi792 – 802FADBy similarityAdd BLAST11

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase family member 10 (EC:1.3.99.-)
Short name:
ACAD-10
Gene namesi
Name:Acad10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919235 Acad10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847711 – 1069Acyl-CoA dehydrogenase family member 10Add BLAST1069

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei413N6-succinyllysineCombined sources1
Modified residuei427N6-acetyllysine; alternateCombined sources1
Modified residuei427N6-succinyllysine; alternateCombined sources1
Modified residuei1052N6-acetyllysine; alternateCombined sources1
Modified residuei1052N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8K370
MaxQBiQ8K370
PaxDbiQ8K370
PeptideAtlasiQ8K370
PRIDEiQ8K370

PTM databases

iPTMnetiQ8K370
PhosphoSitePlusiQ8K370
SwissPalmiQ8K370

Expressioni

Gene expression databases

BgeeiENSMUSG00000029456 Expressed in 148 organ(s), highest expression level in brown adipose tissue
CleanExiMM_ACAD10
GenevisibleiQ8K370 MM

Interactioni

Protein-protein interaction databases

BioGridi215074, 1 interactor
IntActiQ8K370, 3 interactors
MINTiQ8K370
STRINGi10090.ENSMUSP00000031412

Structurei

3D structure databases

ProteinModelPortaliQ8K370
SMRiQ8K370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG1469 Eukaryota
KOG3085 Eukaryota
COG3173 LUCA
GeneTreeiENSGT00910000144198
HOGENOMiHOG000131666
HOVERGENiHBG057142
InParanoidiQ8K370
KOiK11729
OMAiCMRLIGY
OrthoDBiEOG091G03B8
TreeFamiTF333953

Family and domain databases

Gene3Di1.10.150.240, 1 hit
1.10.540.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR002575 Aminoglycoside_PTrfase
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011945 HAD-SF_ppase_IA/epoxid_hydro_N
IPR023214 HAD_sf
IPR011009 Kinase-like_dom_sf
IPR023198 PGP-like_dom2
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
PF01636 APH, 1 hit
PRINTSiPR00413 HADHALOGNASE
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56112 SSF56112, 1 hit
SSF56645 SSF56645, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02247 HAD-1A3-hyp, 1 hit
TIGR01509 HAD-SF-IA-v3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVRRLFQPS TLHWAWRTTA LNHPLGRHQG GLRWTHSGGR SYRAVIFDTG
60 70 80 90 100
GVLVPSPGTV AVGWEVQNHV PSGTIVKAFI RGGDSGPWIR FIKGEITTEH
110 120 130 140 150
FLEEFGRLCS EIAKTSVPVS SYFSLLTSEQ VTKQFPVMTQ AISQIRAKGL
160 170 180 190 200
QTAVLTNNFH LSSGESFLPL DRKQFDVVVE SCLEGICKPD PRIFQLCLQR
210 220 230 240 250
LSLQPSEAIF LDDLGSNLKV AASLGIHTIK VDRPETAVKE LEALLGFPLH
260 270 280 290 300
LGVPNTRPVR KTMAIPQDAL EKYLKGLLGT HSTGPMELLQ FDHGQSNPTY
310 320 330 340 350
YIRLADRQLV LRKKPSGTLL PSAHAIEREF RIMKALANAG VPVPTVLDLC
360 370 380 390 400
EDSSIIGTPF YLMEYCPGII YKDPSLPGLE PSRREAIYTA MNQVLCRIHS
410 420 430 440 450
VDLQATSLDS FGKQGDYIPR QVQTWTKQYR AAETSSIPAM ERLIQWLPLH
460 470 480 490 500
LPRQQRTTLV HGDFRLDNLI FHPEKAEVLA VLDWELSTLG DPFADVAYSC
510 520 530 540 550
LAYYLPSSFP ILRGFRDQDV TKLGIPTVEE YFRMYCLNMG IPPIDNWNFY
560 570 580 590 600
MAFSFFRVAA ILQGVYKRSL TGQASSATAQ QSGKLTESMA ELAWDFATKE
610 620 630 640 650
GFRVFKEMPA TKTLSRSYHA WAGPRSPRTP KGVRGHSTVA AASPSHEAKG
660 670 680 690 700
GLVISPEGLS PAVRKLYEQL VQFIEQKVYP LEPELQRHQA SADRWSPSPL
710 720 730 740 750
IEDLKEKAKA EGLWNLFLPL ETDPEKKYGA GLTNVEYAHL CEVMGMSLYA
760 770 780 790 800
SEIFNCSAPD TGNMEILVRY GTEEQKARWL VPLLEGRIRS CFAMTEPQVA
810 820 830 840 850
SSDASNIEAS IKEEDGCYVI NGHKWWTSGI LDPRCKLCVF MGKTDPQAPR
860 870 880 890 900
HQQQSMLLVP MDSPGITVIR PLSVFGLEDP PGGHGEVRFK DVRVPKENIL
910 920 930 940 950
LGPGRGFEIA QGRLGPGRIH HCMRLIGYSE RALALMKTRV MSRTAFGKPL
960 970 980 990 1000
VEQGTILADI ARSRVEIEQA RLLVLKAAHL MDVAGNKTAA LDIAMIKMVV
1010 1020 1030 1040 1050
PSMAYHVIDR AIQAFGAAGL SSDYPLAQFF GWARALRFAD GPDEVHQLTV
1060
AKMELKNQSR MQEPAVPRV
Length:1,069
Mass (Da):118,979
Last modified:October 1, 2002 - v1
Checksum:i27A4D0823FDAA3D5
GO

Sequence cautioni

The sequence AAH29047 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC34193 differs from that shown. Reason: Frameshift at position 59.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti511 – 512IL → MM in AAH29047 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050332 mRNA Translation: BAC34193.1 Frameshift.
BC027825 mRNA Translation: AAH27825.1
BC029047 mRNA Translation: AAH29047.1 Different initiation.
CCDSiCCDS51643.1
RefSeqiNP_082313.2, NM_028037.4
XP_006530521.1, XM_006530458.3
XP_006530523.1, XM_006530460.3
XP_006530524.1, XM_006530461.3
UniGeneiMm.45423

Genome annotation databases

EnsembliENSMUST00000031412; ENSMUSP00000031412; ENSMUSG00000029456
ENSMUST00000111770; ENSMUSP00000107400; ENSMUSG00000029456
GeneIDi71985
KEGGimmu:71985
UCSCiuc008zjy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050332 mRNA Translation: BAC34193.1 Frameshift.
BC027825 mRNA Translation: AAH27825.1
BC029047 mRNA Translation: AAH29047.1 Different initiation.
CCDSiCCDS51643.1
RefSeqiNP_082313.2, NM_028037.4
XP_006530521.1, XM_006530458.3
XP_006530523.1, XM_006530460.3
XP_006530524.1, XM_006530461.3
UniGeneiMm.45423

3D structure databases

ProteinModelPortaliQ8K370
SMRiQ8K370
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215074, 1 interactor
IntActiQ8K370, 3 interactors
MINTiQ8K370
STRINGi10090.ENSMUSP00000031412

PTM databases

iPTMnetiQ8K370
PhosphoSitePlusiQ8K370
SwissPalmiQ8K370

Proteomic databases

EPDiQ8K370
MaxQBiQ8K370
PaxDbiQ8K370
PeptideAtlasiQ8K370
PRIDEiQ8K370

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031412; ENSMUSP00000031412; ENSMUSG00000029456
ENSMUST00000111770; ENSMUSP00000107400; ENSMUSG00000029456
GeneIDi71985
KEGGimmu:71985
UCSCiuc008zjy.1 mouse

Organism-specific databases

CTDi80724
MGIiMGI:1919235 Acad10

Phylogenomic databases

eggNOGiKOG1469 Eukaryota
KOG3085 Eukaryota
COG3173 LUCA
GeneTreeiENSGT00910000144198
HOGENOMiHOG000131666
HOVERGENiHBG057142
InParanoidiQ8K370
KOiK11729
OMAiCMRLIGY
OrthoDBiEOG091G03B8
TreeFamiTF333953

Enzyme and pathway databases

ReactomeiR-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation

Miscellaneous databases

PROiPR:Q8K370
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029456 Expressed in 148 organ(s), highest expression level in brown adipose tissue
CleanExiMM_ACAD10
GenevisibleiQ8K370 MM

Family and domain databases

Gene3Di1.10.150.240, 1 hit
1.10.540.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR002575 Aminoglycoside_PTrfase
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011945 HAD-SF_ppase_IA/epoxid_hydro_N
IPR023214 HAD_sf
IPR011009 Kinase-like_dom_sf
IPR023198 PGP-like_dom2
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
PF01636 APH, 1 hit
PRINTSiPR00413 HADHALOGNASE
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56112 SSF56112, 1 hit
SSF56645 SSF56645, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02247 HAD-1A3-hyp, 1 hit
TIGR01509 HAD-SF-IA-v3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACD10_MOUSE
AccessioniPrimary (citable) accession number: Q8K370
Secondary accession number(s): Q8BWQ0, Q8K313
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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