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Protein

Kinetochore-associated protein NSL1 homolog

Gene

Nsl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.By similarity

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic sister chromatid segregation Source: GO_Central

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore-associated protein NSL1 homolog
Gene namesi
Name:Nsl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2685830 Nsl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892611 – 281Kinetochore-associated protein NSL1 homologAdd BLAST281

Proteomic databases

EPDiQ8K305
MaxQBiQ8K305
PaxDbiQ8K305
PeptideAtlasiQ8K305
PRIDEiQ8K305

PTM databases

iPTMnetiQ8K305
PhosphoSitePlusiQ8K305

Interactioni

Subunit structurei

Component of the MIS12 complex composed of MIS12, DSN1, NSL1/DC8 and PMF1. Interacts with KNL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077380

Structurei

3D structure databases

SMRiQ8K305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXS8 Eukaryota
ENOG41125EG LUCA
HOGENOMiHOG000113863
HOVERGENiHBG080948
InParanoidiQ8K305
PhylomeDBiQ8K305

Family and domain databases

InterProiView protein in InterPro
IPR013950 Mis14/Nsl1
PANTHERiPTHR31749 PTHR31749, 1 hit
PfamiView protein in Pfam
PF08641 Mis14, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8K305-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVSETVLV SAPQDHDAQA ASDPQATAAD SPLEDFRVRC TLKRAVMEVM
60 70 80 90 100
EMCGRFVQEL GAVLPEDVRE LALRDAQWTF ESAVQENVSF NGQAWEEAKE
110 120 130 140 150
HGLMDSDIKV LEDEFDELIV DVATKRRQYP RRILESVIKT LKAQHASLKQ
160 170 180 190 200
YHPVVHPLDL KCDPDPASRV EDLKCRGEAI AKEMSEAMKA LPVLIEQGEG
210 220 230 240 250
FSQVLKMRPV IQLQRINQEV FSSLYRKADF KPDTCVTHVE TTPAETGARK
260 270 280
ASNIVLKRKK APDCAQRKRY PLRLQRINLD M
Length:281
Mass (Da):31,739
Last modified:October 1, 2002 - v1
Checksum:iBDA83C7766EF1FA0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QME3E9QME3_MOUSE
Kinetochore-associated protein NSL1...
Nsl1
281Annotation score:
E9Q3W6E9Q3W6_MOUSE
Kinetochore-associated protein NSL1...
Nsl1
174Annotation score:
D3Z4S2D3Z4S2_MOUSE
Kinetochore-associated protein NSL1...
Nsl1
193Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029086 mRNA Translation: AAH29086.1
CCDSiCCDS15614.1
UniGeneiMm.32504

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029086 mRNA Translation: AAH29086.1
CCDSiCCDS15614.1
UniGeneiMm.32504

3D structure databases

SMRiQ8K305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077380

PTM databases

iPTMnetiQ8K305
PhosphoSitePlusiQ8K305

Proteomic databases

EPDiQ8K305
MaxQBiQ8K305
PaxDbiQ8K305
PeptideAtlasiQ8K305
PRIDEiQ8K305

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2685830 Nsl1

Phylogenomic databases

eggNOGiENOG410IXS8 Eukaryota
ENOG41125EG LUCA
HOGENOMiHOG000113863
HOVERGENiHBG080948
InParanoidiQ8K305
PhylomeDBiQ8K305

Miscellaneous databases

ChiTaRSiNsl1 mouse
PROiPR:Q8K305
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013950 Mis14/Nsl1
PANTHERiPTHR31749 PTHR31749, 1 hit
PfamiView protein in Pfam
PF08641 Mis14, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNSL1_MOUSE
AccessioniPrimary (citable) accession number: Q8K305
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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