UniProtKB - Q8K348 (ACV1C_MOUSE)
Protein
Activin receptor type-1C
Gene
Acvr1c
Organism
Mus musculus (Mouse)
Status
Functioni
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 222 | ATPPROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 323 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 201 – 209 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- activin binding Source: MGI
- activin receptor activity, type I Source: UniProtKB
- ATP binding Source: MGI
- BMP receptor binding Source: MGI
- growth factor binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- nodal binding Source: MGI
- protein serine/threonine kinase activity Source: MGI
- SMAD binding Source: MGI
GO - Biological processi
- activin receptor signaling pathway Source: GO_Central
- apoptotic nuclear changes Source: MGI
- cell differentiation Source: UniProtKB
- cellular response to growth factor stimulus Source: GO_Central
- lipid storage Source: MGI
- negative regulation of chorionic trophoblast cell proliferation Source: MGI
- negative regulation of insulin secretion Source: MGI
- negative regulation of trophoblast cell migration Source: MGI
- nervous system development Source: GO_Central
- nodal signaling pathway Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- protein phosphorylation Source: MGI
- regulation of apoptotic process Source: UniProtKB
- response to dietary excess Source: MGI
- response to glucose Source: MGI
- response to insulin Source: MGI
- transforming growth factor beta receptor complex assembly Source: MGI
- trophectodermal cell proliferation Source: MGI
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-1502540, Signaling by Activin |
Names & Taxonomyi
Protein namesi | Recommended name: Activin receptor type-1C (EC:2.7.11.30)Alternative name(s): Activin receptor type IC Short name: ACTR-IC Activin receptor-like kinase 7 Short name: ALK-7 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2661081, Acvr1c |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- activin receptor complex Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 113 | ExtracellularSequence analysisAdd BLAST | 87 | |
Transmembranei | 114 – 134 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 135 – 493 | CytoplasmicSequence analysisAdd BLAST | 359 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000042629 | 26 – 493 | Activin receptor type-1CAdd BLAST | 468 |
Proteomic databases
jPOSTi | Q8K348 |
MaxQBi | Q8K348 |
PaxDbi | Q8K348 |
PRIDEi | Q8K348 |
PTM databases
iPTMneti | Q8K348 |
PhosphoSitePlusi | Q8K348 |
Expressioni
Tissue specificityi
Expressed in interdigital regions in developing limb buds.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000026834, Expressed in epididymal fat pad and 135 other tissues |
ExpressionAtlasi | Q8K348, baseline and differential |
Genevisiblei | Q8K348, MM |
Interactioni
Subunit structurei
Binds the type 2 receptor protein ACVR2A.
By similarityGO - Molecular functioni
- BMP receptor binding Source: MGI
- growth factor binding Source: UniProtKB
- nodal binding Source: MGI
- SMAD binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 234631, 1 interactor |
IntActi | Q8K348, 1 interactor |
MINTi | Q8K348 |
STRINGi | 10090.ENSMUSP00000028178 |
Miscellaneous databases
RNActi | Q8K348, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 165 – 194 | GSPROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 195 – 485 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 291 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000158842 |
InParanoidi | Q8K348 |
OrthoDBi | 776697at2759 |
TreeFami | TF314724 |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q8K348-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPARGSALS LALLLVALAA DLAAGLKCVC LLCDSSNFTC QTEGACWASV
60 70 80 90 100
MLTNGKEQVI KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP
110 120 130 140 150
TASPNAPRLG PTELTVVITV PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN
160 170 180 190 200
VEEALAEYSL VNAGKTLKDL IYDATASGSG SGLPLLVQRT IARTIVLQEI
210 220 230 240 250
VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL
260 270 280 290 300
GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA
310 320 330 340 350
SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS
360 370 380 390 400
IMNTIDIPQN PKVGTKRYMA PEMLDDTMNL SIFESFKRAD IYSVGLVYWE
410 420 430 440 450
IARRCSVGGV VEEYQLPYYD MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS
460 470 480 490
CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED CKA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AJR5 | A2AJR5_MOUSE | Receptor protein serine/threonine k... | Acvr1c | 413 | Annotation score: | ||
A2AJR6 | A2AJR6_MOUSE | Receptor protein serine/threonine k... | Acvr1c | 336 | Annotation score: | ||
Q3V348 | Q3V348_MOUSE | Receptor protein serine/threonine k... | Acvr1c | 363 | Annotation score: | ||
D3Z1K2 | D3Z1K2_MOUSE | Activin receptor type-1C | Acvr1c | 61 | Annotation score: |
Sequence cautioni
The sequence AK142396 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK142396 mRNA No translation available. AL772179 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL26940.1 BC028780 mRNA Translation: AAH28780.1 |
CCDSi | CCDS50586.1 |
RefSeqi | NP_001104500.1, NM_001111030.1 |
Genome annotation databases
Ensembli | ENSMUST00000028178; ENSMUSP00000028178; ENSMUSG00000026834 |
GeneIDi | 269275 |
KEGGi | mmu:269275 |
UCSCi | uc008jsp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK142396 mRNA No translation available. AL772179 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL26940.1 BC028780 mRNA Translation: AAH28780.1 |
CCDSi | CCDS50586.1 |
RefSeqi | NP_001104500.1, NM_001111030.1 |
3D structure databases
SMRi | Q8K348 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 234631, 1 interactor |
IntActi | Q8K348, 1 interactor |
MINTi | Q8K348 |
STRINGi | 10090.ENSMUSP00000028178 |
PTM databases
iPTMneti | Q8K348 |
PhosphoSitePlusi | Q8K348 |
Proteomic databases
jPOSTi | Q8K348 |
MaxQBi | Q8K348 |
PaxDbi | Q8K348 |
PRIDEi | Q8K348 |
Protocols and materials databases
Antibodypediai | 2075, 403 antibodies |
DNASUi | 269275 |
Genome annotation databases
Ensembli | ENSMUST00000028178; ENSMUSP00000028178; ENSMUSG00000026834 |
GeneIDi | 269275 |
KEGGi | mmu:269275 |
UCSCi | uc008jsp.2, mouse |
Organism-specific databases
CTDi | 130399 |
MGIi | MGI:2661081, Acvr1c |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000158842 |
InParanoidi | Q8K348 |
OrthoDBi | 776697at2759 |
TreeFami | TF314724 |
Enzyme and pathway databases
Reactomei | R-MMU-1502540, Signaling by Activin |
Miscellaneous databases
BioGRID-ORCSi | 269275, 0 hits in 17 CRISPR screens |
PROi | PR:Q8K348 |
RNActi | Q8K348, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026834, Expressed in epididymal fat pad and 135 other tissues |
ExpressionAtlasi | Q8K348, baseline and differential |
Genevisiblei | Q8K348, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACV1C_MOUSE | |
Accessioni | Q8K348Primary (citable) accession number: Q8K348 Secondary accession number(s): A2AJR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index