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Entry version 138 (07 Apr 2021)
Sequence version 2 (24 Oct 2003)
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Protein

SAM and SH3 domain-containing protein 3

Gene

Sash3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a signaling adapter protein in lymphocytes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SAM and SH3 domain-containing protein 3
Alternative name(s):
SH3 protein expressed in lymphocytes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sash3
Synonyms:Sly
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921381, Sash3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000719631 – 380SAM and SH3 domain-containing protein 3Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei42PhosphoserineCombined sources1
Modified residuei61PhosphothreonineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei112PhosphothreonineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8K352

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K352

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8K352

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K352

PeptideAtlas

More...
PeptideAtlasi
Q8K352

PRoteomics IDEntifications database

More...
PRIDEi
Q8K352

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
256731

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K352

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K352

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in lymphoid tissues. Expressed in bone marrow, thymus, spleen, lymph nodes and Peyer patches of gut. In the spleen and lymph nodes, expressed in both T- and B-cells. In the thymus, in the medulla and cortex.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031101, Expressed in thymus and 141 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K352, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
216514, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8K352

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033427

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K352, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K352

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini173 – 234SH3PROSITE-ProRule annotationAdd BLAST62
Domaini252 – 316SAMPROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4384, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027875_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K352

Identification of Orthologs from Complete Genome Data

More...
OMAi
DKEPTQK

Database of Orthologous Groups

More...
OrthoDBi
278880at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K352

TreeFam database of animal gene trees

More...
TreeFami
TF350709

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11968, SH3_SASH3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021090, rSAM/SH3_domain-containing
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR035722, SASH3
IPR035721, SASH3_SH3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR12301:SF5, PTHR12301:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07647, SAM_2, 1 hit
PF07653, SH3_2, 1 hit
PF12485, SLY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454, SAM, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8K352-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRKPSNAS DKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD
60 70 80 90 100
NIPEDDSGVL TPEDSGKSGK KLGKKWRAVI SRTMNRKMGK MMVKALSEEM
110 120 130 140 150
GDTLEEGSAS PTSPDCSLDS PGPEKMALAF TEQEEREPPS LSRQTSTGSE
160 170 180 190 200
LCSPGPGSGS FLEESPAPQY TGPFCGRARV HTDFTPSPYD HDSLKLQKGD
210 220 230 240 250
VIQIVEKPPV GTWLGLLNGK LGSFKFIYVD VLPEEAVGPV RPSRRQSKGK
260 270 280 290 300
RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
310 320 330 340 350
QHRAKLLTAA ELLLDYDTGS EEAEEGAESS QEPVAHTVSE PKVDIPRDSG
360 370 380
CFEGSESGRD EAELAGTEEQ LQGLSLSGAP
Length:380
Mass (Da):41,609
Last modified:October 24, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A3F19F0D79F66EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti318T → TA in AAH28773 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ306422 mRNA Translation: CAC67499.1
AK004734 mRNA Translation: BAB23516.1
AK156202 mRNA Translation: BAE33623.1
AK171017 mRNA Translation: BAE42187.1
BC028773 mRNA Translation: AAH28773.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40959.1

NCBI Reference Sequences

More...
RefSeqi
NP_001300678.1, NM_001313749.1
NP_083049.1, NM_028773.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033427; ENSMUSP00000033427; ENSMUSG00000031101

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74131

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74131

UCSC genome browser

More...
UCSCi
uc009tbw.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306422 mRNA Translation: CAC67499.1
AK004734 mRNA Translation: BAB23516.1
AK156202 mRNA Translation: BAE33623.1
AK171017 mRNA Translation: BAE42187.1
BC028773 mRNA Translation: AAH28773.1
CCDSiCCDS40959.1
RefSeqiNP_001300678.1, NM_001313749.1
NP_083049.1, NM_028773.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FXFX-ray2.05A254-317[»]
6G8ONMR-A/B254-321[»]
SMRiQ8K352
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi216514, 1 interactor
MINTiQ8K352
STRINGi10090.ENSMUSP00000033427

PTM databases

iPTMnetiQ8K352
PhosphoSitePlusiQ8K352

Proteomic databases

EPDiQ8K352
jPOSTiQ8K352
MaxQBiQ8K352
PaxDbiQ8K352
PeptideAtlasiQ8K352
PRIDEiQ8K352
ProteomicsDBi256731

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
381, 51 antibodies

The DNASU plasmid repository

More...
DNASUi
74131

Genome annotation databases

EnsembliENSMUST00000033427; ENSMUSP00000033427; ENSMUSG00000031101
GeneIDi74131
KEGGimmu:74131
UCSCiuc009tbw.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54440
MGIiMGI:1921381, Sash3

Phylogenomic databases

eggNOGiKOG4384, Eukaryota
GeneTreeiENSGT00940000160111
HOGENOMiCLU_027875_0_0_1
InParanoidiQ8K352
OMAiDKEPTQK
OrthoDBi278880at2759
PhylomeDBiQ8K352
TreeFamiTF350709

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
74131, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sly, mouse

Protein Ontology

More...
PROi
PR:Q8K352
RNActiQ8K352, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031101, Expressed in thymus and 141 other tissues
GenevisibleiQ8K352, MM

Family and domain databases

CDDicd11968, SH3_SASH3, 1 hit
Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR021090, rSAM/SH3_domain-containing
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR035722, SASH3
IPR035721, SASH3_SH3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR12301:SF5, PTHR12301:SF5, 1 hit
PfamiView protein in Pfam
PF07647, SAM_2, 1 hit
PF07653, SH3_2, 1 hit
PF12485, SLY, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSASH3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K352
Secondary accession number(s): Q3TBX0, Q9DBV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: April 7, 2021
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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