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UniProtKB - Q8K358 (PIGU_MOUSE)
Protein
Phosphatidylinositol glycan anchor biosynthesis class U protein
Gene
Pigu
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI (By similarity).
By similarity: glycosylphosphatidylinositol-anchor biosynthesis Pathwayi
This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.
GO - Biological processi
- attachment of GPI anchor to protein Source: MGI
- GPI anchor biosynthetic process Source: MGI
- protein localization to cell surface Source: GO_Central
- regulation of receptor signaling pathway via JAK-STAT Source: MGI
Keywordsi
Biological process | GPI-anchor biosynthesis |
Enzyme and pathway databases
Reactomei | R-MMU-162791, Attachment of GPI anchor to uPAR |
UniPathwayi | UPA00196 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol glycan anchor biosynthesis class U proteinAlternative name(s): Cell division cycle protein 91-like 1 Short name: Protein CDC91-like 1 GPI transamidase component PIG-U |
Gene namesi | Name:Pigu Synonyms:Cdc91l1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3039607, Pigu |
VEuPathDBi | HostDB:ENSMUSG00000038383 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- GPI-anchor transamidase complex Source: UniProtKB
Plasma Membrane
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 258 – 278 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 285 – 305 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 312 – 332 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 354 – 374 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 385 – 405 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121395 | 1 – 434 | Phosphatidylinositol glycan anchor biosynthesis class U proteinAdd BLAST | 434 |
Proteomic databases
EPDi | Q8K358 |
MaxQBi | Q8K358 |
PaxDbi | Q8K358 |
PRIDEi | Q8K358 |
ProteomicsDBi | 288159 |
PTM databases
iPTMneti | Q8K358 |
PhosphoSitePlusi | Q8K358 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038383, Expressed in undifferentiated genital tubercle and 307 other tissues |
ExpressionAtlasi | Q8K358, baseline and differential |
Genevisiblei | Q8K358, MM |
Interactioni
Subunit structurei
Forms a complex with PIGK/GPI8, PIGS, PIGT and GPAA1/GAA1.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000076816 |
Miscellaneous databases
RNActi | Q8K358, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 268 – 288 | May be involved in recognition of long-chain fatty acids in GPIBy similarityAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the PIGU family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2552, Eukaryota |
GeneTreei | ENSGT00390000014941 |
InParanoidi | Q8K358 |
Family and domain databases
InterProi | View protein in InterPro IPR009600, PIG-U |
PANTHERi | PTHR13121, PTHR13121, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8K358-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPLALVLV VAVTVRAALF RSSLAEFISE RVEVVSPLSS WKRVVEGLAL
60 70 80 90 100
LDLGVSPYSG AVFHETPLII YLFHFLIDYA ELVFMITDAL TAIALYFAIQ
110 120 130 140 150
DFNKVVFKKQ KLLLELDQYA PDVAELIRTP MEMRYIPLKV ALYLLNPYTI
160 170 180 190 200
LSCVAKSTCA INNTLIAFFI LTTIKGSVFL SAVFLALATY QSLYPVTLFA
210 220 230 240 250
PGLLYLLQRQ YIPVKVKSKA FWIFSWEYAM MYTGSLVVIV CLSFFLLSSW
260 270 280 290 300
DFIPAVYGFI LSVPDLTPNI GLFWYFFAEM FEHFSLFFVC VFQINVFFYT
310 320 330 340 350
VPLAIKLKEH PIFFMFIQIA IISIFKSYPT VGDVALYMAF FPVWNHLYRF
360 370 380 390 400
LRNIFVLTCI IIVCSLLFPV LWHLWIYAGS ANSNFFYAIT LTFNVGQILL
410 420 430
ISDYFYAFLR REYYLTHGLY LTAKDGTEAM LVLK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3TAA8 | Q3TAA8_MOUSE | Phosphatidylinositol glycan anchor ... | Pigu Cdc91l1 | 435 | Annotation score: |
Sequence cautioni
The sequence AAH28278 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL845325 Genomic DNA No translation available. AL929588 Genomic DNA No translation available. BC028278 mRNA Translation: AAH28278.1 Different initiation. |
Genome annotation databases
Ensembli | ENSMUST00000165234; ENSMUSP00000126236; ENSMUSG00000038383 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL845325 Genomic DNA No translation available. AL929588 Genomic DNA No translation available. BC028278 mRNA Translation: AAH28278.1 Different initiation. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000076816 |
PTM databases
iPTMneti | Q8K358 |
PhosphoSitePlusi | Q8K358 |
Proteomic databases
EPDi | Q8K358 |
MaxQBi | Q8K358 |
PaxDbi | Q8K358 |
PRIDEi | Q8K358 |
ProteomicsDBi | 288159 |
Protocols and materials databases
Antibodypediai | 60375, 31 antibodies from 11 providers |
Genome annotation databases
Ensembli | ENSMUST00000165234; ENSMUSP00000126236; ENSMUSG00000038383 |
Organism-specific databases
MGIi | MGI:3039607, Pigu |
VEuPathDBi | HostDB:ENSMUSG00000038383 |
Phylogenomic databases
eggNOGi | KOG2552, Eukaryota |
GeneTreei | ENSGT00390000014941 |
InParanoidi | Q8K358 |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Reactomei | R-MMU-162791, Attachment of GPI anchor to uPAR |
Miscellaneous databases
ChiTaRSi | Pigu, mouse |
PROi | PR:Q8K358 |
RNActi | Q8K358, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038383, Expressed in undifferentiated genital tubercle and 307 other tissues |
ExpressionAtlasi | Q8K358, baseline and differential |
Genevisiblei | Q8K358, MM |
Family and domain databases
InterProi | View protein in InterPro IPR009600, PIG-U |
PANTHERi | PTHR13121, PTHR13121, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PIGU_MOUSE | |
Accessioni | Q8K358Primary (citable) accession number: Q8K358 Secondary accession number(s): Q921E1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 25, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 116 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families